KEGG   ENZYME: 4.3.1.14
Entry
EC 4.3.1.14                 Enzyme                                 
Name
3-aminobutyryl-CoA ammonia-lyase;
L-3-aminobutyryl-CoA deaminase;
L-3-aminobutyryl-CoA ammonia-lyase
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
Sysname
L-3-aminobutyryl-CoA ammonia-lyase (crotonoyl-CoA-forming)
Reaction(IUBMB)
L-3-aminobutyryl-CoA = crotonoyl-CoA + NH3 [RN:R03030]
Reaction(KEGG)
R03030
Substrate
L-3-aminobutyryl-CoA [CPD:C05231]
Product
crotonoyl-CoA [CPD:C00877];
NH3 [CPD:C00014]
Comment
Hydroxylamine can replace ammonia as a substrate. Crotonoyl-pantetheine can replace crotonoyl-CoA but it is a poorer substrate.
History
EC 4.3.1.14 created 1999
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
Orthology
K18014  3-aminobutyryl-CoA ammonia-lyase
Genes
PUSCKA81_12900
RFRRfer_3886
NOKFAY22_04150
ARESIWH25_08680
APETToN1_41390
AZAAZKH_1578
AZIAzCIB_1070
DEKDSLASN_49380(kal)
ADEAdeh_1486
ACPA2cp1_2469
AFWAnae109_2346
ANKAnaeK_2381
MXAMXAN_4385
MSDMYSTI_04874
MYMA176_002518
MFBMFUL124B02_26675
CCXCOCOR_03528
MFULILAB_30015
MMASMYMAC_004299
SURSTAUR_4745
AGEAA314_04549
AVMJQX13_36725
MBDMEBOL_007832
VINAKJ08_2030
BSEDDN745_10920
PCAYFRD00_15180
BBAEFRD01_09525
SVCSTVA_53550
AFXJZ786_00695
ACURJZ785_19585
TUMCBW65_05390
TABCIG75_01725
LFBC1X05_16285
TVUAB849_005245
KPULGXN76_15670
KEBGXN75_17005
PABSJIR001_30740(kal)
CTCCTC_00606 CTC_02085 CTC_02086
CTETBN906_00630 BN906_02286 BN906_02287(kal_2)
CBNCbC4_0397 CbC4_0398
CLSCXIVA_06670
CPATCLPA_c31510(kal)
CPAECPAST_c31510(kal)
CSQCSCA_1551 CSCA_1552
CCKCcar_06920 Ccar_06925 Ccar_23765 Ccar_23770
CEUA7L45_04270
CCHVBTM20_08305 BTM20_08310
CARGRSJ17_19920
CDRKB9W14_11515 B9W14_11520
CSEPCP523_14780 CP523_14785
CCOHSAMEA4530647_0507 SAMEA4530647_0508 SAMEA4530647_1851 SAMEA4530647_1852
CFERD4Z93_08140 D4Z93_08145 D4Z93_08150
CRWCROST_000160(kal)
CFBCLFE_002840(kal)
AMTAmet_0317
AOEClos_2598
GFEGferi_11200
CRSFQB35_13740
CPRFK7H06_00145
FPLAA4U99_05315 A4U99_11310
PFAAMM59RIKEN_10260 MM59RIKEN_18360
VFAMM35RIKEN_07370(kal)
VCOPMM50RIKEN_12240(kal)
BPRLCL2_22180 CL2_22190 CL2_22290
ARFAR1Y2_3399 AR1Y2_3400
ACACEYQ97_00795 EYQ97_00800
CPROCPRO_06750(kal_1) CPRO_16260(kal_2) CPRO_21580(kal_3) CPRO_21590(kal_4)
LUAD4A81_03610
EHLEHLA_1857 EHLA_1858
CSTCLOST_1385(kal)
TEMJW646_01955 JW646_01960 JW646_07185
TEBT8CH_2407(kal)
STHSTH63
DAIDesaci_1865
AACXDEACI_2075
VGUHYG85_18510
VPYHZI73_18020
ACAEHYG86_10525
IBUIB211_00976
AMIJEQM06_11675
AMICAmi3637_09120
ABUTAmi103574_15025
ETMCE91St48_07350(kal)
EUUADJ67_02620
TTETTE0718
TWIThewi_0849
NTHNther_1882
HPKHprae_1558
HALSD7D81_18050
IFNGM661_14615
AFTBBF96_12055
AMEILV469_06380
SPOAEQM13_03150
KPARJL105_08400
CAZOG3A45_10610
SEDZJYG23_14270
PUFUFO1_1642
PFTJBW_02723
MANRMPAN_016030(kal)
MBJKQ51_00860(kal)
TBMBK010_00730
