Entry
Name
4-hydroxy-2-oxoglutarate aldolase;
2-oxo-4-hydroxyglutarate aldolase;
hydroxyketoglutaric aldolase;
4-hydroxy-2-ketoglutaric aldolase;
2-keto-4-hydroxyglutaric aldolase;
4-hydroxy-2-ketoglutarate aldolase;
2-keto-4-hydroxyglutarate aldolase;
2-oxo-4-hydroxyglutaric aldolase;
DL-4-hydroxy-2-ketoglutarate aldolase;
hydroxyketoglutarate aldolase;
2-keto-4-hydroxybutyrate aldolase;
4-hydroxy-2-oxoglutarate glyoxylate-lyase;
KHGA
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
Reaction(IUBMB)
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate [RN:
R00470 ]
Reaction(KEGG)
Substrate
4-hydroxy-2-oxoglutarate [CPD:
C01127 ]
Product
Comment
The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. cf. EC
4.1.3.42 , (4S)-4-hydroxy-2-oxoglutarate aldolase.
History
EC 4.1.3.16 created 1972 (EC 4.1.2.1 created 1961, incorporated 1972, EC 4.1.2.31 created 1978, incorporated 1982)
Pathway
ec00330 Arginine and proline metabolism
ec00630 Glyoxylate and dicarboxylate metabolism
Orthology
K18123 4-hydroxy-2-oxoglutarate aldolase
Genes
LVE : 103077167 103089444(HOGA1)
BGAR : 122941075 122942538
MUO : 115459261 115470032(HOGA1)
SGH : 107551368 107588470(hoga1)
PPRM : 120468726 120468763(hoga1)
SASA : 106591168(hoga1) 106591313
SNH : 120032829(hoga1) 120032838
LPIC : 129273310 129273313
BTAB : 109031207 109033146 109037695
CLEC : 106664885 106665585
HVI : 124369256 124370050 124374619
MQU : 128987472 128998301 129004190
RPHI : 132717755 132721141
NTE : NEUTE1DRAFT148948(NEUTE1DRAFT_148948) NEUTE1DRAFT48910(NEUTE1DRAFT_48910)
SMP : 10805247(SMAC4_03823) 10808176(SMAC4_07903)
PAN : PODANSg09878 PODANSg3113 PODANSg3131
PBEL : QC761_106120 QC761_407320 QC761_407500
PPSD : QC762_106120 QC762_407320 QC762_407500
PPSP : QC763_106120 QC763_407320 QC763_407500
PPSA : QC764_106120 QC764_407320 QC764_407500
TTT : THITE_2041371 THITE_2110019 THITE_2122366
CTHR : CTHT_0040680 CTHT_0055950
MGR : MGG_05159 MGG_07933 MGG_08615 MGG_16966
PPEI : PpBr36_03531 PpBr36_03838 PpBr36_03851
PGRI : PgNI_02808 PgNI_09163 PgNI_09179 PgNI_09601
TMN : UCRPA7_1105 UCRPA7_1858 UCRPA7_4535 UCRPA7_6686 UCRPA7_7278 UCRPA7_729 UCRPA7_7973
SSCK : SPSK_00143 SPSK_01848 SPSK_03433 SPSK_03475 SPSK_07785
FGR : FGSG_01813 FGSG_02063 FGSG_03069 FGSG_03647 FGSG_05048 FGSG_09521
FPU : FPSE_01888 FPSE_02157 FPSE_03347 FPSE_04939 FPSE_05154 FPSE_11340
FPOA : FPOAC1_002206 FPOAC1_005426 FPOAC1_007947 FPOAC1_012140
FVN : FVRRES_02444 FVRRES_05983 FVRRES_08483 FVRRES_13215
FVR : FVEG_04070 FVEG_06008 FVEG_07522 FVEG_07725 FVEG_08807 FVEG_10721
FOX : FOXG_04402 FOXG_04587 FOXG_06217 FOXG_08665 FOXG_09663 FOXG_12147
NHE : NECHADRAFT_103547 NECHADRAFT_41228 NECHADRAFT_51004 NECHADRAFT_53351 NECHADRAFT_73269 NECHADRAFT_75207 NECHADRAFT_82289 NECHADRAFT_99111
