Entry
Name
Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase;
Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase;
ADPRibase-Mn
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
CDP-choline phosphohydrolase
Reaction(IUBMB)
(1) CDP-choline + H2O = CMP + phosphocholine [RN:
R09538 ];
(2) ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate [RN:
R01054 ]
Reaction(KEGG)
Substrate
Product
Comment
Requires Mn2+. Unlike EC
3.6.1.13 , ADP-ribose diphosphatase, it cannot utilize Mg2+. ADP-D-ribose, CDP-choline, CDP-ethanolamine and ADP are substrates for this enzyme but ADP-D-glucose, UDP-D-glucose, CDP-D-glucose, CDP, CMP and AMP are not hydrolysed [2]. The mammalian enzyme hydrolyses cyclic ADP-ribose to 1-(5-phospho-beta-D-ribosyl)-AMP with ~100-fold lower efficiency than ADP-D-ribose [3]. In rat, the enzyme is found predominantly in thymus and spleen.
History
EC 3.6.1.53 created 2008
Orthology
K01517 manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
Genes
CPOC : 100728957 100735078
MYD : 102759013(ADPRM) 102769086
XLA : 108701161(adprm.2.L) 380120(adprm.L)
XTR : 100498212(adprm.2) 493375(adprm)
NPR : 108800850 108801529(ADPRM)
RTEM : 120918990 120919145(ADPRM)
BBUF : 121004707(ADPRM) 121005235
BGAR : 122924105 122931349
PWL : 138246128 138246129 138246130
GSH : 117367400 117367401(ADPRM)
CCAR : 109060013 109103884
PDAB : 135734670(adprm) 135739418
AMEX : 103043761 103044468(adprm)
MSAM : 119894653 119916291(adprm)
PSPA : 121295923 121296479
ARUT : 117423255(adprm) 117424544
CPLA : 122562028(adprm) 122562029
HOC : 132827659(adprm) 132827660
APLC : 110978621 110989831
MYI : 110448605 110448607 110448642
PMAX : 117331538 117331549 117331556
AIRR : 138313926 138324038 138324040 138324041
PDAM : 113672215 113672221
SPIS : 111329389 111329411
HMG : 100198316 100198467 105843075
CSAT : 104717803 104722510 104730974
GHI : 107887289 107946572 107949731 121224249
HSYR : 120122201 120155034 120155035
GMX : 100780293 100792911 100808714 100815255
GSJ : 114394051 114412007 114416398 114416400
PVU : 137807928 137821610 137821672 137822049
VRA : 106753290 106761055 106761199 106761426
VAR : 108330242 108330655 108330910 108334577
VUN : 114162196 114162277 114164439 114177949
VUM : 124824375 124824376 124824378 124841351 124846211
CCAJ : 109791847 109797016
APRC : 113847274 113847696
TPRA : 123884721 123898115
PSAT : 127073983 127083725
AHF : 112722265 112736302 112790435 112805522
LANG : 109328725 109362447 109362932
QSA : O6P43_022644 O6P43_030818
CSAV : 115711595 115711700
CMAX : 111490346 111495463
CPEP : 111782649 111802590
NTA : 107766620 107813486 107817197 107821971
SIND : 105157296 105179367
SSPL : 121754155 121758132 121761779 121763377 121763557 121789649 121789652
SMIL : 131005113 131019671 131019672
SHIS : 125200587 125212528 125223717
APAN : 127252867 127255344
HAN : 110879851 110879853 110879854
CSIN : 114281386 114290194
AEW : 130755831 130761416 130773301
OSA : 4344352(OsJ_25650) 4346295
DOSA : Os07g0688000 Os08g0557200
ATS : 109779171 109779172 109782101
TDC : 119302974 119302975 119311650 119311651 119330944 119340739
TAES : 123104872 123104873 123113158 123113159 123122678 123122679 123152762 123161595 123169332
TUA : 125510473 125510475 125521051 125527443 125527445 125556628 125556630
LPER : 127303041 127316255
LRD : 124652517 124672775 124680375
MFLO : 136473030 136477018 136545856
SITA : 101771143 101781539
PVIR : 120659981 120671022 120679067 120713827
PHAI : 112883342 112897528
PAUA : 133897158 133899784
ZOF : 121971410 121976251 122021109 122025701
SMO : SELMODRAFT_112495 SELMODRAFT_78013
CVR : CHLNCDRAFT_138033 CHLNCDRAFT_36248
OLU : OSTLU_5767 OSTLU_5807
OTA : OT_ostta01g03460 OT_ostta09g01710
BPG : Bathy01g04470 Bathy10g02940
MIS : MICPUN_60963 MICPUN_88004
MPP : MICPUCDRAFT_5295 MICPUCDRAFT_58423
CCP : CHC_T00008291001 CHC_T00009409001
EHX : EMIHUDRAFT_239808 EMIHUDRAFT_55032
» show all
Taxonomy
Reference
Authors
Canales J, Pinto RM, Costas MJ, Hernandez MT, Miro A, Bernet D, Fernandez A, Cameselle JC
Title
Rat liver nucleoside diphosphosugar or diphosphoalcohol pyrophosphatases different from nucleotide pyrophosphatase or phosphodiesterase I: substrate specificities of Mg(2+)-and/or Mn(2+)-dependent hydrolases acting on ADP-ribose.
Journal
Reference
Authors
Canales J, Fernandez A, Ribeiro JM, Cabezas A, Rodrigues JR, Cameselle JC, Costas MJ
Title
Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells.
Journal
Sequence
Reference
Authors
Canales J, Fernandez A, Rodrigues JR, Ferreira R, Ribeiro JM, Cabezas A, Costas MJ, Cameselle JC
Title
Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase.
Journal
Sequence
Reference
Authors
Rodrigues JR, Fernandez A, Canales J, Cabezas A, Ribeiro JM, Costas MJ, Cameselle JC
Title
Characterization of Danio rerio Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, the structural prototype of the ADPRibase-Mn-like protein family.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.53
ExPASy - ENZYME nomenclature database: 3.6.1.53
LinkDB
All DBs