Entry
Name
(S)-citramalyl-CoA lyase;
citramalyl coenzyme A lyase (ambiguous);
(+)-CMA-CoA lyase;
(3S)-citramalyl-CoA pyruvate-lyase;
Mcl (ambiguous);
citramalyl-CoA lyase (ambiguous)
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
(3S)-citramalyl-CoA pyruvate-lyase (acetyl-CoA-forming)
Reaction(IUBMB)
(3S)-citramalyl-CoA = acetyl-CoA + pyruvate [RN:
R00237 ]
Reaction(KEGG)
Substrate
(3S)-citramalyl-CoA [CPD:
C01011 ]
Product
Comment
Requires Mg2+ ions for activity [3]. The enzyme from the bacterium Clostridium tetanomorphum is a component of EC
4.1.3.22 , citramalate lyase [2]. It also acts on (3S)-citramalyl thioacyl-carrier protein [2]. The enzyme from the bacterium Chloroflexus aurantiacus also has the activity of EC
4.1.3.24 , malyl-CoA lyase [3]. It has no activity with (3R)-citramalyl-CoA (cf. EC
4.1.3.46 , (R)-citramalyl-CoA lyase) [3].
History
EC 4.1.3.25 created 1972, modified 2014
Pathway
ec00660 C5-Branched dibasic acid metabolism
ec00720 Other carbon fixation pathways
ec01120 Microbial metabolism in diverse environments
Orthology
K08691 malyl-CoA/(S)-citramalyl-CoA lyase
K18292 (S)-citramalyl-CoA lyase
Genes
PPRC : PFLCHA0_c27180(citE)
PMUD : NCTC8068_02067(citE_1) NCTC8068_02524(citE_2)
PLUL : FOB45_02115 FOB45_04005
PPUU : PputUW4_01805(citE) PputUW4_03343
PTAE : NCTC10697_01930(citE)
MCAT : MC25239_00424(mcl2)
MCUN : NCTC10297_00920(mcl2)
MICT : FIU95_07930(citE1) FIU95_13375(citE2)
MICZ : GL2_28690 GL2_29040
LLG : 44548918_02118(mcl1)
LCJ : NCTC11976_03020(citE)
CBLY : IPM89_03270 IPM89_04980
BPD : BURPS668_A2305(cilB)
BUM : AXG89_23905 AXG89_28785
PTER : C2L65_26290 C2L65_44450
PSAA : QEN71_12140 QEN71_33975
PLG : NCTC10937_02759(citE)
BTRM : SAMEA390648700434(citE)
APES : FOC84_07870 FOC84_30065
PIG : EGT29_18045 EGT29_20250
MNR : ACZ75_13510 ACZ75_18260
XYK : GT347_04005 GT347_12545
URU : DSM104443_00577(mcl1_1) DSM104443_03118(citE_2)
RBS : RHODOSMS8_01011(mcl)
SFH : SFHH103_02474(cite1)
SFD : USDA257_c22030(mcl1)
SAME : SAMCFNEI73_pC0656(mcl)
MEA : Mex_1p1733(mcl) Mex_1p4295
MDI : METDI2485(mcl) METDI4906
MZA : B2G69_01480 B2G69_16670
MRD : Mrad2831_1650 Mrad2831_3663
META : Y590_08615 Y590_19480
MAQU : Maq22A_c18385(citE) Maq22A_c19250(mcl)
MPHY : MCBMB27_01298 MCBMB27_03145
MEE : DA075_20140 DA075_27160
METD : C0214_10380 C0214_21595
METX : A3862_13170 A3862_22625
METS : DK389_15360 DK389_27325
METI : DK427_15555 DK427_17480
MMES : MMSR116_01155 MMSR116_21315
MTEA : DK419_14290 DK419_26925
MIND : mvi_25720 mvi_28860
MOG : MMB17_01150 MMB17_19730
MTAD : M6G65_09600 M6G65_20420
MTUN : MTUNDRAET4_3402(mcl)
HDT : HYPDE_30183 HYPDE_38943
HMC : HYPMC_1941 HYPMC_4395(mcl)
HNI : W911_10365 W911_15805
FIL : BN1229_v1_1240(mcl) BN1229_v1_2672
FIY : BN1229_v1_1238(mcl) BN1229_v1_3242
MBRY : B1812_00060 B1812_17545
MROS : EHO51_12185 EHO51_15075
MHEY : H2LOC_011805 H2LOC_014625
MPAR : F7D14_06360 F7D14_09175
MIWA : SS37A_01470 SS37A_07190
MTW : CQW49_12235 CQW49_16215
MECQ : MSC49_04610 MSC49_35030(mclA)
CMET : K6K41_15080 K6K41_22170
PLEO : OHA_1_00681(mcl) OHA_1_00777(citE)
HDI : HDIA_2217(mcl1_1) HDIA_2467(mcl1_2)
PSF : PSE_3167(clybl) PSE_3192
CFH : C1707_10190 C1707_19785
