KEGG   ENZYME: 3.7.1.28
Entry
EC 3.7.1.28                 Enzyme                                 
Name
3-oxoisoapionate-4-phosphate transcarboxylase/hydrolase;
oiaT (gene name)
Class
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
Sysname
3-oxoisoapionate-4-phosphate transcarboxylase/glycolylhydrolase (3-phospho-D-glycerate-forming)
Reaction(IUBMB)
3-oxoisoapionate 4-phosphate + H2O = glycolate + 3-phospho-D-glycerate [RN:R12802]
Reaction(KEGG)
R12802
Substrate
3-oxoisoapionate 4-phosphate [CPD:C22278];
H2O [CPD:C00001]
Product
glycolate [CPD:C00160];
3-phospho-D-glycerate [CPD:C00197]
Comment
The enzyme, which belongs to the RuBisCO-like-protein (RLP) superfamily, has been characterized from several bacterial species. It participates in the degradation of D-apionate. The reaction is initiated by decarboxylation to generate a stabilized enediolate intermediate, with the sequestered CO2 carboxylating the adjacent enediolate carbon atom. The resulting 3-ketose-1-phosphate intermediate is hydrolysed, as in the authentic RuBisCO-catalysed reaction, to generate glycolate and 3-phospho-D-glycerate. Stereospecificity of 3-oxoisoapionate 4-phosphate has not been determined.
History
EC 3.7.1.28 created 2021
Orthology
K01559  3-oxoisoapionate-4-phosphate transcarboxylase/hydrolase
Genes
PPFPput_1846
PPIYSA_08807
CSACsal_3215
HELHELO_1481
HHUAR456_04995 AR456_16020
HSVHNO53_09515
MARSA8C75_12440
LLPGH975_02715
CNCCNE_BB1p11580
BACBamMC406_5257
BYIBYI23_D003670
BUEBRPE67_DCDS05390 BRPE67_ECDS01780 BRPE67_ECDS02670
BUQAC233_23005
BXEBxe_B0441
BXBDR64_5776
BPYBphyt_7230
BFNOI25_6152
BCAIK788_0005390
PSPWBJG93_30055
PARBCJU94_27285
PHSC2L64_29625
PTERC2L65_16650 C2L65_18755
PGPCUJ91_20530 CUJ91_23785
PCJCUJ87_28980
PTSCUJ90_22835 CUJ90_28695
PGISI6I06_27060
PACPFAZ97_28260
PACSFAZ98_29665
PEWKZJ38_24885
PDIOPDMSB3_2982.1
PPKU875_18470
PPNODA70_10980
PPNMLV28_20070
PRBX636_15640
PPULRO07_13870
PTXABW99_02175
PFGAB870_16575
PANDDRB87_06415
PCOMNTU39_07900
BUOBRPE64_DCDS09220
BBHBN112_2412
BBRBB1035
BBMBN115_0985
BBXBBS798_1005
BBROBAU06_24370
BFZBAU07_24495
BOHAKI39_23265
AXYAXYL_03869
AXNAX27061_4162
AXXERS451415_04183(rlp2)
ADTAPT56_19350
AISBUW96_08995
ASWCVS48_21430
ACHBDVB37_15635
ADYHLG70_04065
ACHOH4P35_15350
PUSCKA81_16385
AKATKWG_05245
AMIMMIM_c08190
CDNBN940_16196
AFAUZ73_01640
ODIODI_R0401
PACRFXN63_06645 FXN63_20015
PARKLSG25_01380
RSBRS694_11675
RHFEUB48_12900
POLBpro_0032 Bpro_0093
ACKC380_11440
AMONH9L24_19555
AANTHUK68_07530
DACDaci_5642
DLAI6G47_07630
VAPVapar_1945
VPEVarpa_3886
VPDVAPA_1c20780 VAPA_2c01390
VBOCKY39_06165
VAMC4F17_28265
HYLLPB072_19490
HYNF9K07_21480
HHTF506_02375 F506_07875
HEEhmeg3_05695
HFRG5S34_07110
RGUA4W93_18610
MAMMesau_05257
PHTBLM14_21745
ORMHTY61_08790
KMNHW532_08980
RHKKim5_PD00202
