EC                Enzyme                                 

2-iminoacetate synthase;
thiH (gene name)
Carbon-carbon lyases;
Other carbon-carbon lyases
L-tyrosine 4-methylphenol-lyase (2-iminoacetate-forming)
L-tyrosine + S-adenosyl-L-methionine + NADPH = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + NADP+ + H+ [RN:R10246]
L-tyrosine [CPD:C00082];
S-adenosyl-L-methionine [CPD:C00019];
NADPH [CPD:C00005]
2-iminoacetate [CPD:C15809];
4-methylphenol [CPD:C01468];
5'-deoxyadenosine [CPD:C05198];
L-methionine [CPD:C00073];
NADP+ [CPD:C00006];
H+ [CPD:C00080]
Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The first stage of catalysis is reduction of the S-adenosyl-L-methionine to produce methionine and a 5-deoxyadenosin-5-yl radical that is crucial for the conversion of the substrate. The reductant is assumed to be NADPH, which is provided by a flavoprotein:NADPH oxidoreductase system [4]. Part of the pathway for thiamine biosynthesis.
EC created 2011, modified 2014
ec00730  Thiamine metabolism
ec01100  Metabolic pathways
K03150  2-iminoacetate synthase
ECO: b3990(thiH)
ECJ: JW3953(thiH)
ECD: ECDH10B_4178(thiH)
EBW: BWG_3649(thiH)
ECOK: ECMDS42_3427(thiH)
ECE: Z5564(thiH)
ECS: ECs4913(thiH)
ECF: ECH74115_5457(thiH)
ETW: ECSP_5060(thiH)
ELX: CDCO157_4653(thiH)
EOI: ECO111_4806(thiH)
EOJ: ECO26_5098(thiH)
EOH: ECO103_4738(thiH)
ECOO: ECRM13514_5110(thiH)
ECOH: ECRM13516_4846(thiH)
ESL: O3K_23910(thiH)
ESO: O3O_01435(thiH)
ESM: O3M_23830(thiH)
ECK: EC55989_4474(thiH)
ECG: E2348C_4296(thiH)
EOK: G2583_4807(thiH)
ELR: ECO55CA74_23005(thiH)
ELH: ETEC_4249
ECW: EcE24377A_4531(thiH)
EUN: UMNK88_4830(thiH)
ECP: ECP_4202
ENA: ECNA114_3432(thiH)
ECOS: EC958_5100
ECV: APECO1_2484(thiH)
ECX: EcHS_A4223(thiH)
ECM: EcSMS35_4437(thiH)
ECY: ECSE_4277
ECR: ECIAI1_4204(thiH)
ECQ: ECED1_4696(thiH)
EUM: ECUMN_4513(thiH)
ECT: ECIAI39_4379(thiH)
EOC: CE10_4669(thiH)
EBR: ECB_03866(thiH)
EBL: ECD_03866(thiH)
EBE: B21_03819(thiH)
EBD: ECBD_4043
ECI: UTI89_C3830(thiH)
EIH: ECOK1_4465(thiH)
ECZ: ECS88_4450(thiH)
ECC: c4946(thiH)
ELO: EC042_4357(thiH)
ELN: NRG857_19905(thiH)
ESE: ECSF_3843
EKF: KO11_02425(thiH)
EAB: ECABU_c45050(thiH)
EDJ: ECDH1ME8569_3849(thiH)
ELU: UM146_16720(thiH)
ELW: ECW_m4347(thiH)
ELL: WFL_21160(thiH)
ELC: i14_4536(thiH)
ELD: i02_4536(thiH)
ELP: P12B_c4102(thiH)
ELF: LF82_2251(thiH)
ECOL: LY180_20920(thiH)
ECOI: ECOPMV1_02800(thiH)
ECOJ: P423_22115(thiH)
EFE: EFER_3765(thiH)
EAL: EAKF1_ch1927(thiH)
ESZ: FEM44_11680(thiH)
STY: STY3726(thiH)
STT: t3472(thiH)
SENT: TY21A_17550(thiH)
STM: STM4159(thiH)
SEO: STM14_5000(thiH)
SEY: SL1344_4098(thiH)
SEM: STMDT12_C42960(thiH)
SEJ: STMUK_4143(thiH)
SEB: STM474_4345(thiH)
SEF: UMN798_4506(thiH)
SETU: STU288_20900(thiH)
SETC: CFSAN001921_19635(thiH)
SENR: STMDT2_40121(thiH)
SEND: DT104_41561(thiH)
SENI: CY43_21715(thiH)
SEEN: SE451236_00105(thiH)
SPT: SPA3996(thiH)
SEI: SPC_3990(thiH)
SEC: SCH_4041(thiH)
SEH: SeHA_C4489(thiH)
SHB: SU5_0238
SENH: CFSAN002069_11320(thiH)
SEEH: SEEH1578_06975(thiH)
SEE: SNSL254_A4491(thiH)
SEW: SeSA_A4369(thiH)
SEA: SeAg_B4402(thiH)
SENS: Q786_20370(thiH)
SED: SeD_A4565(thiH)
SEG: SG3447(thiH)
SEL: SPUL_3425(thiH)
