KEGG   ENZYME: 3.6.1.8
Entry
EC 3.6.1.8                  Enzyme                                 
Name
ATP diphosphatase;
ATPase (ambiguous);
ATP pyrophosphatase;
adenosine triphosphate pyrophosphatase;
ATP diphosphohydrolase (ambiguous)
Class
Hydrolases;
Acting on acid anhydrides;
In phosphorus-containing anhydrides
Sysname
ATP diphosphohydrolase (diphosphate-forming)
Reaction(IUBMB)
ATP + H2O = AMP + diphosphate [RN:R00087]
Reaction(KEGG)
R00087;
(other) R00086
Substrate
ATP [CPD:C00002];
H2O [CPD:C00001]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013]
Comment
Also acts on ITP, GTP, CTP and UTP.
History
EC 3.6.1.8 created 1961
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:13061448]
  Authors
HEPPEL LA, HILMOE RJ.
  Title
Mechanism of enzymatic hydrolysis of adenosinetriphosphate.
  Journal
J Biol Chem 202:217-26 (1953)
Reference
2  [PMID:13058963]
  Authors
JOHNSON M, KAYE MA, HEMS R, KREBS HA.
  Title
Enzymic hydrolysis of adenosine phosphates by cobra venom.
  Journal
Biochem J 54:625-9 (1953)
DOI:10.1042/bj0540625
Other DBs
ExplorEnz - The Enzyme Database: 3.6.1.8
IUBMB Enzyme Nomenclature: 3.6.1.8
ExPASy - ENZYME nomenclature database: 3.6.1.8
BRENDA, the Enzyme Database: 3.6.1.8
CAS: 37289-25-1
LinkDB

KEGG   REACTION: R00087
Entry
R00087                      Reaction                               
Name
ATP diphosphohydrolase (diphosphate-forming);
ATP pyrophosphohydrolase
Definition
ATP + H2O <=> AMP + Diphosphate
Equation
Reaction class
RC00002  C00002_C00020
Enzyme
3.6.1.8         3.6.1.9
Pathway
rn00230  Purine metabolism
rn01100  Metabolic pathways
rn01232  Nucleotide metabolism
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.6  Acting on acid anhydrides
   3.6.1  In phosphorus-containing anhydrides
    3.6.1.8
     R00087  ATP + H2O <=> AMP + Diphosphate
    3.6.1.9
     R00087  ATP + H2O <=> AMP + Diphosphate
IUBMB reaction hierarchy [BR:br08202]
 3. Hydrolase reactions
  3.6.1.9
   R01532  Nucleoside triphosphate <=> Nucleotide
    R00087  ATP <=> AMP
Orthology
K01513  ectonucleotide pyrophosphatase/phosphodiesterase family member 1/3 [EC:3.1.4.1 3.6.1.9]
K04765  nucleoside triphosphate diphosphatase [EC:3.6.1.9]
Other DBs
RHEA: 14248
LinkDB

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