Entry
Name
lactoyl-CoA dehydratase;
lactoyl coenzyme A dehydratase;
lactyl-coenzyme A dehydrase;
lactyl CoA dehydratase;
acrylyl coenzyme A hydratase;
lactoyl-CoA hydro-lyase
Class
Lyases;
Carbon-oxygen lyases;
Hydro-lyases
BRITE hierarchy
Sysname
(R)-lactoyl-CoA hydro-lyase (acryloyl-CoA-forming)
Reaction(IUBMB)
(R)-lactoyl-CoA = acryloyl-CoA + H2O [RN:
R02963 ]
Reaction(KEGG)
Substrate
(R)-lactoyl-CoA
Product
Comment
A bacterial enzyme that is involved in propanoate fermentation (also known as the acrylate pathway).
History
EC 4.2.1.54 created 1972, modified 2012
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K20626 lactoyl-CoA dehydratase subunit alpha
K20627 lactoyl-CoA dehydratase subunit beta
Genes
CNO : NT01CX_2368(hgdB) NT01CX_2369(hgdA)
CLOD : C820_001397(hadB) C820_001398(hadC)
DOR : Desor_3092 Desor_3093
DMI : Desmer_1800 Desmer_1801
CPRO : CPRO_08380(fldB) CPRO_08390(fldC)
ANV : RBQ60_10360 RBQ60_10365
MEG : DKB62_04095 DKB62_04100
MMAX : LCQ47_06140 LCQ47_06145
FNF : BSQ88_08500 BSQ88_08505
» show all
Taxonomy
Reference
Authors
BALDWIN RL, WOOD WA, EMERY RS.
Title
LACTATE METABOLISM BY PEPTOSTREPTOCOCCUS ELSDENII: EVIDENCE FOR LACTYL COENZYME A DEHYDRASE.
Journal
Reference
Authors
Schweiger G, Buckel W
Title
On the dehydration of (R)-lactate in the fermentation of alanine to propionate by Clostridium propionicum.
Journal
Reference
Authors
Kuchta RD, Abeles RH
Title
Lactate reduction in Clostridium propionicum. Purification and properties of lactyl-CoA dehydratase.
Journal
J Biol Chem 260:13181-9 (1985)
Sequence
Reference
Authors
Kuchta RD, Hanson GR, Holmquist B, Abeles RH
Title
Fe-S centers in lactyl-CoA dehydratase.
Journal
Reference
Authors
Hofmeister AE, Buckel W
Title
(R)-lactyl-CoA dehydratase from Clostridium propionicum. Stereochemistry of the dehydration of (R)-2-hydroxybutyryl-CoA to crotonyl-CoA.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.1.54
ExPASy - ENZYME nomenclature database: 4.2.1.54
UM-BBD (Biocatalysis/Biodegradation Database): 4.2.1.54
LinkDB
All DBs