SEGA: SPUCDC_3411(thiH)
SET: SEN3945(thiH)
SENA: AU38_20415(thiH)
SENO: AU37_20430(thiH)
SENV: AU39_20450(thiH)
SENQ: AU40_22825(thiH)
SENL: IY59_20920(thiH)
SENJ: CFSAN001992_12965(thiH)
SEEC: CFSAN002050_03610(thiH)
SEEB: SEEB0189_021565(thiH)
SEEP: I137_16370(thiH)
SENE: IA1_20225(thiH)
SENC: SEET0819_04590(thiH)
SBG: SBG_3634(thiH)
SBZ: A464_4171
SBV: N643_18315(thiH)
SALZ: EOS98_21535(thiH)
SFL: SF4062(thiH)
SFX: S3673(thiH)
SFV: SFV_4061(thiH)
SFE: SFxv_4429(thiH)
SFN: SFy_5818
SFS: SFyv_5885
SFT: NCTC1_04407(thiH)
SSN: SSON_4162(thiH)
SBO: SBO_4010(thiH)
SBC: SbBS512_E4480(thiH)
SDY: SDY_3737(thiH)
SHQ: A0259_01535(thiH)
ENC: ECL_00250(thiH)
ENL: A3UG_01255(thiH)
ECLE: ECNIH2_01900(thiH)
ECLN: ECNIH4_01225(thiH)
ECLI: ECNIH5_01450(thiH)
ECLX: LI66_01295(thiH)
ECLY: LI62_01705(thiH)
ECLZ: LI64_01430(thiH)
ECLO: ENC_01340
EHM: AB284_24110(thiH)
ECLA: ECNIH3_01440(thiH)
ECLC: ECR091_01440(thiH)
EAU: DI57_17450(thiH)
ENO: ECENHK_01190(thiH)
EEC: EcWSU1_00216(thiH)
ECLS: LI67_002010(thiH)
ECHG: FY206_01170(thiH)
ENR: H650_16530(thiH)
ENX: NI40_000995(thiH)
ENF: AKI40_4720(thiH)
LNI: CWR52_11445(thiH)
EBG: FAI37_05510(thiH)
END: A4308_08205(thiH)
ESA: ESA_03684
CSK: ES15_3624(thiH)
CSZ: CSSP291_17085(thiH)
CCON: AFK62_01715(thiH)
CDM: AFK67_01680(thiH)
CMJ: AFK66_018410(thiH)
CUI: AFK65_01625(thiH)
CMW: AFK63_16930(thiH)
CTU: CTU_03000(thiH)
KPN: KPN_04371(thiH)
KPU: KP1_0229(thiH)
KPP: A79E_4816
KPH: KPNIH24_01140(thiH)
KPZ: KPNIH27_01165(thiH)
KPV: KPNIH29_01130(thiH)
KPW: KPNIH30_01165(thiH)
KPY: KPNIH31_01160(thiH)
KPG: KPNIH32_01170(thiH)
KPC: KPNIH10_01135(thiH)
KPQ: KPR0928_01140(thiH)
KPT: VK055_3103(thiH)
KPO: KPN2242_24805(thiH)
KPR: KPR_0309(thiH)
KPJ: N559_4926
KPI: D364_22260(thiH)
KPX: PMK1_01854(thiH)
KPB: FH42_18215(thiH)
KPNE: KU54_025565(thiH)
KPNU: LI86_25405(thiH)
KPNK: BN49_4469(thiH)
KVA: Kvar_4871
KPE: KPK_5303(thiH)
KPK: A593_11945(thiH)
KOX: KOX_07940(thiH)
KOE: A225_0247
KOY: J415_01805(thiH)
KOM: HR38_06590(thiH)
KMI: VW41_18160(thiH)
KOK: KONIH1_01455(thiH)
KOC: AB185_05760(thiH)
EAE: EAE_08155(thiH)
EAR: CCG32367
KLW: DA718_27845(thiH)
KAR: LGL98_23815(thiH)
ROR: RORB6_17570(thiH)
RON: TE10_03475(thiH)
RTG: NCTC13098_06937(thiH_1) NCTC13098_06938(thiH_2)
REE: electrica_04816(thiH)
CRO: ROD_37631(thiH)
CKO: CKO_02997
CFD: CFNIH1_07550(thiH)
CPOT: FOB25_09990(thiH)
CAMA: F384_21960(thiH)
CTEL: GBC03_06175(thiH)
CITZ: E4Z61_15745(thiH)
CARS: E1B03_02380(thiH)
EBT: EBL_c37180(thiH)
CNT: JT31_11275(thiH)
CEM: LH23_06435(thiH)
CEN: LH86_06365(thiH)
CLAP: NCTC11466_04350(thiH)
PGE: LG71_01845(thiH)
KLE: AO703_01085(thiH)
KOR: AWR26_25365(thiH)
KRD: A3780_25960(thiH)
KOT: EH164_21090(thiH)
KPSE: IP581_01160(thiH)
KIE: NCTC12125_03515(thiH)
KAS: KATP_42810(thiH)
LAX: APT61_21175(thiH)
LER: GNG29_00955(thiH)
LEA: GNG26_00980(thiH)
BUF: D8682_14270(thiH)
SYM: K6K13_22490(thiH)
METY: MRY16398_53710(thiH)
AHN: NCTC12129_04662(thiH_2)
YRE: HEC60_19095(thiH)
SGOE: A8O29_021345(thiH)
KIN: AB182_23790(thiH)
PDZ: HHA33_00795(thiH)
IZH: FEM41_07010(thiH)
PSHI: SAMEA2665130_3032(thiH)
EBF: D782_4280
YPE: YPO3743(thiH)
YPK: y0487(thiH)
YPA: YPA_3616
YPN: YPN_0222
YPM: YP_3107(thiH)
