KEGG   ENZYME: 3.6.1.53
Entry
EC 3.6.1.53                 Enzyme                                 
Name
Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase;
Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase;
ADPRibase-Mn
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
Sysname
CDP-choline phosphohydrolase
Reaction(IUBMB)
(1) CDP-choline + H2O = CMP + phosphocholine [RN:R09538];
(2) ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate [RN:R01054]
Reaction(KEGG)
R01054 R09538
Substrate
CDP-choline [CPD:C00307];
H2O [CPD:C00001];
ADP-D-ribose [CPD:C00301]
Product
CMP [CPD:C00055];
phosphocholine [CPD:C00588];
AMP [CPD:C00020];
D-ribose 5-phosphate [CPD:C00117]
Comment
Requires Mn2+. Unlike EC 3.6.1.13, ADP-ribose diphosphatase, it cannot utilize Mg2+. ADP-D-ribose, CDP-choline, CDP-ethanolamine and ADP are substrates for this enzyme but ADP-D-glucose, UDP-D-glucose, CDP-D-glucose, CDP, CMP and AMP are not hydrolysed [2]. The mammalian enzyme hydrolyses cyclic ADP-ribose to 1-(5-phospho-beta-D-ribosyl)-AMP with ~100-fold lower efficiency than ADP-D-ribose [3]. In rat, the enzyme is found predominantly in thymus and spleen.
History
EC 3.6.1.53 created 2008
Orthology
K01517  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
Genes
HSA56985(ADPRM)
PTR745728(ADPRM)
PPS100989248(ADPRM)
GGO101139187(ADPRM)
PON100436862(ADPRM)
NLE100601662(ADPRM)
MCC717991(ADPRM)
MCF102147209(ADPRM)
CSAB103242388(ADPRM)
CATY105581448(ADPRM)
PANU101011738(ADPRM)
TGE112609623(ADPRM)
RRO104675129(ADPRM)
RBB108520319(ADPRM)
TFN117067688(ADPRM)
PTEH111525452(ADPRM)
CJC100399298(ADPRM)
SBQ101035686(ADPRM)
CSYR103252151(ADPRM)
MMUR105878313(ADPRM)
OGA100947880(ADPRM)
MMU66358(Adprm)
MCAL110305174(Adprm)
MPAH110332174(Adprm)
RNO287406(Adprm)
MCOC116077456(Adprm)
MUN110552777(Adprm)
CGE100767531(Adprm)
MAUA101825901(Adprm)
PLEU114693125(Adprm)
MORG121456418(Adprm)
NGI103752060(Adprm)
HGL101700336(Adprm)
CPOC100728957 100735078
CCAN109697084(Adprm)
DORD105983501(Adprm)
DSP122117185(Adprm)
NCAR124979804
OCU100350105(ADPRM)
OPI101531379(ADPRM)
TUP102478915(ADPRM)
CFA479504(ADPRM)
VVP112924903(ADPRM)
VLG121499597(ADPRM)
AML100484618(ADPRM)
UMR103660405(ADPRM)
UAH113271215(ADPRM)
UAR123792077(ADPRM)
ELK111161136
LLV125087124
MPUF101676533(ADPRM)
ORO101374847(ADPRM)
EJU114225347(ADPRM)
ZCA113939129(ADPRM)
MLX118000074(ADPRM)
FCA101085161(ADPRM)
PYU121015893(ADPRM)
PBG122484963(ADPRM)
PTG102965979(ADPRM)
PPAD109245856(ADPRM)
AJU106983330(ADPRM)
HHV120231401(ADPRM)
BTA534038(ADPRM)
BOM102283155(ADPRM)
BIU109573878(ADPRM)
BBUB102391966(ADPRM)
CHX102181988(ADPRM)
OAS101113772(ADPRM)
ODA120865978(ADPRM)
CCAD122445103(ADPRM)
SSC100519388(ADPRM)
CFR102511144(ADPRM)
CBAI105077565(ADPRM)
CDK105095885(ADPRM)
VPC102542518(ADPRM)
BACU103010454(ADPRM)
LVE103089607(ADPRM)
OOR101271746(ADPRM)
DLE111186014(ADPRM)
PCAD102975974(ADPRM)
PSIU116745527(ADPRM)
ECB100073085(ADPRM)
EPZ103557154(ADPRM)
EAI106845767(ADPRM)
MYB102260362(ADPRM)
MYD102759013(ADPRM) 102769086
MMYO118672158(ADPRM)
MLF102438238(ADPRM)
MNA107544565(ADPRM)
PKL118726904(ADPRM)
