Entry
Name
chorismate lyase;
CL;
CPL;
UbiC
Class
Lyases;
Carbon-carbon lyases;
Oxo-acid-lyases
BRITE hierarchy
Sysname
chorismate pyruvate-lyase (4-hydroxybenzoate-forming)
Reaction(IUBMB)
chorismate = 4-hydroxybenzoate + pyruvate [RN:
R01302 ]
Reaction(KEGG)
Substrate
Product
Comment
This enzyme catalyses the first step in the biosynthesis of ubiquinone in Escherichia coli and other Gram-negative bacteria [1]. The yeast Saccharomyces cerevisiae can synthesize ubiquinone from either chorismate or tyrosine [3].
History
EC 4.1.3.40 created 2007
Pathway
ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K18240 chorismate lyase / 3-hydroxybenzoate synthase
Genes
ECOO : ECRM13514_5174(ubiC)
ECOH : ECRM13516_4911(ubiC)
ELR : ECO55CA74_23290(ubiC)
ECW : EcE24377A_4592(ubiC)
ECOA : APECO78_01015(ubiC)
EDJ : ECDH1ME8569_3896(ubiC)
ECOI : ECOPMV1_04420(ubiC)
SEM : STMDT12_C43690(ubiC)
SETC : CFSAN001921_19250(ubiC)
SEEN : SE451236_04200(ubiC)
SENH : CFSAN002069_10935(ubiC)
SEEH : SEEH1578_07335(ubiC)
SENJ : CFSAN001992_12710(ubiC)
SEEC : CFSAN002050_03995(ubiC)
SEEB : SEEB0189_021280(ubiC)
SENC : SEET0819_04980(ubiC)
REE : electrica_04762(ubiC)
RTG : NCTC13098_06864(ubiC)
CLAP : NCTC11466_04302(ubiC)
KIE : NCTC12125_03451(ubiC)
AHN : NCTC12129_04605(ubiC)
METY : MRY16398_53170(ubiC)
PSHI : SAMEA2665130_0182(ubiC)
YPG : YpAngola_A0678(ubiC)
YPI : YpsIP31758_3774(ubiC)
SMW : SMWW4_v1c44320(ubiC)
SERS : SERRSCBI_21405(ubiC)
SFG : AV650_00805 AV650_27645
SFJ : SAMEA4384070_4432(ubiC)
SOF : NCTC11214_02143(ubiC)
SSAR : SSARUM_004326(ubiC)
PAQU : DMB82_0002955(ubiC)
PARL : PEC302110_34340(ubiC)
DIC : Dpoa569_003387(ubiC)
TPTY : NCTC11468_03420(ubiC)
PHEI : NCTC12003_00440(ubiC)
PRJ : NCTC6933_00509(ubiC)
LRI : NCTC12151_00437(ubiC)
PDAG : 4362423_01268(ubiC)
ALIG : NCTC10568_02219(ubiC)
ASEG : NCTC10977_00955(ubiC)
AVT : NCTC3438_00671(ubiC)
PAET : NCTC13378_01205(ubiC)
XFU : XFF4834R_chr39700(xanB2)
XAL : XALC_0126 XALC_1522(albXX)
XPH : XppCFBP6546_13945(XppCFBP6546P_13945)
LAQ : GLA29479_4083(xanB2)
LLZ : LYB30171_00206(rapK)
VAU : VANGNB10_cI0108(ubiC)
VAQ : FIV01_13790(ubiC1) FIV01_19280(ubiC2)
VPL : SA104470976_02635(ubiC)
PAEB : NCGM1900_6202(ubiC)
PVD : CFBP1590__5342(ubiC)
PPRC : PFLCHA0_c60640(ubiC)
PFO : Pfl01_0710 Pfl01_5603(ubiC)
PMUD : NCTC8068_05315(ubiC)
PFW : PF1751_v1c54460(ubiC)
PPUU : PputUW4_05351(ubiC)
PSEC : CCOS191_5211(ubiC2)