YPZ: YPZ3_3303(thiH)
YPT: A1122_07140(thiH)
YPD: YPD4_3295(thiH)
YPX: YPD8_3295(thiH)
YPW: CH59_1667(thiH)
YPJ: CH55_3283(thiH)
YPV: BZ15_3982(thiH)
YPL: CH46_1333(thiH)
YPS: YPTB0285(thiH)
YPO: BZ17_2288(thiH)
YPI: YpsIP31758_3857(thiH)
YPY: YPK_0342
YPB: YPTS_0306
YPQ: DJ40_2126(thiH)
YPU: BZ21_3652(thiH)
YPR: BZ20_1829(thiH)
YPC: BZ23_3924(thiH)
YPF: BZ19_3755(thiH)
YEN: YE0289(thiH)
YEY: Y11_34971
YEW: CH47_3188(thiH)
YET: CH48_1997(thiH)
YEE: YE5303_43521(thiH)
YSI: BF17_09520(thiH)
YAL: AT01_2176(thiH)
YFR: AW19_2907(thiH)
YIN: CH53_2097(thiH)
YKR: CH54_2882(thiH)
YRO: CH64_2886(thiH)
YRU: BD65_1647(thiH)
YRB: UGYR_08765(thiH)
YAK: ACZ76_07455(thiH)
YHI: D5F51_01560(thiH)
YCA: F0T03_20115(thiH)
YMO: HRD69_03685(thiH)
SMAR: SM39_4222(thiH)
SMAC: SMDB11_4383(thiH)
SMW: SMWW4_v1c02850(thiH)
SPE: Spro_0279
SRL: SOD_c02400(thiH)
SRY: M621_01220(thiH)
SPLY: Q5A_001330(thiH)
SMAF: D781_0257
SLQ: M495_25120(thiH)
SERF: L085_05810(thiH)
SERS: SERRSCBI_01285(thiH)
SFW: WN53_09925(thiH)
SFG: AV650_01070(thiH)
SQU: E4343_14810(thiH)
SFJ: SAMEA4384070_0268(thiH)
SOF: NCTC11214_02087(thiH)
SURI: J0X03_22585(thiH)
SRHZ: FO014_08575(thiH)
SFO: Z042_13525(thiH)
RAA: Q7S_20990(thiH)
RACE: JHW33_15005(thiH)
GQU: AWC35_10075(thiH)
EAME: GXP68_19775(thiH)
RBAD: H2866_09450(thiH)
ECA: ECA0228(thiH)
PATR: EV46_01235(thiH)
PATO: GZ59_02510(thiH)
PCT: PC1_0211
PCV: BCS7_00990(thiH)
PEC: W5S_0226
PPUJ: E2566_01290(thiH)
PARI: I2D83_20805(thiH)
PAQU: DMB82_0001020(thiH)
DDD: Dda3937_00230(thiH)
DZC: W909_01155(thiH)
DSO: A4U42_10320(thiH)
CED: LH89_11020(thiH)
DDQ: DDI_4553
DAQ: DAQ1742_00300(thiH)
DIC: Dpoa569_000208(thiH)
BGJ: AWC36_17190(thiH)
BRB: EH207_16460(thiH)
BNG: EH206_21175(thiH)
BIZ: HC231_22360(thiH)
LPOP: I6N93_15970(thiH)
SGL: SG0136
SOD: Sant_3921(thiH)
EBI: EbC_02630(thiH)
EHD: ERCIPSTX3056_677(thiH)
WBR: thiH
WGL: WIGMOR_0253(thiH)
PANP: PSNIH2_19455(thiH)
MINT: C7M51_03126(thiH)
MTHI: C7M52_03867(thiH)
TPTY: NCTC11468_00192(thiH_1)
PLU: plu0481(thiH)
PLUM: A4R40_02360(thiH)
PAY: PAU_00389(thiH)
PTT: VY86_05730(thiH)
PMR: PMI2782(thiH)
PMIB: BB2000_2793(thiH)
PVL: AOB99_15165(thiH)
PHAU: PH4a_05490
PCOL: F1325_17430(thiH)
PCIB: F9282_18080(thiH)
PPEE: I6G31_11185(thiH)
XBO: XBJ1_4033(thiH)
XBV: XBW1_0427(thiH)
XNE: XNC1_0581(thiH)
XNM: XNC2_0568(thiH)
XDO: XDD1_3620(thiH)
XPO: XPG1_3152(thiH)
XBU: HGO23_01590(thiH)
PSI: S70_08585(thiH)
PSX: DR96_1461(thiH)
PRG: RB151_004010(thiH)
PHEI: NCTC12003_00399(thiH)
PRQ: CYG50_14140(thiH)
PRJ: NCTC6933_00455(thiH)
PVC: G3341_01740(thiH)
MMK: MU9_696
ANS: ArsFIN_41460(thiH)
ETE: ETEE_2786(thiH)
EDW: QY76_15670(thiH)
EDL: AAZ33_04785(thiH)
HAV: AT03_02255(thiH)
OPO: DSM2777_01735(thiH)
PFQ: QQ39_15900(thiH)
LRI: NCTC12151_00406(thiH)
APL: APL_0536(thiH)
APJ: APJL_0527(thiH)
APA: APP7_0576(thiH)
AEU: ACEE_04485(thiH)
ALIG: NCTC10568_01005(thiH)
VCH: VC_0066
VCF: IR04_05270(thiH)
VCS: MS6_2552
VCE: Vch1786_I2341(thiH)
VCQ: EN18_17200(thiH)
VCI: O3Y_00310(thiH)
VCO: VC0395_A2448(thiH)
VCR: VC395_0114(thiH)
VCM: VCM66_0066(thiH)
VCL: VCLMA_A0062(thiH)
VCX: VAA049_58(thiH)
VCZ: VAB027_58(thiH)
VVU: VV1_0959(thiH)
VVY: VV3202
VVL: VV93_v1c29210(thiH)
