Entry
Name
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical);
bis(5'-guanosyl)-tetraphosphatase;
bis(5'-adenosyl)-tetraphosphatase;
diguanosinetetraphosphatase (asymmetrical);
dinucleosidetetraphosphatase (asymmetrical);
diadenosine P1,P4-tetraphosphatase;
dinucleoside tetraphosphatase;
1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase
Reaction(IUBMB)
P1,P4-bis(5'-guanosyl) tetraphosphate + H2O = GTP + GMP [RN:
R01232 ]
Reaction(KEGG)
Substrate
P1,P4-bis(5'-guanosyl) tetraphosphate [CPD:
C01261 ];
H2O [CPD:
C00001 ]
Product
Comment
Also acts on bis(5'-xanthosyl)-tetraphosphate and, more slowly, on bis(5'-adenosyl)-tetraphosphate and bis(5'-uridyl)-tetraphosphate [cf. EC
3.6.1.41 bis(5'-nucleosyl)-tetraphosphatase (symmetrical)]
History
EC 3.6.1.17 created 1972, modified 1976, modified 1986
Pathway
Orthology
K01518 bis(5'-nucleosidyl)-tetraphosphatase
K26955 bis(5'-nucleosidyl)-tetraphosphatase
Genes
MCF : 102126600 102144582(NUDT2)
MTHB : 126937430 126963246
AAMP : 119803077 119826791(Nudt2)
OPI : 101525497(NUDT2) 101525854
MMYO : 118653338 118667381(NUDT2)
MDT : 132212082(NUDT2) 132224316
ACYG : 106045165(NUDT2) 125181766
GJA : 107122912(NUDT2) 107125474
XLA : 100049779(nudt2.S) 108707300
SANH : 107661859 107665228
SGH : 107579639 107584670 107600925 107600926
CCAR : 109045220 109054174
PPRM : 120490613 120490632
MASI : 127428813 127430937
MSAM : 119886827(nudt2) 119890904
PSPA : 121304784 121307145(nudt2)
ARUT : 117403958 117962531
BBEL : 109482408 109482409
DSI : Dsimw501_GD11976(Dsim_GD11976)
CNS : 116341551 116341593 116351956
MGEN : 117221589 117221590
TPRE : 106650894 106654969
PPYR : 116158745 116182759
CFEL : 113370351 113370355 113371571
ACOO : 126833687 126842436 126845095 126847656
CLEC : 106662726 106663629 106666860 106666862
MQU : 128992322 128992529 129004009
FCD : 110844934 110846021 110858643
PPOI : 119111952 119112497
CSCU : 111616147 111622491
PMEO : 129586173 129589138
CEL : CELE_Y37H9A.6(ndx-4)
CBR : CBG_13634(Cbr-ndx-4)
BMY : BM_BM6409(Bma-ndx-4)
GAE : 121368762 121377048 121391491
MAEA : 128206964 128228755 128228798
CSAT : 104741604 104757353 104777037
BNA : 106356271 106367362 106370538 111214017
RSZ : 108818636 108828937 108851682 108859629
MINC : 123213841 123215693
HSYR : 120118028 120134360 120145295 120179605 120197170 120211519
DZI : 111282489 111287452 111318045
AHF : 112740369 112741650 112796330 112796723
LANG : 109339258 109359192
PCIN : 129284357 129310449
QSA : O6P43_025837 O6P43_032604
PAVI : 110745084 110765378
MSYL : 126595717 126606233
PALZ : 118039843 118046384
CILL : 122311995 122313545
SIND : 105156247 105160000
SSPL : 121746971 121751511 121778306 121780687
SHIS : 125187438 125211871
PLAG : 39740511(PADL01_0519600)
PMAL : PMUG01_10024000(Ap4AH)
PBRS : 92371278(MKS88_003191)
BBO : BBOV_II002610 BBOV_II002850 BBOV_II002910
BBIG : BBBOND_0202780 BBBOND_0202820
NGR : NAEGRDRAFT_49610 NAEGRDRAFT_76393
LJF : FI9785_468 FI9785_756
LCR : LCRIS_00471 LCRIS_01264
LAMY : B1745_02815 B1745_02820
LPW : LpgJCM5343_03900(mutT) LpgJCM5343_07450(mutT)
LOR : AYI71_10300 AYI71_15225
RUC : LCN94_00630 LCN94_05365
LET : O77CONTIG1_03305(mutT4)
CHON : NIES4102_21770(rppH)
PYW : PYWP30_01139 PYWP30_02258
NGA : Ngar_c21350 Ngar_c34350
NVN : NVIE_007940 NVIE_017110
TAA : NMY3_02118(ndx1) NMY3_03349(mutT4)
NFN : NFRAN_0755(mutT) NFRAN_2909(ndx)
CCAI : NAS2_1107 NAS2_1117
» show all
Taxonomy
Reference
Authors
Jakubowski H, Guranowski A.
Title
Enzymes hydrolyzing ApppA and/or AppppA in higher plants. Purification and some properties of diadenosine triphosphatase, diadenosine tetraphosphatase, and phosphodiesterase from yellow lupin (Lupinus luteus) seeds.
Journal
J Biol Chem 258:9982-9 (1983)
Reference
Authors
Vallejo CG, Lobaton CD, Quintanilla M, Sillero A, Sillero MA.
Title
Dinucleosidasetetraphosphatase in rat liver and Artemia salina.
Journal
Reference
Authors
Warner AH, Finamore FJ.
Title
Isolation, purification, and characterization of P1,P4-diguanosine 5'-tetraphosphate asymmetrical-pyrophosphohydrolase from brine shrimp eggs.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.17
ExPASy - ENZYME nomenclature database: 3.6.1.17
LinkDB
All DBs