UDP-N-acetyl-alpha-D-xylosamine [CPD:C22938];
CO2 [CPD:C00011]
Comment
The enzyme has been described from pathogenic Bacillus species, including Bacillus anthracis, Bacillus thuringiensis, and Bacillus cereus. The enzyme requires an NAD cofactor, and the reaction proceeds via a 4-dehydro intermediate, resulting in reduction of NAD+ to NADH (cf. EC 1.1.1.305, UDP-glucuronic acid dehydrogenase (UDP-4-keto-hexauronic acid decarboxylating)). However, NADH is not released from the enzyme and is recycled back to NAD+ at the completion of the reaction cycle. The product is incorporated into an extracellular polysaccharide known as pzX.
