KEGG   ENZYME: 4.2.2.1
Entry
EC 4.2.2.1                  Enzyme                                 
Name
hyaluronate lyase;
hyaluronidase (ambiguous);
glucuronoglycosaminoglycan lyase (ambiguous);
spreading factor;
mucinase (ambiguous)
Class
Lyases;
Carbon-oxygen lyases;
Acting on polysaccharides
Sysname
hyaluronate lyase
Reaction(IUBMB)
Cleaves hyaluronate chains at a beta-D-GlcNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine. [RN:R02465 R06242]
Reaction(KEGG)
R02465 R06242(G)
Comment
The enzyme catalyses the degradation of hyaluronan by a beta-elimination reaction. Also acts on chondroitin. The product is more systematically known as 3-(4-deoxy-alpha-L-threo-hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose
History
EC 4.2.2.1 created 1961 as EC 4.2.99.1, transferred 1972 to EC 4.2.2.1, modified 2001
Orthology
K01727  hyaluronate lyase
Genes
CTU: CTU_30970
YEF: FORC2_p069
YRU: BD65_2430
MWI: MNY66_01525
VVY: VV0533 VV0534
VFI: VF_A0994
VFM: VFMJ11_A1113
PTRE: I9H09_17445
ABES: IU367_09085
BUT: X994_6505(xly)
PAQA: K9V56_007150
MALI: EYF70_16965
PLUE: EWM63_01225 EWM63_03305 EWM63_03315 EWM63_06965 EWM63_11635
TMJ: P0M04_03865
HFE: HFELIS_14140
HBI: HBZC1_15820
HHM: BN341_6200
BCZ: pE33L466_0352(xalA)
BBY: CY96_17710
BWD: CT694_29655
BCIR: C2I06_04330
BLEN: NCTC4824_01128 NCTC4824_01130 NCTC4824_03984
BSE: Bsel_0843
SAU: SA2003(hysA)
SAV: SAV2202(hysA)
SAW: SAHV_2186(hysA)
SAH: SaurJH1_2271
SAJ: SaurJH9_2232
SAM: MW2129(hysA)
SAS: SAS2103
SAR: SAR1892(hysA1) SAR2292(hysA2)
SAC: SACOL2194(hysA)
SAX: USA300HOU_2197(hysA)
SAA: SAUSA300_2161(hysA)
SAO: SAOUHSC_02463
SAE: NWMN_2106(hysA)
SAD: SAAV_2263
SUU: M013TW_2169
SUV: SAVC_09900
SUE: SAOV_2247
SUJ: SAA6159_01731 SAA6159_02114
SUK: SAA6008_02243(hysA)
SUC: ECTR2_2063
SUT: SAT0131_02378
SUQ: HMPREF0772_10989 HMPREF0772_11345
SUZ: MS7_2224
SUD: ST398NM01_1880 ST398NM01_2262
SUX: SAEMRSA15_21070(hysA2)
SUW: SATW20_23400(hysA)
SUG: SAPIG1880 SAPIG2262
SUF: SARLGA251_16860(hysA) SARLGA251_19960(hysA)
SAUA: SAAG_00036 SAAG_01706
SAUE: RSAU_001662(hysA) RSAU_002045(hysA2)
SAUN: SAKOR_02172
SAUS: SA40_1956(hysA)
SAUU: SA957_2040(hysA)
SAUG: SA268_2111(hysA)
SAUZ: SAZ172_2305(hysA)
SAUT: SAI1T1_2016390(hysA)
SAUJ: SAI2T2_1016400(hysA)
SAUK: SAI3T3_1016390(hysA)
SAUQ: SAI4T8_1016400(hysA)
