KEGG   ENZYME: 3.6.1.17
Entry
EC 3.6.1.17                 Enzyme                                 
Name
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical);
bis(5'-guanosyl)-tetraphosphatase;
bis(5'-adenosyl)-tetraphosphatase;
diguanosinetetraphosphatase (asymmetrical);
dinucleosidetetraphosphatase (asymmetrical);
diadenosine P1,P4-tetraphosphatase;
dinucleoside tetraphosphatase;
1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
Sysname
P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase
Reaction(IUBMB)
P1,P4-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP [RN:R01232]
Reaction(KEGG)
R01232;
(other) R00184 R00969 R02805
Substrate
P1,P4-bis(5'-guanosyl) tetraphosphate [CPD:C01261];
H2O [CPD:C00001]
Product
GTP [CPD:C00044];
GMP [CPD:C00144]
Comment
Also acts on bis(5'-xanthosyl)-tetraphosphate and, more slowly, on bis(5'-adenosyl)-tetraphosphate and bis(5'-uridyl)-tetraphosphate [cf. EC 3.6.1.41 bis(5'-nucleosyl)-tetraphosphatase (symmetrical)]
History
EC 3.6.1.17 created 1972, modified 1976, modified 1986
Pathway
ec00230  Purine metabolism
ec00240  Pyrimidine metabolism
ec01100  Metabolic pathways
Orthology
K01518  bis(5'-nucleosidyl)-tetraphosphatase
Genes
HSA318(NUDT2)
PTR465056(NUDT2)
PPS100971204(NUDT2)
GGO101152305(NUDT2)
PON100457720(NUDT2)
NLE100585591(NUDT2)
MCC701795(NUDT2)
MCF102126600 102144582(NUDT2)
MTHB126937430 126963246
CSAB103219273(NUDT2)
CATY105590062(NUDT2)
PANU101012330(NUDT2)
TGE112608093(NUDT2)
RRO104680000(NUDT2)
RBB108542177(NUDT2)
TFN117099055(NUDT2)
PTEH111536796(NUDT2)
CJC100391999(NUDT2)
SBQ101041101(NUDT2)
CSYR103273491(NUDT2)
MMUR105874358(NUDT2)
LCAT123646201(NUDT2)
OGA100959596(NUDT2)
MMU66401(Nudt2)
MCAL110293240(Nudt2)
MPAH110338907(Nudt2)
RNO297998(Nudt2)
MCOC116095839(Nudt2)
MUN110547105(Nudt2)
CGE100769146(Nudt2)
MAUA101844845(Nudt2)
PLEU114703240(Nudt2)
MORG121458439(Nudt2)
MFOT126509922
AAMP119803077 119826791(Nudt2)
NGI103741578(Nudt2)
HGL101699878(Nudt2)
CPOC100721527(Nudt2)
CCAN109686494(Nudt2)
DORD105993363(Nudt2)
DSP122122490(Nudt2)
NCAR124964549
OCU100343183(NUDT2)
OPI101525497(NUDT2) 101525854
TUP102486667(NUDT2)
CFA474746(NUDT2)
CLUD112649875(NUDT2)
VVP112927541(NUDT2)
VLG121495458(NUDT2)
AML100480031(NUDT2)
UMR103667047(NUDT2)
UAH113260512(NUDT2)
UAR123781242(NUDT2)
ELK111146086
LLV125083967
MPUF101676772(NUDT2)
ORO101367590(NUDT2)
EJU114218271(NUDT2)
ZCA113933944(NUDT2)
MLX118018012(NUDT2)
