KEGG ENZYME: 4.2.1.160

ENZYME: 4.2.1.160

Entry

EC 4.2.1.160                Enzyme

Name

2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase

Class

Lyases;
Carbon-oxygen lyases;
Hydro-lyases

Sysname

2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one cyclohydrolase

Reaction(IUBMB)

2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one = 7,8-dihydroneopterin 3'-phosphate + H2O [RN:R11072]

Reaction(KEGG)

R11072

Substrate

2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one [CPD:C01304]

Product

7,8-dihydroneopterin 3'-phosphate [CPD:C05925];
H2O [CPD:C00001]

Comment

The enzyme participates in a folate biosynthesis pathway in Chlamydia.

History

EC 4.2.1.160 created 2015

Pathway

ec00790

Folate biosynthesis

ec01100

Metabolic pathways

Orthology

K22100

2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase

Genes

CTR:	CT_327(trpC)

CTD:	CTDEC_0327(trpC)

CTF:	CTDLC_0327(trpC)

CTRD:

SOTOND1_00344

CTRO:

SOTOND5_00341

CTRT:

SOTOND6_00341

CTA:	CTA_0354(trpC)

CTY:	CTR_3231(trpC)

CRA:

CTO_0354

CTRQ:

A363_00348

CTRX:

A5291_00347

CTRZ:

A7249_00347

CTRP:

L11322_00337

CTLJ:

L1115_00337

CTLX:

L1224_00337

CTLL:

L1440_00339

CTB:	CTL0581(trpC)

CTRR:

L225667R_00338

CTLF:

CTLFINAL_03030

CTLI:

CTLINITIAL_03025

CTL:	CTLon_0577(trpC)

CTRU:

L2BUCH2_00336

CTRL:

L2BLST_00336

CTRV:

L2BCV204_00336

CTRM:

L2BAMS1_00336

CTLA:

L2BAMS2_00336

CTLM:

L2BAMS3_00336

CTLS:

L2BAMS4_00337

CTLZ:

L2BAMS5_00337

CTLC:

L2BCAN1_00338

CTLN:

L2BCAN2_00337

CTLB:

L2B795_00337

CTLQ:

L2B8200_00336

CTO:

CTL2C_17

CTRN:

L3404_00337

CTJ:	JALI_3231(trpC)

CTZ:	CTB_3231(trpC)

CTG:	E11023_01700

CTK:	E150_01710

CSW:	SW2_3301(trpC)

CES:	ESW3_3301(trpC)

CTRB:

BOUR_00345

CTRE:

SOTONE4_00341

CTRS:

SOTONE8_00347

CTEC:

EC599_3351(trpC)

CFS:	FSW4_3301(trpC)

CFW:	FSW5_3301(trpC)

CTFW:

SWFP_3511(trpC)

CTRF:

SOTONF3_00342

CTCH:

O173_01780

CTN:	G11074_01675

CTQ:	G11222_01680

CTV:	CTG9301_01675

CTW:	G9768_01675

CTRG:

SOTONG1_00342

CTRI:

BN197_3281(trpC)

CTRA:

BN442_3281(trpC)

CTRH:

SOTONIA1_00343

CTRJ:

SOTONIA3_00343

CTRK:

SOTONK1_00341

CTJT:

CTJTET1_01695

CTCF:

CTRC69_01715

CTFS:

CTRC342_01730

CTHF:

CTRC852_01735

CTCJ:

CTRC943_01685

CTHJ:

CTRC953_01680

CTMJ:

CTRC966_01690

CTTJ:

CTRC971_01680

CTJS:

CTRC122_01715

CTRC:

CTRC55_01695

CTRW:

CTRC3_01715

CTRY:

CTRC46_01695

CTCT:

CTW3_01780

CMU:	TC_0603(trpF)

CMUR:

Y015_03180

CMN:	BB17_03230

CMM:	NC80_03040

CMG:	NC81_03055

CMX:

DNC_03060

CMZ:

TAC_03180

CPM:	G5S_1085(trpF)

CPEC:

CPE3_0675(trpF)

CPEO:

CPE1_0674(trpF)

CPER:

CPE2_0675(trpF)

CCA:	CCA_00565(trpF)

CFE:	CF0437(trpF)

CSUI:

Chls_650(trpC)

SNG:	SNE_A10200(tRPF)

» show all

Reference

1 [PMID:25006229]

Authors

Adams NE, Thiaville JJ, Proestos J, Juarez-Vazquez AL, McCoy AJ, Barona-Gomez F, Iwata-Reuyl D, de Crecy-Lagard V, Maurelli AT

Title

Promiscuous and adaptable enzymes fill "holes" in the tetrahydrofolate pathway in Chlamydia species.

Journal

MBio 5:e01378-14 (2014)
DOI:10.1128/mBio.01378-14

Sequence

[ctb:CTL0581]

Other DBs

ExplorEnz - The Enzyme Database:

4.2.1.160

IUBMB Enzyme Nomenclature:

4.2.1.160

ExPASy - ENZYME nomenclature database:

4.2.1.160

BRENDA, the Enzyme Database:

4.2.1.160

LinkDB

DBGET integrated database retrieval system