VPA: VP3022
VPB: VPBB_2853
VPK: M636_22155(thiH)
VPF: M634_01645(thiH)
VCA: M892_10925(thiH)
VAG: N646_2117
VDB: AL552_24170(thiH)
VHR: AL538_09320(thiH)
VNA: PN96_13685(thiH)
VSP: VS_3093
VEJ: VEJY3_15225(thiH)
VNI: VIBNI_A3813(thiH)
VAN: VAA_00209
LAG: N175_01290(thiH)
VAU: VANGNB10_cI2684c(thiH)
VCY: IX92_00205(thiH)
VCT: JV59_39485(thiH)
VTU: IX91_15220(thiH)
VEU: IXK98_23930(thiH)
VFL: AL536_20500(thiH)
VMI: AL543_09245(thiH)
VSC: VSVS12_00158(thiH)
VQI: CCZ37_13105(thiH)
VTA: A3227(thiH)
VAF: D1115_00235(thiH)
VNL: D3H41_16390(thiH)
VCC: FAZ90_00185(thiH)
VAS: GT360_14460(thiH)
VAQ: FIV01_14520(thiH)
VSR: Vspart_03402(thiH)
VKA: BTD91_06590(thiH)
VZI: G5S32_14670(thiH)
VFI: VF_0036(thiH)
VFM: VFMJ11_0038(thiH)
VSA: VSAL_I2988(thiH)
AWD: AWOD_I_0037(thiH)
PPR: PBPRA0110(Z5564)
PGH: FH974_00220(thiH)
GHO: AL542_09975(thiH)
SALY: E8E00_13480(thiH)
SKS: FCN78_00160(thiH)
SCOT: HBA18_00165(thiH)
MNN: I6G26_06945(thiH)
SON: SO_2440(thiH) SO_3923(hydG)
SDN: Sden_1775
SFR: Sfri_2196
SAZ: Sama_1855
SBL: Sbal_2027
SLO: Shew_2091
SSE: Ssed_2018
SPL: Spea_2378
SWD: Swoo_2587
SWP: swp_2336
SVO: SVI_2366(thiH)
SPSW: Sps_01179
SMAV: CFF01_08825(thiH)
SHEW: CKQ84_20485(thiH)
SLJ: EGC82_10160(thiH)
SMAI: EXU30_20110(thiH)
SPOL: FH971_11045(thiH)
SBK: SHEWBE_2571(thiH)
SKH: STH12_01545(thiH)
SAES: HBH39_09835(thiH)
SLIT: JQC75_09415(thiH)
SCAA: TUM17387_19050(thiH) TUM17387_33960(hydG)
ILO: IL0770(thiH)
ILI: K734_03860(thiH)
IAB: K5X84_07095(thiH)
AMC: MADE_1000695(thiH)
AMH: I633_00775(thiH)
AMAA: amad1_00640(thiH)
AMAL: I607_00595(thiH)
AMAE: I876_00610(thiH)
AMAO: I634_00600(thiH)
AMAD: I636_00635(thiH)
AMAI: I635_00635(thiH)
AMAG: I533_00620(thiH)
AMAC: MASE_00445(thiH)
AMB: AMBAS45_00485(thiH)
AMG: AMEC673_00495(thiH)
AMK: AMBLS11_00470(thiH)
AAL: EP13_00515(thiH)
AAUS: EP12_00490(thiH)
ASQ: AVL57_01880(thiH)
AAW: AVL56_00690(thiH)
ALR: DS731_01890(thiH)
ALE: AV939_00695(thiH)
ALZ: AV940_00695(thiH)
APEL: CA267_010230(thiH)
GPS: C427_5283(thiH)
LAL: AT746_14840(thiH)
SALM: D0Y50_18710(thiH)
SALK: FBQ74_00595(thiH)
PIN: Ping_0365
MVS: MVIS_0226(thiH)
MYA: MORIYA_2738(thiH)
MMAA: FR932_16520(thiH)
RHH: E0Z06_06850(thiH)
MARD: IBG28_08835(thiH)
MFOI: JSY38_01400(thiH)
AHA: AHA_0444(thiH)
AHD: AI20_17165(thiH)
AHR: V428_02435(thiH)
AHP: V429_02435(thiH)
AHJ: V469_20885(thiH)
AHH: RY45_02535(thiH)
AHI: VU14_20265(thiH)
ASA: ASA_3900(thiH)
AVR: B565_3620
AVO: AMS64_21135(thiH)
AMED: B224_6001
ASR: WL1483_2883(thiH)
AEL: NCTC12917_00357(thiH)
ASIM: FE240_00790(thiH)
AALL: I6G90_17970(thiH)
TAU: Tola_1079
OCE: GU3_01660(thiH)
ZDF: AN401_00280(thiH)
SEDS: AAY24_00555(thiH)
BCI: BCI_0046(thiH)
BCIB: IM45_110
LHK: LHK_02327(thiH)
SUTT: SUTMEG_09160(thiH)
SUTK: FG381_12055(hydG)
SWS: I6J16_06400(hydG)
CJE: Cj1044c(thiH)
CJB: BN148_1044c(thiH)
CJJ: CJJ81176_1065(thiH)
CJU: C8J_0981(thiH)
CJI: CJSA_0987(thiH)
CJM: CJM1_1019(thiH)
CJS: CJS3_1093(thiH)
CJP: A911_05050(thiH)
CJEJ: N564_01011
CJEU: N565_01057
CJEN: N755_01050
CJEI: N135_01080
CJER: H730_06195(thiH)
CJV: MTVDSCj20_1046(thiH)
CJY: QZ67_01117(thiH)
CJQ: UC78_1001(thiH)
CJR: CJE1188(thiH)
CJD: JJD26997_0737(thiH)
CFF: CFF8240_0076(thiH)
CFT: CFF04554_0076(thiH)