HAI109389128(ADPRM)
DRO112308415(ADPRM)
SHON118974743(ADPRM)
AJM119056602(ADPRM)
PDIC114515391(ADPRM)
PHAS123809179(ADPRM)
MMF118634441(ADPRM)
RFQ117012874(ADPRM)
PALE102882253(ADPRM)
PGIG120589741(ADPRM)
PVP105291270(ADPRM)
RAY107498319(ADPRM)
MJV108392721(ADPRM)
TOD119230843(ADPRM)
SARA101552793(ADPRM)
LAV100672645(ADPRM)
TMU101361939
DNM101447474(ADPRM)
MDO100031391(ADPRM)
GAS123245031(ADPRM)
SHR100918137(ADPRM)
PCW110193957(ADPRM)
OAA100089526(ADPRM)
GGA768578(ADPRM)
PCOC116235560(ADPRM)
MGP100544671(ADPRM)
CJO107321978(ADPRM)
NMEL110407346(ADPRM)
APLA101805114(ADPRM)
AFUL116496663(ADPRM)
TGU100232304(ADPRM)
LSR110474918(ADPRM)
SCAN103823912(ADPRM)
PMOA120498260(ADPRM)
OTC121348142(ADPRM)
PRUF121352717(ADPRM)
GFR102037693(ADPRM)
FAB101822214(ADPRM)
PHI102102216(ADPRM)
PMAJ107212591(ADPRM)
CCAE111937534(ADPRM)
CCW104695677(ADPRM)
ETL114067596(ADPRM)
ZAB102068717(ADPRM)
FPG101917811(ADPRM)
FCH102046962(ADPRM)
CLV102096818(ADPRM)
NNI104014562(ADPRM)
ACUN113490956(ADPRM)
TALA104358472(ADPRM)
PADL103925367(ADPRM)
ACHC115342335(ADPRM)
AAM106496876(ADPRM)
AROW112970885(ADPRM)
DNE112995542(ADPRM)
ASN102378502(ADPRM)
AMJ102564317(ADPRM)
CPOO109311086(ADPRM)
PSS102454910(ADPRM)
CMY102947863(ADPRM)
CPIC101938771(ADPRM)
TST117887304(ADPRM)
CABI116838534(ADPRM)
MRV120383222(ADPRM)
ACS100557018(adprm)
PVT110075038(ADPRM)
SUND121921434(ADPRM)
PBI103062440(ADPRM)
PMUR107282490(ADPRM)
TSR106542940(ADPRM)
PGUT117660436(ADPRM)
VKO123035487(ADPRM)
PMUA114590700(ADPRM)
ZVI118079905(ADPRM)
STOW125428388(ADPRM)
XLA108701161(adprm.2.L) 380120(adprm.L)
XTR100498212(adprm.2) 493375(adprm)
NPR108800850 108801529(ADPRM)
RTEM120918990 120919145(ADPRM)
BBUF121004707(ADPRM) 121005235
BGAR122924105 122931349
DRE393393(adprm)
SANH107653999(adprm)
SGH107556466(adprm)
CCAR109060013 109103884
CAUA113112013(adprm)
PPRM120464390(adprm)
MAMB125255884(adprm)
IPU108274373(adprm)
PHYP113527145(adprm)
SMEO124388762(adprm)
TFD113662614(adprm)
AMEX103043761 103044468
EEE113570913(adprm)
TNGGSTEN00021735G001
LCO104919483(adprm)
NCC104963227(adprm)
CGOB115024397(adprm)
ELY117246741(adprm)
PLEP121958470(adprm)
SLUC116067530(adprm)
ECRA117936605(adprm)
PFLV114548639(adprm)
GAT120819488(adprm)
PPUG119212515(adprm)
MSAM119894653 119916291(adprm)
CUD121527869(adprm)
ALAT119009365(adprm)
MZE101478096(adprm)
ONL100710111(adprm)
OAU116330879(adprm)
OLA105356600 111946384
OML112153871(adprm)
XMA102227889(adprm)
XCO114151735(adprm)
XHE116726664(adprm)
PRET103481918(adprm)
PFOR103144496(adprm)
PLAI106964992(adprm)
PMEI106924853(adprm)
GAF122823157(adprm)
CVG107096249(adprm)
CTUL119796022(adprm)
GMU124875574(adprm)
NFU107373834 107397354
KMR108235853(adprm)
ALIM106531924
NWH119423774(adprm)
AOCE111572502(adprm)
CSEM103382417(adprm)
POV109643054(adprm)
SSEN122760971(adprm)
HHIP117753109(adprm)
HSP118101073(adprm)
LCF108890898(adprm)
SDU111219537(adprm)
SLAL111667088(adprm)
XGL120793977(adprm)
HCQ109512603(adprm)
BPEC110154055(adprm)
MALB109966666(adprm)
BSPL114845947(adprm)
SASA106589237(adprm)
OTW112233704(adprm)
OMY110498890(adprm)
OGO124040121(adprm)
ONE115144576(adprm)
