Entry
Name
XTP/dITP diphosphatase;
hypoxanthine/xanthine dNTP pyrophosphatase;
rdgB (gene name)
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
BRITE hierarchy
Sysname
XTP/dITP diphosphohydrolase (diphosphate-forming)
Reaction(IUBMB)
(1) XTP + H2O = XMP + diphosphate [RN:
R02720 ];
(2) dITP + H2O = dIMP + diphosphate [RN:
R03531 ];
(3) ITP + H2O = IMP + diphosphate [RN:
R00720 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzymes from the bacterium Escherichia coli and the archaea Methanococcus jannaschii and Archaeoglobus fulgidus are highly specific for XTP, dITP and ITP. The activity is dependent on divalent cations, Mg2+ is preferred.
History
EC 3.6.1.66 created 2013
Pathway
ec00983 Drug metabolism - other enzymes
Orthology
K01519 XTP/dITP diphosphohydrolase
Genes
CCAN : 109686524(Itpa) 109693595
PCAD : 102979298 112062521
XLA : 108714409 735008(itpa.S)
SANH : 107669137(itpa) 107687326
SGH : 107581499 107597797(itpa)
CCAR : 109046889 109083978
CAUA : 113063057 113121140
SNH : 120037205 120037206 120052485 120052559
ARUT : 117412529(itpa) 117970169
DSI : Dsimw501_GD22671(Dsim_GD22671)
AALB : 109417504 109419921 115261784
CQU : CpipJ_CPIJ001739 CpipJ_CPIJ019949
AGB : 108906524 108917045 111691473 111693116
PXU : 106123678 106127705 106128618
SLIU : 111349890 111352556
BTAB : 109030032 109030100
CBR : CBG_21178(Cbr-hap-1)
BMY : BM_BM14031(Bma-hap-1)
OSN : 115210684 115229406 115230896
CSAT : 104719083 104723817 104732335
RSZ : 108820098 108851509 108854762
PVU : PHAVU_007G236900g PHAVU_007G237000g
MTR : MTR_1g047390 MTR_1g047400
LJA : Lj0g3v0172749.1(Lj0g3v0172749.1)
PDUL : 117615008 117616212
HBR : 110632209 110635300 110638440
MESC : 110601789 110610489
PALZ : 118054532 118061369
QSU : 112001171 112007802 112029651 112037852
NTA : 107767540 107783471 107827163
SSPL : 121802308 121808518
CSIN : 114268387 114278304
PSOM : 113276227 113302834
NCOL : 116265953 116267949
DOSA : Os10t0457500-01(Os10g0457500)
TAES : 123044734 123119641 123180960
ZMA : 100283993 103642814 103655317 118476241
SMO : SELMODRAFT_74723 SELMODRAFT_86893
CRE : CHLRE_02g095089v5 CHLRE_13g568950v5
OLU : OSTLU_12168 OSTLU_35233 OSTLU_35591
OTA : OT_ostta01g06270 OT_ostta07g00250
BPG : Bathy15g02360 Bathy17g00050
MIS : MICPUN_61716 MICPUN_87659
MPP : MICPUCDRAFT_52462 MICPUCDRAFT_53623
NCS : NCAS_0G03460(NCAS0G03460)
NDI : NDAI_0D01490(NDAI0D01490)
TPF : TPHA_0O00210(TPHA0O00210)
TBL : TBLA_0A08640(TBLA0A08640)
TDL : TDEL_0F00410(TDEL0F00410)
KAF : KAFR_0E00280(KAFR0E00280)
KNG : KNAG_0G00240(KNAG0G00240)
CAL : CAALFM_C503860WA(HAM1)
NTE : NEUTE1DRAFT56913(NEUTE1DRAFT_56913)
FVR : FVEG_07787 FVEG_17509
FOX : FOXG_01422 FOXG_14510
PFY : PFICI_10300 PFICI_12095
BFU : BCIN_03g06060(Bcham1)
