KEGG ENZYME: 4.1.1.123

ENZYME: 4.1.1.123

Entry

EC 4.1.1.123                Enzyme

Name

phenyl-phosphate phosphatase/carboxylase;
phenyl phosphate carboxylase

Class

Lyases;
Carbon-carbon lyases;
Carboxy-lyases

Sysname

4-hydroxybenzoate carboxy-lyase (phenyl phosphate-forming)

Reaction(IUBMB)

4-hydroxybenzoate + phosphate = phenyl phosphate + CO2 + H2O [RN:R05603]

Reaction(KEGG)

R05603

Substrate

4-hydroxybenzoate [CPD:C00156];
phosphate [CPD:C00009]

Product

phenyl phosphate [CPD:C02734];
CO2 [CPD:C00011];
H2O [CPD:C00001]

Comment

The enzyme, characterized from the bacterium Thauera aromatica, participates in an anaerobic phenol degradation pathway. It catalyses the para dephosphorylation and carboxylation of phenylphosphate to 4-hydroxybenzoate. The enzyme from Thauera aromatica consists of four different subunits and requires K+ and a divalent metal cation (Mg2+ or Mn2+) for activity. It is strongly inhibited by oxygen.

History

EC 4.1.1.123 created 2022

Pathway

ec00627

Aminobenzoate degradation

ec01120

Microbial metabolism in diverse environments

Orthology

K25932

phenyl-phosphate phosphatase/carboxylase subunit alpha

K25933

phenyl-phosphate phosphatase/carboxylase subunit beta