NSU110581541(NUDT2)
FCA101082099(NUDT2)
PYU121034586(NUDT2)
PBG122474900(NUDT2)
LRUF124525918
PTG102968333(NUDT2)
PPAD109252028(NUDT2)
AJU106975853(NUDT2)
HHV120241745(NUDT2)
BTA768044(NUDT2)
BOM102273937(NUDT2)
BIU109563186(NUDT2)
BBUB102400876(NUDT2)
CHX102169758(NUDT2)
OAS101123091(NUDT2)
ODA120860322 120866378
CCAD122431815(NUDT2)
SSC397577(NUDT2)
CFR102521003(NUDT2)
CBAI105078758(NUDT2)
CDK105085587(NUDT2)
VPC102534467(NUDT2)
BACU103006665(NUDT2)
LVE103079666(NUDT2)
OOR101278417(NUDT2)
DLE111163157(NUDT2)
PCAD102988464(NUDT2)
PSIU116754929(NUDT2)
ECB100054044(NUDT2)
EPZ103564364(NUDT2)
EAI106841396(NUDT2)
MYB102259354(NUDT2)
MYD102754972(NUDT2)
MMYO118653338 118667381(NUDT2)
MLF102429432(NUDT2)
PKL118716397(NUDT2)
HAI109371792(NUDT2)
DRO112304497(NUDT2)
SHON118979874(NUDT2)
AJM119053824(NUDT2)
PDIC114498659(NUDT2)
PHAS123820020(NUDT2)
MMF118629709(NUDT2)
RFQ117031977(NUDT2)
PALE102896710(NUDT2)
PGIG120612906(NUDT2)
PVP105306425(NUDT2)
RAY107502797(NUDT2)
MJV108395430(NUDT2)
TOD119231863(NUDT2)
SARA101545181(NUDT2)
LAV100657619(NUDT2)
TMU101361419
DNM101425616(NUDT2)
MDO100021241(NUDT2)
GAS123231041(NUDT2)
SHR100923669(NUDT2)
PCW110194532(NUDT2)
OAA100088234(NUDT2)
GGA427399(NUDT2)
MGP100549295(NUDT2)
CJO107305739(NUDT2)
NMEL110389297(NUDT2)
APLA101790344(NUDT2)
ACYG106045165(NUDT2)
AFUL116500658(NUDT2)
TGU100225183(NUDT2)
LSR110484147(NUDT2)
SCAN103820656(NUDT2)
PMOA120500081(NUDT2)
OTC121345269(NUDT2)
PRUF121350460(NUDT2)
GFR102037058(NUDT2)
FAB101813659(NUDT2)
PHI102108717(NUDT2)
PMAJ107216319(NUDT2)
CCAE111941034(NUDT2)
CCW104686550(NUDT2)
CBRC103623837(NUDT2)
ETL114060147(NUDT2)
ZAB106629169(NUDT2)
ACHL103809706(NUDT2)
FPG101924519(NUDT2)
FCH102057462(NUDT2)
CLV102090406(NUDT2)
EGZ104133822(NUDT2)
NNI104017972(NUDT2)
PLET104624009(NUDT2)
PCRI104024248(NUDT2)
PCAO104046049(NUDT2)
ACUN113489663(NUDT2)
TALA104367338(NUDT2)
PADL103923258(NUDT2)
AFOR103906351(NUDT2)
ACHC115336634(NUDT2)
HALD104319071(NUDT2)
CCRI104154907(NUDT2)
CSTI104562606(NUDT2)
EHS104510714(NUDT2)
CMAC104473235(NUDT2)
MUI104543019(NUDT2)
FGA104082884(NUDT2)
GSTE104250717(NUDT2)
LDI104352976(NUDT2)
OHA104337949(NUDT2)
NNT104400027(NUDT2)
DPUB104307802(NUDT2)
PGUU104457804(NUDT2)
ACAR104517763(NUDT2)
AVIT104267018(NUDT2)
CVF104290615(NUDT2)
CUCA104056542(NUDT2)
AAM106493695(NUDT2)
AROW112974596(NUDT2)
NPD112947372(NUDT2)
TGT104566545(NUDT2)
DNE112987800(NUDT2)
SCAM104152002(NUDT2)
ASN102378006(NUDT2)
