KEGG ENZYME: 4.2.3.56

ENZYME: 4.2.3.56

Entry

EC 4.2.3.56                 Enzyme

Name

gamma-humulene synthase;
humulene cyclase

Class

Lyases;
Carbon-oxygen lyases;
Acting on phosphates

Sysname

(2E,6E)-farnesyl-diphosphate diphosphate-lyase (gamma-humulene-forming)

Reaction(IUBMB)

(2E,6E)-farnesyl diphosphate = gamma-humulene + diphosphate [RN:R08540]

Reaction(KEGG)

R08540

Substrate

(2E,6E)-farnesyl diphosphate [CPD:C00448]

Product

gamma-humulene [CPD:C16829];
diphosphate [CPD:C00013]

History

EC 4.2.3.56 created 2011

Pathway

ec00909

Sesquiterpenoid and triterpenoid biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K14186

gamma-humulene synthase

Reference

1 [PMID:9442047]

Authors

Steele CL, Crock J, Bohlmann J, Croteau R

Title

Sesquiterpene synthases from grand fir (Abies grandis). Comparison of constitutive and wound-induced activities, and cDNA isolation, characterization, and bacterial expression of delta-selinene synthase and gamma-humulene synthase.

Journal

J Biol Chem 273:2078-89 (1998)
DOI:10.1074/jbc.273.4.2078

Sequence

[ag:AAC05728]

Reference

2 [PMID:12051690]

Authors

Little DB, Croteau RB

Title

Alteration of product formation by directed mutagenesis and truncation of the multiple-product sesquiterpene synthases delta-selinene synthase and gamma-humulene synthase.

Journal

Arch Biochem Biophys 402:120-35 (2002)
DOI:10.1016/S0003-9861(02)00068-1

Other DBs

ExplorEnz - The Enzyme Database:

4.2.3.56

IUBMB Enzyme Nomenclature:

4.2.3.56

ExPASy - ENZYME nomenclature database:

4.2.3.56

BRENDA, the Enzyme Database:

4.2.3.56

CAS:	110639-19-5

LinkDB

DBGET integrated database retrieval system