CFV: CFVI03293_0076(thiH)
CFX: CFV97608_0076(thiH)
CFZ: CSG_780
CAMP: CFT03427_0081(thiH)
CCV: CCV52592_1868(thiH)
CHA: CHAB381_1176(thiH)
CCO: CCC13826_1278(thiH)
CCOC: CCON33237_0909(thiH)
CLA: CLA_1146(thiH)
CLR: UPTC16701_1120(thiH)
CLM: UPTC16712_1151(thiH)
CLQ: UPTC4110_1130(thiH)
CLN: UPTC3659_1363(thiH)
CLL: CONCH_1101(thiH)
CCC: G157_03755(thiH)
CCQ: N149_0979(thiH)
CCF: YSQ_03800
CCY: YSS_05645
CCOI: YSU_03830
CCOF: VC76_05080(thiH)
CCOO: ATE51_01532(thiH)
CAJ: CIG1485E_0486(thiH)
CIS: CINS_1108(thiH)
CVO: CVOL_1121(thiH)
CPEL: CPEL_1255(thiH)
CSM: CSUB8521_1313(thiH)
CSF: CSUB8523_1418(thiH)
CGRA: CGRAC_1778(thiH)
CURE: CUREO_0458 CUREO_0574(thiH)
CHYO: CHH_0074 CHH_1391(thiH)
CHV: CHELV3228_0785(thiH)
CSPF: CSF_0428(thiH)
CCUN: CCUN_1182(thiH)
CLX: CLAN_0986(thiH)
CAVI: CAV_0326(thiH)
CHW: A2J15_001740(thiH)
CAMZ: CVIC12175_0606(thiH)
CAMY: CSUIS_1037(thiH)
COJ: CORN_1218(thiH)
CUX: CUP3940_0960(thiH)
CGEO: CGEO_1453(thiH)
CBLA: CBLAS_1321(thiH)
CCOR: CCORG_0924(thiH)
CSHO: CSHOW_1348(thiH)
CINF: CINF_0026(thiH)
CNV: CNZW441b_1028(thiH)
ASK: EI285_00380(thiH)
APOC: APORC_0156(thiH)
ATHR: ATH_0151(thiH)
GEB: GM18_1846
PCA: Pcar_0340(thiH-1) Pcar_0608(thiH-2) Pcar_1631(hydG)
PPD: Ppro_1492
DES: DSOUD_3001(thiH)
DEU: DBW_1045(thiH)
DVU: DVU_1765 DVU_2093(thiH)
DVM: DvMF_0799
DMA: DMR_33030(thiH)
DTR: RSDT_0014(thiH)
DFL: DFE_1468
DMS: E8L03_18910(hydG)
DSD: GD606_03070(hydG)
DPI: BN4_10829
PPRF: DPRO_1002 DPRO_1177(thiH)
PSEL: GM415_11365(thiH) GM415_17555(hydG)
LIP: LI0505(thiH)
LIR: LAW_00520(thiH)
DBA: Dbac_0775
DRT: Dret_0728
DSF: UWK_01892
DOG: HP555_11260(thiH)
DTO: TOL2_C00590(thiH)
DWD: DSCW_39390(thiH_1) DSCW_62780(thiH_2)
DALK: DSCA_39370(thiH_1) DSCA_59010(thiH_2)
POF: GS400_16475(thiH)
AIA: AWH56_009710(thiH)
PPY: PPE_02675(thiH)
PPM: PPSC2_14265(thiH)
PPO: PPM_2869(thiH)
PPOL: X809_30655
PPOY: RE92_22435
PTA: HPL003_23070(thiH)
PSAB: PSAB_08650 PSAB_11965(thiH)
PRI: PRIO_2354 PRIO_3930(thiH)
PSON: JI735_20530(thiH) JI735_26695(hydG)
PSOP: KP014_12375(thiH) KP014_16780(hydG)
PTRI: KDC22_10060(thiH)
CAC: CA_C1356(thiH) CA_C2921(thiH)
CAE: SMB_G1379(thiH) SMB_G2957(thiH)
CAY: CEA_G1370(thiH) CEA_G2928
CPF: CPF_0106 CPF_1853(thiH)
CPR: CPR_0108 CPR_1570(thiH)
CTC: CTC_01326(thiH) CTC_01748(thiH)
CBO: CBO3583(thiH)
CBA: CLB_3663
CBH: CLC_3561(thiH)
CBY: CLM_4075
CBL: CLK_3056
CBK: CLL_A1999
CBB: CLD_0903
CBN: CbC4_0657(thiH) CbC4_0678
CBT: CLH_1823
CBF: CLI_3808
CBM: CBF_3774
CBZ: Cbs_1520(thiH1) Cbs_4439(thiH2)
CBEI: LF65_01734 LF65_04975(thiH)
CKL: CKL_1636(thiH) CKL_3829(hydG)
CSR: Cspa_c46690(hydG) Cspa_c49000(thiH)
CPAT: CLPA_c11910(thiH1) CLPA_c33350(thiH2)
CPAE: CPAST_c11910(thiH1) CPAST_c33350(thiH2)
CSB: CLSA_c07640(thiH1) CLSA_c25130(thiH2)
CBV: U729_165(hydG) U729_166(hydG)
CSQ: CSCA_1808
CLD: CLSPO_c21810(thiH) CLSPO_c37660(hydG)
CACE: CACET_c35700(hydG) CACET_c37730(thiH)
CTYK: CTK_C12380(thiH) CTK_C21780
CTAE: BGI42_08160(hydG)
CDY: F3K33_07895(thiH) F3K33_22740(hydG)
CCOH: SAMEA4530647_1147(thiH_1)
CGAS: J1C67_02010(hydG)
AOE: Clos_0992
ASF: SFBM_0916(thiH)
ASM: MOUSESFB_0854(thiH)
ASO: SFBmNL_00991(thiH)
ASB: RATSFB_0773(thiH)
HHW: NCTC503_02725(thiH)
