Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds
BRITE hierarchy

(S)-norcoclaurine dopamine hydrolase (4-hydroxyphenylacetaldehyde-forming)

(S)-norcoclaurine + H2O = dopamine + 4-hydroxyphenylacetaldehyde [RN:R04305]

R04305;
(other) R04084
Reaction

(S)-norcoclaurine [CPD:C06160];
H2O [CPD:C00001]

The reaction makes a six-membered ring by forming a bond between C-6 of the 3,4-dihydroxyphenyl group of the dopamine and C-1 of the aldehyde in the imine formed between the substrates. The product is the precursor of the benzylisoquinoline alkaloids in plants. The enzyme, formerly known as (S)-norlaudanosoline synthase, will also catalyse the reaction of 4-(2-aminoethyl)benzene-1,2-diol + (3,4-dihydroxyphenyl)acetaldehyde to form (S)-norlaudanosoline, but this alkaloid has not been found to occur in plants.

EC 3.5.99.14 created 1984 as EC 4.2.1.78, modified 1999, transferred 2024 to EC 3.5.99.14

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