PKE : DLD99_03920 DLD99_28450
PTW : TUM18999_01300(ubiC)
PTAE : NCTC10697_00119(ubiC)
PFIT : KJY40_00410 KJY40_04660
PSHS : JJN09_03780 JJN09_19625
PSYC : DABAL43B_0370(ubiC)
ACAL : BUM88_13425 BUM88_14090
ACIG : BS636_00165 BS636_15410
MCAT : MC25239_01549(ubiC)
MCUN : NCTC10297_00216(ubiC)
SCAA : TUM17387_37900(ubiC)
ALR : DS731_00355 DS731_16695
APEL : CA267_009185 CA267_009755
SALM : D0Y50_15440 D0Y50_19060
SALH : HMF8227_00069(ubiC)
MOQ : HWV03_15130 HWV03_21440
CJA : CJA_0104(fkbO) CJA_0152(ubiC)
CEB : B0D95_12335 B0D95_13775
CEK : D0B88_04510 D0B88_05945
LLG : 44548918_01064(ubiC)
LJR : NCTC11533_01586(ubiC)
LSS : NCTC12082_00425(ubiC)
METU : GNH96_08985 GNH96_09190
MMEO : OOT43_00985 OOT43_01470
MSZE : MSZNOR_1179(ubiC) MSZNOR_3700
MMOB : F6R98_00895 F6R98_11350
MISZ : MishRS11D_00380(rapK) MishRS11D_28710(ubiC)
TSE : THMIRHAS_24640(ubiC)
TZO : THMIRHAT_01540(ubiC)
TTI : THITH_00615 THITH_04285
THIC : TspCOW1_26670(ubiC)
HAXI : HAALTHF_10960n(ubiC)
HAAH : HALA3H3_360136(ubiC)
ALCA : ASALC70_02478(ubiC)
AEL : NCTC12917_03974(ubiC)
CHJ : NCTC10426_00115(ubiC)
CDIZ : CEDIAZO_00589(ubiC)
CBLY : IPM89_02165 IPM89_14095
NMQ : NMBM04240196_1430(ubiC)
NMZ : NMBNZ0533_0784(ubiC)
CCAH : DWG20_02025 DWG20_05510
PSE : NH8B_0792(ubiC) NH8B_1247
AQS : DKK66_11625 DKK66_12230
REH : H16_A3165(h16_A3165)
BMV : BMASAVP1_1583 BMASAVP1_A1006
BMAL : DM55_2496 DM55_3357
BMAE : DM78_2483 DM78_4292
BMAQ : DM76_2481 DM76_4055
BMAI : DM57_13555 DM57_744
BMAF : DM51_1617 DM51_4112
BMAZ : BM44_2706 BM44_3317
BMAB : BM45_2272 BM45_4155
BPM : BURPS1710b_1319(albXX) BURPS1710b_A1215
BPL : BURPS1106A_1168(ubiC) BURPS1106A_A2851
BPD : BURPS668_1159(ubiC) BURPS668_A2975
BPZ : BP1026B_I2448 BP1026B_II2273
BPQ : BPC006_I1217 BPC006_II2813
BPSO : X996_3111 X996_5400
BUR : Bcep18194_A5685 Bcep18194_A6087
BCH : Bcen2424_2346 Bcen2424_2757
BCEN : DM39_2455 DM39_2849
BAC : BamMC406_2262 BamMC406_2676
BCED : DM42_2314 DM42_2715
BCEP : APZ15_01650 APZ15_17080
BPYR : ABD05_01760 ABD05_03820
BCON : NL30_26875 NL30_29765
BDF : WI26_11380 WI26_13300
BTEI : WS51_22100 WS51_24135
BSEM : WJ12_11870 WJ12_13795
BPSL : WS57_30580 WS57_32540
BSTL : BBJ41_14985 BBJ41_17220
BANN : JFN94_12040 JFN94_14155
BARI : NLX30_13680 NLX30_15985
BAEN : L3V59_13730 L3V59_15805
BYI : BYI23_A007900 BYI23_C009530
BUE : BRPE67_ACDS07880(ubiC) BRPE67_CCDS01610
BURK : DM992_06160 DM992_08315
