Entry
Name
S-ribosylhomocysteine lyase;
S-ribosylhomocysteinase;
LuxS
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine L-homocysteine-lyase [(4S)-4,5-dihydroxypentan-2,3-dione-forming]
Reaction(IUBMB)
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione [RN:
R01291 ]
Reaction(KEGG)
Substrate
S-(5-deoxy-D-ribos-5-yl)-L-homocysteine [CPD:
C03539 ]
Product
L-homocysteine [CPD:
C00155 ];
(4S)-4,5-dihydroxypentane-2,3-dione [CPD:
C11838 ]
Comment
Contains Fe2+. The 4,5-dihydroxypentan-2,3-dione formed spontaneously cyclizes and combines with borate to form an autoinducer (AI-2) in the bacterial quorum-sensing mechanism, which is used by many bacteria to control gene expression in response to cell density [2].
History
EC 4.4.1.21 created 2004
Pathway
ec00270 Cysteine and methionine metabolism
Orthology
K07173 S-ribosylhomocysteine lyase
Genes
ECOO : ECRM13514_3531(luxS)
ECOH : ECRM13516_3397(luxS)
ECW : EcE24377A_2970(luxS)
ECOI : ECOPMV1_02943(luxS)
REE : electrica_01032(luxS)
RTG : NCTC13098_01553(luxS)
CLAP : NCTC11466_00809(luxS)
KOR : AWR26_03035 AWR26_05605(luxS)
KRD : A3780_18415 A3780_21700
KOU : C0557_19875 C0557_23090
KIE : NCTC12125_05027(luxS)
AHN : NCTC12129_03923(luxS)
KIN : AB182_05000 AB182_28780
PDZ : HHA33_05540 HHA33_07870(luxS)
METY : MRY16398_06640(luxS) MRY16398_11330(luxS)
PSHI : SAMEA2665130_2320(luxS)
EBC : C2U52_11720 C2U52_14815
YPG : YpAngola_A0890(luxS)
YPI : YpsIP31758_3233(luxS)
SMW : SMWW4_v1c08320(luxS)
SFJ : SAMEA4384070_0888(luxS)
SOF : NCTC11214_00646(luxS)
SSAR : SSARUM_000780(luxS)
PAQU : DMB82_0005430(luxS)
PARL : PEC302110_29580(luxS)
DIC : Dpoa569_003064(luxS)
BGJ : AWC36_01400 AWC36_20645
BIZ : HC231_01860 HC231_05235(luxS)
ERP : LJN55_04070 LJN55_17885(luxS)
TPTY : NCTC11468_00982(luxS)
PHEI : NCTC12003_00911(luxS)
PRJ : NCTC6933_00997(luxS_1) NCTC6933_00998(luxS_2)
LRI : NCTC12151_01059(luxS)
HIC : NTHIC486_00496(luxS)
HPIT : NCTC13334_00684(luxS)
HHZ : NCTC10839_00370(luxS)
HAEG : NCTC8502_00643(luxS)
PDAG : 4362423_00041(luxS)
ALIG : NCTC10568_01518(luxS)
ASEG : NCTC10977_00504(luxS)
AVT : NCTC3438_00609(luxS)
RPNE : NCTC8284_00303(luxS_1)
PAET : NCTC13378_00384(luxS)
VAU : VANGNB10_cI0460(vanS)
VPL : SA104470976_02165(luxS)
SCAA : TUM17387_10600(luxS)
TIB : THMIRHAM_21840(luxS)
TSE : THMIRHAS_24070(luxS)
TZO : THMIRHAT_22080(luxS)
RHEI : ATY27_10450 ATY27_19205
HBE : BEI_1338(luxS1) BEI_1717(luxS2)
HAG : BB497_00030 BB497_12695
HAXI : HAALTHF_21830n(luxS)
HASO : B2G49_00910 B2G49_12650
HAAH : HALA3H3_660038(luxS)
HAXH : J4377_08635 J4377_14175
HVN : EI420_03835 EI420_15790
SAJS : QO259_07045(luxS) QO259_17510
AEL : NCTC12917_00640(luxS)
CHJ : NCTC10426_01128(luxS)
