Entry Name diadenosine hexaphosphate hydrolase (ATP-forming);
Class Hydrolases;BRITE hierarchy
Sysname P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming)
Reaction(IUBMB) (1) P1,P6-bis(5'-adenosyl)hexaphosphate + H2O = 2 ATP [RN:
R09879 ];
(2) P1,P5-bis(5'-adenosyl)pentaphosphate + H2O = ATP + ADP [RN:
R09880 ];
(3) P1,P4-bis(5'-adenosyl)tetraphosphate + H2O = ATP + AMP [RN:
R00184 ]
Reaction(KEGG) Substrate P1,P6-bis(5'-adenosyl)hexaphosphate [CPD:
C20190 ];
H2O [CPD:
C00001 ];
P1,P5-bis(5'-adenosyl)pentaphosphate [CPD:
C04058 ];
P1,P4-bis(5'-adenosyl)tetraphosphate [CPD:
C01260 ]
Product Comment The enzyme requires the presence of the divalent cations (Mn2+, Mg2+, Zn2+, and Co2+). It hydrolyses P1,P4-bis(5'-guanosyl) tetraphosphate very slowly [cf. EC
3.6.1.17 , bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)].
History EC 3.6.1.61 created 2012
Pathway Orthology K18445 diadenosine hexaphosphate hydrolase (ATP-forming)
Genes » show all Taxonomy Reference Authors Iwai T, Kuramitsu S, Masui R
Title The Nudix hydrolase Ndx1 from Thermus thermophilus HB8 is a diadenosine hexaphosphate hydrolase with a novel activity.
Journal Sequence Other DBs ExplorEnz - The Enzyme Database: 3.6.1.61
ExPASy - ENZYME nomenclature database: 3.6.1.61
LinkDB All DBs
