KEGG   ENZYME: 3.6.1.65
Entry
EC 3.6.1.65                 Enzyme                                 
Name
(d)CTP diphosphatase;
(d)CTP pyrophosphohydrolase;
(d)CTP diphosphohydrolase;
nudG (gene name)
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
Sysname
(deoxy)cytidine 5'-triphosphate diphosphohydrolase
Reaction(IUBMB)
(1) CTP + H2O = CMP + diphosphate [RN:R00515];
(2) dCTP + H2O = dCMP + diphosphate [RN:R01668]
Reaction(KEGG)
R00515 R01668
Substrate
CTP [CPD:C00063];
H2O [CPD:C00001];
dCTP [CPD:C00458]
Product
CMP [CPD:C00055];
diphosphate [CPD:C00013];
dCMP [CPD:C00239]
Comment
The enzyme, characterized from the bacterium Escherichia coli, is specific for the pyrimidine nucleotides CTP and dCTP. It also acts on 5-methyl-dCTP, 5-hydroxy-dCTP and 8-hydroxy-dGTP.
History
EC 3.6.1.65 created 2013
Pathway
ec00240  Pyrimidine metabolism
ec01100  Metabolic pathways
Orthology
K08320  (d)CTP diphosphatase
Genes
ECO: b1759(nudG)
ECJ: JW1748(nudG)
ECD: ECDH10B_1897(nudG)
EBW: BWG_1572(nudG)
ECOK: ECMDS42_1434(nudG)
ECOC: C3026_10040
ECE: Z2791
ECS: ECs_2465(nudG)
ECF: ECH74115_2479(nudG)
ETW: ECSP_2327(nudG)
ELX: CDCO157_2299
EOI: ECO111_2270(nudG)
EOJ: ECO26_2534(nudG)
EOH: ECO103_1952(nudG)
ECOO: ECRM13514_2257
ECOH: ECRM13516_2162
ESL: O3K_11165
ESO: O3O_14450
ESM: O3M_11145
ECK: EC55989_1927(nudG)
ECG: E2348C_1887(nudG)
EOK: G2583_2205(nudG)
ELR: ECO55CA74_10595
ELH: ETEC_1791
ECW: EcE24377A_1983(nudG)
EUN: UMNK88_2225
ECP: ECP_1705
ENA: ECNA114_1805
ECOS: EC958_1980(nudG)
ECV: APECO1_829(ynjG)
ECOA: APECO78_12630
ECX: EcHS_A1843(nudG)
ECM: EcSMS35_1430(nudG)
ECY: ECSE_1930
ECR: ECIAI1_1820(nudG)
ECQ: ECED1_1961(nudG)
EUM: ECUMN_2048(nudG)
ECT: ECIAI39_1295(nudG)
EOC: CE10_2039(nudG)
EBR: ECB_01728(nudG)
ECOB: C3029_13190
EBL: ECD_01728(nudG)
EBE: B21_01716(nudG)
EBD: ECBD_1885
ECI: UTI89_C1955(ynjG)
EIH: ECOK1_1880(nudG)
ECZ: ECS88_1811(nudG)
ECC: c2160
ELO: EC042_1924(nudG)
ELN: NRG857_08815
ESE: ECSF_1620
ECL: EcolC_1873
EKO: EKO11_2016
EKF: KO11_13935(nudG)
EAB: ECABU_c20160(nudG)
EDH: EcDH1_1883
EDJ: ECDH1ME8569_1703(nudG)
ELU: UM146_08345
ELW: ECW_m1928(nudG)
ELL: WFL_09460(nudG)
ELC: i14_1979
ELD: i02_1979
ELP: P12B_c1324(nudG)
ELF: LF82_1533(nudG)
ECOL: LY180_09160
ECOI: ECOPMV1_01857(nudG)
ECOJ: P423_09365
EFE: EFER_1306(nudG)
EAL: EAKF1_ch4290c(nudG)
EMA: C1192_03500
ESZ: FEM44_23725
ERUY: OSH18_03520(nudG)
STY: STY1813
STT: t1180
SEX: STBHUCCB_12670
SENT: TY21A_05995
STM: STM1301
SEO: STM14_1579
SEV: STMMW_13081
SEY: SL1344_1236
SEM: STMDT12_C13180
SEJ: STMUK_1268
SEB: STM474_1305(nudg)
SEF: UMN798_1357
SETU: STU288_02830
SETC: CFSAN001921_10650
SENR: STMDT2_12341
SEND: DT104_12771
