Entry |
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Name |
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Class |
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
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Sysname |
L-kynurenine hydrolase
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Reaction(IUBMB) |
L-kynurenine + H2O = anthranilate + L-alanine [RN: R00987]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
A pyridoxal-phosphate protein. Also acts on 3'-hydroxy-L-kynurenine and some other (3-arylcarbonyl)-alanines.
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History |
EC 3.7.1.3 created 1965
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Pathway |
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Orthology |
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Genes |
MMUR: | 105859104(KYNU) 105862101 |
MORG: | 121433212 121462857 |
TUP: | 102491675(KYNU) 102501389 |
SHON: | 118984195 119001767 |
PBI: | 103055247(KYNU) 103059530 |
PMUA: | 114604750 114604774 |
PPRM: | 120467928 120467932 |
AFB: | 129095429 129095430 129112008 |
ALIM: | 106532507 106535286 |
SASA: | 106574376 106575231 |
SALP: | 111953727 111970992(kynu) |
PSPA: | 121321512 121323363 |
ARUT: | 117403699 117426435 |
CIN: | 100176031 100176511 100183020 100183055 100186313 100186525 |
SCLV: | 120326257 120344458 |
PCHN: | 125025024 125025096 |
PMOO: | 119575144 119593621 |
PPOI: | 119114558 119114567 |
RSAN: | 119376822 119396761 119396948 |
CEL: | CELE_C15H9.7(kynu-1) |
MYI: | 110457375 110461101 110467004 |
PMAX: | 117316421 117317299 117340677 |
TAD: | TRIADDRAFT_28018 TRIADDRAFT_58136 |
TPF: | TPHA_0L01030(TPHA0L01030) |
TDL: | TDEL_0F05410(TDEL0F05410) |
LBG: | 92205662(LODBEIA_P04660) |
CAL: | CAALFM_C108490WA(CaO19.394) |
YLI: | 2906903(YALI2_C00594g) |
NTE: | NEUTE1DRAFT145950(NEUTE1DRAFT_145950) NEUTE1DRAFT82447(NEUTE1DRAFT_82447) |
SMP: | 10806334(SMAC4_01897) 10810850(SMAC4_08947) |
PAN: | PODANSg2503 PODANSg5014 |
PBEL: | QC761_700770(BNA5_1) QC761_706230(BNA5_2) |
PPSD: | QC762_700770(BNA5_1) QC762_706230(BNA5_2) |
PPSP: | QC763_700770(BNA5_1) QC763_706230(BNA5_2) |
PPSA: | QC764_700770(BNA5_1) QC764_706230(BNA5_2) |
MTM: | MYCTH_2303251 MYCTH_2304561 |
TMN: | UCRPA7_3885 UCRPA7_8044 |
SSCK: | SPSK_03144 SPSK_06212 |
FGR: | FGSG_04131 FGSG_04829 |
FPU: | FPSE_00151 FPSE_04049 |
FPOA: | FPOAC1_006578(KYN2) FPOAC1_007668(KYN1) |
FVN: | FVRRES_07187 FVRRES_08131 |
FVR: | FVEG_03513 FVEG_10317 |
FOX: | FOXG_05660 FOXG_11506 |
NHE: | NECHADRAFT_104778 NECHADRAFT_49794 |
FFC: | NCS54_00833300 NCS54_01207900 |
FKR: | NCS57_00876500 NCS57_01198700 |
FMU: | J7337_003527(KYN1) J7337_011591(KYN2) |
TATV: | 25780244(TrAtP1_003160) |
PCHM: | VFPPC_08815 VFPPC_11155 VFPPC_14764 |
AMUS: | LMH87_007129 LMH87_008564 |
