KEGG   ENZYME: 4.3.2.9
Entry
EC 4.3.2.9                  Enzyme                                 
Name
gamma-glutamylcyclotransferase;
gamma-glutamyl-amino acid cyclotransferase;
gamma-L-glutamylcyclotransferase;
L-glutamic cyclase;
(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing);
GGCT
Class
Lyases;
Carbon-nitrogen lyases;
Amidine-lyases
Sysname
alpha-(gamma-L-glutamyl)-L-amino-acid gamma-glutamyl cyclotransferase (5-oxo-L-proline producing)
Reaction(IUBMB)
alpha-(gamma-L-glutamyl)-L-amino acid = alpha-L-amino acid + 5-oxo-L-proline [RN:R03749]
Reaction(KEGG)
R03749;
(other) R02743
Substrate
alpha-(gamma-L-glutamyl)-L-amino acid [CPD:C03740]
Product
alpha-L-amino acid;
5-oxo-L-proline [CPD:C01879]
Comment
The enzyme, found in animals and plants, acts on derivatives of L-glutamate, L-2-aminobutanoate, L-alanine and glycine. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
History
EC 4.3.2.9 created 1972 as EC 2.3.2.4, transferred 2017 to EC 4.3.2.9
Pathway
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Orthology
K00682  gamma-glutamylcyclotransferase
K22596  gamma-glutamylcyclotransferase, plant
Genes
HSA79017(GGCT)
PTR463327(GGCT)
PPS100984104(GGCT)
GGO101138956(GGCT)
PON100444244(GGCT)
NLE100600608(GGCT)
MCC695547(GGCT)
MCF102142709(GGCT)
CSAB103226276(GGCT)
CATY105596146(GGCT)
PANU100999777(GGCT)
TGE112621323(GGCT)
RRO104668447(GGCT)
RBB108533407(GGCT)
TFN117073666(GGCT)
PTEH111523630(GGCT)
CJC100389077(GGCT)
SBQ101033297(GGCT)
CSYR103270036(GGCT)
MMUR105855110(GGCT)
OGA100956580(GGCT)
MMU110175(Ggct)
MCAL110296364(Ggct)
MPAH110316963(Ggct)
RNO362368(Ggct)
MCOC116098953(Ggct)
MUN110555071(Ggct)
CGE100774679(Ggct)
PLEU114689711(Ggct)
NGI103740842(Ggct)
HGL101723887(Ggct)
CPOC100723170(Ggct)
CCAN109701127(Ggct)
DORD105999985(Ggct)
DSP122120878(Ggct)
NCAR124990841
OCU100337901(GGCT)
OPI101533005(GGCT)
TUP102497631(GGCT)
CFA611603(GGCT)
VVP112935405(GGCT)
VLG121475140(GGCT)
AML100475961(GGCT)
UMR103658939(GGCT)
UAH113262388(GGCT)
UAR123789108(GGCT)
ELK111147302
LLV125081184
MPUF101682326(GGCT)
ORO101381331(GGCT)
EJU114221157(GGCT)
ZCA113911457(GGCT)
MLX118020929(GGCT)
FCA101087219(GGCT)
PYU121028528(GGCT)
PBG122488064(GGCT)
PTG102972301(GGCT)
PPAD109263921(GGCT)
AJU106968672(GGCT)
HHV120230344(GGCT)
BTA533374(GGCT)
BOM102265622(GGCT)
BIU109557476(GGCT)
BBUB102412357(GGCT)
CHX102187188(GGCT)
OAS101102474(GGCT)
ODA120877398(GGCT)
CCAD122438426(GGCT)
SSC100512447(GGCT)
CFR102512131(GGCT)
CBAI105081920(GGCT)
CDK105095846(GGCT)
VPC102542935(GGCT)
BACU102997196(GGCT)
LVE103085194(GGCT)
OOR101278558(GGCT)
DLE111180063(GGCT)
PCAD102983283(GGCT)
PSIU116759010(GGCT)
ECB100069874(GGCT)
EPZ103552750
EAI106831060(GGCT)
MYB102257993(GGCT)
MYD102766806(GGCT)
MMYO118666061(GGCT)
MLF102436341(GGCT)
MNA107544417(GGCT)
PKL118727813(GGCT)
HAI109381318(GGCT)
DRO112306962(GGCT)