SAUV: SAI7S6_1016390
SAUW: SAI5S5_1016330
SAUX: SAI6T6_1016340
SAUY: SAI8T7_1016370
SAUF: X998_2189
SAB: SAB1663(hysA1) SAB2082(hysA2)
SUY: SA2981_2139(hysA)
SAUB: C248_1856(hysA1) C248_2244(hysA2)
SAUM: BN843_22440
SAUC: CA347_2289
SAUR: SABB_04270(hysA)
SAUI: AZ30_11650
SAUD: CH52_07940
SAMS: NI36_10880
SUH: SAMSHR1132_20330
SHU: SHYC_11715(hysA)
SAGQ: EP23_10455
SSH: NCTC13712_02147(hylB)
SSAC: I6I31_03920
SRAI: LN051_02175
LWI: UE46_14495 UE46_15580
LNW: OTR81_07225
PJD: Pjdr2_3195
PMS: KNP414_02262 KNP414_05237 KNP414_05560
PMQ: PM3016_2533 PM3016_4630 PM3016_4924
PMW: B2K_12830 B2K_24000 B2K_25515
PLV: ERIC2_c23740
PBD: PBOR_18695
PAEN: P40081_18995
PAEQ: R50912_17565
PSON: JI735_00335 JI735_00345
PSWU: SY83_13390
PVO: PVOR_25993
PLUT: EI981_02180 EI981_02185
PCHI: PC41400_11265
PBK: Back11_31760 Back11_31770
PBAC: HUB98_02505
PTRI: KDC22_23180 KDC22_23190
PALO: E6C60_3615
PTHI: NDS46_04215
PDY: QJQ58_18420
PAUN: MJA45_14235
PHK: SK066_18190
PGLU: A3958_01915
CCHL: FPL14_08820
LPET: lgb_01413
LFO: LMK00_08220
SPY: SPy_1032(hylA)
SPZ: M5005_Spy0757(hylA)
SPYM: M1GAS476_0819(hylA)
SPYA: A20_0798c
SPM: spyM18_1014(hylA)
SPG: SpyM3_0665(hylA)
SPS: SPs1188
SPH: MGAS10270_Spy0874(hylA)
SPI: MGAS10750_Spy0909(hylA)
SPJ: MGAS2096_Spy0830(hylA)
SPK: MGAS9429_Spy0871(hylA)
SPA: M6_Spy0782
SPB: M28_Spy0736(hylA)
STG: MGAS15252_0784(hylA)
STX: MGAS1882_0780(hylA)
SOZ: Spy49_0811c(hylA)
STZ: SPYALAB49_000782
SPYH: L897_03945
SPN: SP_0314
SPD: SPD_0287
SPR: spr0286(hysA)
SPW: SPCG_0322
SJJ: SPJ_0310
SNV: SPNINV200_02820
SPX: SPG_0285(hyl)
SNT: SPT_0364
SND: MYY_0397
SPNN: T308_01575
SNE: SPN23F02890
SPV: SPH_0426
SNC: HMPREF0837_10617
SNM: SP70585_0379
SPP: SPP_0350
SNI: INV104_02610
SPNG: HMPREF1038_00364(hysA)
SNB: SP670_0382
SNP: SPAP_0347
SNU: SPNA45_01722
SAG: SAG1197
SAN: gbs1270
SAK: SAK_1284(hylB)
SGC: A964_1170
SAGS: SaSA20_1016(hylB)
SAGL: GBS222_1026(hylB)
SAGM: BSA_12760
SAGI: MSA_13200
SAGR: SAIL_13150
SAGP: V193_05585
SAGC: DN94_05585
SAGT: GBSCOH1_1103
SAGE: EN72_06630
SAGG: EN73_06165
SAGJ: ID870_03375(hylB)
SUP: YYK_05005
SST: SSUST3_1226
SSUY: YB51_6050
SSQ: SSUD9_1371
SRP: SSUST1_0748
SSUI: T15_0747
SEZ: Sez_1299(hylB)
SEQ: SZO_06680
SEQU: Q426_02630
SDS: SDEG_0654
SDG: SDE12394_03510
SDA: GGS_0628(hylB)
SDC: SDSE_0694(hylB)
