ENZYME: 18.104.22.168 Help
epsilon-(gamma-L-glutamyl)-L-lysine gamma-glutamyl cyclotransferase (5-oxo-L-proline producing)
epsilon-(gamma-L-glutamyl)-L-lysine = L-lysine + 5-oxo-L-proline [RN:
The enzyme, found in vertebrates, has no activity toward alpha-(gamma-L-glutamyl)-L-amino acids (cf. EC
, gamma-glutamylcyclotransferase). The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the gamma-L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
EC 22.214.171.124 created 2017
Fink ML, Chung SI, Folk JE
gamma-Glutamylamine cyclotransferase: specificity toward epsilon-(L-gamma-glutamyl)-L-lysine and related compounds.
Oakley AJ, Coggan M, Board PG
Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism.
ExplorEnz - The Enzyme Database: 126.96.36.199
ExPASy - ENZYME nomenclature database: 188.8.131.52
BRENDA, the Enzyme Database: 184.108.40.206
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