KEGG   ENZYME: 4.2.3.8
Entry
EC 4.2.3.8                  Enzyme                                 
Name
casbene synthase;
casbene synthetase;
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
Sysname
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming)
Reaction(IUBMB)
geranylgeranyl diphosphate = casbene + diphosphate [RN:R02064]
Reaction(KEGG)
R02064
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
casbene [CPD:C01414];
diphosphate [CPD:C00013]
Comment
The enzyme from castor bean (Ricinus communis) produces the antifungal diterpene casbene.
History
EC 4.2.3.8 created 1989 as EC 4.6.1.7, transferred 2000 to EC 4.2.3.8, modified 2024
Pathway
ec00904  Diterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K12929  casbene synthase
Genes
RCU: 8259981 8259984
Reference
1  [PMID:3985625]
  Authors
Moesta P, West CA.
  Title
Casbene synthetase: regulation of phytoalexin biosynthesis in Ricinus communis L. seedlings. Purification of casbene synthetase and regulation of its biosynthesis during elicitation.
  Journal
Arch Biochem Biophys 238:325-33 (1985)
DOI:10.1016/0003-9861(85)90171-7
Reference
2  [PMID:8078910]
  Authors
Mau CJ, West CA.
  Title
Cloning of casbene synthase cDNA: evidence for conserved structural features among terpenoid cyclases in plants.
  Journal
Proc Natl Acad Sci U S A 91:8497-501 (1994)
DOI:10.1073/pnas.91.18.8497
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.8
IUBMB Enzyme Nomenclature: 4.2.3.8
ExPASy - ENZYME nomenclature database: 4.2.3.8
BRENDA, the Enzyme Database: 4.2.3.8
CAS: 69106-45-2
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