SHON118983562(GGCT)
AJM119035259(GGCT)
PDIC114508089(GGCT)
PHAS123811697(GGCT)
MMF118620042(GGCT)
RFQ117012093(GGCT) 117028261
PALE102887499(GGCT)
PGIG120602408(GGCT)
PVP105308613(GGCT)
RAY107499554(GGCT)
MJV108410147(GGCT)
TOD119244102(GGCT)
SARA101551902(GGCT)
LAV100673070(GGCT)
TMU101349289
DNM101436405 101447508(GGCT)
MDO100032519(GGCT)
GAS123250462(GGCT)
SHR100919793(GGCT)
PCW110213108(GGCT)
OAA100081401(GGCT)
GGA420676(GGCT)
PCOC116227149(GGCT)
MGP100550241(GGCT)
CJO107309325(GGCT)
NMEL110394942(GGCT)
APLA101805349(GGCT)
ACYG106046640(GGCT)
AFUL116486552(GGCT)
TGU100190607(GGCT)
LSR110468221(GGCT)
SCAN103813162(GGCT)
PMOA120503975(GGCT)
OTC121337610(GGCT)
PRUF121353197(GGCT)
GFR102039424(GGCT)
FAB101818892(GGCT)
PHI102099497(GGCT)
PMAJ107200351(GGCT)
CCAE111923889(GGCT)
CCW104689028(GGCT)
ETL114064384(GGCT)
ZAB102072814(GGCT)
FPG101921074(GGCT)
FCH102047880(GGCT)
CLV102083440(GGCT)
EGZ104127521(GGCT)
NNI104018492(GGCT)
ACUN113477173(GGCT)
TALA104368926(GGCT)
PADL103917094(GGCT)
ACHC115339007(GGCT)
AAM106491250(GGCT)
AROW112967160(GGCT)
NPD112952612(GGCT)
DNE112982411(GGCT)
ASN102385482(GGCT)
AMJ102567732(GGCT)
CPOO109311129(GGCT)
GGN109291730(GGCT)
PSS102455884(GGCT)
CMY102934944(GGCT)
CPIC101951537(GGCT)
TST117872437(GGCT)
CABI116827003(GGCT)
MRV120399512(GGCT)
ACS100558545(ggct)
PVT110082168(GGCT)
SUND121935638(GGCT)
PBI103053081(GGCT)
PMUR107294022(GGCT)
TSR106545488(GGCT)
PGUT117656101(GGCT)
VKO123016594(GGCT)
PMUA114607207(GGCT)
ZVI118091808(GGCT)
GJA107111522(GGCT)
STOW125441373(GGCT)
XLA108701001 108719977
XTR613056(ggct)
NPR108791133(GGCT)
RTEM120913573(GGCT)
BBUF121002124(GGCT)
BGAR122938406(GGCT)
DRE100149204(ggcta) 406278(ggctb)
SRX107709544 107714254 107751821
SANH107655114 107659081 107673341
SGH107557442 107565307 107601985
CCAR109102943 109107899(ggct)
CAUA113062554 113115779
PPRM120471172(ggctb) 120483458(ggcta)
MAMB125243691(ggctb) 125275851(ggcta)
IPU100528263(ggctb) 108256920(ggcta)
PHYP113525565 113536025(ggct)
SMEO124375698(ggcta) 124403746(ggctb)
TFD113661467(ggcta)
AMEX103033278 103036016
EEE113571945 113590649
TRU101065518 101077496
TNGGSTEN00017404G001 GSTEN00021982G001
LCO104937169(ggct)
NCC104963997(ggct)
CGOB115016263(ggct)
ELY117263598(ggcta) 117264499(ggctb)
PLEP121945344(ggctb) 121965390
SLUC116047477(ggcta) 116066659(ggctb)
ECRA117946539(ggctb) 117957359(ggcta)
PFLV114557381 114567936
GAT120826125(ggcta)
PPUG119197695(ggctb) 119219422(ggcta)
MSAM119896837(ggctb) 119907115(ggcta)
CUD121523347(ggcta)
ALAT119006214(ggctb) 119016635(ggcta)
MZE101475529 101483555
ONL100703332 100712042
OAU116312060(ggcta) 116318459(ggctb)
OLA101162615 101170211
OML112139477(ggctb) 112160429(ggcta)
XMA102218941 102224050
XCO114152740 114156261
XHE116716788 116731276
PRET103472371 103478774
PFOR103129844 103135107
PLAI106938332 106949292
PMEI106912476 106918604
