KEGG   ENZYME: 4.2.3.26
Entry
EC 4.2.3.26                 Enzyme                                 
Name
R-linalool synthase;
(3R)-linalool synthase;
(-)-3R-linalool synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranyl-diphosphate diphosphate-lyase [(3R)-linalool-forming]
Reaction(IUBMB)
geranyl diphosphate + H2O = (3R)-linalool + diphosphate [RN:R07632]
Reaction(KEGG)
R07632
Substrate
geranyl diphosphate [CPD:C00341];
H2O [CPD:C00001]
Product
(3R)-linalool [CPD:C11388];
diphosphate [CPD:C00013]
Comment
Geranyl diphosphate cannot be replaced by isopentenyl diphosphate (3-methylbut-3-en-1-yl diphosphate), prenyl diphosphate, farnesyl diphosphate or geranylgeranyl diphosphate as substrate [1]. Requires Mg2+ or Mn2+ for activity. Unlike many other monoterpene synthases, only a single product, (3R)-linalool, is formed.
History
EC 4.2.3.26 created 2006
Pathway
ec00902  Monoterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K15087  (3R)-linalool synthase
Reference
1  [PMID:10562427]
  Authors
Jia JW, Crock J, Lu S, Croteau R, Chen XY
  Title
(3R)-Linalool synthase from Artemisia annua L.: cDNA isolation, characterization, and wound induction.
  Journal
Arch Biochem Biophys 372:143-9 (1999)
DOI:10.1006/abbi.1999.1466
  Sequence
[ag:AAF13356 AAF13357]
Reference
2  [PMID:12176064]
  Authors
Crowell AL, Williams DC, Davis EM, Wildung MR, Croteau R
  Title
Molecular cloning and characterization of a new linalool synthase.
  Journal
Arch Biochem Biophys 405:112-21 (2002)
DOI:10.1016/S0003-9861(02)00348-X
  Sequence
[ag:AAL99381]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.26
IUBMB Enzyme Nomenclature: 4.2.3.26
ExPASy - ENZYME nomenclature database: 4.2.3.26
BRENDA, the Enzyme Database: 4.2.3.26
CAS: 254993-26-5
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