Entry
Name
phenylalanine ammonia-lyase;
phenylalanine deaminase;
phenylalanine ammonium-lyase;
PAL;
L-phenylalanine ammonia-lyase;
Phe ammonia-lyase
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
BRITE hierarchy
Sysname
L-phenylalanine ammonia-lyase (trans-cinnamate-forming)
Reaction(IUBMB)
L-phenylalanine = trans-cinnamate + NH3 [RN:
R00697 ]
Reaction(KEGG)
Substrate
Product
Comment
This enzyme is a member of the aromatic amino acid lyase family, other members of which are EC
4.3.1.3 (histidine ammonia-lyase) and EC
4.3.1.23 (tyrosine ammonia-lyase) and EC
4.3.1.25 (phenylalanine/tyrosine ammonia-lyase). The enzyme contains the cofactor 3,5-dihydro-5-methylidene-4H-imidazol-4-one (MIO), which is common to this family [3]. This unique cofactor is formed autocatalytically by cyclization and dehydration of the three amino-acid residues alanine, serine and glycine [9]. The enzyme from some species is highly specific for phenylalanine [7,8].
History
EC 4.3.1.24 created 2008 (EC 4.3.1.5 created 1965, part-incorporated 2008)
Pathway
ec00940 Phenylpropanoid biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K10775 phenylalanine ammonia-lyase
Genes
BTAB : 109033333 109040176
HRO : HELRODRAFT_78004 HELRODRAFT_78007
MMER : 123546922 123547246 123547312
RPHI : 132719246 132739082
MAEA : 128237618 128238809 128239123 128239213
LAK : 106161379 106161381 106161385 106172274 106172288
ATH : AT2G37040(PAL1) AT3G10340(PAL4) AT3G53260(PAL2) AT5G04230(PAL3)
ALY : 9309209 9312266 9317554 9318728
CRB : 17885805 17889220 17892444
CSAT : 104711886 104745212 104761517 104781181 104782125 104785814 104791591 104792487
EUS : EUTSA_v10010153mg EUTSA_v10016314mg EUTSA_v10020168mg
BRP : 103829920 103841251 103863433 103864245 103865574 103867229 103870475
BNA : 106352757 106371449 106371451 106382579 106388514 106389127 106391500 106398793 106452446 111197696 111207414 125575656 125585654 125609089
BOE : 106294585 106300639 106311920 106319945 106338875 106342153 106342166
RSZ : 108812387 108854852 108855076 108857697 108862526
THJ : 104805263 104806492 104816418 104823458
CPAP : 110807260 110811208 110824216
CIT : 102607860 102619342 102620173 102620464
CIC : CICLE_v10011134mg CICLE_v10011175mg CICLE_v10027912mg CICLE_v10027913mg CICLE_v10030821mg
PVY : 116115347 116115436 116143896 116144389 116144452 116144459 116146747
MINC : 123192215 123193566 123201898 123206701 123206728 123209119 123224083 123224091 123225153 123228411
TCC : 18586419 18590901 18597973
GRA : 105761806 105761807 105768043 105773643 105776733 105786418 105799777
GHI : 107891138 107897711 107898808 107899351 107901087 107905303 107915817 107937172 107944640 107947805 107948312 121203612 121206206
GAB : 108453000 108453313 108459788 108467032 108470079 108472628 108473660
HSYR : 120115569 120129529 120129609 120129821 120144025 120156680 120173194 120176691 120180916 120201311 120201341 120213237 120214498 120214499
DZI : 111284826 111286787 111293967 111295400 111296231 111296683 111310322 111311841
EGR : 104421642 104421783 104438154 104454225 104454226 104454227 104454228 104454229 104454954 120289656 120290387
GMX : 100302735(PAL2.1) 100787872(PAL3.1) 100787902(PAL1.3) 100788438(PAL1.2) 100801470(PAL2.4) 100803857(PAL2.3) 100811101(PAL1.1) 100818777(PAL2.2)
GSJ : 114371207 114371946 114382723 114399496 114402244 114403853 114407085 114407086
PVU : 137814458 137814459 137825574 137828483 137828852 137828859
VRA : 106755252 106764951 106772062 106772504 106778742