GAF122830665(ggctb) 122843621(ggcta)
CVG107092462 107100568
CTUL119792168(ggctb) 119795304(ggcta)
GMU124878982(ggcta)
NFU107379004 107397246 107397248
KMR108240813(ggcta) 108250051
ALIM106515801 106531193
NWH119425359(ggcta)
AOCE111563780 111569446(ggct)
CSEM103388762(ggct) 103394438
POV109631635 109631991
SSEN122774245(ggctb) 122786506
HHIP117770164(ggcta) 117777335(ggctb)
LCF108886121 108898169
SDU111223418 111227777
SLAL111657536(ggct) 111659351 111664184
XGL120783928(ggctb) 120786303(ggcta)
HCQ109516380 109521920(ggct)
BPEC110167470 110173791
MALB109963956(ggct)
BSPL114865528(ggcta)
SASA100196182(cg024) 106579600 106588758 106605510(ggct)
OTW112227899 112236468(ggctb) 112244893 112264468(ggcta)
OMY110496513(ggcta) 110511884 110539228(ggctb) 118938772
OGO123997174(ggctb) 124005857 124013326(ggcta)
ONE115114447 115114455 115128635 115140908
SALP111956202 111964720 111964926(ggct) 112068927
SNH120022529(ggcta) 120031141 120047202 120048522
ELS105009435 105012454 105019182
SFM108942523
PKI111846953 111848848 111848849
AANG118212318(ggctb) 118234751(ggcta)
LOC102683461 102697437
PSPA121312895
ARUT117399772
LCM102345575 102348398(GGCT)
CMK103176267(ggct)
RTP109924666(ggct)
BFO118417214
SCLV120342021 120344808
APLC110981324 110981356
SKO100369875 100374636 102801350
DER6546302 6546438
DSIDsimw501_GD12343(Dsim_GD12343) Dsimw501_GD12344(Dsim_GD12344)
DYADyak_GE22074 Dyak_GE22075
DSR110178935 110178952
DPODpse_GA16751 Dpse_GA18096
DPE6599030 6599031
DMN108153030 108153031
DWI6645562 6645563
DMODmoj_GI11714 Dmoj_GI11715
DAZ108612658 108612672
DNV108650523 108650528
DHE111599245 111599248
DVI6622212
MDE101889069 101889641 101898676
LCQ111675218 111675233
AGAAgaP_AGAP010447 AgaP_AGAP010449
ACOZ120960119
AARA120899701
AAG5570054
AALB109405475
CQUCpipJ_CPIJ008797
CPII120416669
AME725055
ACER108000680
ALAB122711016
BIM100745685
BBIF117207746
BVK117243262
BVAN117154961
BTER100643954
BPYO122574820
CCAL108629753
OBB114876242
MGEN117226300
NMEA116425686
CGIG122404271
SOC105196864
MPHA105835327
AEC105150314
ACEP105621528
PBAR105431273
VEM105566080
HST105183396
DQU106751798
CFO112639205 112639212
FEX115238427
LHU105674071
PGC109853083
OBO105279351
PCF106793959
PFUC122521446
VPS122628419
NVI100122138 100122156
CSOL105361426
TPRE106658159
MDL103578586 103578587 103578589
CGLO123269340
TCA657379
DPA109535153
SOY115880219
ATD109598827 109602561
CSET123313619
LDC111508184
NVL108569857
APLN108734187
BMOR101743698 110385885
BMAN114247235 114247236
MSEX115443784
DPLKGM_215638 KGM_215639 KGM_215777
PMAC106717573 106717575 106717604
PPOT106100348 106100573
PXU106124195 106124282
PRAP111003918
ZCE119829328 119829671 119829749
HAW110370302 110377769 110377784 110377792
TNL113498133 113501842 113501843 113501844
SLIU111353384
PXY105396775 105396923 105396942
API100160827
DNX107167438
AGS114123987
RMD113560882
BTAB109031362