NFI : NFIA_037490 NFIA_094060
ANG : ANI_1_516154(An17g02287)
AFV : AFLA_010664 AFLA_013783
PDP : PDIP_20890 PDIP_22240
TMF : PMAA_071520 PMAA_086280
TRG : TRUGW13939_07960 TRUGW13939_11950
FFU : CLAFUR5_07650 CLAFUR5_07651
PPL : POSPLDRAFT_105335 POSPLDRAFT_96782
DSQ : DICSQDRAFT_58419 DICSQDRAFT_73136
LBC : LACBIDRAFT_246034 LACBIDRAFT_311383
ABP : AGABI1DRAFT116450(AGABI1DRAFT_116450)
ABV : AGABI2DRAFT194330(AGABI2DRAFT_194330)
EHI : EHI_192100(226.t00008)
PCB : PCHAS_062000(PC001086.02.0)
BBO : BBOV_III001450(17.m07147)
TET : TTHERM_00041460 TTHERM_00624470
PTM : GSPATT00005189001 GSPATT00009235001
SMIN : v1.2.026717.t1(symbB.v1.2.026717.t1)
TPS : THAPSDRAFT_1165 THAPSDRAFT_30871
AAF : AURANDRAFT_15727 AURANDRAFT_18344
EHX : EMIHUDRAFT_197297 EMIHUDRAFT_439540 EMIHUDRAFT_447001
ECOO : ECRM13514_3838(yggV)
ECOH : ECRM13516_3683(yggV)
ECW : EcE24377A_3298(rdgB)
EDJ : ECDH1ME8569_2854(rdgB)
ECOI : ECOPMV1_03227(rdgB)
KLL : BJF97_06345 BJF97_24895
REE : electrica_00739(rdgB)
CLAP : NCTC11466_00584(rdgB)
KIE : NCTC12125_04684(rdgB)
METY : MRY16398_08680(rdgB)
AHN : NCTC12129_04149(rdgB)
PSHI : SAMEA2665130_2517(rdgB)
PSTS : E05_22160 E05_39390
YPG : YpAngola_A0142(rdgB)
YPI : YpsIP31758_0826(rdgB)
SMW : SMWW4_v1c41370(rdgB)
SERA : Ser39006_004000(rdgB) Ser39006_006940(rdgB)
SERQ : CWC46_04000(rdgB) CWC46_06935(rdgB)
SFJ : SAMEA4384070_4151(rdgB)
SOF : NCTC11214_02577(rdgB)
DIC : Dpoa569_000708(rdgB)
EGE : EM595_1764 EM595_2927(rdgB)
PAM : PANA_3222(yggV) PANA_3961
PLF : PANA5342_0851(yggV) PANA5342_p10062(ham1)
PAJ : PAJ_2450(yggV) PAJ_p0049
PAQ : PAGR_g0860 PAGR_p050
PVA : Pvag_2567(yggV) Pvag_pPag30326
PAGG : AL522_01895 AL522_19985
PAO : Pat9b_3226 Pat9b_5695
PANT : PSNIH1_02630 PSNIH1_p00595
PANP : PSNIH2_01665 PSNIH2_13115
PAGC : BEE12_03400 BEE12_20470
PSTW : DSJ_04615 DSJ_25635
PALH : B1H58_02235 B1H58_10900
PANS : FCN45_15690 FCN45_19875
PEY : EE896_03675 EE896_21055
PDIS : D8B20_14230 D8B20_18225
PER : LAC65_13175(rdgB) LAC65_16885
PGZ : C2E15_05470 C2E15_17410
PCD : C2E16_05305 C2E16_17410(rdgB)
MINT : C7M51_00321 C7M51_02667(rdgB)
MTHI : C7M52_00190(rdgB) C7M52_02417
TPTY : NCTC11468_00722(rdgB)
PLUM : A4R40_05815 A4R40_14055
PHEI : NCTC12003_00862(rdgB)
PRJ : NCTC6933_00945(rdgB)
LRI : NCTC12151_00513(rdgB)
XFU : XFF4834R_chr12450(rdgB)
XPH : XppCFBP6546_17220(rdgB)
XHD : LMG31886_09800(rdgB)
LUM : CNR27_03100 CNR27_05450(rdgB)
DJI : CH75_00065 CH75_23150
VAU : VANGNB10_cI0330c(rdgB)
PDK : PADK2_01945 PADK2_28020
PCOF : POR16_02050(rdgB) POR16_25240
PFW : PF1751_v1c51880(rdgB)
PSZ : PSTAB_1484 PSTAB_3934
PSR : PSTAA_1603 PSTAA_4123
PSC : A458_01435 A458_08465
PSJ : PSJM300_01560 PSJM300_13795
PSH : Psest_0277 Psest_2799
PSTU : UIB01_01375 UIB01_14160
