KEGG   ENZYME: 4.2.2.5
Entry
EC 4.2.2.5                  Enzyme                                 
Name
chondroitin AC lyase;
chondroitinase (ambiguous);
chondroitin sulfate lyase;
chondroitin AC eliminase;
chondroitinase AC;
ChnAC
Class
Lyases;
Carbon-oxygen lyases;
Acting on polysaccharides
Sysname
chondroitin AC lyase
Reaction(IUBMB)
Eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups
Reaction(KEGG)
(other) R10870 R10872
Comment
Acts on chondroitin 4-sulfate and chondroitin 6-sulfate, but less well on hyaluronate. In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(beta1-3)GalNAc(beta1-]n, which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(alpha1-3)GalNAc(beta1-]n of DS. Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source [4].
History
EC 4.2.2.5 created 1972 (EC 4.2.99.6 created 1965, part incorporated 1976)
Orthology
K19049  chondroitin AC lyase
Genes
LCPLC55x_3170
VVUVV2_1090 VV2_1110
VVYVVA1613 VVA1636
VVMVVMO6_04481 VVMO6_04502
VVLVV93_v1c44830 VV93_v1c45010
VNAPN96_04575 PN96_15915
VEJVEJY3_08795 VEJY3_11250 VEJY3_24021
VNIVIBNI_A2386 VIBNI_B0676
VMIAL543_05760
VZIG5S32_08405
VPLSA104470976_03549(cslA)
VTICEQ48_01545
VMTQYQ96_16390
PSPPSPPH_1510
PCOFPOR16_06570
PPVNJ69_21650
SALHHMF8227_02592(cslA)
DGGDGI_2110
MDGK8L98_24575
SAUSSA40_1662(hysA)
SAUUSA957_1745(hysA)
SAUGSA268_1750(hysA)
PRIPRIO_0266
PSONJI735_09665
CPYCphy_0932
SRCM271_11920
SMALSMALA_8146
SSOII1A49_44455
STRCAA958_33960 AA958_33990
SMAOCAG99_02580
SANTQR300_41865
LEIFHF024_19050
SROSros_7449
NOWGBF35_46940
APRECNX65_02545
AMIAmir_0500
SSYIEKG83_02680
OTEOter_4325
VBHCMV30_16555
LAMBKBB96_20245
VBSEGM51_17765
LPAVPLANPX_5473
AMUCPan181_06230(cslA)
ALUSSTSP2_00558(cslA)
VBCC5Q97_06605 C5Q97_12785 C5Q97_13800
GMAAciX8_2234
BTHBT_2964
BTHOBtheta7330_00132(cslA)
BFRBF1585
BFSBF9343_1519
BFGBF638R_1599
BFBVU15_06680
BHLBache_0581
BCELBcellWH2_00910(cslA_1) BcellWH2_01185(cslA_2) BcellWH2_02524(cslA_3) BcellWH2_03147(cslA_4) BcellWH2_03149(cslA_5)
BCACCGC64_05665 CGC64_15715
BZGC4H11_07720
BHFC3V43_08625
BISDXK01_019240 DXK01_019550 DXK01_020455
BUNBun01g_09450
BSTEK6V31_07645 K6V31_08230 K6V31_15615
BNOK8P02_06975 K8P02_16845 K8P02_18200 K8P02_19545
BHUMJXR92_004880
BFCBacF7301_07350 BacF7301_22440
BSALK6V25_02860 K6V25_04035
PCOPI6J50_11260
PSACPSM36_3149
DYSG7050_01510 G7050_17395
DYHG7051_01930 G7051_18115
PMERINE87_00197
PGOLK6V26_11200 K6V26_24125
PJOLK449_04800
PFAINXY11_09950
COPRCop2CBH44_16400 Cop2CBH44_26110
CFASCfast33896_14460
ASHAL1_00280
MCOSGM418_02630 GM418_02650
MBASALGA_3393
CBAECOR50_19620
CHITFW415_19970 FW415_23020
COYHF329_15635
CHORMKQ68_18545
NKONiako_2983
NSONIASO_08255
NIAA8C56_12645
FGGFSB75_10435 FSB75_19270