SENI: CY43_06625
SEEN: SE451236_12370
SPT: SPA1543
SEK: SSPA1434
SPQ: SPAB_02043
SEI: SPC_2431
SEC: SCH_1323(nudG)
SEH: SeHA_C1428
SHB: SU5_01920
SENH: CFSAN002069_02500
SEEH: SEEH1578_15735
SEE: SNSL254_A1412
SENN: SN31241_23740
SEW: SeSA_A1395
SEA: SeAg_B1874
SENS: Q786_08750
SED: SeD_A2045
SEG: SG1815
SEL: SPUL_1115
SEGA: SPUCDC_1115
SET: SEN1742
SENA: AU38_09015
SENO: AU37_09020
SENV: AU39_09025
SENQ: AU40_10075
SENL: IY59_09220
SENJ: CFSAN001992_05090
SEEC: CFSAN002050_12905
SEEB: SEEB0189_013025
SEEP: I137_05130
SENB: BN855_13350
SENE: IA1_06420
SENC: SEET0819_13155
SES: SARI_01678
SBG: SBG_1154
SBZ: A464_1256
SBV: N643_05505
SALZ: EOS98_12965
SFL: SF1466
SFX: S1581
SFV: SFV_1459
SFE: SFxv_1654(nudG)
SFN: SFy_2095
SFS: SFyv_2149
SFT: NCTC1_01577(nudG)
SSN: SSON_1397
SBO: SBO_1330
SDY: SDY_1516
SDZ: Asd1617_02025
SHQ: A0259_12855
ENC: ECL_02458
ENL: A3UG_08970
ECLG: EC036_17290
ECLE: ECNIH2_09580
ECLN: ECNIH4_13690
ECLI: ECNIH5_08635
ECLX: LI66_08955
ECLY: LI62_09730
ECLZ: LI64_09020
ECLO: ENC_14560
EHM: AB284_16070
EXF: BFV63_08990
ECLA: ECNIH3_08645
ECLC: ECR091_08620
EAU: DI57_09935
EKB: BFV64_09060
ENO: ECENHK_08960
EEC: EcWSU1_01770(nudG)
ELG: BH714_05195
ECAN: CWI88_13455
ERN: BFV67_08510
ECLS: LI67_010015
ECHG: FY206_10365
ESH: C1N69_09110
EPT: HWQ17_03790
ENT: Ent638_1687
EAS: Entas_1704
ENR: H650_04435
ENX: NI40_009075
ENF: AKI40_2720
LNI: CWR52_03220
EBG: FAI37_20375
END: A4308_13655
ENZ: G0034_08780
ENS: HWQ15_17105
ENK: LOC22_19365
EHU: D5067_0013765
EMOR: L6Y89_08650
ENB: ELK40_09320
EQU: OM418_08650
EPU: QVH39_09130
EDY: F0320_08495
ESA: ESA_02159
CSK: ES15_2309(nudG)
CSZ: CSSP291_10245
CSJ: CSK29544_03445
CCON: AFK62_08285
CDM: AFK67_08405
CSI: P262_03343
CMJ: AFK66_011285
CUI: AFK65_08240
CMW: AFK63_10210
CTU: CTU_18130(nudG)
KPN: KPN_01211(nudG)
KPU: KP1_2239(nudG)
KPM: KPHS_21070
KPP: A79E_2975
KPH: KPNIH24_18075
KPZ: KPNIH27_10260
KPV: KPNIH29_10765
KPW: KPNIH30_11010
KPY: KPNIH31_10390
KPG: KPNIH32_10850
KPC: KPNIH10_10455
KPQ: KPR0928_10625
KPT: VK055_1247
KPR: KPR_2256
KPJ: N559_3070
KPI: D364_06280
KPA: KPNJ1_03298
KPS: KPNJ2_03290
KPX: PMK1_03590(nudG)
KPB: FH42_01920
KPNE: KU54_015650
KPNU: LI86_15960
KPNK: BN49_2345
KVA: Kvar_3103
KPE: KPK_3232(nudG)
KPK: A593_20785
KVD: KR75_18630
KVQ: SP68_25075
KOX: KOX_18090
KOE: A225_2474
KOY: J415_19545
KOM: HR38_16380
KMI: VW41_08810
KOK: KONIH1_11885
KOC: AB185_24110
KQU: AVR78_15440
EAE: EAE_21650
EAR: CCG29605
KQV: B8P98_16285
KLL: BJF97_12435
KLW: DA718_16540
KAR: LGL98_14940
KGR: JJJ10_16435
KPAS: LUW96_18460
KLC: K7H21_16435
KLM: BWI76_11620
REE: electrica_03020(nudG)
ROR: RORB6_08610
RON: TE10_12180
RPLN: B1209_15960