PSTT : CH92_06560 CH92_19840
PCHL : LLJ08_01420(rdgB) LLJ08_13670
PLUL : FOB45_09920(rdgB) FOB45_13480
PPUU : PputUW4_05123(rdgB)
PSEM : TO66_29560 TO66_30465
PSED : DM292_11660 DM292_20635(rdgB)
PTRT : HU722_0027845(rdgB)
PFAK : KSS94_13855 KSS94_25440(rdgB)
PTAE : NCTC10697_00290(rdgB)
PBB : AKN87_07440 AKN87_09515
PSYC : DABAL43B_2543(rdgB)
MCAT : MC25239_00124(rdgB)
MCUN : NCTC10297_00427(rdgB)
PLZ : S4054249_04530 S4054249_13330
SALH : HMF8227_02295(rdgB)
LLG : 44548918_00394(yggV)
LJR : NCTC11533_00401(rdgB)
LCJ : NCTC11976_00149(yggV)
LSS : NCTC12082_02519(rdgB)
HTR : EPV75_09055(rdgB) EPV75_11375(rdgB)
HMAR : HVMH_0208 HVMH_2220
TCY : Thicy_0024 Thicy_1550
TAO : THIAE_00215 THIAE_09890
THIO : AYJ59_01730 AYJ59_04860
THIG : FE785_01345(rdgB) FE785_10185(rdgB)
TXA : HQN79_10640(rdgB) HQN79_11220(rdgB)
TSE : THMIRHAS_23620(rdgB) THMIRHAS_24310
TZO : THMIRHAT_18640 THMIRHAT_21100
TNI : TVNIR_3601(yggV_[C])
GAI : IMCC3135_01735(rdgB)
HALO : BWR19_15300 BWR19_18900
PAUR : FGL86_04220(rdgB) FGL86_06070
AEL : NCTC12917_03547(ham1)
CHJ : NCTC10426_01772(rdgB)
CDIZ : CEDIAZO_01160(rdgB)
NMM : NMBM01240149_1458(rdgB)
NMS : NMBM01240355_0640(rdgB)
NMQ : NMBM04240196_1528(rdgB)
NMZ : NMBNZ0533_0681(rdgB)
RSL : RPSI07_1264(rdgB) RPSI07_2957
REH : H16_A0948(h16_A0948)
BPM : BURPS1710b_3052(rdgB)
BPL : BURPS1106A_3018(yggV)
BUE : BRPE67_ACDS06560(rdgB)
PLG : NCTC10937_00362(rdgB)
BTRM : SAMEA390648703177(rdgB)
OTK : C6570_08080 C6570_10260(rdgB)
LIM : L103DPR2_01118(rdgB)
LIH : L63ED372_00411(rdgB)
DPY : BA022_04295 BA022_10510
NLC : EBAPG3_002225(rdgB) EBAPG3_013790
URU : DSM104443_00088(rdgB)
AGE : AA314_03358 AA314_06977
AVM : JQX13_48990 JQX13_52040(rdgB)
MBD : MEBOL_000846 MEBOL_003350
SCL : sce2818 sce7976(yggV)
SCU : SCE1572_17310 SCE1572_45790
SAME : SAMCFNEI73_Ch0381(rdgB)
AGR : AGROH133_03489(ham1)
ALF : CFBP5473_14320(rdgB)
RPUS : CFBP5875_00015(rdgB)
BSEP : HAP48_0015610(rdgB)
VGO : GJW-30_1_04333(rdgB)
BBK : BARBAKC583_1336(rdgB)
MMES : MMSR116_00315(rdgB)
RLI : RLO149_c041740(rdgB)
PHP : PhaeoP97_03443(rdgB)
PPIC : PhaeoP14_03313(rdgB)
NOV : TQ38_004745 TQ38_009705(rdgB)
BAZ : BAMTA208_13930(ysnA)
BSON : S101395_01516(rdgB)
BCIR : C2I06_07195 C2I06_11135
VIM : GWK91_08260 GWK91_10780
FPN : ABE65_011375 ABE65_015190
BLEN : NCTC4824_01515(rdgB)
BVQ : FHE72_03915 FHE72_16185
SUQ : HMPREF0772_12082(rdgB)
SDP : NCTC12225_01885(rdgB)
SSIM : SAMEA4384339_1056(rdgB)
PAEE : R70331_16370 R70331_25150
TAB : CIG75_02640 CIG75_07810
LFB : C1X05_05775 C1X05_15440
TVU : AB849_000220 AB849_005895
KPUL : GXN76_01140 GXN76_05940 GXN76_09270
KEB : GXN75_07025 GXN75_16290
PABS : JIR001_09880 JIR001_29170
STZ : SPYALAB49_000333(rdgB)
SNC : HMPREF0837_12105(rdgB)