FFC : NCS54_00134900 NCS54_00224900 NCS54_00296900 NCS54_00732200 NCS54_00892300 NCS54_01241800 NCS54_01344500 NCS54_01404400
FKR : NCS57_00132300 NCS57_00220400 NCS57_00292100 NCS57_00772600 NCS57_01267600 NCS57_01320100 NCS57_01470900
FMU : J7337_004076 J7337_004761 J7337_010473 J7337_013310
TRE : TRIREDRAFT_122582 TRIREDRAFT_2036 TRIREDRAFT_3717 TRIREDRAFT_53123
TRR : M419DRAFT_129606 M419DRAFT_131928 M419DRAFT_141790 M419DRAFT_88777
TATV : 25775279(TrAtP1_006429) 25781633(TrAtP1_008221) 25785766(TrAtP1_009982)
TASP : 36607632(TrAFT101_003156) 36608606(TrAFT101_005691) 36609779(TrAFT101_011216) 36616874(TrAFT101_006867)
MAW : 19245547(J3458_014426) 19248802(J3458_014343) 19253766(J3458_020054)
MAJ : MAA_00627 MAA_07813 MAA_09251
MBRN : 26242821(G6M90_00g058320) 26246917(G6M90_00g112550)
PCHM : VFPPC_05939 VFPPC_08305 VFPPC_10737
CMT : CCM_05289 CCM_07759 CCM_07861
AMUS : LMH87_003092 LMH87_011155
PLJ : 28884668(PLICBS_005891) 28889587(PLICBS_007988) 28891153(PLICBS_004545) 28893163(PLICBS_009873) 90642997(PLICBS_005219)
PTKZ : JDV02_004118 JDV02_005453 JDV02_008698 JDV02_009402 JDV02_010296
VAL : VDBG_01853 VDBG_03325 VDBG_05072 VDBG_08158 VDBG_09109 VDBG_09557
VDA : VDAG_01702 VDAG_02228 VDAG_04788 VDAG_07257 VDAG_10050 VDAG_10512
CFJ : CFIO01_04102 CFIO01_04988 CFIO01_05142 CFIO01_05423 CFIO01_08392 CFIO01_08695 CFIO01_12712 CFIO01_13735
CLUP : CLUP02_01428 CLUP02_01662 CLUP02_02715 CLUP02_15676 CLUP02_16425 CLUP02_16731
CHIG : CH63R_02055 CH63R_05135 CH63R_06511 CH63R_10333 CH63R_10575 CH63R_11316 CH63R_14095
CDET : 87936785(CDEST_00282) 87942208(CDEST_05705) 87943434(CDEST_06931) 87943683(CDEST_07180) 87946067(CDEST_09564) 87947667(CDEST_11167) 87947894(CDEST_11394)
ELA : UCREL1_1 UCREL1_10034 UCREL1_3023 UCREL1_4493 UCREL1_7875 UCREL1_8344 UCREL1_9767
PFY : PFICI_02155 PFICI_06710 PFICI_10660 PFICI_11183 PFICI_13580 PFICI_14195
SSL : SS1G_02917 SS1G_04053
BFU : BCIN_01g06600 BCIN_06g05360
PSCO : LY89DRAFT_58302 LY89DRAFT_587194 LY89DRAFT_685858 LY89DRAFT_694995 LY89DRAFT_705574
ANI : ANIA_01503 ANIA_10990
AFM : AFUA_2G01230 AFUA_4G08690 AFUA_8G05040
ACT : ACLA_048040 ACLA_058440 ACLA_072950 ACLA_094540
NFI : NFIA_033530 NFIA_089760 NFIA_097850 NFIA_107490
AOR : AO090005000638 AO090701000399
ANG : An03g00040 An10g00330 An15g04230 An16g07700
AFV : AFLA_003449 AFLA_004914
ALUC : AKAW2_50024S AKAW2_70609S AKAW2_71046S
ACHE : ACHE_40068S ACHE_60607S
APUU : APUU_11117S APUU_21711S APUU_40056A APUU_60006S APUU_60054S APUU_80237A
PCS : N7525_006160 N7525_006169 N7525_007792 N7525_009429
PDP : PDIP_02670 PDIP_46650
POU : POX_a01923 POX_h09833
TMF : EYB26_000617 EYB26_004448 EYB26_005107 EYB26_006504 EYB26_009474