VAR : 108322393 108322394 108324009 108324188 108324227 108326061 108337955
VUN : 114165156 114184506 114191008 114192381 114194438
VUM : 124820676 124820899 124830268 124830269 124830270 124830276 124835178 124835449 124847222 124847223
CCAJ : 109793961 109796589 109799986 109810584 109814359
APRC : 113855949 113860764 113872443 113872534 113872797 113874937
MTR : 11414166 11429351 11434138 120576914 25487825 25499316 25499317
TPRA : 123892914 123892915 123892916 123907091 123919623 123923332
CAM : 101493062 101496077 101507594 101509831(PAL2)
PSAT : 127092228 127098546 127117466 127117704 127125804 127125805 127125806 127126312 127132696 127132697
VVO : 131598457 131610247 131610248 131610251 131610252 131610845 131610846 131610847 131610848 131615625 131643745 131644608
LJA : 130717860 130718501 130720363 130723397 130730345 130730346 130730347 130730350 130730351 130730352 130732864 130742692 130748139
ADU : 107461690 107467923 107476298 107493496 107496075
AIP : 107608851 107617800 107626489 107648626
AHF : 112696529 112706813 112712613 112725678 112728963 112759199 112760446 112765227 112765954 112772494 112779615
LANG : 109325320 109328047 109331561 109347601 109348378 109353417 109356621
PCIN : 129300521 129304348 129306018 129313365 129315623 129318588
QSA : O6P43_002699 O6P43_002701 O6P43_005025 O6P43_006656 O6P43_008636 O6P43_010286 O6P43_022448 O6P43_022449 O6P43_022450 O6P43_022453 O6P43_022454 O6P43_022455 O6P43_022456 O6P43_023692 O6P43_028391
AANS : 126798359 126801787
RCN : 112179338 112182368 112191949
PMUM : 103332355 103342143
PAVI : 110748671 110767468
PDUL : 117617858 117629967
MDM : 103419282 103430265 103440652 103450046
MSYL : 126593024 126617791 126619686 126628842
PXB : 103934948 103956742 103962533
ZJU : 107404213 107413687 107418573 107424108
MNT : 21384641 21407112 21407113 21407114 21407115 21409963
CSAV : 115706668 115709282 115709383 115709862 115710186 115710187 115711262
CSV : 101203846(PAL) 101204574 101205510 101206890 101217907 101218144 101218156 101218382 101218617 101218856 101219091 101222092 116401606
CMO : 103491170 103491171 103491172 103491175 103491176 103491177 103492351 103494628 103494629 103494630 103496433 103501962
BHJ : 120071314 120072681 120072682 120072683 120073092 120073093 120073360 120074265 120074610 120074945 120088009
MCHA : 111010268 111011135 111013592 111013637 111013639 111013649 111013660 111013676 111016602 111021691 111021692 111021693 111024306
CMAX : 111466447 111471134 111471135 111471136 111471137 111471138 111471139 111471140 111477962 111477963 111483977 111485128
CMOS : 111433131 111433140 111433142 111449086 111449646 111461649 111463060 111463284 111463285 111463286 111463287 111463288 111463344 111463389 111463390 111463391
CPEP : 111777486 111780357 111780949 111780982 111781009 111781011 111781012 111782232 111782234 111785821 111801921 111803746 111803833 111803837
RCU : 8264881 8272514 8272515 8273543 8284514
MEAN : 126660628 126667577 126677617
JCU : 105637929 105642230 105642233 105650921
HBR : 110642341 110650000 110653783 110655301 110659945 110667843 110668141
MESC : 110603555 110613960 110619505 110620815 110622267 110625014
POP : 18100180 7463441 7479878 7486485
PEU : 105115311 105130758 105137114 105137115 105142552
PALZ : 118045919 118048308 118052332 118060001 118060002
PNZ : 133677693 133690046 133695775 133695951 133704474
JRE : 108988497 108995854 108997102 109008959 109009407 109017562 109021248 118349603 118349731