CDIZ : CEDIAZO_01136(luxS)
NMQ : NMBM04240196_1918(luxS)
NMZ : NMBNZ0533_0342(luxS)
NMX : NMA510612_0504(luxS)
NWE : SAMEA3174300_1748(luxS)
NZO : SAMEA4504057_0777(luxS)
NCI : NCTC10296_01015(luxS)
NCZ : NCTC10294_01437(luxS)
NANI : NCTC12227_00289(luxS)
ECOR : SAMEA4412678_0707(luxS)
HPO : HMPREF4655_20349(luxS)
HPX : HMPREF0462_0160(luxS)
HSH : NHP194022_07870(luxS)
HPUL : NCTC13154_00586(ygaG)
CJV : MTVDSCj20_1203(luxS)
CFV : CFVI03293_0113(luxS)
CAMP : CFT03427_0118(luxS)
CCOC : CCON33237_1846(luxS)
CHV : CHELV3228_0188(luxS)
CAMZ : CVIC12175_0957(luxS)
BAZ : BAMTA208_15030(luxS)
BSON : S101395_01289(luxS)
BFD : NCTC4823_04179(luxS)
BACA : FAY30_03755 FAY30_18915 FAY30_23960
OCN : CUC15_06020 CUC15_06670
OCB : CV093_06340 CV093_07015
OJD : NP439_01065 NP439_11015
PARG : PspKH34_06390(luxS)
GCS : MUN88_00380 MUN88_11620
GSM : MUN87_07245 MUN87_19620
BLEN : NCTC4824_00044(luxS_1) NCTC4824_04126(luxS_2)
SLMS : MM221_01315 MM221_11365
SAX : USA300HOU_2123(luxS)
SUQ : HMPREF0772_11056(luxS)
SUX : SAEMRSA15_20420(luxS)
SUF : SARLGA251_19350(luxS)
SAUT : SAI1T1_2015740(luxS)
SAUJ : SAI2T2_1015750(luxS)
SAUK : SAI3T3_1015740(luxS)
SAUQ : SAI4T8_1015750(luxS)
SAUV : SAI7S6_1015750(luxS)
SAUW : SAI5S5_1015690(luxS)
SAUX : SAI6T6_1015700(luxS)
SAUY : SAI8T7_1015730(luxS)
SDP : NCTC12225_00755(luxS)
SPIC : SAMEA4384060_0901(luxS)
SSH : NCTC13712_02075(luxS)
SSIM : SAMEA4384339_1969(luxS)
SSTE : SAMEA4384403_0611(luxS)
LMOC : LMOSLCC5850_1346(luxS)
LMW : LMOSLCC2755_1291(luxS)
LMX : LMOSLCC2372_1349(luxS)
LMZ : LMOSLCC2482_1337(luxS)
LMON : LMOSLCC2376_1239(luxS)
LMOS : LMOSLCC7179_1258(luxS)
LMOO : LMOSLCC2378_1303(luxS)
LMOY : LMOSLCC2479_1348(luxS)
LMOT : LMOSLCC2540_1339(luxS)
LMOA : LMOATCC19117_1297(luxS)
LGZ : NCTC10812_01674(luxS)
GMO : NCTC11323_00593(luxS)
GHA : NCTC10459_01161(luxS)
PPQ : PPSQR21_005820(luxS)
SIV : SSIL_0938(luxS) SSIL_2814(luxS)
SSIL : SOLI23_04565 SOLI23_13915
SPSY : AZE41_06750 AZE41_18085
SPOO : J3U78_10525 J3U78_15475
SPYM : M1GAS476_1427(luxS)
SPH : MGAS10270_Spy1466(luxS)
SPI : MGAS10750_Spy1458(luxS)
SPJ : MGAS2096_Spy1371(luxS)
SPK : MGAS9429_Spy1345(luxS)
STG : MGAS15252_1245(luxS)
STZ : SPYALAB49_001391(luxS)
SNV : SPNINV200_03060(luxS)
SNC : HMPREF0837_10642(luxS)
SPNE : SPN034156_14050(luxS)
SPNU : SPN034183_03550(luxS)
SPNM : SPN994038_03430(luxS)
SPNO : SPN994039_03440(luxS)
SMC : SmuNN2025_0080 SmuNN2025_1495(luxS)
SMJ : SMULJ23_1415(ycgE) SMULJ23_1514(luxS)
SGG : SGGBAA2069_c04220(luxS)
SCP : HMPREF0833_12008(luxS)
SVB : NCTC12167_00429(luxS)
SMEN : SAMEA4412692_0193(luxS)
SFER : NCTC12278_00435(luxS)
SCAI : NCTC12191_01111(luxS)
SPSU : NCTC13786_01633(luxS)
