The enzyme, which participates in a pathway for folate biosynthesis, is found in the Stramenopiles, a large group that includes oomycetes, various microalgae and brown algae, as well as in several bacterial phyla. It provides a bypass mechanism compensating for the lack of EC 184.108.40.206, dihydroneopterin aldolase. In the malaria parasite Plasmodium falciparum the enzyme is bifunctional and also catalyses the activity of EC 220.127.116.11, 6-pyruvoyltetrahydropterin synthase. cf. EC 18.104.22.168, dihydroneopterin phosphate aldolase.