PLJ: | 28892309(PLICBS_009944) |
CFJ: | CFIO01_12865 CFIO01_12905 |
CLUP: | CLUP02_02600 CLUP02_17213 |
CHIG: | CH63R_01974 CH63R_06939 |
SAPO: | SAPIO_CDS2111 SAPIO_CDS9354 |
PFY: | PFICI_05600 PFICI_14030 |
SSL: | SS1G_00001 SS1G_08223 |
BFU: | BCIN_03g07660 BCIN_12g01070 |
PSCO: | LY89DRAFT_574578 LY89DRAFT_580496 |
GLZ: | GLAREA_07128 GLAREA_11410 |
ANI: | ANIA_01857 ANIA_05952 |
AFM: | AFUA_2G10360 AFUA_4G09840 |
ACT: | ACLA_049070 ACLA_069390 |
NFI: | NFIA_085760 NFIA_106210 |
AOR: | AO090003001247 AO090011000602 |
ANG: | An04g07200 An16g04630 |
AFV: | AFLA_000426 AFLA_008003 |
ALUC: | AKAW2_30286S(BNA5_1) AKAW2_70393S(BNA5_2) |
ACHE: | ACHE_10704S(BNA5_1) ACHE_40130A(BNA5_3) |
APUU: | APUU_10989A(BNA5_1) APUU_21223S(BNA5_2) APUU_30008A(BNA5_4) |
PDP: | PDIP_25590 PDIP_64250 |
POU: | POX_e06476 POX_f07930 |
TMF: | EYB26_003485 EYB26_006843 |
TRG: | TRUGW13939_07834 TRUGW13939_11420 |
PNO: | SNOG_02814 SNOG_08382 |
PTRR: | 6339899(PtrM4_024550) 6346975(PtrM4_145220) |
BZE: | COCCADRAFT_84232 COCCADRAFT_98086 |
BSC: | COCSADRAFT_124375 COCSADRAFT_35240 |
BOR: | COCMIDRAFT_1969 COCMIDRAFT_84295 |
AALT: | CC77DRAFT_1065023 CC77DRAFT_982447 |
ARAB: | EKO05_0001380 EKO05_0005002 |
ZTR: | MYCGRDRAFT_107825(Kyn1) MYCGRDRAFT_45707(Kyn2) |
CBET: | CB0940_06303 CB0940_09212 |
NPA: | UCRNP2_2917 UCRNP2_9453 |
CDEP: | 91085211(L203_100997) |
KMG: | 30167419(I203_106329) |
KNE: | 92178233(IAR55_000974) |
CCAC: | CcaHIS019_0407830(BNA5) |
ABP: | AGABI1DRAFT111339(AGABI1DRAFT_111339) |
ABV: | AGABI2DRAFT190561(AGABI2DRAFT_190561) |
SCM: | SCHCO_02019170(SCHCODRAFT_02019170) SCHCO_02606037(SCHCODRAFT_02606037) |
PFP: | PFL1_04475 PFL1_05150 |
TCR: | 503881.10 508119.110 |
LMAT: | 92514263(LSCM1_04238) |
LOI: | 92361115(LSCM4_05231) |
XPH: | XppCFBP6546_18290(kynU) |
XHD: | LMG31886_27250(kynU) |
LLZ: | LYB30171_01464(kynU) |
PPRC: | PFLCHA0_c07730(kynU) |
PMUD: | NCTC8068_00692(kynU) |
PFW: | PF1751_v1c46380(kynU) |
PSOS: | POS17_0751 POS17_2251 |
PSEP: | C4K39_0752 C4K39_5752 |
PPII: | QL104_03780(kynU) QL104_11970(kynU) |
PTRT: | HU722_0024710(kynU) |
PTW: | TUM18999_37400(kynU) |
PTAE: | NCTC10697_02300(kynU) |
PSOA: | PSm6_33950(kynU_1) PSm6_58740(kynU_2) |
PKJ: | Q1W70_06595(kynU) Q1W70_06710(kynU) |
SCAA: | TUM17387_27820(kynU) |
TPSY: | RGQ13_03515 RGQ13_14700(kynU) |
TNN: | RI845_05000(kynU) RI845_15700 |
TFT: | RI844_09505 RI844_19205(kynU) |
PIA: | PI2015_0052 PI2015_0601 |
PTD: | PTET_a0059 PTET_a0629(kynU) |
PMAA: | CPA52_13025(kynU) CPA52_15740 |
GAG: | Glaag_0486 Glaag_1405 |
PMES: | FX988_02169 FX988_03995 |
SALH: | HMF8227_02729(kynU) |
ALII: | QR722_00905 QR722_04585(kynU) |
SAGA: | M5M_05920 M5M_17220 |
KIM: | G3T16_03160 G3T16_07020 G3T16_17490(kynU) |
LCJ: | NCTC11976_01792(kynU) |
GAI: | IMCC3135_26495(kynU) |
