Entry
Name
diadenosine hexaphosphate hydrolase (ATP-forming);
Ndx1
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
P1,P6-bis(5'-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming)
Reaction(IUBMB)
(1) P1,P6-bis(5'-adenosyl)hexaphosphate + H2O = 2 ATP [RN:
R09879 ];
(2) P1,P5-bis(5'-adenosyl)pentaphosphate + H2O = ATP + ADP [RN:
R09880 ];
(3) P1,P4-bis(5'-adenosyl)tetraphosphate + H2O = ATP + AMP [RN:
R00184 ]
Reaction(KEGG)
Substrate
P1,P6-bis(5'-adenosyl)hexaphosphate [CPD:
C20190 ];
H2O [CPD:
C00001 ];
P1,P5-bis(5'-adenosyl)pentaphosphate [CPD:
C04058 ];
P1,P4-bis(5'-adenosyl)tetraphosphate [CPD:
C01260 ]
Product
Comment
The enzyme requires the presence of the divalent cations (Mn2+, Mg2+, Zn2+, and Co2+). It hydrolyses P1,P4-bis(5'-guanosyl) tetraphosphate very slowly [cf. EC
3.6.1.17 , bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)].
History
EC 3.6.1.61 created 2012
Pathway
Orthology
K18445 diadenosine hexaphosphate hydrolase (ATP-forming)
Genes
» show all
Taxonomy
Reference
Authors
Iwai T, Kuramitsu S, Masui R
Title
The Nudix hydrolase Ndx1 from Thermus thermophilus HB8 is a diadenosine hexaphosphate hydrolase with a novel activity.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.61
ExPASy - ENZYME nomenclature database: 3.6.1.61
LinkDB
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