RAO: DSD31_15190
RTG: NCTC13098_04217(nudG)
CRO: ROD_12991(nudG)
CKO: CKO_01786
CFD: CFNIH1_16170
CBRA: A6J81_02600
CWE: CO701_11820
CYO: CD187_13695
CPOT: FOB25_01465
CFQ: C2U38_13680
CSED: JY391_12360
CAMA: F384_05870
CAF: AL524_16450
CIF: AL515_10675
CFAR: CI104_11735
CIR: C2U53_20940
CIE: AN232_19445
CPAR: CUC49_06260
CTEL: GBC03_18840
CITZ: E4Z61_03635
CARS: E1B03_11705
CIX: M4I31_13415
CIB: HF677_013385
CENS: P2W74_13365
EBT: EBL_c23440(nudG)
CNT: JT31_03780
CEM: LH23_14460
CEN: LH86_13640
CLAP: NCTC11466_02677(nudG)
PGE: LG71_18500
ESC: Entcl_2598
KLE: AO703_09225
KSA: C813_05065
KOR: AWR26_14900
KRD: A3780_09295
KCO: BWI95_15030
KOT: EH164_12955
KPSE: IP581_09770
KOB: HF650_10135
KOO: O9K67_14575
KOU: C0557_09795
KGO: CEW81_14295
KIE: NCTC12125_01678(nudG)
KAS: KATP_26020
KLU: K7B04_15510
KCY: RIN60_13215
LAX: APT61_13225
LEI: C2U54_14515
LEH: C3F35_02255
LEE: DVA44_14290
LER: GNG29_09360
LEA: GNG26_09020
LPNU: KQ929_11800
LEY: DVA43_08410
LAZ: A8A57_08840
LEF: LJPFL01_1716
LEW: DAI21_17800
BUF: D8682_24895
BAGE: BADSM9389_24810
BFT: MNO13_14925
BSEL: RHD99_14520
AHN: NCTC12129_02264(nudG)
ASUB: NLZ15_12250
YRE: HEC60_04120
SGOE: A8O29_013700
KIN: AB182_10015
PDZ: HHA33_12620
METY: MRY16398_22170(nudG)
IZH: FEM41_15975
PSHI: SAMEA2665130_2102(nudG_2)
PSGC: G163CM_15360(nudG)
SCOL: KFZ77_07815
SUPE: P0H77_09835
AAPT: QNH14_09815
EBF: D782_2568
EBC: C2U52_20590
EBU: CUC76_04640
EBB: F652_1564
YPE: YPO2167(nudG)
YPK: y2154
YPH: YPC_2144(nudG)
YPA: YPA_1524
YPN: YPN_1633
YPM: YP_1967(nudG)
YPP: YPDSF_0967
YPG: YpAngola_A2341(nudG)
YPZ: YPZ3_1678(nudG)
YPT: A1122_15320
YPD: YPD4_1905(nudG)
YPX: YPD8_1644(nudG)
YPW: CH59_3956(nudG)
YPJ: CH55_571(nudG)
YPV: BZ15_1373(nudG)
YPL: CH46_2946(nudG)
YPS: YPTB2093(nudG)
YPO: BZ17_371(nudG)
YPI: YpsIP31758_1977(nudG)
YPY: YPK_2086
YPB: YPTS_2157
YPQ: DJ40_212(nudG)
YPU: BZ21_1373(nudG)
YPR: BZ20_17(nudG)
YPC: BZ23_1656(nudG)
YPF: BZ19_1449(nudG)
YEN: YE2255(nudG)
YEP: YE105_C2293
YEY: Y11_11171
YEW: CH47_1682(nudG)
YET: CH48_3944(nudG)
YEF: FORC2_1925
YEE: YE5303_17571(nudG)
YSI: BF17_19510
YAL: AT01_535(nudG)
YFR: AW19_1095(nudG)
YIN: CH53_3857(nudG)
YKR: CH54_567
YRO: CH64_459(nudG)
YRU: BD65_236(nudG)
YRB: UGYR_01260
YMA: DA391_10675
YHI: D5F51_09400
YEL: LC20_02530
YCA: F0T03_11490
YMO: HRD69_14980
YAS: N0H69_14895
YKI: HRD70_16100
YEG: PL78_04750
SMAR: SM39_2189(nudG)
SMAC: SMDB11_1985(nudG)
SMW: SMWW4_v1c27290(nudG)
SPE: Spro_2716
SRR: SerAS9_2747
SRL: SOD_c25580(nudG)
SRY: M621_13960
SPLY: Q5A_014175(nudG)
SRS: SerAS12_2748
SRA: SerAS13_2749
SMAF: D781_2464
SLQ: M495_13620
SERF: L085_15165
SERS: SERRSCBI_12815
SFW: WN53_22310
SFG: AV650_18140
SRZ: AXX16_2663