CILL : 122276709 122289177 122301292 122307886 122307887 122307888
CAVE : 132164899 132165223 132166394 132166395 132166396 132166427 132166707 132166803 132186144 132186162 132186175 132187588 132191837
AGLU : 133857119 133857669 133857919 133858076 133858169 133863558 133864389 133872522
QSU : 112009271 112023493 112025299 112025332
QLO : 115952784 115953247 115955447 115973405 115973406 115976049 115976061
TWL : 119988554 119989362 119991195 119998706 120005523 120013902
VVI : 100233012 100240904 100241377 100241575 100245997(PAL) 100251137 100252889 100255939 100256293 100263160 100266224 100266593 100853659 100855356
VRI : 117915571 117920417 117925483 117925495 117928585 117932190 117932191 117932192 117932448 117933071 117933074 117933075 117933076
SLY : 101243631 101243656 101243922(PAL3) 101244220(PAL5) 101246969 101249824(PAL2) 101253989 101261892 112941051 138337110 138339114 138347807
SPEN : 107002228 107013137 107014419 107020424 107030967 107031255 107031390 107032649
SOT : 102582618 102585026 102585357 102587888 102595248 102596017(PAL) 102596343 102596891 102597781 102605661 107057661
SSTN : 125845819 125857497 125859798 125863624 125864552 125864554 125866946 125870205 125871461 125871462
SDUL : 129875908 129877809 129881153
CANN : 107843092 107854291 107863937 107871487
LBB : 132606885 132630037 132630038 132640013
NTA : 107761482(palB) 107769293(pal4) 107786762(TOBPAL1) 107792668(NtPAL) 107802063 107820497 107831213
NSY : 104212402 104218178 104230518 104241192
NTO : 104092690 104100767 104116279 104119303
NAU : 109209019 109212354 109231224 109233353
INI : 109148785 109148795 109148804 109148811 109181625 109187876 109192698
ITR : 116006484 116008405 116022516 116028398 116028538 116030458
SIND : 105161317 105161378 105174307
OEU : 111399604 111402181 111403111
EGT : 105955553 105956685 105961230
SSPL : 121748231 121748279 121787281 121792223 121795447 121799006
SMIL : 130997735 130997738 131014843 131020540
SHIS : 125204027 125213447 125219905
APAN : 127250896 127251261 127252199
HAN : 110868345 110877696 110898342 110898343 110898344 110904470 110924687 110924718 110925465
ECAD : 122586736 122602813 122602814 122602815 122604858
LSV : 111893052 111894107 111915057 111916376 111916377
CCAV : 112508463 112511516 112512533 112521371 112521561
DCR : 108217754 108223317 108224761 108227736
CSIN : 114262497 114269233 114273057 114302746 114308066 114309513
RVL : 131314929 131318698 131324739
AEW : 130753481 130753571 130764547 130767957 130770795 130771720 130795441
ATRI : 130812846 130827609
MOF : 131147872 131165388 131167927 131167930
NNU : 104589393 104595050 104600622 104601277
MING : 122058157 122061512 122061513 122061804 122069916 122081057 122086992
TSS : 122646812 122647453 122652028 122664470
PSOM : 113294591 113298633 113310130 113310719 113328160 113338846
OSA : 4330036 4330037 4330040(PAL06) 4336415 4338861 4351235 4352358
DOSA : Os02g0626400 Os02g0626600 Os02g0627100 Os04g0518400 Os05g0427400 Os11g0708900 Os12g0520200
OBR : 102709455 102714183 102715460 102717957 102718239
OGL : 127754932 127756722 127761514 127763090 127764562 127772145 127774730
BDI : 100829928 100840340 100841149 100841454 100843583 100844192 100845653
ATS : 109736056 109750201 109750202 109750206 109750207 109752036 109752043 109758771 109758772 109758784 109758790 109760444 109764463 109764464 109767405 109777317
