KEGG   ENZYME: 4.2.1.133
Entry
EC 4.2.1.133                Enzyme                                 
Name
copal-8-ol diphosphate hydratase;
CcCLS
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
geranylgeranyl-diphosphate hydro-lyase [(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate-forming]
Reaction(IUBMB)
(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate = geranylgeranyl diphosphate + H2O [RN:R09967]
Reaction(KEGG)
R09967
Substrate
(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate [CPD:C20270]
Product
geranylgeranyl diphosphate [CPD:C00353];
H2O [CPD:C00001]
Comment
Requires Mg2+. The enzyme was characterized from the plant Cistus creticus subsp. creticus.
History
EC 4.2.1.133 created 2012
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K20516  copal-8-ol diphosphate hydratase
K20518  copal-8-ol diphosphate hydratase / cis-abienol synthase
Reference
1  [PMID:20595348]
  Authors
Falara V, Pichersky E, Kanellis AK
  Title
A copal-8-ol diphosphate synthase from the angiosperm Cistus creticus subsp. creticus is a putative key enzyme for the formation of pharmacologically active, oxygen-containing labdane-type diterpenes.
  Journal
Plant Physiol 154:301-10 (2010)
DOI:10.1104/pp.110.159566
  Sequence
[ag:ADJ93862]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.133
IUBMB Enzyme Nomenclature: 4.2.1.133
ExPASy - ENZYME nomenclature database: 4.2.1.133
BRENDA, the Enzyme Database: 4.2.1.133
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