DCI103512087
CLEC106662315 106670618
NLU111061213
PHUPhum_PHUM041020
FOC113206849
ZNE110832632
CSEC111875463
FCD110862377
DPXDAPPUDRAFT_303711
DMK116916916
PVM113828393
PJA122248962
PCHN125041435
HAME121866518 121870035
PCLA123774182
PTRU123498548
HAZT108674748
EAF111700289
LSM121125869
DSV119432428
RSAN119376671 119404896
RMP119181365 119181366
TUT107359593
DFR124491626
CSCU111625598
PTEP107456735
CELCELE_C44B7.7(C44B7.7)
CBRCBG_11175
LOALOAG_08543
NAINECAME_13395
HROHELRODRAFT_186293
LGILOTGIDRAFT_123575 LOTGIDRAFT_164301
PCAN112576588
BGT106062447 106069328 106069361
GAE121371862
HRF124147247 124147278 124147279 124147280 124147281
HRJ124292196 124292221 124292232
CRG105327160
MYI110466847 110466858
PMAX117337406
MMER123550318 123550319
OBI106878407 106882979
OSN115213134 115213150
LAK106170080
SMMSmp_098340
NVE5518185
EPA110243206 110246329
ATEN116286406
ADF107327495
AMIL114951909 114952501
PDAM113664494 113677322
SPIS111333813 111338839
TADTRIADDRAFT_20381
AQU100640069
ATHAT1G44790 AT4G31290 AT5G26220
ALY9305409 9310372 9327358
CRB17878856 17882261 17898278
CSAT104706945 104717066 104721711 104730170 104736648 104757964 104771108 109124741
EUSEUTSA_v10004888mg EUTSA_v10011803mg EUTSA_v10026164mg
BRP103834622 103837115 103847733 103851987
BNA106354720 106364013 106375433 106381093 106386242 106397053 106424106 106424107 106444452 106444453
BOE106296270 106303209 106316472 106332741 106342556
RSZ108821926 108821932 108825773 108825774 108828905 108844319
THJ104811222 104813146 104819923
CPAP110816712 110825227
CIT102621501 102624007
CICCICLE_v10002572mg CICLE_v10009681mg
PVY116113062 116139717
MINC123194056 123228869
TCC18587580 18587748 18592315
GRA105773070 105774461 105787418
GHI107893895 107901405 107930786 107932947 107959977 107962505
GAB108470497 108484627 108485529
DZI111286390 111315625
EGR104437272 104450944
GMX100305985 100778704 100793027
GSJ114380872 114409059 114415082
PVUPHAVU_008G163900g PHAVU_009G103300g
VRA106760885 106764169
VAR108330026 108337478
VUN114164739 114193777
CCAJ109796148 109796453 109798174
APRC113847740 113865395
MTRMTR_1g009210 MTR_1g030430 MTR_3g109250
CAM101511126 101514800
LJALj1g3v1991800.1(Lj1g3v1991800.1) Lj1g3v4314270.1(Lj1g3v4314270.1)
ADU107469832 107470940
AIP107622968 107623752
AHF112715651 112716197 112783003 112784304
LANG109326518 109327376 109344182 109359215
FVE101301837 101304934 105350857
RCN112169047 112174395
PPER18788851 18790271
PMUM103319845 103320123
PAVI110750525 110761222
PDUL117621777 117638595
MDM103424725 103441211 103450651
PXB103938071 103953177 103957519 103964523
ZJU107404632 107421053 107421054 107429933
MNT21402790 21405139
CSV101208455 101209842 101217290
CMO103488216 103503734 103504050
BHJ120075179 120075407 120084920
MCHA111005209 111011188 111011785
CMAX111476702 111480746 111487769 111491933 111496304