SPOC : NCTC10925_01524(luxS)
SAUP : NCTC3168_00263(luxS)
SURN : NCTC13766_00455(luxS)
SVF : NCTC3166_00510(luxS)
SMIE : NCTC11169_00361(luxS)
LHL : LBHH_0647(luxS) LBHH_1887
LKE : WANG_1326(luxS) WANG_1787
LPW : LpgJCM5343_15910(luxS)
LRU : HMPREF0538_20734(luxS)
LHW : BSQ49_03120 BSQ49_09640
LJI : ELX58_04630 ELX58_04635
LAGL : BEN83_00895 BEN83_02340
LNN : F0161_09020 F0161_10635
LPD : AYR62_09625 AYR62_10930
EFAU : EFAU085_00401(luxS)
EFU : HMPREF0351_10470(luxS)
ESS : ATZ33_02485 ATZ33_08555
ECEC : NCTC12421_01716(luxS)
AUR : HMPREF9243_1947(luxS)
AUI : APT62_01500 APT62_08705
CAW : Q783_03730 Q783_09795
CARC : NY10_1404 NY10_1527
CVD : LHA31_02835 LHA31_08780
DPM : FNV33_00795 FNV33_02385
DST : VUQ06_01980 VUQ06_03590
CBK : CLL_A2855(luxS) CLL_A3319(luxS)
CBB : CLD_0027(luxS) CLD_3204(luxS)
CTAE : BGI42_10855 BGI42_13250
CIA : BEN51_07600 BEN51_08320
CCOH : SAMEA4530647_1143(luxS)
CGAS : J1C67_02400 J1C67_18520
CGEL : psyc5s11_16640(luxS)
SARJ : HH195_01330 HH195_10760
SMAN : C12CBH8_08150(luxS)
VFA : MM35RIKEN_21450(luxS)
ACAE : HYG86_02785 HYG86_16600
AHC : JYE49_00895 JYE49_07555
CBAF : JS518_01725 JS518_08760
BPRO : PMF13cell1_02764(luxS)
CSCI : HDCHBGLK_03274(luxS)
CHYL : CE91St63_20030(luxS)
ACEL : acsn021_31670(luxS)
ACHT : bsdcttw_34390(luxS)
CPRO : CPRO_10180(luxS_1) CPRO_20430(luxS_2)
ANV : RBQ60_09435 RBQ60_09850
CBAR : PATL70BA_0645(luxS)
PDF : CD630DERM_35980(luxS)
PHX : KGNDJEFE_00285(luxS)
CAZO : G3A45_06740 G3A45_11490
AARG : Aargi30884_19040(luxS)
ABSI : A9CBEGH2_17120(luxS)
EBM : SG0102_04360(luxS_1) SG0102_04600(luxS_2)
FIT : Fi14EGH31_00410(luxS)
PCAT : Pcatena_06890(luxS)
CMIN : NCTC10288_02254(luxS)
MSUW : GCM10025863_15530(luxS)
RDN : HMPREF0733_11556(luxS)
PAK : HMPREF0675_3488(luxS)
CGRN : 4412665_00804(luxS)
PAUS : NCTC13651_01245(luxS)
MCU : HMPREF0573_10603(luxS)
TBW : NCTC13354_01089(luxS)
ANE : ATCC27039_24020(luxS)
AHW : NCTC11636_01667(luxS)
AIR : NCTC12972_01972(luxS)
ASLA : NCTC11923_00587(luxS)
AVC : NCTC10951_02356(luxS)
ACAP : MANAM107_10850(luxS)
BBV : HMPREF9228_1355(luxS)
GVG : HMPREF0421_20913(luxS)
GVA : HMPREF0424_1054(luxS)
GVH : HMPREF9231_0657(luxS)
FPOL : ERS445057_01347(luxS)
PMZ : HMPREF0659_A7345(luxS)
PDN : HMPREF9137_2053(luxS)
PHER : prwr041_15620(luxS)
POC : NCTC13071_02429(luxS)
STHA : NCTC11429_04165(luxS)
» show all
Taxonomy
Reference
Authors
Zhu J, Dizin E, Hu X, Wavreille AS, Park J, Pei D.
Title
S-Ribosylhomocysteinase (LuxS) is a mononuclear iron protein.
Journal
Sequence
Reference
Authors
Miller MB, Bassler BL.
Title
Quorum sensing in bacteria.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.21
ExPASy - ENZYME nomenclature database: 4.4.1.21
LinkDB
All DBs