TRG : TRUGW13939_01370 TRUGW13939_02223 TRUGW13939_02289 TRUGW13939_03930 TRUGW13939_04239 TRUGW13939_07477 TRUGW13939_08086 TRUGW13939_08229 TRUGW13939_08539 TRUGW13939_09259 TRUGW13939_10146
CIM : CIMG_00151 CIMG_06885
CPW : CPC735_032800 CPC735_059910
URE : UREG_00255 UREG_03604
PBL : PAAG_03143 PAAG_03793
PBN : PADG_03024 PADG_03296
AJE : HCAG_01713 HCAG_07219
BGH : BDBG_00749 BDBG_02384 BDBG_03560
PNO : SNOG_03839 SNOG_04544 SNOG_15818
PTE : PTT_08311 PTT_12228 PTT_17993
PTRR : 6344723(PtrM4_049530) 6346091(PtrM4_138340) 6346995(PtrM4_031640)
BZE : COCCADRAFT_109610 COCCADRAFT_37284 COCCADRAFT_9535
BSC : COCSADRAFT_271752 COCSADRAFT_33387 COCSADRAFT_335849
BOR : COCMIDRAFT_23190 COCMIDRAFT_26603 COCMIDRAFT_8673
AALT : CC77DRAFT_1017551 CC77DRAFT_1040104 CC77DRAFT_840448
ARAB : EKO05_0002435 EKO05_0006593 EKO05_0008024 EKO05_0009845
FFU : CLAFUR5_02034 CLAFUR5_09491
BCOM : BAUCODRAFT_150164 BAUCODRAFT_558779 BAUCODRAFT_573577 BAUCODRAFT_68239
NPA : UCRNP2_1393 UCRNP2_68 UCRNP2_7892 UCRNP2_894
KMG : 30167418(I203_106328)
KNE : 92178234(IAR55_000975)
TVS : TRAVEDRAFT_145691 TRAVEDRAFT_29711 TRAVEDRAFT_62801
DSQ : DICSQDRAFT_129292 DICSQDRAFT_152921
PCO : PHACADRAFT_166860 PHACADRAFT_252672 PHACADRAFT_255535 PHACADRAFT_257602
SHS : STEHIDRAFT_119341 STEHIDRAFT_49383
HIR : HETIRDRAFT_157267 HETIRDRAFT_412119 HETIRDRAFT_448998
PSQ : PUNSTDRAFT_52021 PUNSTDRAFT_70957
ADL : AURDEDRAFT_110014 AURDEDRAFT_148009
CCI : CC1G_04219 CC1G_06285
ABP : AGABI1DRAFT111212(AGABI1DRAFT_111212) AGABI1DRAFT114952(AGABI1DRAFT_114952)
ABV : AGABI2DRAFT190432(AGABI2DRAFT_190432) AGABI2DRAFT191181(AGABI2DRAFT_191181)
MRR : Moror_14079 Moror_4689 Moror_8005
MORE : E1B28_006317 E1B28_007270 E1B28_008904
SCM : SCHCO_02605035(SCHCODRAFT_02605035)
CPUT : CONPUDRAFT_129595 CONPUDRAFT_51541
SLA : SERLADRAFT_361556 SERLADRAFT_454235
WSE : WALSEDRAFT_29927 WALSEDRAFT_61673
LCRE : Pla8534_42110(dapA_3)
TRS : Terro_1985 Terro_2351
ABAC : LuPra_06084(dapA_3)
» show all
Taxonomy
Reference
Authors
KURATOMI K, FUKUNAGA K.
Title
THE METABOLISM OF GAMMA-HYDROXYGLUTAMATE IN RAT LIVER. I. ENZYMIC SYNTHESIS OF GAMMA-HYDROXY-ALPHA-KETOGLUTARATE FROM PYRUVATE AND GLYOXYLATE.
Journal
Reference
Authors
Kobes RD, Dekker EE
Title
2-Keto-4-hydroxyglutarate aldolase of bovine liver. Purification, criteria of purity, and general properties.
Journal
J Biol Chem 244:1919-25 (1969)
Reference
Authors
Lane RS, Shapley A, Dekker EE.
Title
2-keto-4-hydroxybutyrate aldolase. Identification as 2-keto-4-hydroxyglutarate aldolase, catalytic properties, and role in the mammalian metabolism of L-homoserine.
Journal
Reference
Authors
Scholtz JM, Schuster SM
Title
Regulation of rat liver 4-hydroxy-2-ketoglutarate aldolase.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.16
ExPASy - ENZYME nomenclature database: 4.1.3.16
LinkDB
All DBs