SERM: CLM71_12810
SQU: E4343_02490
SFJ: SAMEA4384070_2761(nudG)
SOF: NCTC11214_04164(nudG)
SSUR: ATE40_010280
SURI: J0X03_10310
SRHZ: FO014_20885
SENP: KHA73_13420
SNEM: NLX84_13760
SNEV: OI978_18895
SGRI: SGBXF1_02761(nudG)
SSAR: SSARUM_002644
SFO: Z042_00485
RAH: Rahaq_2058
RACE: JHW33_06535
RAQ: Rahaq2_2191
RAA: Q7S_10440
ROX: BV494_05020
RVC: J9880_19190
RIU: I2123_12295
GQU: AWC35_00110
EAME: GXP68_09885
RBAD: H2866_18235
RCB: O1V66_05810
CARU: P0E69_09955
NIG: C1N62_08010
SGL: SG1362
SOD: Sant_1823(nudG)
EIC: NT01EI_1652
ETD: ETAF_1388
ETE: ETEE_3499
ETR: ETAE_1495(nudG)
ETC: ETAC_07035
EDW: QY76_12445
EDL: AAZ33_07765
EHO: A9798_09530
HAV: AT03_10085
HPAR: AL518_13500
OPO: DSM2777_10135
LPV: HYN51_00160
PRAG: EKN56_04855
PFQ: QQ39_11215
LRI: NCTC12151_01462(nudG)
LGB: V8L73_07925
PGB: H744_2c2750
PGH: FH974_10805
GKD: K6Q96_12195
TACT: SG35_014315
FBL: Fbal_0702
TKM: TK90_2491
TVR: TVD_00210
RLAC: QMO75_02580
DEK: DSLASN_26880
DMP: FAK_19290(nudG)
CTHI: THC_0949
BREY: MNR06_02445
PSTI: SOO65_02820
ANQ: PYS63_00085
PMET: G4Y79_08730
DMB: E5F05_20255
LPRO: PQO03_19505
TMED: DWB79_06215
TPER: IWA51_07860
SASS: MUG09_10230
GEX: GETHOR_18980
MSIL: METEAL_29150(nudG)
MSEA: METESE_30880
SGN: SGRA_2437(nudG)
FCU: NOX80_18275
DAP: Dacet_2915
SCHV: BRCON_1511
 » show all
Reference
1  [PMID:11053429]
  Authors
O'Handley SF, Dunn CA, Bessman MJ
  Title
Orf135 from Escherichia coli Is a Nudix hydrolase specific for CTP, dCTP, and 5-methyl-dCTP.
  Journal
J Biol Chem 276:5421-6 (2001)
DOI:10.1074/jbc.M004100200
  Sequence
[eco:b1759]
Reference
2  [PMID:12509230]
  Authors
Fujikawa K, Kasai H
  Title
The oxidized pyrimidine ribonucleotide, 5-hydroxy-CTP, is hydrolyzed efficiently  by the Escherichia coli recombinant Orf135 protein.
  Journal
DNA Repair (Amst) 1:571-6 (2002)
DOI:10.1016/S1568-7864(02)00057-5
  Sequence
[eco:b1759]
Reference
3  [PMID:15381107]
  Authors
Kamiya H, Iida E, Harashima H
  Title
Important amino acids in the phosphohydrolase module of Escherichia coli Orf135.
  Journal
Biochem Biophys Res Commun 323:1063-8 (2004)
DOI:10.1016/j.bbrc.2004.08.201
  Sequence
[eco:b1759]
Reference
4  [PMID:15823026]
  Authors
Iida E, Satou K, Mishima M, Kojima C, Harashima H, Kamiya H
  Title
Amino acid residues involved in substrate recognition of the Escherichia coli Orf135 protein.
  Journal
Biochemistry 44:5683-9 (2005)
DOI:10.1021/bi048071o
  Sequence
[eco:b1759]
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.65
IUBMB Enzyme Nomenclature: 3.6.1.65
ExPASy - ENZYME nomenclature database: 3.6.1.65
BRENDA, the Enzyme Database: 3.6.1.65
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