HAAH: | HALA3H3_910071(kynU) |
TSN: | W908_06070 W908_08205 |
RIN: | ACS15_0861 ACS15_4678 |
RME: | Rmet_2650(kynU) Rmet_5192 |
BMV: | BMASAVP1_A0651(kynU) |
BML: | BMA10229_A2486(kynU) |
BPM: | BURPS1710b_1054(kynU) |
BPL: | BURPS1106A_0896(kynU) |
BUR: | Bcep18194_A5909 Bcep18194_C7639 |
BSTL: | BBJ41_15915 BBJ41_33935 |
BARI: | NLX30_15080(kynU) NLX30_35170(kynU) |
BGL: | bglu_1g29390 bglu_2g11770 |
BGU: | KS03_390(kynU) KS03_4747 |
BUG: | BC1001_2071 BC1001_2077 BC1001_2879 BC1001_5425 |
BGF: | BC1003_2814 BC1003_3995 BC1003_4451 |
BUE: | BRPE67_ACDS22250(kynU) |
BGE: | BC1002_2485 BC1002_6996 BC1002_7002 |
BPX: | BUPH_01854 BUPH_03406 BUPH_05660 |
BPY: | Bphyt_1473 Bphyt_3228 |
BFN: | OI25_2194(kynU) OI25_250(kynU) |
PARB: | CJU94_08805(kynU) CJU94_34110 |
PGIS: | I6I06_15265(kynU) I6I06_27380 |
PACS: | FAZ98_02555(kynU) FAZ98_25460 FAZ98_29580 |
PDIO: | PDMSB3_0611(kynU) PDMSB3_3633(kynU) |
PBRY: | NDK50_06205(kynU) NDK50_17230(kynU) |
PSAA: | QEN71_02675(kynU) QEN71_41530 |
PPAI: | E1956_00220(kynU) E1956_27335(kynU) |
PTX: | ABW99_00910 ABW99_20520 |
BTRM: | SAMEA390648701452(kynU) |
AXX: | ERS451415_05091(kynU) |
ACHR: | C2U31_04745 C2U31_29075(kynU) |
AFA: | UZ73_08295 UZ73_16185 |
AFQ: | AFA_02245(kynU) AFA_06600 |
AAQU: | D3M96_02255(kynU) D3M96_08330 |
AAMM: | FE795_02225(kynU) FE795_06475 |
LIM: | L103DPR2_00867(kynU) |
LIH: | L63ED372_01899(kynU) |
PKT: | AT984_10515 AT984_18800 |
PAIS: | PFX98_12125(kynU) PFX98_16440(kynU) |
SMIO: | CATMQ487_42220(kynU) |
TMJ: | P0M04_01755(kynU) P0M04_18815(kynU) |
MESR: | FGU64_16555(kynU) FGU64_19205(kynU) |
NKI: | KW403_03970(kynU) KW403_07255 |
AAK: | AA2016_0864 AA2016_5741 |
AMIS: | Amn_53650 Amn_pa02400 |
EAH: | FA04_32135 FA04_32400 |
ENP: | JVX98_29310(kynU) JVX98_29840(kynU) |
RTR: | RTCIAT899_PC06620(kynU) |
ABAW: | D5400_01495 D5400_01535(kynU) |
HOE: | IMCC20628_01394 IMCC20628_01402 |
BGQ: | X265_17375(kynU) X265_37525(kynU) |
BGZ: | XH91_20005(kynU) XH91_36725(kynU) |
BSEP: | HAP48_0033960(kynU) |
BCAN: | BcanWSM471_18105(kynU) |
MMYR: | MXMO3_01144 MXMO3_02967 |
JAV: | OXU80_15245(kynU) OXU80_25480 |
NOH: | G5V57_08195(kynU) G5V57_32505 |
LAP: | ACP90_18810 ACP90_24000 |
LABR: | CHH27_24635(kynU) CHH27_27230 |
LABT: | FIU93_01835(kynU1) FIU93_25470(kynU2) |
LAGG: | B0E33_02580 B0E33_07455 |
RLI: | RLO149_c008190(kynU) |
PHP: | PhaeoP97_00969(kynU) PhaeoP97_03815 |
PPIC: | PhaeoP14_00916(kynU) |
YPAC: | CEW88_08065(kynU) CEW88_22520 |
SUAM: | BOO69_10900 BOO69_18200 |
SULZ: | C1J03_14385(kynU) C1J03_22290 |
SMED: | JNX03_02605(kynU) JNX03_20225 |
SINL: | DSM14862_00575(kynU_1) DSM14862_01900(kynU_2) |
SFAV: | PL335_02795 PL335_09480(kynU) |
SDUB: | R1T39_01455(kynU) R1T39_08370 |
SPSE: | SULPSESMR1_00940(kynU) |
AHT: | ANTHELSMS3_02500(kynU) |
