KEGG   ENZYME: 4.2.3.140
Entry
EC 4.2.3.140                Enzyme                                 
Name
cis-abienol synthase;
Z-abienol synthase;
CAS;
ABS
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
(13E)-8alpha-hydroxylabd-13-en-15-yl-diphosphate-lyase (cis-abienol-forming)
Reaction(IUBMB)
(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate = cis-abienol + diphosphate [RN:R10276]
Reaction(KEGG)
R10276
Substrate
(13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate [CPD:C20270]
Product
cis-abienol [CPD:C20481];
diphosphate [CPD:C00013]
Comment
Isolated from the plants Abies balsamea (balsam fir) [1] and Nicotiana tabacum (tobacco) [2].
History
EC 4.2.3.140 created 2012
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K20517  cis-abienol synthase
K20518  copal-8-ol diphosphate hydratase / cis-abienol synthase
Genes
SSTN: 125851100
LBB: 132609618
NTA: 107816701 142169410 142169411 142169412
APAN: 127254110
CARB: 113702909 113705546 113705934
Reference
1  [PMID:22337889]
  Authors
Zerbe P, Chiang A, Yuen M, Hamberger B, Hamberger B, Draper JA, Britton R, Bohlmann J
  Title
Bifunctional cis-abienol synthase from Abies balsamea discovered by transcriptome sequencing and its implications for diterpenoid fragrance production.
  Journal
J Biol Chem 287:12121-31 (2012)
DOI:10.1074/jbc.M111.317669
  Sequence
[ag:AEL99953]
Reference
2  [PMID:22672125]
  Authors
Sallaud C, Giacalone C, Topfer R, Goepfert S, Bakaher N, Rosti S, Tissier A
  Title
Characterization of two genes for the biosynthesis of the labdane diterpene Z-abienol in tobacco (Nicotiana tabacum) glandular trichomes.
  Journal
Plant J 72:1-17 (2012)
DOI:10.1111/j.1365-313X.2012.05068.x
  Sequence
[ag:CCD33019]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.140
IUBMB Enzyme Nomenclature: 4.2.3.140
ExPASy - ENZYME nomenclature database: 4.2.3.140
BRENDA, the Enzyme Database: 4.2.3.140
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