Entry
Name
gamma-glutamylcyclotransferase;
gamma-glutamyl-amino acid cyclotransferase;
gamma-L-glutamylcyclotransferase;
L-glutamic cyclase;
(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing);
GGCT
Class
Lyases;
Carbon-nitrogen lyases;
Amidine-lyases
BRITE hierarchy
Sysname
alpha-(gamma-L-glutamyl)-L-amino-acid gamma-glutamyl cyclotransferase (5-oxo-L-proline producing)
Reaction(IUBMB)
alpha-(gamma-L-glutamyl)-L-amino acid = alpha-L-amino acid + 5-oxo-L-proline [RN:
R03749 ]
Reaction(KEGG)
Substrate
alpha-(gamma-L-glutamyl)-L-amino acid [CPD:
C03740 ]
Product
alpha-L-amino acid;
5-oxo-L-proline [CPD:
C01879 ]
Comment
The enzyme, found in animals and plants, acts on derivatives of L-glutamate, L-2-aminobutanoate, L-alanine and glycine. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
History
EC 4.3.2.9 created 1972 as EC 2.3.2.4, transferred 2017 to EC 4.3.2.9
Pathway
Orthology
K00682 gamma-glutamylcyclotransferase
K22596 gamma-glutamylcyclotransferase, plant
Genes
NSU : 110577369 110579985(GGCT)
RFQ : 117012093(GGCT) 117028261
DNM : 101436405 101447508(GGCT)
DRE : 100149204(ggcta) 406278(ggctb)
SRX : 107709544 107714254 107751821
SANH : 107655114 107659081 107673341
SGH : 107557442 107565307 107601985
CCAR : 109102943 109107899(ggct)
CAUA : 113062554 113115779
CGIB : 127935239 127974506
PTET : 122335163(ggcta) 122360077(ggctb)
LROH : 127178544(ggctb) 127181797(ggcta)
OMC : 131521398(ggctb) 131526373(ggcta)
PPRM : 120471172(ggctb) 120483458(ggcta)
RKG : 130078424(ggcta) 130091533(ggctb)
MAMB : 125243691(ggctb) 125275851(ggcta)
CIDE : 127497678 127500967
MASI : 127425250 127453208 127453673
TROS : 130558042(ggctb) 130566575(ggcta)
TDW : 130415264(ggcta) 130432758(ggctb)
MANU : 129448901(ggctb) 129455934(ggcta)
IPU : 100528263(ggctb) 108256920(ggcta)
PHYP : 113525565 113536025(ggct)
SMEO : 124375698(ggcta) 124403746(ggctb)
AMEX : 103033278 103036016
CMAO : 118799091(ggctb) 118806177(ggcta)
CHAR : 105903728(ggcta) 105910028(ggctb)
TFS : 130517897(ggcta) 130532630(ggctb)
TNG : GSTEN00017404G001 GSTEN00021982G001
PGEO : 117451113 117451395 117455238
GACU : 117555219(ggctb) 117562900(ggcta)
EMAC : 134862008(ggctb) 134874771(ggcta)
ELY : 117263598(ggcta) 117264499(ggctb)
EFO : 125892887(ggctb) 125904973(ggcta)
PLEP : 121945344(ggctb) 121965390
SLUC : 116047477(ggcta) 116066659(ggctb)
ECRA : 117946539(ggctb) 117957359(ggcta)
PFLV : 114557381 114567936
PPUG : 119197695(ggctb) 119219422(ggcta)
AFB : 129097357(ggcta) 129109241(ggctb)
CLUM : 117727946(ggctb) 117739422(ggcta)
MSAM : 119896837(ggctb) 119907115(ggcta)
SCHU : 122863929(ggcta) 122880964(ggctb)
ALAT : 119006214(ggctb) 119016635(ggcta)
OAU : 116312060(ggcta) 116318459(ggctb)
OML : 112139477(ggctb) 112160429(ggcta)
CSAI : 133424133 133440834 133461518(ggcta)
PRET : 103472371 103478774
PFOR : 103129844 103135107
PLAI : 106938332 106949292
PMEI : 106912476 106918604
GAF : 122830665(ggctb) 122843621(ggcta)
PPRL : 129353761(ggctb) 129375138(ggcta)
CTUL : 119792168(ggctb) 119795304(ggcta)
NFU : 107379004 107397246 107397248
KMR : 108240813(ggcta) 108250051
ALIM : 106515801 106531193
AOCE : 111563780 111569446(ggct)
MCEP : 125016602(ggctb) 125020163(ggcta)
CSEM : 103388762(ggct) 103394438
SSEN : 122774245(ggctb) 122786506
HHIP : 117770164(ggcta) 117777335(ggctb)
HSP : 118113916(ggctb) 118124376(ggcta)
SMAU : 118284693(ggctb) 118292103(ggcta)
LCF : 108886121 108898169(ggcta)
SLAL : 111657536(ggct) 111659351 111664184
XGL : 120783928(ggctb) 120786303(ggcta)
HCQ : 109516380 109521920(ggct)
SSCV : 125975220 125986921
PTAO : 133471207 133479709
BPEC : 110167470 110173791
SJO : 128366887(ggctb) 128373679
SASA : 100196182(cg024) 106579600 106588758 106605510(ggct)
STRU : 115173880 115177047 115181724
