KEGG   ENZYME: 4.2.3.15
Entry
EC 4.2.3.15                 Enzyme                                 
Name
myrcene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranyl-diphosphate diphosphate-lyase (myrcene-forming)
Reaction(IUBMB)
geranyl diphosphate = myrcene + diphosphate [RN:R02009]
Reaction(KEGG)
R02009
Substrate
geranyl diphosphate [CPD:C00341]
Product
myrcene [CPD:C06074];
diphosphate [CPD:C00013]
Comment
A recombinant enzyme (also known as a monoterpene synthase or cyclase) from the grand fir (Abies grandis) requires Mn2+ and K+ for activity. Mg2+ is essentially ineffective as the divalent metal ion cofactor.
History
EC 4.2.3.15 created 2000 as EC 4.1.99.9, transferred 2000 to EC 4.2.3.15
Pathway
ec00902  Monoterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K12467  myrcene/ocimene synthase
K21925  (-)-camphene/tricyclene/(4S)-limonene/myrcene synthase
Genes
ATH: AT2G24210(TPS10) AT3G25810
CRB: 17889158 17889311
CSAT: 104702938
BRP: 103858386 103858582
BNA: 106385578 106402047 106443840
BOE: 106328108 106334082
RSZ: 108837661 108846403 108846672
TWL: 119980547
SLY: 101245212(TPS3) 101249864
SPEN: 107012939 107012948
SOT: 102591915 102602070
SSTN: 125861389 125861571
CANN: 107840093
LBB: 132598839
NTA: 107785945 107787835
NSY: 104238653
NTO: 104090536
NAU: 109214608
SSPL: 121755010
SMIL: 131005775 131026618 131026619
SHIS: 125185612 125185636 125193586 125197284 125200997 125204274 125208619 125218604 125219856 125220542 125224358
CJF: 131027736 131030273 131030284 131036390 131039800 131040614 131042617 131042631 131042632 131042634 131042635 131042678 131042692 131042757 131046574 131049606 131050055 131051798 131051812 131051813 131053066 131053802 131054885 131056546 131056704 131058258 131058925 131058926 131058927 131058928 131060558 131061200 131064577 131065313 131065363 131066127 131066129 131066130 131066145 131066146 131067592 131067684 131067686 131067688 131067689 131067913 131067914 131067929 131068917 131068918 131068927 131068928 131068932 131068933 131068962 131068963 131068964 131068965 131070110 131073180 131073183 131073184 131073222 131073234 131073236 131073238 131076545 131079059 131079061 131856196 131862178 131863424 131863425 131873601 131873643
 » show all
Reference
1  [PMID:9268308]
  Authors
Bohlmann J, Steele CL, Croteau R
  Title
Monoterpene synthases from grand fir (Abies grandis). cDNA isolation, characterization, and functional expression of myrcene synthase, (-)-(4S)-limonene synthase, and (-)-(1S,5S)-pinene synthase.
  Journal
J Biol Chem 272:21784-92 (1997)
DOI:10.1074/jbc.272.35.21784
  Sequence
[ag:AAB71084]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.15
IUBMB Enzyme Nomenclature: 4.2.3.15
ExPASy - ENZYME nomenclature database: 4.2.3.15
BRENDA, the Enzyme Database: 4.2.3.15
CAS: 197462-59-2
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