TBZBK011_00630
TBKHF295_06565
MPHLMPHLCCUG_04684(kal)
NFRERS450000_00652
NCYNOCYR_3011
NADNCTC11293_03485
NHUH0264_26270
RHARHA1_ro05324
ROPROP_36710
ROAPd630_LPD04266
RAVAAT18_13600
RKOJWS14_20695 JWS14_45620
SVTSVTN_37435
SCYAEJ357_39475
SCINCP977_30445
SPEUCGZ69_32325
STRYEQG64_12900
AAUAAur_pTC10059
ICAIntca_1793
ARSADJ73_12500
TEHGKE56_04795
PEIH9L10_06025
SERWFY030_07850
ORNDV701_02945
RAINRai3103_14395
NCANoca_2665
NOYEXE57_02170
NOIFCL41_08540
NOOFE634_10530
NDPE2C04_09140
NSNEXE58_17590
NANOG5V58_11095
NMESH9L09_20175
NPIG7071_14770
NAQUENKNEFLB_02383(kal)
NROK8W59_08660
NOQLN652_02055
NCQK6T13_09135
KFLKfla_3600
TCUTcur_2348
AGRAAGRA3207_000440
MMARMODMU_2633
AOIAORI_4736
AJAAJAP_28630
APRECNX65_17225
AMIAmir_3398
SESPBN6_43160
SSYIEKG83_24025
KALKALB_4417
KPHYAOZ06_27980
LEDBBK82_41110
ALOCRK56466
STPStrop_2267
SAQSare_2386
MAUMicau_3124
MILML5_5271
MICBMicB006_2178
MTUACSH63_09495
MICHFJK98_17885
MTEMGCE86_10840
MCABHXZ27_19845
MSAGGCM10017556_54760
VMAVAB18032_20390 VAB18032_22295
ASEACPL_2801
AMSAMIS_47580
ACTNL083_3929
AFSAFR_21800
ACTSACWT_2745
AIHAiant_75480
PLKCIK06_14150
PLABC6361_03365
PLATC6W10_18260
PFLAPflav_024660
PSUUPsuf_079170
VERHUT12_17890
ATLAthai_29160
ASERAsera_45380
PRYPrubr_60580(kal)
CATICS0771_51120
DVCDvina_27765
NHYJQS43_13145
CCAZCOUCH_20875
SNASnas_3948
NAVJQS30_07350
GLYK3N28_19450
FNUFN1869
FNCHMPREF0946_01617
FNTHMPREF0405_01361
FUSHMPREF0409_01397
FNEFSDG_01972
FHWRN87_00410
FPDCTM68_06720
FVAFV113G1_13750
FULC4N20_15470
FGOC4N16_05130
FNFBSQ88_03845
FPEIC4N17_12355
FCII6I83_03000
PGIPG_1067
PGNPGN_1163
PGTPGTDC60_1141
PAHPoras_0573
PCRENCTC12858_01513
PCAGNCTC12856_01002
PENDLA319_06735
PSOECE91St14_15610(kal)
PETPEIBARAKI_4152
OSPOdosp_3170
BUYD8S85_10210
BVIRI6J59_05620
BACCBRDCF_p1075
MBASALGA_2254
TLETlet_0225
PHYAJ81_05560
TMETmel_0189
TAFTHA_421
THPBG95_02080
THERY592_02085
TFEJYK00_06050
FNOFnod_0210
FPEFerpe_0538
FIANA23_03005
OCYOSSY52_05690(kal)
PMOPmob_1077
MPZMarpi_0475
MARNLN42_02750
KOLKole_0966
KPFIX53_04755
MPGTheba_2114
MINFMESINF_1633(kal)
ASACATHSA_1429
NMRNmar_0564
PSYTDSAG12_00569
 » show all
Reference
1  [PMID:4420467]
  Authors
Jeng I, Barker HA.
  Title
Purification and properties of l-3-aminobutyryl coenzyme A deaminase from a lysine-fermenting Clostridium.
  Journal
J Biol Chem 249:6578-84 (1974)
Reference
2  [PMID:7410315]
  Authors
Barker HA, Kahn JM, Chew S.
  Title
Enzymes involved in 3,5-diaminohexanoate degradation by Brevibacterium sp.
  Journal
J Bacteriol 143:1165-70 (1980)
DOI:10.1128/JB.143.3.1165-1170.1980
Other DBs
ExplorEnz - The Enzyme Database: 4.3.1.14
IUBMB Enzyme Nomenclature: 4.3.1.14
ExPASy - ENZYME nomenclature database: 4.3.1.14
BRENDA, the Enzyme Database: 4.3.1.14
CAS: 55467-41-9
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