Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy

(R)[or (S)]-2-hydroxypropyl-CoM:2-sulfanylethane-1-sulfonate lyase (epoxyalkane-ring-forming)

(1) (R)-2-hydroxypropyl-CoM = (R)-1,2-epoxypropane + HS-CoM [RN:R05761];
(2) (S)-2-hydroxypropyl-CoM = (S)-1,2-epoxypropane + HS-CoM [RN:R05762]

R05761 R05762;
(other) R11897 R11899
Reaction

(R)-2-hydroxypropyl-CoM [CPD:C11496];
(S)-2-hydroxypropyl-CoM [CPD:C11498]

Requires zinc. Acts on both enantiomers of chiral epoxyalkanes to form the corresponding (R)- and (S)-2-hydroxyalkyl-CoM adducts. The enzyme will function with some other thiols (e.g., 2-sulfanylethanol) as the nucleophile. Uses short-chain epoxyalkanes from C2 (epoxyethane) to C6 (1,2-epoxyhexane). This enzyme forms component I of a four-component enzyme system (comprising EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.

EC 4.4.1.23 created 2001 as EC 4.2.99.19, transferred 2005 to EC 4.4.1.23

1  [PMID:10411892]

2  [PMID:11939797]

3  [PMID:12949106]