SDQ: SDSE167_0713(hylB)
STK: STP_1167
SIE: SCIM_1362
SIB: SIR_1547
SIU: SII_1533
SANC: SANR_1718
SCG: SCI_1642
SCON: SCRE_1598
SCOS: SCR2_1598
SIK: K710_0217
SIQ: DQ08_01045
SIO: DW64_01040
SIZ: SI82_01295
SRQ: SR187_3375
SMEN: SAMEA4412692_1386(hylA)
SURN: NCTC13766_00112(hylB_1) NCTC13766_00113(hylB_2)
SOS: INT76_10670
LCA: LSEI_2686
LCZ: LCAZH_2685
LCS: LCBD_2903
LCE: LC2W_2877
LCW: BN194_28200
LCL: LOCK919_2937
LPI: LBPG_01276
LPAP: LBPC_2659
LCB: LCABL_28750(xalA)
LCX: LCA12A_0375
LRL: LC705_02696(xalA)
LRA: LRHK_2805
LRO: LOCK900_2695
LRC: LOCK908_2776
LPAH: LACPH_002585
LSB: LACSTY_002665
CPAB: G6534_05695
EFA: EF0818 EF3023
EFL: EF62_0109
EFI: OG1RF_10550 OG1RF_12303
EFD: EFD32_0629 EFD32_2606
EFS: EFS1_2467
EFN: DENG_02916
EFQ: DR75_1758
ENE: ENT_22740
EFT: M395_11255
EHR: EHR_14305
EMU: EMQU_2462
EGA: AL523_06180
ESS: ATZ33_14390
ETH: CK496_10330
ELAC: I4Q40_11295
ECEC: NCTC12421_00019
EIE: ENLAB_20640
ENI: CXM95_01160
GAD: K8O88_08775
GEG: LK443_01000
CPF: CPF_0394
CPR: CPR_0390
CBN: CbC4_2106
CBV: U729_2500
CSEP: CP523_01355
BHAN: CGC63_02885 CGC63_14875
CSH: Closa_2597
LBW: C3V36_09935
HOV: EQF90_007695
HKU: HIF96_07580
ERH: ERH_0150(hylA) ERH_0765(hylB)
ERS: K210_01660 K210_07905
EEH: LLS04_04075
ERV: MX850_05775
BULL: JOS54_07575
TSF: NQ543_01375
SCO: SCO5534(SC1C2.15)
SMA: SAVERM_2704
SGR: SGR_291
SGB: WQO_33115
SFI: SFUL_16
SANL: KZO11_00745 KZO11_37140
SGRF: SGFS_040030
SCYE: R2B67_00610
SCB: SCAB_26801
SHY: SHJG_6645
SHO: SHJGH_6405
SVE: SVEN_5221
SDV: BN159_0958 BN159_2862
SALS: SLNWT_4661
SCI: B446_25985
SLV: SLIV_10835
SGU: SGLAU_23805
SVT: SVTN_26825
STRE: GZL_03204
SCW: TU94_23365
SLD: T261_2519
SLC: SL103_28195
STRC: AA958_24125
SAMB: SAM23877_5289
SPRI: SPRI_4720
SCZ: ABE83_00480
SCX: AS200_15735
SRW: TUE45_06045(xly)
SLE: sle_21210(sle_21210)
SPAV: Spa2297_23435
STRT: A8713_00365 A8713_22525
SCLF: BB341_06495
SGS: AVL59_08750
STSI: A4E84_28340
SALW: CP975_31340
SGM: GCM10017557_23350
SLS: SLINC_5976
SNR: SNOUR_13955
SALU: DC74_5664
SALL: SAZ_29920
STRD: NI25_11545
SVU: B1H20_33735
SPUN: BFF78_03435
SGV: B1H19_28315
SLAU: SLA_5431
SALF: SMD44_01144
SALJ: SMD11_2031
SLX: SLAV_04325(xly)
STRO: STRMOE7_27170
SFK: KY5_5711
SNZ: DC008_24835
SGE: DWG14_02529(xly)
SRJ: SRO_0644
SLK: SLUN_28075
SGD: ELQ87_11925