CMOS111443344 111446683 111454251 111459557 111462945
CPEP111788277 111790483 111797190 111798504 111805026
RCU8274106 8282096
JCU105637441 105638920
HBR110640417 110654001
MESC110603046 110606600
POP18100791 18107563 7469146
PEU105107220 105109830 105112611
PALZ118029315 118030654 118055722 118059469
JRE108992156 109009548
QSU111983373 112009561 112012644 112015572 112015980 112032345
QLO115960247 115972252
TWL119996263 120006465 120010594
VVI100261255 100264430
VRI117906131 117911979
SLY101246397 101258241 101259958
SPEN107003194 107005374 107026636
SOT102578210 102584350 102592696 102603766
CANN107849334 107851197 107868061
NTA107779373 107779408 107780043 107789157 107789186 107813044
NSY104221251 104226848 104246856
NTO104090560 104105646 104120800
NAU109205458 109213980 109238253
INI109162618 109191401
ITR115995816 116032162
SIND105159476 105160644 105164943
OEU111380792 111380821 111385982 111398212
EGT105972991 105975356
SSPL121746164 121751589 121753706 121758269 121779078 121780432 121780781 121784005
HAN110885602 110899266 110930152
ECAD122580292 122599451
LSV111904171 111908087
CCAV112510820 112529281
DCR108205073 108206540 108221913
CSIN114286208 114311236
BVG104886716 104891090
SOE110783915 110797987
CQI110696276 110709595 110710198 110728547
NNU104601638 104609647
MING122071607 122079645
TSS122653581 122661978
PSOM113300000 113346330 113356209 113358780
NCOL116249217 116262524
OSA4329321 4335982
DOSAOs02t0465900-01(Os02g0465900) Os04t0448600-01(Os04g0448600)
OBR102712078 102720950
BDI100832571 100833954
ATS109743898 109782856
TDC119314497 119322790 119329206 119355292 119364426
TAES123045600 123053442 123131885 123135861 123143384 123189350
TUA125538438
SBI110434709 8073384
ZMA100193117 100284213 103632484 109945950 109945951
SITA101768570 101779265
SVS117841535 117865446
PVIR120641158 120655690 120682803 120700942
PHAI112877649 112899877
PDA103697269 103700223 103701451 103702255
EGU105039351 105050450 105050890 105060924
MUS103973129 103976860 103977548 103991763 103996023
DCT110100720 110103744 110104628 110106274
PEQ110023085 110023425 110024594 110027757 110039043
AOF109821597 109842906 109848877
ATR18433775 18440759 18446481
SMOSELMODRAFT_48672 SELMODRAFT_58744 SELMODRAFT_58757 SELMODRAFT_85708
PPP112280397 112281175 112285362 112288003 112289734
CRECHLRE_10g452000v5
VCNVOLCADRAFT_46802
CSLCOCSUDRAFT_18395
CVRCHLNCDRAFT_12490
APROF751_4836
OLUOSTLU_13383
OTAOT_ostta17g02340
BPGBathy12g00210
MISMICPUN_81834
MPPMICPUCDRAFT_43343
PANPODANSg4048
CTHRCTHT_0006380
TRRM419DRAFT_65302
MAWMAC_04864
MAJMAA_00851
GLZGLAREA_04058
PNOSNOG_12675
BZECOCCADRAFT_88969
BORCOCMIDRAFT_99394
PFJMYCFIDRAFT_142157
FFUCLAFUR5_08410
BCOMBAUCODRAFT_229127 BAUCODRAFT_61477
PSQPUNSTDRAFT_47894
LBCLACBIDRAFT_306191
MPRMPER_15124
MRRMoror_842
MOREE1B28_009017
CCICC1G_01036
