| Entry |
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| Name |
(R)-mandelonitrile lyase;
(R)-oxynitrilase;
oxynitrilase;
D-oxynitrilase;
D-alpha-hydroxynitrile lyase;
mandelonitrile benzaldehyde-lyase;
PaHNL;
AtHNL;
PhaMDL;
(R)-HNL;
(R)-PeHNL;
(R)-hydroxynitrile lyase;
R-selective hydroxynitrile lyase;
R-selective HNL;
(R)-(+)-mandelonitrile lyase
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| Class |
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
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| Sysname |
(R)-mandelonitrile benzaldehyde-lyase (cyanide-forming)
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| Reaction(IUBMB) |
(R)-mandelonitrile = cyanide + benzaldehyde [RN: R01767]
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| Reaction(KEGG) |
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| Substrate |
(R)-mandelonitrile [CPD: C00561]
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| Product |
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| Comment |
A variety of enzymes from different sources and with different properties. Some are flavoproteins, others are not. Active towards a number of aromatic and aliphatic hydroxynitriles (cyanohydrins).
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| History |
EC 4.1.2.10 created 1961, modified 1999, modified 2011
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| Pathway |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K08248 | (R)-mandelonitrile lyase |
| K20802 | (R)-mandelonitrile lyase |
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| Genes |
» show all
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| Reference |
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| Authors |
Ueatrongchit T, Kayo A, Komeda H, Asano Y, H-Kittikun A |
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| Title |
Purification and characterization of a novel (R)-hydroxynitrile lyase from Eriobotrya japonica (Loquat). |
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| Journal |
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| Reference |
2 |
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| Authors |
Lin, G., Han, S. and Li, Z. |
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| Title |
Enzymic synthesis of (R)-cyanohydrins by three (R)-oxynitrilase sources in micro-aqueous organic medium. |
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| Journal |
Tetrahedron 55:3531-3540 (1999) |
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| Reference |
3 |
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| Authors |
de Gonzalo, G., Brieva, R. and Gotor, V. |
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| Title |
(R)-Oxynitrilase-catalyzed transformation of omega-hydroxyalkanals. |
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| Journal |
J Mol Catal B 19-20:223-230 (2002) |
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| Reference |
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| Authors |
Ueatrongchit T, Tamura K, Ohmiya T, H-Kittikun A, Asano Y |
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| Title |
Hydroxynitrile lyase from Passiflora edulis: Purification, characteristics and application in asymmetric synthesis of (R)-mandelonitrile. |
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| Journal |
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| Reference |
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| Authors |
Andexer J, von Langermann J, Mell A, Bocola M, Kragl U, Eggert T, Pohl M |
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| Title |
An R-selective hydroxynitrile lyase from Arabidopsis thaliana with an alpha/beta-hydrolase fold. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Guterl JK, Andexer JN, Sehl T, von Langermann J, Frindi-Wosch I, Rosenkranz T, Fitter J, Gruber K, Kragl U, Eggert T, Pohl M |
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| Title |
Uneven twins: comparison of two enantiocomplementary hydroxynitrile lyases with alpha/beta-hydrolase fold. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 4.1.2.10 |
| ExPASy - ENZYME nomenclature database: | 4.1.2.10 |
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| LinkDB |
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