TDC : 119287720 119312374 119317182 119317183 119317577 119317588 119317599 119317608 119324608 119326421 119326448 119354057 119354220 119355847 119355848 119360139 119360153 119360164 119360175 119363245 119363247 119364987 119364990 119364991 119364992 119367766
TAES : 123044473 123044475 123046102 123046106 123046108 123052332 123052335 123052459 123053982 123053983 123053984 123053985 123053986 123088069 123105200 123105206 123105215 123105222 123105228 123113082 123113856 123113857 123127714 123127715 123137535 123137536 123141544 123144879 123180005 123180007 123180011 123180545 123187330 123187336 123187343 123188184 123188342 123189877 123189878 123189879 123189880
TUA : 125513870 125513871 125528418 125528663 125536554 125536720 125539132 125539133 125539134 125539135 125539136 125539137 125544157 125544164 125544174 125549968 125550027
LPER : 127307029 127326489 127335611 127335613 127335616 127343773 127343774 127343775 127344933 127344934
LRD : 124660634 124660745 124661086 124661149 124665331 124667241 124667243 124671371 124673965 124674091 124676164 124676165 124676660 124676972 124678149 124678150 124678980 124687892 124687903 124692160 124692161 124692183 124692569 124692571 124692591
SBI : 8054283 8062467 8066166 8066167 8066169 8066170
ZMA : 100273579 100281042 100281532 100285115 100381820 103627433 103655990 109943525
MFLO : 136467341 136467342 136467343 136467365 136467366 136467367 136468824 136477727 136477728 136477730 136477732 136477789 136477792 136477793 136488335 136488336 136488339 136490959 136491075 136492953 136496868
SITA : 101756700 101780720 101781123 101781518 101781925
SVS : 117836977 117857065 117857515 117862857 117865862
PVIR : 120642390 120656507 120656508 120656509 120683054 120709314 120709328
PHAI : 112873613 112881643 112881654 112881665 112890395 112899882
PAUA : 133888715 133919355 133919356 133921730 133921731 133921732 133924592
PDA : 103703950 103708643 103708669 103718264
EGU : 105033424 105035781 105041875 105054501 105055673
MUS : 103972164 103978140 103983874 104000863 135612719 135619233 135623111 135626494
ZOF : 121971250 121971251 121971253 121976421 121976422 121976423 121980934 121984822 121988754 121997687 122007921 122007922 122017157 122051562 122056089
AOF : 109826061 109836321 109836322 109836343 109848011
MSIN : 131220948 131220950 131220951 131220952 131227149 131236916 131240365 131245919
ACAK : 137944981 137950575 137950583 137956630 137959631 137961862 137962280
NCOL : 116252865 116260476 116263014 116265747 116267544
ATR : 18439368 18439369 18439372 18443160 18995827
CJF : 131039416 131051385 131062655 131065056 131067796 131067797 131069178 131069179 131076342 131077153 131077155 131078832
SMO : SELMODRAFT_450474(PAL1-1) SELMODRAFT_450478(PAL1-2) SELMODRAFT_450479(PAL2-1) SELMODRAFT_450480(PAL3-1) SELMODRAFT_450481(PAL4-1) SELMODRAFT_450482(PAL2-2) SELMODRAFT_450483(PAL3-2a) SELMODRAFT_450484(PAL3-2b) SELMODRAFT_450485(PAL4-2)
PPP : 112273833 112273834 112276937 112277636 112278877 112285521 112286715 112287672 112290398 112290843 112291346 112294398 112295966
NTE : NEUTE1DRAFT85424(NEUTE1DRAFT_85424)
SMP : 10806096(SMAC4_05651) 10807808(SMAC4_01196)
FVR : FVEG_03798 FVEG_10552
FOX : FOXG_05927 FOXG_11971
FMU : J7337_003806 J7337_013105
TATV : 25779096(TrAtP1_002676)
MAW : 19250313(J3458_020783)
MBRN : 26237386(PAL1_0) 26243091(cctP_3) 26245029(cctP_0) 26247838(cctP_1)
PLJ : 28886167(PLICBS_007659) 28886669(PLICBS_002002)
VAL : VDBG_06765 VDBG_08166
VDA : VDAG_05831 VDAG_10058