SALP111967034(adprm)
SNH120029905(adprm)
ELS105023010(adprm)
SFM108939934 114909203
PKI111856920(adprm)
AANG118220164(adprm)
LOC102683124(adprm)
PSPA121295923 121296479
ARUT117423255(adprm) 117424544
LCM102354487(ADPRM)
CMK103175697(adprm)
RTP109912985 109912988(adprm)
BFO118429669
BBEL109483378
SCLV120330472
APLC110978621 110989831
SKO100369075
DSV119453708
RSAN119399329
RMP119179522
TUT107361847
DPTE113799744
DFR124494090
CSCU111636117
PTEP107445858
SDM118188538
HROHELRODRAFT_123984
LGILOTGIDRAFT_149678
PCAN112566952
BGT106056255 106058336
GAE121375974
HRF124142690 124142692
HRJ124290179
CRG105341087
MYI110448605 110448607 110448642
PMAX117331538 117331549 117331556
MMER123563371
OBI106867761
OSN115231016
LAK106161328
EPA110231729
ADF107346478
AMIL114976828
PDAM113672215 113672221
SPIS111329389 111329411
HMG100198316 100198467 105843075
ATHAT4G24730
ALY9303721
CRB17878964
CSAT104717803 104722510 104730974
EUSEUTSA_v10025788mg
BRP108868780
BNA111198213 111198217
RSZ108839677
THJ104824991
CPAP110814750
CIT102626985
CICCICLE_v10021198mg
PVY116137190
MINC123211286
TCC18604977
GRA105764744 105788525
GHI107887289 107946572 107949731 121224249
GAB108483804 108486747
DZI111284677
EGR104417636
GMX100780293 100792911 100808714 100815255
GSJ114394051 114412007 114416398 114416400
PVUPHAVU_003G206000g PHAVU_009G172700g PHAVU_009G172800g PHAVU_009G172900g
VRA106753290 106761055 106761199 106761426
VAR108330242 108330655 108330910 108334577
VUN114162196 114162277 114164439 114177949
CCAJ109791847 109797016
APRC113847274 113847696
MTRMTR_3g076590 MTR_4g104690
CAM101501360 101505685
LJALj0g3v0335139.1(Lj0g3v0335139.1) Lj0g3v0335139.2(Lj0g3v0335139.2)
ADU107478909 107489578
AIP107629382 107631189
AHF112722265 112736302 112790435 112805522
LANG109328725 109362447 109362932
FVE101314949
RCN112175288
PPER18777900
PMUM103337949
PAVI110745894
PDUL117627823
MDM103455068
PXB103952940
ZJU107418316
MNT21401927
CSV101207870
CMO103483938
BHJ120082712
MCHA111009099
CMAX111490346 111495463
CMOS111431448
CPEP111782649 111802590
RCU8278270
JCU105640292
HBR110648058
MESC110617701
POP7484431
PEU105118923 105136717
PALZ118044772
JRE108986726
QSU112033540
QLO115964155
TWL119985279
VVI100265684
VRI117904811
SLY101246124
SPEN107012378
SOT102587466
CANN107862601
NTA107766620 107813486 107817197 107821971
NSY104218770 104242644
NTO104099242 104104495
NAU109208701 109239772
INI109180078
ITR116010271
SIND105157296 105179367
OEU111396293 111407625
EGT105950434 105975095
SSPL121754155 121758132 121761779 121763377 121763557 121789649 121789652
HAN110879851 110879853 110879854
ECAD122590303
LSV111907042
CCAV112508842
DCR108206584
CSIN114281386 114290194
BVG104884525
SOE110802382
CQI110687827 110715551
NNU104591517
MING122079719
TSS122670842
PSOM113341967
NCOL116250524
OSA4344352 4346295
DOSAOs07t0688000-01(Os07g0688000) Os08t0557200-01(Os08g0557200)
OBR102712498
BDI100823930 100846848
ATS109779171 109779172 109782101
TDC119302974 119302975 119311650 119311651 119330944 119340739
TAES123104872 123104873 123113158 123113159 123122678 123122679 123152762 123161595 123169332