SQZ: FQU76_24730
SCYA: EJ357_32680
SAST: CD934_09335
SKA: CP970_04240 CP970_12530
SVN: CP980_03870
SHAW: CEB94_28975
SRK: FGW37_23350
SFIC: EIZ62_08725
SPAD: DVK44_25640
SAQU: EJC51_33905 EJC51_41950
SGF: HEP81_00629
SCAV: CVT27_32625
SRIM: CP984_11465
SSUB: CP968_31185
SPHV: F9278_35050
SCIN: CP977_33110
SPAC: B1H29_10935
STSU: B7R87_24740
SCHA: CP983_12950
SGX: H4W23_28340
SCOE: CP976_30575
SSPB: CP982_06315
SPLA: CP981_27530
SBRO: GQF42_30420 GQF42_39675
STUI: GCM10017668_50460
SATA: C5746_03170 C5746_29510 C5746_36050
SHUN: DWB77_02354(xly_1) DWB77_06443(xly_2) DWB77_06490(xly_3)
SCYG: S1361_27505(xly)
SFEU: IM697_35535
SLIA: HA039_09355
SDW: K7C20_26190
SCAL: I6J39_33470
SAUH: SU9_024925
SMOB: J7W19_23170
SXN: IAG42_02145 IAG42_05180 IAG42_32435
SGJ: IAG43_30120
SHK: J2N69_32955
SANU: K7396_10630
SDD: D9753_10340
SACT: DMT42_10045
SGOB: test1122_22970
SINE: KI385_31415
SLF: JEQ17_14750
SDEC: L3078_32175
SAOV: G3H79_33140
SDUR: M4V62_03810 M4V62_07500
SAKB: K1J60_13055
STAA: LDH80_12570
SNIG: HEK616_54990
SCAE: IHE65_12565
STUB: MMF93_02035
SSPN: LXH13_28065
SCIR: STRCI_005716 STRCI_007476
SXT: KPP03845_100338(xly_1) KPP03845_106619(xly_2)
SLON: LGI35_07780 LGI35_30395 LGI35_35640
SDRZ: NEH16_03190
STUD: STRTU_002005
SENG: OJ254_01650
SYUN: MOV08_13800
SARG: HKX69_09970
SJN: RI060_11845
SOV: QZH56_08835
SHAU: K9S39_14835
SKG: KJK29_09930
SCOA: QU709_11630
SLAI: P8A22_02080 P8A22_03890 P8A22_10750 P8A22_36685
SROC: RGF97_30970
SFP: QUY26_35460
SCHG: NRO40_21400
SINN: ABB07_02650
KBU: Q4V64_37430
STPB: QR97_09255
SRPA: HEP86_28570
SMIB: SMIR_37530
SCAJ: O1G22_12885
STRW: QHG49_32270
STRL: HEP84_07625
SCT: SCAT_4363
SCY: SCATT_43510
KAB: B7C62_00095
LXL: KDY119_02305(hysA)
MTS: MTES_2849
MIX: AB663_001102
MAZA: NFX31_16015
MEST: PTQ19_00485 PTQ19_12450
FRP: AX769_05830
ART: Arth_1698
ARR: ARUE_c32170
ARM: ART_3702
ARE: AL755_00180 AL755_04595
ARW: MB46_19365
ARN: CGK93_17430
AWW: G8758_10730
AAU: AAur_3068
PNV: JMY29_14850 JMY29_16365
PAGO: IRJ34_15385
BCV: Bcav_4062
LMOI: VV02_06880
PSEI: GCE65_02310
HALT: IM660_00335 IM660_00365 IM660_14490
RHAL: LQF10_05115 LQF10_16250
RSUA: LQF12_12370
PAC: PPA0380
PAK: HMPREF0675_3415
PAV: TIA2EST22_01875
PAX: TIA2EST36_01855
PAZ: TIA2EST2_01795
PAW: PAZ_c03930(hylB)
PAD: TIIST44_06625
