KEGG ENZYME: 4.2.3.109

ENZYME: 4.2.3.109

Entry

EC 4.2.3.109                Enzyme

Name

(-)-sabinene synthase

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

geranyl-diphosphate diphosphate-lyase [cyclizing, (-)-sabinene-forming]

Reaction(IUBMB)

geranyl diphosphate = (-)-sabinene + diphosphate [RN:R09965]

Reaction(KEGG)

Substrate

geranyl diphosphate [CPD:C00341]

Product

(-)-sabinene [CPD:C20242];
diphosphate [CPD:C00013]

Comment

Requires Mg2+. Isolated from Pinus contorta (lodgepole pine) as cyclase I [1] and from Conocephalum conicum (liverwort) [2].

History

EC 4.2.3.109 created 2012

Reference

1 [PMID:8307957]

Authors

Savage TJ, Hatch MW, Croteau R

Title

Monoterpene synthases of Pinus contorta and related conifers. A new class of terpenoid cyclase.

Journal

J Biol Chem 269:4012-20 (1994)

Reference

2 [PMID:12941302]

Authors

Peters RJ, Croteau RB

Title

Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases.

Journal

Arch Biochem Biophys 417:203-11 (2003)
DOI:10.1016/S0003-9861(03)00347-3

Other DBs

ExplorEnz - The Enzyme Database:

IUBMB Enzyme Nomenclature:

ExPASy - ENZYME nomenclature database:

BRENDA, the Enzyme Database:

LinkDB

DBGET integrated database retrieval system