TSV : DSM104635_00778(mcl1)
SIL : SPO1565 SPO3608(mclA)
RUA : D1823_18170 D1823_20490
RUT : FIU92_13270(mcl2) FIU92_19865(mcl3)
RCON : K3740_00765 K3740_20040
RUY : NOR97_12580 NOR97_17625
RDE : RD1_1001(citE) RD1_1160(mclA) RD1_4242(mclA)
RLI : RLO149_c002070(mcl1) RLO149_c036850(mcl2)
RFU : ROLI_001060(mcl1_1) ROLI_003020(mcl1_2)
DSH : Dshi_2490(citE1) Dshi_3050(citE2)
LMD : METH_02340 METH_18390
LEJ : ETW24_03080 ETW24_17910
LAQU : R2C4_14570 R2C4_19790
LEV : ETW23_00250 ETW23_17075
LCAE : K3721_02490 K3721_16185
RED : roselon_01454 roselon_02260
SINL : DSM14862_03056(mcl1)
SPSE : SULPSESMR1_03496(mcl1)
RMM : ROSMUCSMR3_02149(mcl1) ROSMUCSMR3_03455(mcl1)
ROK : RAK1035_1037 RAK1035_2340
RID : RIdsm_02779(mcl1_1) RIdsm_05011(mcl1_2)
ROM : EI983_00710 EI983_08270
RPEL : N7U68_03480 N7U68_09695
AHT : ANTHELSMS3_00280(mcl1)
SAGU : CDO87_13335 CDO87_15505
MALU : KU6B_08980(mcl1) KU6B_14460 KU6B_40050
TGL : HFZ77_14905 HFZ77_15575
PALX : GQA70_15345 GQA70_23220
RMAI : MACH21_17090 MACH21_30420(mcl1)
RCP : RCAP_rcc03164(citE2)
FYT : QF092_14495 QF092_14520
PAMI : JCM7686_2763 JCM7686_3168
PZH : CX676_04845 CX676_15565
PAMN : JCM7685_2683 pAMV1p0135(mcl) pAMV3p0611(mcal)
PSAP : JHX88_01975 JHX88_17895 JHX88_20315
PALP : JHW40_15150 JHW40_18530
LVS : LOKVESSMR4R_02838(mcl1)
GEH : HYN69_16130 HYN69_16155
GFU : KM031_08955 KM031_11830
TAW : EI545_00080 EI545_09215
SEDI : EBB79_18450 EBB79_24155
PAED : G5B38_01665 G5B38_14245
NSM : JO391_00315 JO391_12675
AMYL : QBD29_03580 QBD29_08415
AMAQ : GO499_03725 GO499_18685
RBG : BG454_02060 BG454_05615
BOSG : GKR98_07030 GKR98_16035
HBC : AEM38_14745 AEM38_15995
SFLA : SPHFLASMR4Y_02129(mcl1)
ABS : AZOBR_p270295 AZOBR_p310067 AZOBR_p460037
ABQ : ABAZ39_29510 ABAZ39_31970
ABF : AMK58_11080 AMK58_24910 AMK58_27775
AZT : TSH58p_20915 TSH58p_30490
AARE : D3093_28150 D3093_30530
NCB : C0V82_13810 C0V82_17295
SKT : IGS68_03250 IGS68_27860
SMUC : JL100_003365 JL100_031220
SROE : JL101_003125 JL101_033645
HADH : FRZ61_42590 FRZ61_45950
TMO : TMO_0350(citE) TMO_b0387 TMO_d0041(citE)
MSD : MYSTI_02520 MYSTI_04299
MYM : A176_003301 A176_004228
MFB : MFUL124B02_13445 MFUL124B02_23090
PARH : I5S86_16395 I5S86_16865
MMAE : MMARE11_39680(citE_1)
MBAI : MB901379_00391(mcl1_1)
SCAD : DN051_00525 DN051_40285
SNW : BBN63_24165 BBN63_32950
SNIG : HEK616_29400(citE_1)
STUD : STRTU_000263 STRTU_001461
NAQU : ENKNEFLB_04247(mcl)
AORI : SD37_10615 SD37_41460
ACOR : LCL61_06605 LCL61_28765
BALA : DSM104299_01895(mcl)
SBAE : DSM104329_01824(mcl) DSM104329_03745(mcl1)
» show all
Taxonomy
Reference
Authors
Cooper RA, Kornberg HL.
Title
The utilization of itaconate by Pseudomonas sp.
Journal
Reference
Authors
Dimroth P, Buckel W, Loyal R, Eggerer H.
Title
Isolation and function of the subunits of citramalate lyase and formation of hybrids with the subunits of citrate lyase.
Journal
Reference
Authors
Friedmann S, Alber BE, Fuchs G
Title
Properties of R-citramalyl-coenzyme A lyase and its role in the autotrophic 3-hydroxypropionate cycle of Chloroflexus aurantiacus.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.25
ExPASy - ENZYME nomenclature database: 4.1.3.25
LinkDB
All DBs