AMJ102575786(NUDT2)
CPOO109307782(NUDT2)
GGN109297969(NUDT2)
PSS102448176(NUDT2)
CMY102936506(NUDT2)
CPIC101952762(NUDT2)
TST117886595(NUDT2)
CABI116824510(NUDT2)
MRV120408480(NUDT2)
ACS100565132(nudt2)
PVT110080485(NUDT2)
SUND121924178(NUDT2)
PBI103055787(NUDT2)
PMUR107298975(NUDT2)
CTIG120320211(NUDT2)
TSR106555387(NUDT2)
PGUT117659798(NUDT2)
VKO123030273(NUDT2)
PMUA114606354(NUDT2)
ZVI118077353(NUDT2)
GJA107122912(NUDT2) 107125474
STOW125436618(NUDT2)
XLA100049779(nudt2.S) 108707300
XTR448765(nudt2)
NPR108797456(NUDT2)
RTEM120925594(NUDT2)
BBUF120992298(NUDT2)
BGAR122924819(NUDT2)
DRE436595(nudt2)
SRX107739745 107754633
SANH107661859 107665228
SGH107579639 107584670 107600925 107600926
CCAR109045220 109054174
CAUA113038843(nudt2)
PPRM120490613 120490632
MAMB125252162(nudt2)
IPU108278969(nudt2)
PHYP113535629(nudt2)
SMEO124397863(nudt2)
TFD113646425(nudt2)
AMEX103027026(nudt2)
EEE113573439(nudt2)
TRU101079847(nudt2)
TNGGSTEN00020159G001
LCO104928938(nudt2)
NCC104941147(nudt2)
CGOB115008456(nudt2)
ELY117256602(nudt2)
EFO125893981(nudt2)
PLEP121953633(nudt2)
SLUC116034765(nudt2)
ECRA117944022(nudt2)
ESP116688551(nudt2)
PFLV114554646(nudt2)
GAT120834604(nudt2)
PPUG119193926(nudt2)
MSAM119886827(nudt2) 119890904
CUD121507186(nudt2)
ALAT119021951(nudt2)
MZE101464848(nudt2)
ONL100691256(nudt2)
OAU116326528(nudt2)
OLA101167782(nudt2)
OML112144648(nudt2)
XMA102237226(nudt2)
XCO114135263(nudt2)
XHE116710235(nudt2)
PRET103464996(nudt2)
PFOR103139584(nudt2)
PLAI106949156(nudt2)
PMEI106931326(nudt2)
GAF122834419(nudt2)
CVG107087980(nudt2)
CTUL119778558(nudt2)
GMU124856137(nudt2)
NFU107385477(nudt2)
KMR108239825(nudt2)
ALIM106523571(nudt2)
NWH119412207(nudt2)
AOCE111581206(nudt2)
MCEP125006322(nudt2)
CSEM103386417(nudt2)
POV109629183(nudt2)
SSEN122768031(nudt2)
HHIP117762239(nudt2)
HSP118104700(nudt2)
LCF108899692
SDU111221872(nudt2)
SLAL111670920(nudt2)
XGL120807364(nudt2)
HCQ109522578(nudt2)
BPEC110166722(nudt2)
MALB109956140(nudt2)
BSPL114856310(nudt2)
SASA106583421(nudt2)
STRU115150209(nudt2)
OTW112254934(nudt2)
OMY110528456(nudt2)
OGO124027662(nudt2)
ONE115143264(nudt2)
SALP111970424(nudt2)
SNH120064633(nudt2)
CCLU121578049(nudt2)
ELS105016785(nudt2)
SFM108931196
PKI111843780(nudt2)
AANG118212079(nudt2)
LOC102683637(nudt2)
PSPA121304784 121307145(nudt2)
ARUT117403958 117962531
CMK103180986(nudt2)
RTP109934791(nudt2)
BFO118410414
BBEL109482408 109482409
SPU756144 756973
APLC110987942
