KEGG   ENZYME: 4.2.1.180
Entry
EC 4.2.1.180                Enzyme                                 
Name
(E)-benzylidenesuccinyl-CoA hydratase;
bbsH (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
Sysname
(R,S)-2-(alpha-hydroxybenzyl)succinyl-CoA hydro-lyase
Reaction(IUBMB)
(R,S)-2-(alpha-hydroxybenzyl)succinyl-CoA = (E)-benzylidenesuccinyl-CoA + H2O [RN:R05599]
Reaction(KEGG)
R05599
Substrate
(R,S)-2-(alpha-hydroxybenzyl)succinyl-CoA [CPD:C09819]
Product
(E)-benzylidenesuccinyl-CoA [CPD:C09818];
H2O [CPD:C00001]
Comment
The enzyme, purified from the bacterium Thauera aromatica, is involved in an anaerobic toluene degradation pathway in which it catalyses the hydration of (E)-benzylidenesuccinyl-CoA.
History
EC 4.2.1.180 created 2022
Pathway
ec00623  Toluene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K07546  (E)-benzylidenesuccinyl-CoA hydratase
Genes
PREPCA10_26500
PMUIG4G71_17125
PMANOU5_6050
PPUUPputUW4_02070
PLALFXN65_14895
PAZEKSS91_11305
SMAVCFF01_02735
RPJN234_31185
REHH16_B1905(h16_B1905)
CNCCNE_2c18660(caiD2) CNE_BB2p01290
COXE0W60_03075 E0W60_35025
CCAMM5D45_25520
BYIBYI23_D000190 BYI23_D015950
BUEBRPE67_DCDS02180 BRPE67_ECDS03050
BXBDR64_8166
BCAIK788_0001079
PHSC2L64_18845
PTERC2L65_16730
PPKU875_00905
PPNMLV28_12090
PRBX636_08490
PVEUC34_12395
POXMB84_16750
PFGAB870_22545
PFIBPI93_015345
PCOMNTU39_13845
BFZBAU07_03780
BGMCAL15_20540
AXYAXYL_00935
AISBUW96_15820
ADYHLG70_07290
BOZDBV39_02115 DBV39_02665
PIGEGT29_02605
VEIVeis_4267
VAPVapar_4306
VAMC4F17_28090
HYNF9K07_04540 F9K07_12795 F9K07_30315
EBAc2A309(bbsH)
ABREpbN1_02910 pbN1_41240
APETToN1_01530(bbsH) ToN1_01950
AZIAzCIB_4518
AZDCDA09_07460 CDA09_21955
TCLTchl_1392
TAKTharo_3083
GMEGmet_1524(bbsH)
GEOGeob_2423(bbsH)
DTOTOL2_C01540(bbsH) TOL2_C04970(bhsH)
DOVDSCO28_00450 DSCO28_15530(crt_1) DSCO28_65690
DWDDSCW_52990
DMMdnm_089830(bhsH)
MESPC1M53_21095
MESRFGU64_03160 FGU64_18225
BOIBLM15_17800
XDIEZH22_10235
MNOMnod_3481
DEAFPZ08_05385
SIWGH266_20290
TPROGa0080559_TMP200
AHTANTHELSMS3_05105(dpgD)
SALOEF888_14740
CMAGCBW24_16040
NPNJI59_22085
SWISwit_1831
SPHDHY78_16425
SMICSmB9_10450
GOYGLS_c14570
AZLAZL_a11240
ABFAMK58_28010
AOZHUE56_26015
DGIDesgi_0648 Desgi_0671
MPAMAP_1681c
MAOMAP4_2154
MAVIRC58_10730
MAVURE97_10740
MAVMAV_1898 MAV_2609 MAV_2740
MITOCO_13910
MIAOCU_14380
MIROCQ_28520
MMALCKJ54_11550
MMANMMAN_42740(paaG_2)
MMCMmcs_2664
MKMMkms_2709
MJLMjls_2694 Mjls_4074
MGOAFA91_20450
MSAKMSAS_08870
MXEMYXE_08760(paaG_1)
MGORH0P51_13730
MBAIMB901379_02694(echA8_7)
MSEOMSEO_16210
MHEKJMUB5695_00854(paaG_1)
MSPGF6B93_12730
MVMMJO54_11515
MVQMYVA_1802(paaG)
MHASMHAS_01402(dpgD_4) MHAS_02973(crt_5) MHAS_03145(crt_8)
MDUMDUV_18880(paaG_2) MDUV_30820(paaG_5)
MCHTMCHIJ_11390(paaG_1)
MMORMMOR_28350(paaG_7)
MALVMALV_21510(paaG_2)
MHEVMHEL_51450
MPOFMPOR_04110
MBOKMBOE_58920(paaG)
MJDJDM601_3786(echA16_1)
MTER4434518_02926(caiD_2)
MHIBMHIB_00880(paaG_1)
SALUDC74_1107
SALLSAZ_06030
SCADDN051_35625
LDNH9L06_08065
CHREIE160_04085
ARRARUE_c19020
PSULAU252_00885
FALFRAAL3397
AMQAMETH_4631(paaG)
AMYYYIM_21815(caiD3)
BSOLFSW04_12815
TBHTbon_00390 Tbon_03710
 » show all
Reference
1  [PMID:34601806]
  Authors
von Horsten S, Lippert ML, Geisselbrecht Y, Schuhle K, Schall I, Essen LO, Heider J.
  Title
Inactive pseudoenzyme subunits in heterotetrameric BbsCD, a novel short-chain alcohol dehydrogenase involved in anaerobic toluene degradation.
  Journal
FEBS J 289:1023-1042 (2022)
DOI:10.1111/febs.16216
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.180
IUBMB Enzyme Nomenclature: 4.2.1.180
ExPASy - ENZYME nomenclature database: 4.2.1.180
BRENDA, the Enzyme Database: 4.2.1.180
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