EC 220.127.116.11 Enzyme
guluronate-specific alginate lyase;
polyguluronate-specific alginate lyase;
Acting on polysaccharides
alginate alpha-L-guluronate---uronate lyase
Eliminative cleavage of alginate to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and alpha-L-guluronate at their reducing end.
The enzyme catalyses the degradation of alginate by a beta-elimination reaction. It cleaves the (1->4) bond between alpha-L-guluronate and either alpha-L-guluronate or beta-D-mannuronate, generating oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enuronosyl groups at their non-reducing ends and alpha-L-guluronate at the reducing end. Depending on the composition of the substrate, the enzyme produces oligosaccharides ranging from two to six residues, with preference for shorter products. cf. EC
, mannuronate-specific alginate lyase.
EC 18.104.22.168 created 1990, modified 2015
Fructose and mannose metabolism
Boyd J, Turvey JR.
Isolation of poly-alpha-L-guluronate lyase from Klebsiella aerogenes.
Carbohydr Res 57:163-71 (1977)
Davidson IW, Sutherland IW, Lawson CJ.
Purification and properties of an alginate lyase from a marine bacterium.
Biochem J 159:707-13 (1976)
ExplorEnz - The Enzyme Database:
IUBMB Enzyme Nomenclature:
ExPASy - ENZYME nomenclature database:
BRENDA, the Enzyme Database:
integrated database retrieval system