CFJ : CFIO01_05132 CFIO01_12530
CLUP : CLUP02_06377 CLUP02_16442
CDET : 87947683(CDEST_11183) 87951698(CDEST_15198)
ELA : UCREL1_5223 UCREL1_6869
AOR : AO090005000532 AO090011000788 AO090026000586 AO090701000601
ANG : An04g04370 An08g07740 An13g02640
AFV : AFLA_003340 AFLA_005128 AFLA_008180
ALUC : AKAW2_50697S AKAW2_51436S AKAW2_51617S
POU : POX_c04347 POX_g09079
TMF : EYB26_001823 EYB26_006196
TRG : TRUGW13939_02554 TRUGW13939_04868 TRUGW13939_05485 TRUGW13939_08765 TRUGW13939_09869
PNO : SNOG_08528 SNOG_09914 SNOG_16362
CCAC : CcaHIS019_0207040(CcaverHIS019_0207040)
DSQ : DICSQDRAFT_52356 DICSQDRAFT_92085
PCO : PHACADRAFT_130223 PHACADRAFT_213633 PHACADRAFT_213640 PHACADRAFT_213646 PHACADRAFT_259798
SHS : STEHIDRAFT_142351 STEHIDRAFT_160287 STEHIDRAFT_61084
HIR : HETIRDRAFT_423519 HETIRDRAFT_481650 HETIRDRAFT_66536
ADL : AURDEDRAFT_113627 AURDEDRAFT_115168 AURDEDRAFT_117508 AURDEDRAFT_73911
LBC : LACBIDRAFT_184628 LACBIDRAFT_291120
CCI : CC1G_06838 CC1G_14161
ABP : AGABI1DRAFT112726(AGABI1DRAFT_112726) AGABI1DRAFT112810(AGABI1DRAFT_112810)
ABV : AGABI2DRAFT192690(PAL2) AGABI2DRAFT192776(PAL1)
PCUB : JR316_0002356 JR316_0002394
MRR : Moror_10348 Moror_6316
MORE : E1B28_000528(STR11_1) E1B28_010076(STR11_2)
SCM : SCHCO_02368049(SCHCODRAFT_02368049) SCHCO_02631394(SCHCODRAFT_02631394)
SLA : SERLADRAFT_416426(pal1) SERLADRAFT_418655 SERLADRAFT_447477
UMA : UMAG_00078 UMAG_06509
PGR : PGTG_10006 PGTG_12283
PTRC : PtA15_11A447 PtA15_4A275
PSTR : Pst134EA_011368 Pst134EA_017483 Pst134EA_032475
MLR : MELLADRAFT_44072 MELLADRAFT_49604
LCJ : NCTC11976_00157(cmdF)
» show all
Taxonomy
Reference
Authors
KOUKOL J, CONN EE.
Title
The metabolism of aromatic compounds in higher plans. IV. Purification and properties of the phenylalanine deaminase of Hordeum vulgare.
Journal
J Biol Chem 236:2692-8 (1961)
Reference
2
Authors
Young MR, Neish AC.
Title
Properties of the ammonia-lyases deaminating phenylalanine and related compounds in Triticum sestivum and Pteridium aquilinum.
Journal
Phytochemistry 5:1121-1132 (1966)
Reference
Authors
Louie GV, Bowman ME, Moffitt MC, Baiga TJ, Moore BS, Noel JP.
Title
Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases.
Journal
Reference
Authors
Calabrese JC, Jordan DB, Boodhoo A, Sariaslani S, Vannelli T.
Title
Crystal structure of phenylalanine ammonia lyase: multiple helix dipoles implicated in catalysis.
Journal
Reference
Authors
Ritter H, Schulz GE
Title
Structural basis for the entrance into the phenylpropanoid metabolism catalyzed by phenylalanine ammonia-lyase.
Journal
Sequence
Reference
Authors
Watts KT, Mijts BN, Lee PC, Manning AJ, Schmidt-Dannert C
Title
Discovery of a substrate selectivity switch in tyrosine ammonia-lyase, a member of the aromatic amino acid lyase family.
Journal
Sequence
Reference
Authors
Appert C, Logemann E, Hahlbrock K, Schmid J, Amrhein N
Title
Structural and catalytic properties of the four phenylalanine ammonia-lyase isoenzymes from parsley (Petroselinum crispum Nym.).
Journal
Sequence
Reference
Authors
Cochrane FC, Davin LB, Lewis NG
Title
The Arabidopsis phenylalanine ammonia lyase gene family: kinetic characterization of the four PAL isoforms.
Journal
Sequence
Reference
Authors
Schwede TF, Retey J, Schulz GE
Title
Crystal structure of histidine ammonia-lyase revealing a novel polypeptide modification as the catalytic electrophile.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 4.3.1.24
ExPASy - ENZYME nomenclature database: 4.3.1.24
LinkDB
All DBs