LALG: | LentiSH36_00934(kynU) |
RBL: | B6K69_02955 B6K69_12475 |
PAMI: | JCM7686_0332 JCM7686_pAMI4p046 |
PARS: | DRW48_02425(kynU) DRW48_13545(kynU) |
PSAP: | JHX88_13790 JHX88_16560(kynU) |
PVER: | E3U25_02470 E3U25_20550(kynU) |
TSCO: | R1T40_03585 R1T40_10725(kynU) R1T40_19650(kynU) R1T40_21725(kynU) |
LVS: | LOKVESSMR4R_01830(kynU) |
GEH: | HYN69_05650(kynU) HYN69_07135 |
TAW: | EI545_03055 EI545_20265(kynU) |
GYJ: | AADW23_09345(kynU) AADW23_12385(kynU) |
NSM: | JO391_04315(kynU) JO391_16880 |
AALK: | LGT41_0011660(kynU) |
NOG: | GKE62_03990(kynU) GKE62_14755(kynU) |
SMAG: | AN936_00670 AN936_11265 |
SMAZ: | LH19_00680 LH19_12415 |
STER: | AOA14_04945 AOA14_11345 |
SGI: | SGRAN_3416 SGRAN_3565(kynU) |
SPHQ: | BWQ93_12785 BWQ93_19170 |
SPHO: | C3E99_11900 C3E99_12640(kynU) |
NCB: | C0V82_23380(kynU) C0V82_24610(kynU) |
HFL: | PUV54_06735 PUV54_10165 |
GSO: | PH603_06075(kynU) PH603_12440(kynU) |
SUR: | STAUR_2727(kynU) STAUR_7559 |
AGE: | AA314_01336 AA314_03255 |
VIN: | AKJ08_2009 AKJ08_2101 |
MRM: | A7982_02006 A7982_03753 |
BFD: | NCTC4823_00731(kynU_1) |
LLB: | R6U77_10375(kynU) R6U77_10580(kynU) |
PBUT: | DTO10_06315(kynU) DTO10_19010(kynU) |
PERI: | RE409_07210(kynU) RE409_22180(kynU) |
NNV: | QNH39_03240(kynU) QNH39_24850(kynU) |
GAJ: | MY490_16185(kynU) MY490_19655(kynU) |
SSTE: | SAMEA4384403_0151(kynU) |
MCAK: | MCCS_15040(kynU_1) MCCS_15430(kynU_2) |
LGZ: | NCTC10812_00541(kynU) |
SPOO: | J3U78_11220(kynU) J3U78_14115(kynU) |
CHYL: | CE91St63_27270(kynU) |
NBR: | O3I_014095 O3I_021180 O3I_022630 |
NTP: | CRH09_08900 CRH09_29400 |
NOZ: | DMB37_03180 DMB37_34430 DMB37_35925 |
NAH: | F5544_08855(kynU) F5544_39855 |
NWL: | NWFMUON74_37050(kynU) |
RANT: | RHODO2019_15365(kynU) |
SANL: | KZO11_19260(kynU) KZO11_29735 KZO11_33870(kynU) |
SCB: | SCAB_15241 SCAB_42121 |
SHO: | SHJGH_1086 SHJGH_5154 |
SAMB: | SAM23877_0413 SAM23877_3973(kynU) |
STRF: | ASR50_01440 ASR50_15510 |
SLE: | sle_33780(sle_33780) |
SPAV: | Spa2297_02660 Spa2297_17605 |
SGM: | GCM10017557_44930(kynU) |
SPHW: | NFX46_01265(kynU) NFX46_22090 |
SLS: | SLINC_4601 SLINC_8374 |
SPLU: | LK06_014560 LK06_031310 |
SGE: | DWG14_03960(kynU_1) DWG14_08252(kynU_2) |
SDX: | C4B68_18575(kynU) C4B68_39095 |
SAST: | CD934_16250(kynU) CD934_28990 |
SSUB: | CP968_15770(kynU) CP968_28035(kynU) |
SFUG: | CNQ36_01395 CNQ36_18645(kynU) |
STUI: | GCM10017668_37520(kynU) |
SDW: | K7C20_09155 K7C20_17820(kynU) |
SCAL: | I6J39_15635(kynU) I6J39_28910(kynU) |
SROI: | IAG44_00565 IAG44_01310(kynU) IAG44_18505(kynU) |
SACT: | DMT42_00415 DMT42_20910(kynU) |
SGOB: | test1122_13975(kynU) |
SINE: | KI385_12270 KI385_21870(kynU) |
SXT: | KPP03845_103681(kynU) |
STEE: | F3L20_01135(kynU) F3L20_18850 |
SOV: | QZH56_07085 QZH56_18870(kynU) |
MLV: | CVS47_00179(kynU_1) CVS47_00299(kynU_2) |