PCN: TIB1ST10_01945
PACC: PAC1_01925
PACH: PAGK_0394
PACN: TIA1EST1_01875
CACN: RN83_02370
PRL: BCB70_04600
MIK: FOE78_16715
TES: BW730_12375
PRV: G7070_17430
KFL: Kfla_2021
KQI: F1D05_13565
KSL: OG809_24590
KRI: OX958_07760
SRO: Sros_4208
NOA: BKM31_31155 BKM31_46745 BKM31_51920 BKM31_55970
NOW: GBF35_40595 GBF35_50865
NCX: Nocox_19595(xly1) Nocox_41810(xly4)
NGN: LCN96_14075 LCN96_45090 LCN96_49450 LCN96_55380
NFS: OIE67_23030 OIE67_46880 OIE67_54920
MHAI: OHB01_09145
AMD: AMED_5970
AMN: RAM_30620
AMM: AMES_5886
AMZ: B737_5886
AOI: AORI_4997
AJA: AJAP_14535
AMYC: CU254_22185
AMYB: BKN51_17440
AAB: A4R43_15665
AMYY: YIM_14790(xly)
AORI: SD37_24605
AACD: LWP59_20510
APRT: MUY14_06020
AROO: NQK81_41985
ARHD: VSH64_17275
AMOG: QRX60_46655
ACOR: LCL61_04680
PHH: AFB00_01910
KAL: KALB_2559
KUT: JJ691_100600 JJ691_33230
CROS: N8J89_17545
ACTL: L3i22_010680
ACTE: ACTI_51170
ATL: Athai_07180 Athai_37990 Athai_61400 Athai_66290
CAI: Caci_4980 Caci_6725
SNA: Snas_0850
GLY: K3N28_09530
BNK: KIM372_13280
VBA: IMCC26134_14310
TBE: Trebr_1552 Trebr_1554 Trebr_1556
FMO: C4N19_04620 C4N19_04660
CSOM: MKD34_01125 MKD34_01155
LGO: JCM16774_1532
SMF: Smon_0117 Smon_0125
PMER: INE87_03105
COPR: Cop2CBH44_00640
CFAS: Cfast33896_14490
AIT: AI2BBH_05660 AI2BBH_05670 AI2BBH_18540
HMU: Hmuk_3227
HALZ: E5139_16020
HALL: LC1Hm_4133(hysA)
 » show all
Reference
1  [PMID:13762462]
  Authors
LINKER A, HOFFMAN P, MEYER K, SAMPSON P, KORN ED.
  Title
The formation of unsaturated disacharides from mucopoly-saccharides and their cleavage to alpha-keto acid by bacterial enzymes.
  Journal
J Biol Chem 235:3061-5 (1960)
Reference
2  [PMID:14943668]
  Authors
MEYER K, RAPPORT MM.
  Title
Hyaluronidases.
  Journal
Adv Enzymol Relat Subj Biochem 13:199-236 (1952)
DOI:10.1002/9780470122587.ch6
Reference
3  [PMID:5642600]
  Authors
Moran F, Nasuno S, Starr MP.
  Title
Extracellular and intracellular polygllacturonic acid trans-eliminases of Erwinia carotovora.
  Journal
Arch Biochem Biophys 123:298-306 (1968)
DOI:10.1016/0003-9861(68)90138-0
Other DBs
ExplorEnz - The Enzyme Database: 4.2.2.1
IUBMB Enzyme Nomenclature: 4.2.2.1
ExPASy - ENZYME nomenclature database: 4.2.2.1
BRENDA, the Enzyme Database: 4.2.2.1
CAS: 37259-53-3
LinkDB

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