KEGG ENZYME: 4.2.3.48

ENZYME: 4.2.3.48

Entry

EC 4.2.3.48                 Enzyme

Name

(3S,6E)-nerolidol synthase;
(E)-nerolidol synthase;
nerolidol synthase;
(3S)-(E)-nerolidol synthase;
FaNES1

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(3S,6E)-nerolidol-forming]

Reaction(IUBMB)

(2E,6E)-farnesyl diphosphate + H2O = (3S,6E)-nerolidol + diphosphate [RN:R08374]

Reaction(KEGG)

R08374

Substrate

(2E,6E)-farnesyl diphosphate [CPD:C00448];
H2O [CPD:C00001]

Product

(3S,6E)-nerolidol [CPD:C09704];
diphosphate [CPD:C00013]

Comment

The enzyme catalyses a step in the formation of (3E)-4,8-dimethylnona-1,3,7-triene, a key signal molecule in induced plant defense mediated by the attraction of enemies of herbivores [2]. Nerolidol is a naturally occurring sesquiterpene found in the essential oils of many types of plants.

History

EC 4.2.3.48 created 2010

Pathway

ec00909

Sesquiterpenoid and triterpenoid biosynthesis

Orthology

K14175

(3S,6E)-nerolidol synthase

Genes

CRB:

17896330

THJ:

104809526

CIT:	102617431 102617651 102617908 102620886

CIC:	CICLE_v10004558mg CICLE_v10014632mg CICLE_v10014707mg

PVY:	116111381 116121150 116145960

MINC:

123192358 123192360 123192601 123192665 123192702

TCC:	108662607 18597023 18597024

GRA:

105777993

GHI:	107924963 107940942

GAB:

108452092

DZI:	111281010 111318783

EGR:	104445481 104447370 104447372 104447373 104447374 104447375 104447392 104447394 104447396 104447399

GMX:	100782471(TPS4) 100783015(TPS5) 100814957(TPS6)

GSJ:	114419462 114419463

PVU:	PHAVU_002G219100g PHAVU_002G219300g

VRA:	106765590 106766355 106766356 106766374

VAR:	108326386 108338184 108338349

VUN:	114177509 114178712 114178713 114179677

CCAJ:

109814060 109817871 109817878

APRC:

113858784

MTR:	MTR_4g092010 MTR_4g092020

CAM:	101494917 101495572 101503644

LJA:	Lj0g3v0198989.1(Lj0g3v0198989.1) Lj0g3v0198989.2(Lj0g3v0198989.2)

ADU:	107468751 107480611

AIP:	107623232 107626247

AHF:	112714726 112728647 112784898 112791359

LANG:

109334775

FVE:	101299453 101302321

RCN:	112165597 112166460 112202907

PPER:

18778181

PMUM:

103324596 103343969

PAVI:

110752892 110768753

PDUL:

117625092 117626312

MDM:	103434640 103446596 103446597 103446598(LIS) 114827793

PXB:	103941370 103941371 103958297

ZJU:	107421470 107421878

MNT:	21385024 21408693 21408694

CSV:	101204794 101215070

CMO:	103485748 103485753 103485759 103489227

BHJ:	120080989 120082587 120082664 120082764 120083563

MCHA:

111010706 111010875 111010876 111010887

CMAX:

111484385 111490118

CMOS:

111434067 111434068 111447175 111456834

CPEP:

111783518 111802148

RCU:

8259987

JCU:	105629808 105629819 105629820 105649410

HBR:	110635396 110644414 110654947 110661963

MESC:

110603115 110604308 110604309 110605593

POP:	18102943 7490762 7490764

PEU:	105107363 105110145

PALZ:

118031658 118031660 118031663 118042815

JRE:	108979322 108979323 108989344 109004686 109004723 109007398 109013445

QSU:	111988830 111989102 111989152

QLO:	115988645 115991201 115992647 115992733

TWL:	119990104 119990105

VVI:	100248531 100266449(LinNer) 100267150 100852561 100852596 100852776 100853562 100853639 100853679 100854717 100854809

VRI:	117910457 117910459 117910461 117910462 117918890 117923388 117924000 117924001 117924133

SLY:	101244812(TPS37) 101245403(TPS39)

SPEN:

107019618 107032586

SOT:	102580873 102592813

CANN:

107845646

NTA:

107828192

NTO:

104117466

NAU:

109230989

INI:	109163834 109167275 109167276 109167277 109167278 109167279

ITR:	116029121 116029228 116029229 116029230 116029231 116029232 116029233 116030387 116030506 116030578

SIND:

105156792 105175396 105175430 105175469 105175470

OEU:	111395219 111396005 111396006 111396009 111396013 111396015 111396016

EGT:	105962255 105962256

SSPL:

121759727 121783505 121787949 121794424

HAN:	110884314 110889629 110915780 110916766 110919641

ECAD:

122597840 122599361 122608148

LSV:	111884934 111897116 111897141 111897149

CCAV:

112527638 112527948

DCR:	108194757 108195481 108195714 108195795 108195952

CSIN:

114261430 114266222 114282497 114288835 114290333

BVG:	104883052 104901069 104901071

SOE:	110789690 110789691

CQI:	110687149 110687263 110693359 110693461 110693462

NNU:	104591086 104591099

MING:

122059466 122059660 122061859 122072008 122072223 122092317 122092318

TSS:	122638603 122639517 122667458 122667459 122668202

NCOL:

116246448 116246454 116247351

MUS:

103973658

AOF:

109820753

ATR:	18431529 18440985 18440990

» show all

Reference

1 [PMID:15522848]

Authors

Aharoni A, Giri AP, Verstappen FW, Bertea CM, Sevenier R, Sun Z, Jongsma MA, Schwab W, Bouwmeester HJ

Title

Gain and loss of fruit flavor compounds produced by wild and cultivated strawberry species.

Journal

Plant Cell 16:3110-31 (2004)
DOI:10.1105/tpc.104.023895

Reference

2 [PMID:10482672]

Authors

Bouwmeester HJ, Verstappen FW, Posthumus MA, Dicke M

Title

Spider mite-induced (3S)-(E)-nerolidol synthase activity in cucumber and lima bean. The first dedicated step in acyclic C11-homoterpene biosynthesis.

Journal

Plant Physiol 121:173-80 (1999)
DOI:10.1104/pp.121.1.173

Reference

3 [PMID:10805454]

Authors

Degenhardt J, Gershenzon J

Title

Demonstration and characterization of (E)-nerolidol synthase from maize: a herbivore-inducible terpene synthase participating in (3E)-4,8-dimethyl-1,3,7-nonatriene biosynthesis.

Journal

Planta 210:815-22 (2000)
DOI:10.1007/s004250050684

Reference

4 [PMID:17924138]

Authors

Arimura G, Garms S, Maffei M, Bossi S, Schulze B, Leitner M, Mithofer A, Boland W

Title

Herbivore-induced terpenoid emission in Medicago truncatula: concerted action of jasmonate, ethylene and calcium signaling.

Journal

Planta 227:453-64 (2008)
DOI:10.1007/s00425-007-0631-y

Sequence

[mtr:MTR_4g092010]