KEGG   ENZYME: 4.1.2.60
Entry
EC 4.1.2.60                 Enzyme                                 

Name
dihydroneopterin triphosphate aldolase;
PTPS-III
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
Sysname
7,8-dihydroneopterin 3'-triphosphate glycolaldehyde phosphate-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]
Reaction(IUBMB)
7,8-dihydroneopterin 3'-triphosphate = 6-(hydroxymethyl)-7,8-dihydropterin + glycolaldehyde triphosphate [RN:R11719]
Reaction(KEGG)
R11719
Substrate
7,8-dihydroneopterin 3'-triphosphate [CPD:C04895]
Product
6-(hydroxymethyl)-7,8-dihydropterin [CPD:C01300];
glycolaldehyde triphosphate [CPD:C21615]
Comment
The enzyme, which participates in a pathway for folate biosynthesis, is found in the Stramenopiles, a large group that includes oomycetes, various microalgae and brown algae, as well as in several bacterial phyla. It provides a bypass mechanism compensating for the lack of EC 4.1.2.25, dihydroneopterin aldolase. In the malaria parasite Plasmodium falciparum the enzyme is bifunctional and also catalyses the activity of EC 4.2.3.12, 6-pyruvoyltetrahydropterin synthase. cf. EC 4.1.2.59, dihydroneopterin phosphate aldolase.
History
EC 4.1.2.60 created 2017
Pathway
ec00790  Folate biosynthesis
ec01100  Metabolic pathways
Orthology
K22101  dihydroneopterin triphosphate aldolase (PTPS-III) / 6-pyruvoyltetrahydropterin synthase
Genes
PFA: PF3D7_0628000
PFD: PFDG_00795
PFH: PFHG_00633
PYO: PY17X_1128200
PCB: PCHAS_112620(PC000014.00.0)
PBE: PBANKA_1126700
PKN: PKNH_1121800
PVX: PVX_114505
PCY: PCYB_113000
PTI: PHATRDRAFT_50741
SPAR: SPRG_04534
 » show all
Reference
1  [PMID:18093090]
  Authors
Dittrich S, Mitchell SL, Blagborough AM, Wang Q, Wang P, Sims PF, Hyde JE
  Title
An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites.
  Journal
Mol Microbiol 67:609-18 (2008)
DOI:10.1111/j.1365-2958.2007.06073.x
  Sequence
Reference
2  [PMID:18805734]
  Authors
Hyde JE, Dittrich S, Wang P, Sims PF, de Crecy-Lagard V, Hanson AD
  Title
Plasmodium falciparum: a paradigm for alternative folate biosynthesis in diverse  microorganisms?
  Journal
Trends Parasitol 24:502-8 (2008)
DOI:10.1016/j.pt.2008.08.004
  Sequence
Reference
3  [PMID:19395485]
  Authors
Pribat A, Jeanguenin L, Lara-Nunez A, Ziemak MJ, Hyde JE, de Crecy-Lagard V, Hanson AD
  Title
6-pyruvoyltetrahydropterin synthase paralogs replace the folate synthesis enzyme  dihydroneopterin aldolase in diverse bacteria.
  Journal
J Bacteriol 191:4158-65 (2009)
DOI:10.1128/JB.00416-09
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.60
IUBMB Enzyme Nomenclature: 4.1.2.60
ExPASy - ENZYME nomenclature database: 4.1.2.60
BRENDA, the Enzyme Database: 4.1.2.60
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