CALE: FDN13_06360(hydG)
CRS: FQB35_00650(thiH) FQB35_03925(hydG)
CPRF: K7H06_03145(hydG) K7H06_06115(hydG) K7H06_12520(thiH)
SARJ: HH195_05665(thiH) HH195_05695(hydG)
PBIF: KXZ80_02655(thiH) KXZ80_05620(hydG)
CAZO: G3A45_00590(thiH) G3A45_06760(hydG)
CLO: HMPREF0868_0738(thiH)
HSC: HVS_07275(thiH1) HVS_12680(thiH3)
CCE: Ccel_3104
RHER: EHE19_008515(hydG)
CSS: Cst_c06970(thiH)
CSD: Clst_0663(hydG)
CTHD: CDO33_03610(hydG)
ESR: ES1_19410
ESU: EUS_11890
RCH: RUM_12730
RUM: CK1_28860
RUJ: E5Z56_05910(hydG) E5Z56_11420(thiH)
SMAN: C12CBH8_00940(thiH)
CEW: EKH84_16110(hydG)
RHO: RHOM_04680(thiH)
CCT: CC1_29710
CCOM: I6K69_08135(thiH)
ROB: CK5_02840
BPRO: PMF13cell1_01243(thiH_1) PMF13cell1_04612(thiH_2)
BLAB: EYS05_06525(thiH)
CPY: Cphy_2082
CSCI: HDCHBGLK_00596(thiH_1) HDCHBGLK_02708(thiH_2)
CSO: CLS_36020
ACAC: EYQ97_03415(hydG) EYQ97_11220(thiH)
CPRO: CPRO_14530(thiH_1) CPRO_15950(thiH_3)
LUA: D4A81_03570(hydG)
EHL: EHLA_1352
PXV: FXF36_02685(hydG)
ACEL: acsn021_08630(thiH)
ACHT: bsdcttw_39470(thiH)
RTO: RTO_25300
RGN: RGna_12565(hydG)
CBOL: CGC65_10935(hydG)
CDF: CD630_17050(thiH) CD630_21560(thiH)
PDC: CDIF630_01893(thiH1) CDIF630_02387(thiH2)
EAC: EAL2_808p03510(thiH) EAL2_c00360(thiH1) EAL2_c04210(thiH2)
CST: CLOST_0846(hydG)
FAA: HMPREF0389_01137(hydG)
ROC: HF520_00625(hydG) HF520_01930(hydG)
PHX: KGNDJEFE_01024(thiH)
TEM: JW646_04960(thiH) JW646_05870(hydG)
PBQ: C3V37_04565(hydG)
SWO: Swol_1022
SLP: Slip_0120
DMT: DESME_02050(thiH)
PTH: PTH_0641(ThiH) PTH_0984(ThiH)
DAU: Daud_0163
DED: DHBDCA_p1778(thiH)
DRS: DEHRE_03630(thiH)
TFR: BR63_18280(hydG) BR63_18825(thiH)
HMO: HM1_2030(thiH)
HCV: FTV88_1003(hydG) FTV88_1718(thiH)
AWO: Awo_c00520(thiH1) Awo_c28130(thiH2)
CMIU: B1H56_02590(hydG)
VGU: HYG85_03350(thiH) HYG85_05910(hydG)
VPY: HZI73_01490(hydG) HZI73_14345(thiH)
BPRM: CL3_00350
TTE: TTE1568(ThiH)
THX: Thet_0583
TIT: Thit_0582
TKI: TKV_c05810(thiH1) TKV_c08370(thiH2) TKV_c11110(thiH3)
CHY: CHY_1263(thiH) CHY_1549
MTHO: MOTHE_c16710(thiH1) MOTHE_c17450(thiH2)
MTHZ: MOTHA_c17540(thiH1) MOTHA_c18280(thiH2)
ADG: Adeg_1241
TPZ: Tph_c17860(thiH)
GEK: kuro4_02100(thiH)
CCHA: ELD05_01270(thiH) ELD05_12785(hydG)
TTM: Tthe_1964
TSH: Tsac_2363
TOC: Toce_2273
HALS: D7D81_08725(hydG)
KME: H0A61_01597(thiH)
FMA: FMG_0063
AVG: I6H45_05445(hydG) I6H45_07435(thiH)
AOB: I6H46_01300(thiH)
PIV: NCTC13079_00531(thiH_2) NCTC13079_01343(thiH_3)
CAD: Curi_c11660(thiH)
SPOA: EQM13_16755(hydG)
KPAR: JL105_01605(hydG) JL105_02555(thiH)
SEDZ: JYG23_02285(hydG)
VRM: 44547418_01296(thiH)
VDN: NCTC11831_00662(thiH)
VNK: VEIT17_06100(thiH)
MED: MELS_0327
MFUN: GXM21_01735(hydG) GXM21_06375(thiH)
MANA: MAMMFC1_03376(thiH_1) MAMMFC1_03516(thiH_2)
STED: SPTER_22510(thiH) SPTER_24200(bioB_3)
AIN: Acin_0255(thiH) Acin_2104(thiH)
PFAC: PFJ30894_00306(thiH_1) PFJ30894_01916(thiH_3)
CIU: G4D55_20705(hydG)
ERM: EYR00_08870(hydG)
MBJ: KQ51_00113(hydG)
NAH: F5544_38790(nocL)
AUS: IPK37_07465(thiH)
RAIN: Rai3103_14105(thiH)
FAL: FRAAL5079(thiH)
ACTA: C1701_00465(nocL)
MCAB: HXZ27_30240(nocL)
ELE: Elen_1746
EGD: GS424_009970(thiH)
AEQ: AEQU_2222
OLO: ADJ70_09985(thiH)
OBT: OPIT5_01395(thiH)
CAA: Caka_2698
RUFI: K0V07_11185(thiH)