ABPAGABI1DRAFT111071(AGABI1DRAFT_111071) AGABI1DRAFT117923(AGABI1DRAFT_117923) AGABI1DRAFT124916(AGABI1DRAFT_124916)
ABVAGABI2DRAFT133726(AGABI2DRAFT_133726) AGABI2DRAFT176448(AGABI2DRAFT_176448)
SRLSOD_c35260
SRYM621_19105
MLQASQ50_06240
MARAD0851_18355
CPSCPS_2442
COZA3Q34_00555
PHAPSHAa0334
PTNPTRA_a0356
PBWD172_002105
PARTPARC_a3561
PNGPNIG_a0384
PMAACPA52_01840
PXIJ5O05_06665
LALAT746_01925
SALHHMF8227_00565
FBLFbal_2422
NOCNoc_2712
TEETel_14445
HHAHhal_0424
HHKHH1059_19950
APRSBI364_16385
NAXHC341_00775 HC341_01590
HAHEENC22_05115
HAKKO116_02365
HAGBB497_01515 BB497_05160
HVNEI420_13115 EI420_13235
HOLHORIV_38510
HTTHZS52_17580
HPIZGYM47_02210
MARDIBG28_12355 IBG28_12860
AJPAMJAP_1356
OMEOLMES_2647
TSNW908_04880
BCTGEM_5817
PACPFAZ97_20230
HYLLPB072_20315
NLCEBAPG3_005780
ADEAdeh_4028
ACPA2cp1_4170
ANKAnaeK_4144
MXAMXAN_3680
MSDMYSTI_04263
MFBMFUL124B02_22960
MFULILAB_26540
CFUSCYFUS_005304
MMYRMXMO3_01195 MXMO3_03588
MEYTM49_01910
TECAKL02_005105
SPKCKC8_09770
BBABd1350
BDCDOE51_06205
BDZDOM22_07135
CCLClocl_1731
COOCCU_03970
CCTCC1_08810
BLABEYS05_05600
DRUDesru_2680
CGCCyagr_2047
AMRAM1_4771
OXYHCG48_17840
DETDET1452
DEHcbdbA1418
DEBDehaBAV1_1254
DEVDhcVS_1231
DEGDehalGT_1163
DMCbtf_1329
DMDdcmb_1310
DMGGY50_1283
DMXX792_06815
DMYX793_06665
DMZX794_06250
DUCUCH007_12060
DLYDehly_1401
DFODform_02141
MINMinf_0575
RULUC8_32080
PNDPla175_41700
GMRGmarT_37160
GIMF1728_27965
GPNPan110_35450
MRIMal4_08100
SDYNMal52_44250
PCORKS4_29090
HBSIPV69_17615
MMABHQ865_11595
NMVNITMOv2_2943
MVUMetvu_1295
 » show all
Reference
1
  Authors
Bodnaryk, R.P. and McGirr, L.
  Title
Purification, properties and function of a unique gamma-glutamyl cyclotransferase from the housefly, Musca domestica L.
  Journal
Biochim Biophys Acta 315:352-362 (1973)
Reference
2  [PMID:5781001]
  Authors
Orlowski M, Richman PG, Meister A.
  Title
Isolation and properties of gamma-L-glutamylcyclotransferase from human brain.
  Journal
Biochemistry 8:1048-55 (1969)
DOI:10.1021/bi00831a036
Reference
3  [PMID:18515354]
  Authors
Oakley AJ, Yamada T, Liu D, Coggan M, Clark AG, Board PG
  Title
The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle.
  Journal
J Biol Chem 283:22031-42 (2008)
DOI:10.1074/jbc.M803623200
  Sequence
[hsa:79017]
Reference
4  [PMID:24214398]
  Authors
Paulose B, Chhikara S, Coomey J, Jung HI, Vatamaniuk O, Dhankher OP
  Title
A gamma-glutamyl cyclotransferase protects Arabidopsis plants from heavy metal toxicity by recycling glutamate to maintain glutathione homeostasis.
  Journal
Plant Cell 25:4580-95 (2013)
DOI:10.1105/tpc.113.111815
  Sequence
[ath:AT5G26220]
Other DBs
ExplorEnz - The Enzyme Database: 4.3.2.9
IUBMB Enzyme Nomenclature: 4.3.2.9
ExPASy - ENZYME nomenclature database: 4.3.2.9
BRENDA, the Enzyme Database: 4.3.2.9
CAS: 9045-44-7
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