OTW : 112227899 112236468(ggctb) 112244893 112264468(ggcta)
OMY : 110496513(ggcta) 110511884 110539228(ggctb) 118938772
OGO : 123997174(ggctb) 124005857 124013326(ggcta)
ONE : 115114447 115114455 115128635 115140908
OKI : 109901755 109901860 109907306
OKE : 118364592 118372610 118372611 118399569(ggcta)
SALP : 111956202 111964720 111964926(ggct) 112068927
SNH : 120022529(ggcta) 120031141 120047202 120048522
CCLU : 121542388 121543020 121585463 121585640(ggcta)
ELS : 105009435 105012454 105019182
PKI : 111846953 111848848 111848849
AANG : 118212318(ggctb) 118234751(ggcta)
LCM : 102345575 102348398(GGCT)
SCLV : 120342021 120344808
LPIC : 129253967 129253974 129270622 129270636 129270690
APLC : 110981324 110981356
SKO : 100369875 100374636 102801350
DSI : Dsimw501_GD12343(Dsim_GD12343) Dsimw501_GD12344(Dsim_GD12344)
DYA : Dyak_GE22074 Dyak_GE22075
DMO : Dmoj_GI11714 Dmoj_GI11715
MDL : 103578586 103578587 103578589
BMOR : 101743698 110385885
BMAN : 114247235 114247236
DPL : KGM_215639 KGM_215777
PMAC : 106717573 106717575
PPOT : 106100348 106100573
HAW : 110377769 110377784 110377792
TNL : 113501842 113501843 113501844
PXY : 105396775 105396923 105396942
CCRN : 123305728 123305791
CLEC : 106662315 106670618
HAME : 121866518 121870035
RSAN : 119376671 119404896
ABRU : 129963705 129974869
CEL : CELE_C44B7.7(C44B7.7)
LGI : LOTGIDRAFT_123575 LOTGIDRAFT_164301
BGT : 106062447 106069328 106069361
HRF : 124147247 124147279 124147280
HRJ : 124292196 124292221 124292232
MMER : 123550318 123550319
AMIL : 114951909 114952501
PDAM : 113664494 113677322
SPIS : 111333813 111338839
ATH : AT1G44790 AT4G31290 AT5G26220
ALY : 9305409 9310372 9327358
CRB : 17878856 17882261 17898278
CSAT : 104706945 104717066 104721711 104730170 104736648 104757964 104771108 109124741
EUS : EUTSA_v10004888mg EUTSA_v10011803mg EUTSA_v10026164mg
BRP : 103834622 103837115 103847733 103851987
BNA : 106354720 106364013 106375433 106381093 106386242 106397053 106424106 106444452
BOE : 106296270 106303209 106316472 106332741 106342556
RSZ : 108821926 108825773 108825774 108828905 108833700 108844319 130507342
THJ : 104811222 104813146 104819923
CPAP : 110816712 110825227
CIC : CICLE_v10002572mg CICLE_v10009681mg
MINC : 123194056 123228869
TCC : 18587580 18587748 18592315
GRA : 105773070 105774461 105787418
GHI : 107893895 107901405 107930786 107932947 107959977 107962505
GAB : 108470497 108484627 108485529
HSYR : 120150067 120173541 120212226
GMX : 100305985 100778704 100793027
GSJ : 114380872 114409059 114415082
PVU : PHAVU_008G163900g PHAVU_009G103300g
VUM : 124821495 124846567 124846568
CCAJ : 109796148 109796453 109798174
APRC : 113847740 113865395
MTR : 11417927 11427354 11432265
TPRA : 123898214 123902103
PSAT : 127085181 127095800
VVO : 131595987 131600436 131654718 131654732
LJA : Lj1g3v1991800.1(Lj1g3v1991800.1) Lj1g3v4314270.1(Lj1g3v4314270.1)
AHF : 112715651 112716197 112783003 112784304
LANG : 109326518 109327376 109344182 109359215
PCIN : 129294298 129294613 129299142 129303074
QSA : O6P43_015198 O6P43_015563 O6P43_019330
FVE : 101301837 101304934 105350857
PMUM : 103319845 103320123
PAVI : 110750525 110761222
PDUL : 117621777 117638595
MDM : 103424725 103441211 103450651
MSYL : 126604283 126632224 126632251
PXB : 103938071 103953177 103957519 103964523
CSAV : 115700246 115718589 115720614
CSV : 101208455 101209842 101217290
CMO : 103488216 103503734 103504050
BHJ : 120075179 120075407 120084920
MCHA : 111005209 111011188 111011785
CMAX : 111476702 111480746 111487769 111491933 111496304
CMOS : 111443344 111446683 111454251 111459557 111462945
CPEP : 111788277 111790483 111797190 111798504 111805026
MESC : 110603046 110606600
POP : 18100791 18107563 7469146