AMU: Amuc_1117
AGL: PYTT_1321
ROO: G5S37_02670(thiH)
LUO: HHL09_01830(thiH)
MIN: Minf_2024(thiH)
MKC: kam1_300
MEAP: MTHMO_0299(thiH)
VBS: EGM51_06760(hydG) EGM51_16710(thiH)
AMUC: Pan181_39540(thiH)
AGV: OJF2_28580(thiH)
KST: KSMBR1_2001(thiH)
PBU: L21SP3_00308(thiH_1) L21SP3_01127(thiH_2)
PBP: STSP1_00008(thiH_1) STSP1_01182(thiH_2)
PBAS: SMSP2_01583(thiH_1) SMSP2_01993(thiH_2)
ALUS: STSP2_00562(thiH_1) STSP2_01436(thiH_2)
VBL: L21SP4_01737(thiH_1) L21SP4_01856(thiH_2)
TRC: DYE49_11370(hydG)
SPER: EW093_10235(hydG) EW093_14535(thiH)
OCK: EXM22_03110(hydG)
LKM: EFP84_04685(thiH)
BHY: BHWA1_00054(thiH)
BRM: Bmur_2637
BPO: BP951000_2017(thiH)
BPJ: B2904_orf1817(thiH)
BPIP: BPP43_05065(thiH)
BPW: WESB_0917(thiH)
BIP: Bint_1947(thiH)
EMI: Emin_1333
EPO: Epro_0732(thiH)
ETI: RSTT_347(thiH)
FNU: FN1753
FPD: CTM68_07170(thiH)
FNF: BSQ88_02560(thiH) BSQ88_07095(hydG)
FPEI: C4N17_00155(thiH)
LWD: JCM16777_1477(thiH)
TAI: Taci_0145
SBR: SY1_09180
FSC: FSU_0173(thiH)
BTHO: Btheta7330_01174(thiH_1) Btheta7330_02231(thiH_2)
BFB: VU15_11030(thiH) VU15_17410(thiH)
BOA: Bovatus_00988(thiH_1) Bovatus_01896(thiH_2)
BCEL: BcellWH2_04992(thiH_1)
BCAC: CGC64_12260(thiH) CGC64_17110(hydG)
BZG: C4H11_01730(thiH) C4H11_02305(hydG)
BHF: C3V43_03055(thiH) C3V43_03940(hydG)
BIS: DXK01_013755(hydG)
BUN: Bun01g_25260(thiH_1) Bun01g_27300(thiH_2)
BDO: EL88_10570(thiH) EL88_21195(thiH)
BDH: GV66_01985(thiH) GV66_18380(thiH)
PCOP: I6J50_04855(thiH) I6J50_05945(hydG)
PGI: PG_2107(thiH)
PGN: PGN_0157
PGT: PGTDC60_1313(thiH)
PCAG: NCTC12856_00571(thiH_1) NCTC12856_01717(thiH_3)
PBT: ING2E5B_2403(thiH)
PMUC: ING2E5A_2494(thiH)
PSAC: PSM36_3017(thiH)
DUN: FDZ78_01980(thiH)
BVS: BARVI_00265(thiH)
BUY: D8S85_01395(thiH) D8S85_19145(hydG)
BVIR: I6J59_07535(hydG) I6J59_13455(thiH)
PRU: PRU_0404(thiH)
ALD: GFH31_06530(thiH)
AIT: AI2BBH_06170(thiH)
TTZ: FHG85_08295(hydG)
BLQ: L21SP5_00576(thiH)
BACC: BRDCF_p1047(thiH)
DORI: FH5T_04505(thiH)
DRC: G0Q07_17790(hydG)
MCOS: GM418_22500(hydG)
CPI: Cpin_0626
CBAE: COR50_04775(thiH)
CHIT: FW415_03975(thiH)
CHIH: GWR21_18760(thiH)
COY: HF329_25950(thiH)
ARK: D6B99_08885(thiH)
AGI: FSB73_01730(thiH)
FLN: FLA_5231
SGN: SGRA_1650(thiH)
PHE: Phep_2471
PEP: AQ505_18195(thiH)
PGS: CPT03_05530(thiH)
PEJ: FYC62_05775(thiH)
PEK: FFJ24_020830(thiH)
PROE: H9L23_20900(thiH)
SHT: KO02_06355(thiH)
SMIZ: 4412673_01356(thiH)
SPSC: E2P86_08330(thiH)
SPHZ: E3D81_05985(thiH)
SPHE: GFH32_05935(thiH)
SPDR: G6053_11105(thiH)
SDJ: NCTC13534_02113(thiH)
STHA: NCTC11429_04811(thiH)
SSPI: I6J01_00295(thiH)
SMUI: I6J00_06560(thiH)
MRUB: DEO27_011480(thiH)
MGOS: DIU38_008185(thiH)
AGD: FRZ59_16330(thiH)
OLI: FKG96_03860(thiH)
EST: DN752_00185(thiH)
ECHI: FKX85_15620(thiH)
CHU: CHU_0244(thiH)
SLI: Slin_6575
SPIB: G8759_19310(thiH)
DFE: Dfer_2462
HSW: Hsw_3969
HYG: AUC43_06720(thiH)
HYZ: AXW84_22775(thiH)
HNV: DDQ68_16265(thiH)
PKO: PKOR_15605(thiH)
RTI: DC20_19575(thiH)
FLM: MY04_2793(thiH)
FLL: EI427_15120(thiH)
FYA: KMW28_02115(thiH)
FKA: KM029_14230(thiH)
FPS: FP0433(thiH)
FPY: FPG101_02385(thiH)
FPO: FPG3_02295(thiH)
FPQ: IB65_02050(thiH)
FPV: IA03_02135(thiH)
FPW: IA04_02075(thiH)
FPK: IA06_02115(thiH)