SKO100371369
DMEDmel_CG31713(Apf)
DER6541522
DSE6611887
DSIDsimw501_GD11976(Dsim_GD11976)
DYADyak_GE10149
DAN6496976
DSR110183217
DPO4817435
DPE6589271
DMN108162604
DWI6642607
DGR6562399
DMODmoj_GI11018
DAZ108610808
DNV115562645
DHE111603945
DVI6633962
CCAT101458320
BOD106623267
MDE101901313
SCAC106086895
LCQ111680238 111688415
LSQ119600804
HIS119651576 119651585
AGAAgaP_AGAP008495
ACOZ120955684
AARA120900671
ASTE118509891
AAG5573956
AALB109621853
CQUCpipJ_CPIJ003519
CPII120423117
CNS116341551 116341593 116351956
BCOO119070885
AME724681
ACER108003652
ALAB122720699
BIM100743272
BBIF117213058
BVK117236196
BVAN117158026
BTER100645111
BPYO122567814
CCAL108622608
OBB114879097
MGEN117221589 117221590
NMEA116433221
CGIG122399812
SOC105203166
MPHA105837502
AEC105154300
ACEP105618775
PBAR105430835
VEM105561993
HST105183962
DQU106745139
CFO105256553
FEX115242606
LHU105675125
PGC109859244
OBO105276354
PCF106786781
PFUC122522930
VPS122629828
NVI100117701
CSOL105359353
TPRE106650894 106654969
MDL103568904
CGLO123260000
FAS105264694
DAM107038214
AGIF122849053
LHT122497909
CCIN107271802
TCA658593
DPA109538612
SOY115884960
ATD109602210
CSET123309412
AGB108905043 111692992
LDC111502668
NVL108565952
PPYR116158745 116182759
OTU111429147
BMOR101741900
BMAN114253193
MSEX115454892
DPLKGM_214333
BANY112052881
NIQ126774690
PMAC106715802
PPOT106102441
PXU106114116
PRAP110994451
ZCE119832032
HAW110371218
HZE124638141
TNL113505248
SLIU111356184
OFU114357504
PXY105390704
CFEL113370351 113370355 113371571
API100164487
DNX107168462
AGS114123408
RMD113553176
BTAB109042310
DCI103511012
CLEC106662726 106663629 106666860 106666862
HHAL106686478
NLU111060252
PHUPhum_PHUM202300
FOC113209989
TPAL117647794
ZNE110837483 110837489
CSEC111865764
FCD110844934 110846021 110858643
DMK116925148
PVM113822959
PJA122247620
HAME121879132
PCLA123769815
PTRU123503804
HAZT108664899
EAF111697162
LSM121126411
PPOI119111952 119112497
CSCU111616147 111622491
CELCELE_Y37H9A.6(ndx-4)
CBRCBG_13634(Cbr-ndx-4)
BMYBM_BM6409(Bma-ndx-4)
LOALOAG_12459
TSPTsp_08826
HROHELRODRAFT_164652
PCAN112553481
BGT106068560
GAE121368762 121377048 121391491
HRF124117455
HRJ124289006
CRG105345601
MYI110444206 110455017
PMAX117334180
MMER123565784
OBI106872785
OSN115223230
NVE5502066
EPA110243084
ATEN116299953
AMIL114959385
PDAM113672949
SPIS111321736
DGT114535854
HMG100200531
SSLSS1G_02416
BFUBCIN_13g02790
GTRGLOTRDRAFT_49751
PFAPF3D7_0520600