TUA125510473 125510475 125521051 125527443 125527445 125556628 125556630
SBI110433154 8057997
ZMA100191359 103653268
SITA101771143 101781539
SVS117846620 117860064
PVIR120659981 120671022 120679067 120713827
PHAI112883342 112897528
PDA103719827
EGU105052964
MUS103970733
DCT110114792
PEQ110018884 110024473
AOF109830064 109843108
ATR18442745
SMOSELMODRAFT_112495 SELMODRAFT_78013
PPP112276109 112292179
MNGMNEG_2546 MNEG_4962
CSLCOCSUDRAFT_12655
CVRCHLNCDRAFT_138033 CHLNCDRAFT_36248
APROF751_1456
OLUOSTLU_5767 OSTLU_5807
OTAOT_ostta01g03460 OT_ostta09g01710
BPGBathy01g04470 Bathy10g02940
MISMICPUN_60963 MICPUN_88004
MPPMICPUCDRAFT_5295 MICPUCDRAFT_58423
CMECYME_CMQ308C
GSLGasu_29190
CCPCHC_T00008291001 CHC_T00009409001
SMINv1.2.028698.t1(symbB.v1.2.028698.t1)
FCYFRACYDRAFT_160037
TPSTHAPSDRAFT_16656
PIFPITG_00701
PSOJPHYSODRAFT_315792
SPARSPRG_19962
EHXEMIHUDRAFT_239808 EMIHUDRAFT_55032
GTTGUITHDRAFT_135549
PBWD172_001300
PAGAPAGA_a0239
SPHKSKP52_05880
GRCGI584_05825
ARUASPU41_17480
ARTHC3B78_11265
LUOHHL09_06745
PBASSMSP2_02132
ALUSSTSP2_00146
PFERIRI77_33965
BCACCGC64_03390
MCOSGM418_24565
CBAECOR50_00170
SPDRG6053_15520
POMMED152_12824
POBLPB03_06815
PRNBW723_00645
POLABXQ17_06130
LULLPB138_09200
CPHCpha266_2539
PPHPpha_2785
PAAPaes_0208
CTSCtha_1338
 » show all
Reference
1  [PMID:7819284]
  Authors
Canales J, Pinto RM, Costas MJ, Hernandez MT, Miro A, Bernet D, Fernandez A, Cameselle JC
  Title
Rat liver nucleoside diphosphosugar or diphosphoalcohol pyrophosphatases different from nucleotide pyrophosphatase or phosphodiesterase I: substrate specificities of Mg(2+)-and/or Mn(2+)-dependent hydrolases acting on ADP-ribose.
  Journal
Biochim Biophys Acta 1246:167-77 (1995)
DOI:10.1016/0167-4838(94)00191-I
Reference
2  [PMID:18352857]
  Authors
Canales J, Fernandez A, Ribeiro JM, Cabezas A, Rodrigues JR, Cameselle JC, Costas MJ
  Title
Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase: a novel metallophosphoesterase family preferentially expressed in rodent immune cells.
  Journal
Biochem J 413:103-13 (2008)
DOI:10.1042/BJ20071471
  Sequence
[rno:287406]
Reference
3  [PMID:19379742]
  Authors
Canales J, Fernandez A, Rodrigues JR, Ferreira R, Ribeiro JM, Cabezas A, Costas MJ, Cameselle JC
  Title
Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn(2+)-dependent ADP-ribose/CDP-alcohol pyrophosphatase.
  Journal
FEBS Lett 583:1593-8 (2009)
DOI:10.1016/j.febslet.2009.04.023
  Sequence
[rno:287406]
Reference
4  [PMID:22848751]
  Authors
Rodrigues JR, Fernandez A, Canales J, Cabezas A, Ribeiro JM, Costas MJ, Cameselle JC
  Title
Characterization of Danio rerio Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, the structural prototype of the ADPRibase-Mn-like protein family.
  Journal
PLoS One 7:e42249 (2012)
DOI:10.1371/journal.pone.0042249
  Sequence
[dre:393393]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.53
IUBMB Enzyme Nomenclature: 3.6.1.53
ExPASy - ENZYME nomenclature database: 3.6.1.53
BRENDA, the Enzyme Database: 3.6.1.53
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