PEU : 105107220 105109830 105112611
PALZ : 118029315 118030654 118055722 118059469
CILL : 122313440 122317099
CAVE : 132167035 132189659
QSU : 112012644 112015572 112015980 112032345
TWL : 119996263 120006465 120010594
SLY : 101246397 101258241 101259958
SPEN : 107003194 107005374 107026636
SOT : 102578210 102584350 102592696 102603766
SSTN : 125841927 125843627 125863162
SDUL : 129882357 129888864 129902764
CANN : 107849334 107851197 107868061
LBB : 132604272 132609539 132627011
NTA : 107779373 107779408 107780043 107789157 107789186 107813044
NSY : 104221251 104226848 104246856
NTO : 104090560 104105646 104120800
NAU : 109205458 109213980 109238253
SIND : 105159476 105160644 105164943
OEU : 111380792 111380821 111385982 111398212
SSPL : 121746164 121751589 121753706 121758269 121779078 121780432 121780781 121784005
SMIL : 130987210 131015072 131024087
SHIS : 125189200 125211740 125211910 125222976
APAN : 127250296 127255615 127256073 127265628
HAN : 110885602 110899266 110930152
ECAD : 122580292 122599451
CCAV : 112510820 112529281
DCR : 108205073 108206540 108221913
CSIN : 114286208 114311236
AEW : 130764530 130787636 130794065
CQI : 110696276 110709595 110710198 110728547
ATRI : 130797775 130809677
MING : 122071607 122079645
PSOM : 113300000 113346330 113356209 113358780
DOSA : Os02t0465900-01(Os02g0465900) Os04t0448600-01(Os04g0448600)
TDC : 119314497 119322790 119329206 119355292 119364426
TAES : 123045600 123053442 123131885 123135861 123143384 123189350
LPER : 127312657 127335044
LRD : 124674619 124676152 124683860 124684070
ZMA : 100193117 100284213 103632484 109945950 109945951
SITA : 101768570 101779265
PVIR : 120641158 120655690 120682803 120700942
PHAI : 112877649 112899877
PDA : 103697269 103700223 103701451 103702255
EGU : 105039351 105050450 105050890 105060924
MUS : 103973129 103976860 103977548 103991763 103996023
ZOF : 122002445 122006697 122009310 122017718 122020038 122022609 122032180 122034775 122034776
DCT : 110100720 110103744 110104628 110106274
PEQ : 110023085 110023425 110024594 110027757 110039043
AOF : 109821597 109842906 109848877
MSIN : 131217559 131242520
NCOL : 116249217 116262524
ATR : 18433775 18440759 18446481
SMO : SELMODRAFT_48672 SELMODRAFT_58744 SELMODRAFT_58757 SELMODRAFT_85708
PPP : 112280397 112281175 112285362 112288003 112289734
MPP : MICPUCDRAFT_43343(JGI:MicpuC2_43343)
BCOM : BAUCODRAFT_229127 BAUCODRAFT_61477
ABP : AGABI1DRAFT111071(AGABI1DRAFT_111071) AGABI1DRAFT117923(AGABI1DRAFT_117923) AGABI1DRAFT124916(AGABI1DRAFT_124916)
ABV : AGABI2DRAFT133726(AGABI2DRAFT_133726) AGABI2DRAFT176448(AGABI2DRAFT_176448)
NAX : HC341_00775 HC341_01590
HAG : BB497_01515 BB497_05160
HVN : EI420_13115 EI420_13235
MARD : IBG28_12355 IBG28_12860
MMYR : MXMO3_01195 MXMO3_03588
» show all
Taxonomy
Reference
1
Authors
Bodnaryk, R.P. and McGirr, L.
Title
Purification, properties and function of a unique gamma-glutamyl cyclotransferase from the housefly, Musca domestica L.
Journal
Biochim Biophys Acta 315:352-362 (1973)
Reference
Authors
Orlowski M, Richman PG, Meister A.
Title
Isolation and properties of gamma-L-glutamylcyclotransferase from human brain.
Journal
Reference
Authors
Oakley AJ, Yamada T, Liu D, Coggan M, Clark AG, Board PG
Title
The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle.
Journal
Sequence
Reference
Authors
Paulose B, Chhikara S, Coomey J, Jung HI, Vatamaniuk O, Dhankher OP
Title
A gamma-glutamyl cyclotransferase protects Arabidopsis plants from heavy metal toxicity by recycling glutamate to maintain glutathione homeostasis.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.3.2.9
ExPASy - ENZYME nomenclature database: 4.3.2.9
BRENDA, the Enzyme Database: 4.3.2.9
LinkDB
All DBs