Entry
Name
(R)-mandelonitrile lyase;
(R)-oxynitrilase;
oxynitrilase;
D-oxynitrilase;
D-alpha-hydroxynitrile lyase;
mandelonitrile benzaldehyde-lyase;
PaHNL;
AtHNL;
PhaMDL;
(R)-HNL;
(R)-PeHNL;
(R)-hydroxynitrile lyase;
R-selective hydroxynitrile lyase;
R-selective HNL;
(R)-(+)-mandelonitrile lyase
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
(R)-mandelonitrile benzaldehyde-lyase (cyanide-forming)
Reaction(IUBMB)
(R)-mandelonitrile = cyanide + benzaldehyde [RN:
R01767 ]
Reaction(KEGG)
Substrate
(R)-mandelonitrile [CPD:
C00561 ]
Product
Comment
A variety of enzymes from different sources and with different properties. Some are flavoproteins, others are not. Active towards a number of aromatic and aliphatic hydroxynitriles (cyanohydrins).
History
EC 4.1.2.10 created 1961, modified 1999, modified 2011
Pathway
ec01110 Biosynthesis of secondary metabolites
Orthology
K08248 (R)-mandelonitrile lyase
K20802 (R)-mandelonitrile lyase
Genes
ATH : AT1G73050 AT5G10300(MES5)
CSAT : 104701992 104712914 104751159
EUS : EUTSA_v10014451mg EUTSA_v10018360mg
BRP : 103831793 103846819 103852822
BNA : 106354249 106372481 106378088 106379433 106381275 106404872
RSZ : 108814498 108841961 108841964
CPAP : 110824699 110824820
MINC : 123212454 123212483
LJA : Lj3g3v2040180.1(Lj3g3v2040180.1)
RCN : 112189159 112195896 112199010 112200405
PPER : 109946273 109946518 109946533 109946707 109946708 109946737 109948219 109948555 18788267 18788307 18789360 18790170 18790921 18792725 18792970
PMUM : 103323319 103323417 103323418 103323458 103323460 103323461 103323462 103323463 103323464 103323465 103323466 103328816 103344346 103344354
PAVI : 110748378 110749710 110752511 110752512 110752514 110752517 110752520 110752523 110752528 110752533 110752546 110767481 110772812 110774301
PDUL : 117614487 117614647 117614649 117615086 117615220 117615239 117615281 117615325 117615505 117617267 117623911 117635510
MDM : 103404510 103416927 103417232 103417299 103420796 103429895 103429959 103443315 103447443 103447445 103447446 114819207 114823910
PXB : 103926833 103926855 103931741 103944089 103944905 103944906 103944908 103954303 108867073
ZJU : 107405923 107405925 107405927 107405928 107407673 107410829 107410921 107411003 107414194 107414223 107414239 107414258 107414277 107414317 107414349 107414388 107415173 107428185 107432121 107432123 107432124 107432125
MNT : 21388472 21405661 21405817 21405818 21405819
CSV : 101211615 101212821 101213062 101213549 101213785 101214030 101214272 101214723 101218493 116401960 116401973 116401986
CMO : 103493044 103493053 103493064 103493073 103493083 103493093 103493130 103493164 103493179 103493189 103500635
BHJ : 120079226 120079227 120079228 120079550 120080282 120080549 120086734
MCHA : 111020834 111020835 111020836 111020841
CMAX : 111465496 111465498 111488606 111492330 111492348 111494473
CMOS : 111436113 111436125 111436223 111444087 111444097 111450816 111456379 111464460
CPEP : 111779136 111799103 111804863 111805062 111805571 111805875 111807599
MESC : 110603558 110628615
PALZ : 118045144 118059813
CILL : 122300687 122300854
INI : 109187446 109187563 109192240
SSPL : 121778127 121781122
HAN : 110874223 110877473 110877524 110877525 110886397 110886885 110886886 110894152 110913082 110916839 110917615 110929299 110929300 110929307 110929308 110931731
ECAD : 122589929 122597922 122599479 122600961
LSV : 111879508 111909027 111910381 111915295
CCAV : 112504716 112509255 112517338
PSOM : 113275657 113277545
DOSA : Os06t0656000-00(Os06g0656000)
TAES : 123154811 123160447 123171371
PVIR : 120671531 120704924
AOF : 109842577 109842578 109842616
» show all
Taxonomy
Reference
Authors
Ueatrongchit T, Kayo A, Komeda H, Asano Y, H-Kittikun A
Title
Purification and characterization of a novel (R)-hydroxynitrile lyase from Eriobotrya japonica (Loquat).
Journal
Reference
2
Authors
Lin, G., Han, S. and Li, Z.
Title
Enzymic synthesis of (R)-cyanohydrins by three (R)-oxynitrilase sources in micro-aqueous organic medium.
Journal
Tetrahedron 55:3531-3540 (1999)
Reference
3
Authors
de Gonzalo, G., Brieva, R. and Gotor, V.
Title
(R)-Oxynitrilase-catalyzed transformation of omega-hydroxyalkanals.
Journal
J Mol Catal B 19-20:223-230 (2002)
Reference
Authors
Ueatrongchit T, Tamura K, Ohmiya T, H-Kittikun A, Asano Y
Title
Hydroxynitrile lyase from Passiflora edulis: Purification, characteristics and application in asymmetric synthesis of (R)-mandelonitrile.
Journal
Reference
Authors
Andexer J, von Langermann J, Mell A, Bocola M, Kragl U, Eggert T, Pohl M
Title
An R-selective hydroxynitrile lyase from Arabidopsis thaliana with an alpha/beta-hydrolase fold.
Journal
Sequence
Reference
Authors
Guterl JK, Andexer JN, Sehl T, von Langermann J, Frindi-Wosch I, Rosenkranz T, Fitter J, Gruber K, Kragl U, Eggert T, Pohl M
Title
Uneven twins: comparison of two enantiocomplementary hydroxynitrile lyases with alpha/beta-hydrolase fold.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.10
ExPASy - ENZYME nomenclature database: 4.1.2.10
LinkDB
All DBs