NENNCHU2750_53910(rbcL)
RFVRFYW14_03809
ABAWD5400_10075 D5400_17915
BJUBJ6T_64220
AOLS58_67690
BRCBCCGELA001_11775
BBANJ4G43_019170
BOPAXW83_25385
BOSBSY19_991
BVVBHK69_06660
BOIBLM15_19235
BOFFQV39_16725
XAUXaut_2924
AZCAZC_2687
SNOSnov_3661
STARG3545_23105
APOLK9D25_01030
METM446_1732
MNOMnod_2420 Mnod_3435
MEEDA075_31215
MINDmvi_54170
MOCBB934_10130 BB934_35070
AUZSa4125_32680
LABTFIU93_28775(rlp2)
LAGGB0E33_28815
SIWGH266_08595 GH266_14655
ACUTMRB58_07260 MRB58_10515 MRB58_21520
JANJann_3063(rbcL)
OATOAN307_c00690
SMEDJNX03_08310
SPSESULPSESMR1_01387(rbcL) SULPSESMR1_03989(rlp2)
OCDFHY55_18970
MARUFIU81_13295(rlp2)
RMHLVO79_19785
MALUKU6B_39550
PALXGQA70_02020
RSKRSKD131_4141
PZHCX676_14915
PTPRCA23_c02820
LVSLOKVESSMR4R_01065(rbcL)
GEHHYN69_13945
PPRUFDP22_18875
PSHQF3W81_19040
HDHG5B40_15355
FAQG5B39_17455
AMAQGO499_13135
SPHITS85_22735
SKRBRX40_01420
SPHCCVN68_12545
SARIH5J25_00385
SCABLZK98_19700
SYAA6768_20210
ACRAcry_1067
AMVACMV_08240(rbcL)
SVCSTVA_34700
ABSAZOBR_p210197
ABQABAZ39_23690
ABFAMK58_21880
ATIAL072_14955
AZTTSH58p_02700
AOZHUE56_07430
AARED3093_22910
SKTIGS68_04940
SMUCJL100_022800
SROEJL101_021490
HADHFRZ61_43900
BACAFAY30_22380
GYMGYMC10_2998
PMSKNP414_04768
PMQPM3016_4181
PMWB2K_21690
POWIJ21_48340
CCHLFPL14_17425 FPL14_17840 FPL14_17895
CHEBHH215_01365 HH215_01515 HH215_27315
ADAUNZD86_00515
GORKTR9_2562
SLSSLINC_0051
MIPAXH82_06850
MHOSCXR34_02835
MLVCVS47_02920(rlp2)
CPHYB5808_01895
HUMDVJ78_00765
HEAHL652_16130
ARRARUE_c20370
AAUAAur_1905
ACHAchl_1739
GARAOZ07_14815
SATKSA2016_2278
GYUFE374_03565
HALTIM660_18330
RHALLQF10_18005
RSUALQF12_15360
MIKFOE78_09050
TEZBKM78_06780
TLATLA_TLA_01370(rlp2)
NOWGBF35_13035
GOBGobs_1448 Gobs_2026
TROtrd_0132
VBHCMV30_04920
VBAIMCC26134_02030
PNDPla175_38210
GRWFTO74_05975
TALBFTW19_18930
NKONiako_3589
NSONIASO_20240
FGGFSB75_07090
LACSH4075_05770
PHEPhep_2747
SHGSph21_2161
MMABHQ865_03615
MDJLLH06_11185
OLIFKG96_07850
EVIEchvi_1692
ESTDN752_14360
ECHIFKX85_08115
SPIBG8759_13900
DFEDfer_2138
RUPDTQ70_04885
HMTMTP16_13560
RTIDC20_22050
FBTD770_14520
FCMBIW12_01680
FCRHYN56_20255
POBLPB03_10325
MARFCJ739_3861
HALJG9465_24115
HRAEI982_03020
HALGHUG10_07090
HSALJMJ58_22925
 » show all
Reference
1  [PMID:29867142]
  Authors
Carter MS, Zhang X, Huang H, Bouvier JT, Francisco BS, Vetting MW, Al-Obaidi N, Bonanno JB, Ghosh A, Zallot RG, Andersen HM, Almo SC, Gerlt JA
  Title
Functional assignment of multiple catabolic pathways for D-apiose.
  Journal
Nat Chem Biol 14:696-705 (2018)
DOI:10.1038/s41589-018-0067-7
  Sequence
[xau:Xaut_2924]
Other DBs
ExplorEnz - The Enzyme Database: 3.7.1.28
IUBMB Enzyme Nomenclature: 3.7.1.28
ExPASy - ENZYME nomenclature database: 3.7.1.28
BRENDA, the Enzyme Database: 3.7.1.28
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