PHS : C2L64_11920 C2L64_49355
PPAI : E1956_13775 E1956_39925
PLG : NCTC10937_05177(ubiC)
BUO : BRPE64_ACDS08870(ubiC) BRPE64_CCDS07270
TCAR : U0034_05610 U0034_14870
BTRM : SAMEA390648703500(ubiC)
ACHR : C2U31_17820 C2U31_29560
RHF : EUB48_12540 EUB48_15470
HTN : KI616_22050 KI616_23100
PBH : AAW51_2908 AAW51_3791
SMIO : CATMQ487_40710(rapK)
ETB : N7L95_03815 N7L95_07340
MPAU : ZMTM_00580(ubiC) ZMTM_13760(rapK)
SDR : SCD_n00507 SCD_n02752
SPLB : SFPGR_06050(ubiC) SFPGR_17920(rapK)
SLAC : SKTS_15010 SKTS_29960(ubiC)
URU : DSM104443_00098(ubiC)
UPL : DSM104440_00097(ubiC)
ARES : IWH25_05135 IWH25_08500
OTR : OTERR_21530 OTERR_22510(ubiC)
APET : ToN1_21550(ubiC) ToN1_47100
DEY : HYN24_03920 HYN24_15675
DDEN : KI615_06490 KI615_21660
DECH : GBK02_01770 GBK02_06045
QAU : KI612_05570 KI612_19805
FLE : KI610_06810 KI610_19855
AZO : azo0478(ubiC) azo3920
AZA : AZKH_1770 AZKH_4237(ubiC)
AZI : AzCIB_1917 AzCIB_4183
AZD : CDA09_13435 CDA09_20430
AZR : CJ010_03260 CJ010_24600
THAG : CKCBHOJB_03109(ubiC)
AZQ : G3580_01750 G3580_03330
APP : CAP2UW1_0289 CAP2UW1_0339
BHS : BM1374165_01199(ubiC)
BBK : BARBAKC583_0971(ubiC)
BTX : BM1374166_01555(ubiC)
BEZ : NCTC12898_01063(ubiC)
AFE : Lferr_0745 Lferr_0932
AFI : Acife_0979 Acife_2838
AFJ : AFERRID_18250 AFERRID_20270
ATX : GCD22_00281 GCD22_00758(ubiC)
AFP : K1Y48_01830 K1Y48_07245
MSHO : MSHO_49820 MSHO_54830 MSHO_58760
MKN : MKAN_01105 MKAN_23935
MBAI : MB901379_01083 MB901379_01575
MLJ : MLAC_20260 MLAC_28880
MAUB : MAUB_28860 MAUB_36900
SACG : FDZ84_20330 FDZ84_26815 FDZ84_28845
TVN : NIES2134_114790(ycf21)
LET : O77CONTIG1_00717(ubiC)
PRUN : PCC7821_03837(ycf21)
HBQ : QI031_06225 QI031_21990
NSPH : BDGGKGIB_04440(ubiC)
TOQ : HCG51_10755 HCG51_28995
SCYT : SAMD_09560 SAMD_17360
SCYS : NIES4073_28530 NIES4073_79510
NCN : BZZ01_00185 BZZ01_27380
» show all
Taxonomy
Reference
Authors
Nichols BP, Green JM
Title
Cloning and sequencing of Escherichia coli ubiC and purification of chorismate lyase.
Journal
Sequence
Reference
Authors
Siebert M, Severin K, Heide L.
Title
Formation of 4-hydroxybenzoate in Escherichia coli: characterization of the ubiC gene and its encoded enzyme chorismate pyruvate-lyase.
Journal
Sequence
Reference
Authors
Meganathan R
Title
Ubiquinone biosynthesis in microorganisms.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 4.1.3.40
ExPASy - ENZYME nomenclature database: 4.1.3.40
LinkDB
All DBs