MAUG: | KV397_02915 KV397_17115(kynU) |
MSUF: | KV394_01750 KV394_04985(kynU) |
MVD: | AWU67_16400 AWU67_16710 |
AGY: | ATC03_02560 ATC03_17775 |
AMAU: | DSM26151_04130(kynU_1) DSM26151_27060(kynU_2) |
ASOI: | MTP13_01940(kynU) MTP13_06735 |
LTR: | EVS81_07960(kynU) EVS81_08515 |
ARE: | AL755_01645 AL755_03250 AL755_03980 |
ACIT: | HPK19_11035(kynU) HPK19_15330(kynU) |
AAGI: | NCTC2676_1_01349(kynU) |
GCR: | GcLGCM259_0194(kynU) |
NAQU: | ENKNEFLB_01283(kynU) |
PSIM: | KR76_14545 KR76_18140 |
AGRA: | AGRA3207_000775(kynU) AGRA3207_003963 |
AJA: | AJAP_06695(kynU) AJAP_30680 |
AMYB: | BKN51_01015 BKN51_25675 |
AAB: | A4R43_37905 A4R43_37985 |
AMYY: | YIM_25135(kynU1) YIM_40140(kynU3) |
AORI: | SD37_08180 SD37_32380 |
SSYI: | EKG83_01455(kynU) EKG83_27615(kynU) |
KPHY: | AOZ06_24255 AOZ06_33165 |
SACE: | GIY23_01170 GIY23_19290(kynU) |
MICH: | FJK98_18195(kynU) FJK98_18635 |
MCAB: | HXZ27_18970(kynU) HXZ27_19955 HXZ27_25060(kynU) |
MSAG: | GCM10017556_55940(kynU) |
VMA: | VAB18032_21815 VAB18032_28771 |
MCRA: | ID554_21650(kynU) ID554_27175 |
VER: | HUT12_16640 HUT12_26080(kynU) |
PFLA: | Pflav_027580(kynU) Pflav_083860 |
DAUR: | Daura_32025(kynU) Daura_46055(kynU) |
NHY: | JQS43_06590(kynU) JQS43_20960(kynU) |
SBAE: | DSM104329_01663(kynU) |
AYM: | YM304_03230 YM304_05020 |
LEPV: | J4558_09270(kynU) J4558_14690 |
DEIN: | DAAJ005_01550(kynU) |
FOK: | KK2020170_10840(kynU) |
PHG: | KCTC32516_00170(kynU) |
MYR: | MYRA21_1882(kynU) MYRA21_2842(kynU) |
MOD: | AS202_08940 AS202_13930 |
MYZ: | BK054_08805 BK054_13480 |
MALS: | NWE55_01720(kynU) NWE55_10340(kynU) |
AALG: | AREALGSMS7_00105(kynU) |
KOS: | KORDIASMS9_02202(kynU) |
KAN: | IMCC3317_39630(kynU) |
SPON: | HME9304_02388(kynU) |
PTAN: | CRYO30217_00914(kynU) |
HALQ: | Hrr1229_004990(kynU) |
HACB: | Hbl1158_11470(kynU) |
HALV: | NGM15_06280(kynU) NGM15_17210(kynU) |
» show all
|
Reference |
|
Authors |
JAKOBY WB, BONNER DM. |
Title |
Kynureninase from Neurospora: purification and properties. |
Journal |
J Biol Chem 205:699-707 (1953) |
Reference |
|
Authors |
JAKOBY WB, BONNER DM. |
Title |
Kynureninase from Neurospora: interaction of enzyme with substrates, coenzyme, and amines. |
Journal |
J Biol Chem 205:709-15 (1953) |
Reference |
|
Authors |
KNOX WE. |
Title |
The relation of liver kynureninase to tryptophan metabolism in pyridoxine deficiency. |
Journal |
|
Reference |
4 |
Authors |
Wiss O, Weber F. |
Title |
Die Reindarstellung der Kynureninase. |
Journal |
Hoppe-Seyler's Z Physiol Chem 304:232-240 (1956) |
Other DBs |
ExplorEnz - The Enzyme Database: | 3.7.1.3 |
ExPASy - ENZYME nomenclature database: | 3.7.1.3 |
BRENDA, the Enzyme Database: | 3.7.1.3 |
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LinkDB |
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