ARKD6B99_12950 D6B99_14525 D6B99_15435
ARACE0W69_012000
PSEGD3H65_05365
PHEPhep_0786 Phep_3863 Phep_3972 Phep_3979
PEPAQ505_08355
PEJFYC62_06810 FYC62_10660
PROEH9L23_01265
PEXIZT61_18275
PRKH9N25_01005
PGJQG516_06545
PSNPedsa_3808
SPHNBV902_04995
SPDRG6053_03770
SSPII6J01_13615 I6J01_21300
SSIYJVX97_28180
MMABHQ865_05340 HQ865_05360 HQ865_11825
SBXCA265_00740 CA265_05500 CA265_06790 CA265_11265 CA265_14190
CMRCycma_3427 Cycma_4185
CAMUCA2015_3294 CA2015_4151
EVIEchvi_2165 Echvi_2985
ESTDN752_16515 DN752_21630
ECHIFKX85_10305 FKX85_14110
SPIBG8759_06620 G8759_10255 G8759_26025
RSIRunsl_2790
RUNDR864_11955
FIBA6C57_21910
RUFTH63_11990
PRHOPZB74_06325
TPELP0M28_17710
FCOFCOL_08260
FGLEM308_13245
FCVAWN65_00325
FOEJJC03_05750
AHZAPS56_13715 APS56_13745
TMARMARIT_2107(cslA)
WFUAXE80_10005
EMARD1013_19905
SINHLS482_10110
ZSPMQE36_13435
ORHOrnrh_0808
ORIQ785_04600
EAOBD94_3101 BD94_3102
EMNM876_12965 M876_12970
EENBBD30_10770 BBD30_10775
ELBVO54_03456(cslA_1) VO54_03457(cslA_2)
EMGBBD33_07420 BBD33_07425
EGOBBD34_05310 BBD34_05315
EGMAYC65_01390 AYC65_01395
ELZFCS00_15295 FCS00_15300
ELTFGE20_09700
ELIZJCR23_06850 JCR23_06855
CPIPCJF12_04375
 » show all
Reference
1  [PMID:13727579]
  Authors
NAKADA HI, WOLFE JB.
  Title
Studies on the enzyme chondroitinase: product structure and ion effects.
  Journal
Arch Biochem Biophys 94:244-51 (1961)
DOI:10.1016/0003-9861(61)90037-6
Reference
2  [PMID:11500043]
  Authors
Pojasek K, Shriver Z, Kiley P, Venkataraman G, Sasisekharan R.
  Title
Recombinant expression, purification, and kinetic characterization of chondroitinase AC and chondroitinase B from Flavobacterium heparinum.
  Journal
Biochem Biophys Res Commun 286:343-51 (2001)
DOI:10.1006/bbrc.2001.5380
Reference
3  [PMID:9761894]
  Authors
Fethiere J, Shilton BH, Li Y, Allaire M, Laliberte M, Eggimann B, Cygler M.
  Title
Crystallization and preliminary analysis of chondroitinase AC from Flavobacterium heparinum.
  Journal
Acta Crystallogr D Biol Crystallogr 54 ( Pt 2):279-80 (1998)
DOI:10.1107/s0907444997009037
  Sequence
[phe:Phep_0786]
Reference
4  [PMID:16336265]
  Authors
Huckerby TN, Nieduszynski IA, Giannopoulos M, Weeks SD, Sadler IH, Lauder RM.
  Title
Characterization of oligosaccharides from the chondroitin/dermatan sulfates. 1H-NMR and 13C-NMR studies of reduced trisaccharides and hexasaccharides.
  Journal
FEBS J 272:6276-86 (2005)
DOI:10.1111/j.1742-4658.2005.05009.x
Other DBs
ExplorEnz - The Enzyme Database: 4.2.2.5
IUBMB Enzyme Nomenclature: 4.2.2.5
ExPASy - ENZYME nomenclature database: 4.2.2.5
BRENDA, the Enzyme Database: 4.2.2.5
CAS: 9047-57-8
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