PFHPFHG_03946
PREIPRSY57_0519700
PGABPGSY75_0520600
PYOPY17X_1238700
PCBPCHAS_1235900
PBEPBANKA_1235300
PVVPVVCY_1203620
PKNPKNH_1012300
PVXPVX_080215
PCYPCYB_102120
TANTA07740
TPVTP04_0303
TOTTOT_040000595
BEQBEWA_005670
BBOBBOV_II002610(18.m06210) BBOV_II002850(18.m06234) BBOV_II002910(18.m06240)
BMICBmR1_04g08620
BBIGBBBOND_0202780 BBBOND_0202820
CPVcgd3_1950
TGOTGME49_214780
TETTTHERM_000498260
NGRNAEGRDRAFT_49610 NAEGRDRAFT_76393
MMAIsS8_1576
NOCNoc_1415
NWRE3U44_14955
TEETel_03045
THIMKFB96_00810
AEHMlg_2766
HHAHhal_1059
HHKHH1059_24780
SSALSPISAL_01345
SPIUSPICUR_01430
SPIZGJ672_01365
NAXHC341_00990
WOCBA177_17835
SLIMSCL_0076
TBNTBH_C0663
RPJN234_36275
CGDCR3_4394(mutT)
CUUBKK79_31250
CPAUEHF44_10220
COXE0W60_30265
VINAKJ08_0363
SATSYN_03150
BMEBMEI0941
BDCDOE51_10590
BDZDOM22_12735
BDKHW988_11790
LJFFI9785_468 FI9785_756
LJHLJP_0715
LJNT285_02145
LACLBA0465(mutT)
LADLA14_0493
LAFSD55_0492
LGALGAS_0791
LHElhv_0501
LHLLBHH_1627
LHRR0052_09395
LHVlhe_0506
LHDHUO_09620
LCRLCRIS_00471 LCRIS_01264
LAMLA2_02490
LAILAC30SC_02430
LAYLAB52_02280
LKEWANG_1192
LGLAO203_05065
LAMYB1745_02815 B1745_02820
LPWLpgJCM5343_03900(mutT) LpgJCM5343_07450(mutT)
LTAH1A07_03610
LUUH4B44_08950
LRELreu_1639
LRFLAR_1530
LRUHMPREF0538_20803
LRTLRI_0349
LRRN134_09020
LFELAF_1667
LFFLBFF_1842
LMULBLM1_00765
LORAYI71_10300 AYI71_15225
LVALV515_08205
LFNLF145_07630
LPONLP475_07335
LGASLG045_08685
LPASKZE55_08665
LLEAYR59_03315
LFVLF543_01610
LBHLbuc_1841
LBNLBUCD034_1927
LPARFAM21731_01585
LCUPL11_006025
LKFDNL43_07905
LHILG8J22_02122(ndx1)
LBRLVIS_1780
LBKLVISKB_1764
LKOABN16_09235
LZYLZ3411_1793
LSUAH3M12_11925
LHOLOOC260_119360
LOLLACOL_0388
LNNF0161_02825
LPDAYR62_09120
PPEPEPE_0383
PPENT256_02005
PACIA4V11_08730
LHBD1010_11340
CAWQ783_09290
CARGRSJ17_06095
HHWNCTC503_00145(MutT)
CLOHMPREF0868_1086
RUKA4V00_00475
CCELCCDG5_0433
RCHRUM_04020
CAPREQM14_14620
BFICIY_19060
ACAEHYG86_15250
TSGHLK68_09950
MSTREGN60_03180
MFRMFE_05870
MFMMfeM64YM_0702
MFPMBIO_0857
MARGMARG145_0692(idi)
MHOMHO_0930
MHOMMLBD4_00500
MCANMCAN360_0541(idi)
MPHODA803_01570
MHYVMHSN_02355
MCLODK849_02510
MPHCDMC14_001290
MALANCTC10135_00815
MSAINCTC10113_01173
CYACYA_2163
CYBCYB_2747
CMPCha6605_2948
LETO77CONTIG1_03305(mutT4)
THEUHPC62_16340
CHONNIES4102_21770(rppH)
OXYHCG48_09920
MICMic7113_2890
ONIOsc7112_1387
MPROBJP34_12340
CSGCylst_2891
CALTCal6303_1193
RIVRiv7116_6423
FISFIS3754_27270(rppH)
TTHTT_C1859
TANTKNN15_07855