FPSZ: AMR72_02750(thiH)
FJO: Fjoh_1598
FJG: BB050_01015(thiH)
FCR: HYN56_08355(thiH)
CSTO: CGC58_09855(thiH)
ZPR: ZPR_0141
MARM: YQ22_17950(thiH)
CLH: IX49_09230(thiH)
CBAL: M667_10615(thiH)
CBAT: M666_10620(thiH)
DOD: DCS32_13930(thiH)
ZGA: ZOBELLIA_3658(thiH)
POA: CW731_01825(thiH)
MYR: MYRA21_0854(thiH)
MPW: MPR_3384
MOD: AS202_03900(thiH)
MOA: I6I89_18295(thiH)
TDI: AUW17_04185(thiH)
TJE: TJEJU_3383(thiH)
TMAR: MARIT_1642(thiH)
TMP: F9Y86_12225(thiH)
WFU: AXE80_12305(thiH)
FOP: FNB79_13085(thiH)
OLL: CW732_12735(thiH)
OAQ: DZC78_02750(thiH)
FEK: C1H87_01960(thiH)
TAJ: C1A40_06665(thiH)
MARF: CJ739_1545
AQB: D1818_16085(thiH)
AQA: D1815_14965(thiH)
AQD: D1816_18205(thiH)
PSYN: E9099_16605(thiH)
GAA: HX109_05150(thiH)
FBU: UJ101_02708(thiH)
RAG: B739_1583
RAT: M949_2009
ORI: Q785_11640(thiH)
EAO: BD94_2840
EMN: M876_11165(thiH)
ELB: VO54_03810(thiH)
EGM: AYC65_03305(thiH)
ELZ: FCS00_16860(thiH)
ELT: FGE20_09870(thiH)
CHZ: CHSO_4712(thiH)
CGN: OK18_06465(thiH)
CIH: ATE47_18255(thiH)
CHH: A0O34_10610(thiH)
CIO: CEQ15_16910(thiH)
CHRY: CEY12_13095(thiH)
CPIP: CJF12_15590(thiH)
CARH: EGY05_20355(thiH)
CSHA: EG350_01275(thiH)
CNK: EG343_12675(thiH)
CJT: EG359_13375(thiH)
CIL: EG358_00385(thiH)
CCAU: EG346_07955(thiH)
CBEN: EG339_04300(thiH)
CGLE: NCTC11432_03026(thiH)
CLAC: EG342_03850(thiH)
FLU: CHH17_13825(thiH)
CTE: CT0697(thiH)
CPC: Cpar_0669
CCH: Cag_1268
CLI: Clim_0664
PVI: Cvib_1361
PLT: Plut_1566
PPH: Ppha_2004
IAL: IALB_0526(hydG)
MRO: MROS_2621
CACI: CLOAM0921(hydG)
TMA: TM1267
TMW: THMA_1292(thiH)
TMQ: THMB_1292(thiH)
TMX: THMC_1292(thiH)
TPT: Tpet_1504
TRQ: TRQ2_1553
TNA: CTN_1306
TNP: Tnap_1527
THQ: T2812B_07705(thiH)
THR: TRQ7_08005(thiH)
TLE: Tlet_1748
TME: Tmel_1599
TAF: THA_1806
THP: BG95_08700(thiH)
THER: Y592_08805
FNO: Fnod_0238
FIA: NA23_01730(thiH)
OCY: OSSY52_09820(thiH_1) OSSY52_15590(thiH_2)
PMO: Pmob_1864
MARN: LN42_00760(thiH) LN42_04890
KOL: Kole_0394
KPF: IX53_07820(thiH)
CPO: COPRO5265_0141(thiH)
DDF: DEFDS_0221(thiH)
GTL: EP073_02325(thiH)
CABY: Cabys_3686
DTH: DICTH_1550(thiH)
DTU: Dtur_1658(thiH)
TCM: HL41_08440(thiH)
THET: F1847_07570(hydG)
ALAM: RT761_01803(thiH)
MEAR: Mpt1_c03070(pylB1)
MARC: AR505_0101
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1  [PMID:12650933]
Leonardi R, Fairhurst SA, Kriek M, Lowe DJ, Roach PL
Thiamine biosynthesis in Escherichia coli: isolation and initial characterisation of the ThiGH complex.
FEBS Lett 539:95-9 (2003)
2  [PMID:17969213]
Kriek M, Martins F, Challand MR, Croft A, Roach PL
Thiamine biosynthesis in Escherichia coli: identification of the intermediate and by-product derived from tyrosine.
Angew Chem Int Ed Engl 46:9223-6 (2007)
3  [PMID:17403671]
Kriek M, Martins F, Leonardi R, Fairhurst SA, Lowe DJ, Roach PL
Thiazole synthase from Escherichia coli: an investigation of the substrates and purified proteins required for activity in vitro.
J Biol Chem 282:17413-23 (2007)
4  [PMID:19923213]
Challand MR, Martins FT, Roach PL
Catalytic activity of the anaerobic tyrosine lyase required for thiamine biosynthesis in Escherichia coli.
J Biol Chem 285:5240-8 (2010)
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