WCHwcw_1373
MINMinf_0419(mutT)
MKCkam1_578
MEAPMTHMO_0645
RBARB2978
PSLPsta_4141
PIRVN12_15900(ndx1)
RULUC8_49690(mutT4)
MFFMFFC18_49080
ROLCA51_04860
AHELQ31a_62270
LCREPla8534_20440
AAGGETAA8_66730(mutT4)
BVOPan97_18320
PLMPlim_3496
PEHSpb1_01810
PLSVT03_05490
PLHVT85_16270(mutT4)
FMRFuma_04506(mutT)
MRIMal4_01190
IPAIsop_0905
PBORBSF38_01662(mutT4)
AGVOJF2_16300(mutT4)
BROCIPI25_05345
HBSIPV69_12890
IPOIlyop_0521
AMOAnamo_1647
BANABARAN1_1119
BIHBIP78_1315
SRBP148_SR1C001G0705
SRGXF24_01035
MOXDAMO_2802(Nudt)
PWOUX70_C0001G0054
MEMMemar_2333
MBGBN140_2478
MEMAMMAB1_3339
MCHKMchiMG62_00640
CDIVCPM_0431
ABIAboo_0905
ACFAciM339_0101
PISPisl_0088 Pisl_0673
PCLPcal_0237 Pcal_2125
PASPars_2202 Pars_2356
PYRP186_0995 P186_2212
POGPogu_2509 Pogu_2686
TNETneu_1020 Tneu_1993
PYWPYWP30_01139 PYWP30_02258
TTNTTX_0860 TTX_1445
TUZTUZN_0609 TUZN_2151
NIRNSED_07780
NKRNKOR_07810
NIDNPIRD3C_2078
NINNADRNF5_0462
NIWNisw_06885
NCLC5F47_07520
NOXC5F49_07400
NUEC5F50_10715
NIPNsoK4_01170
NCTNMSP_0328
NICDSQ20_08345
CSYCENSYa_1469
NGANgar_c21350 Ngar_c34350
NVNNVIE_007940 NVIE_017110
NEVNTE_00652 NTE_02277
TAANMY3_02118(ndx1) NMY3_03349(mutT4)
NFNNFRAN_0755(mutT) NFRAN_2909(ndx)
NCVNCAV_0928
CSUCSUB_C1592
NBVT478_0358
TAHSU86_008610
NDVNDEV_1711
CCAINAS2_1107 NAS2_1117
MARHMia14_0108
 » show all
Reference
1  [PMID:6309793]
  Authors
Jakubowski H, Guranowski A.
  Title
Enzymes hydrolyzing ApppA and/or AppppA in higher plants. Purification and some properties of diadenosine triphosphatase, diadenosine tetraphosphatase, and phosphodiesterase from yellow lupin (Lupinus luteus) seeds.
  Journal
J Biol Chem 258:9982-9 (1983)
Reference
2  [PMID:181087]
  Authors
Vallejo CG, Lobaton CD, Quintanilla M, Sillero A, Sillero MA.
  Title
Dinucleosidasetetraphosphatase in rat liver and Artemia salina.
  Journal
Biochim Biophys Acta 438:304-9 (1976)
DOI:10.1016/0005-2744(76)90246-1
Reference
3  [PMID:4955726]
  Authors
Warner AH, Finamore FJ.
  Title
Isolation, purification, and characterization of P1,P4-diguanosine 5'-tetraphosphate asymmetrical-pyrophosphohydrolase from brine shrimp eggs.
  Journal
Biochemistry 4:1568-75 (1965)
DOI:10.1021/bi00884a016
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.17
IUBMB Enzyme Nomenclature: 3.6.1.17
ExPASy - ENZYME nomenclature database: 3.6.1.17
BRENDA, the Enzyme Database: 3.6.1.17
CAS: 37289-29-5
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