KEGG   ENZYME: 4.4.1.24
Entry
EC 4.4.1.24                 Enzyme                                 
Name
(2R)-sulfolactate sulfo-lyase;
Suy;
SuyAB;
3-sulfolactate bisulfite-lyase;
sulfolactate sulfo-lyase (ambigious);
(2R)-3-sulfolactate bisulfite-lyase (pyruvate-forming)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
Sysname
(2R)-3-sulfolactate hydrogensulfite-lyase (pyruvate-forming)
Reaction(IUBMB)
(2R)-3-sulfolactate = pyruvate + hydrogensulfite [RN:R07633]
Reaction(KEGG)
R07633
Substrate
(2R)-3-sulfolactate [CPD:C11537]
Product
pyruvate [CPD:C00022];
hydrogensulfite
Comment
Requires iron(II). This inducible enzyme participates in cysteate degradation by the bacterium Paracoccus pantotrophus NKNCYSA and in 3-sulfolactate degradation by the bacterium Chromohalobacter salexigens. The enzyme is specific for the (R) isomer of its substrate.
History
EC 4.4.1.24 created 2006, modified 2011
Pathway
ec00270  Cysteine and methionine metabolism
ec01100  Metabolic pathways
Orthology
K16845  (2R)-sulfolactate sulfo-lyase subunit alpha
K16846  (2R)-sulfolactate sulfo-lyase subunit beta
Genes
AHNNCTC12129_02754 NCTC12129_02755(garD_1)
ASUBNLZ15_10125 NLZ15_10130
GHOAL542_00730 AL542_00735
APRSBI364_08775 BI364_08780
CSACsal_1765 Csal_1766
HBEBEI_0833(suyA) BEI_0834(suyB)
HCAMI4484_16845 I4484_16850
HSXHNO51_16745 HNO51_16750
SVASVA_1848 SVA_1849
TSNW908_01095 W908_01100
THINCRN91_00440 CRN91_00445
RPJN234_02625 N234_02630
CUHBJN34_26750 BJN34_26755
REUReut_B3528 Reut_B3529 Reut_C6087 Reut_C6088
CTIRALTA_B0839 RALTA_B0840
CBWRR42_m0459 RR42_m0460
CGDCR3_0181(suyA) CR3_0182(suyB)
COXE0W60_13280 E0W60_13285
BFNOI25_4407 OI25_4408
PARABTO02_21290 BTO02_21295
PGISI6I06_21455 I6I06_21460
PACSFAZ98_25200 FAZ98_25205 FAZ98_25235
PEWKZJ38_22645 KZJ38_22650
PDQCL55_00014410 CL55_00014420
PANIDCO16_07880 DCO16_07885
PTXABW99_10885 ABW99_10890
PANDDRB87_03410 DRB87_03415
CABASBC2_17550 SBC2_17560(suyB_1)
BUOBRPE64_DCDS09670 BRPE64_DCDS09680
BPTBpet0414 Bpet0415
BBROBAU06_18065 BAU06_18070
BFZBAU07_08210 BAU07_08215
BOHAKI39_17260 AKI39_17265
BGMCAL15_02275 CAL15_02280
AXYAXYL_00473 AXYL_00474
AXONH44784_017111 NH44784_017121
AXNAX27061_0479 AX27061_0480
AXXERS451415_00473(garD_1) ERS451415_00474
ADTAPT56_02500 APT56_02505
AISBUW96_28025 BUW96_28030
ACHRC2U31_07150 C2U31_07155
ADYHLG70_19595 HLG70_19600
AKATKWG_23285
AMIMMIM_c37580 MIM_c37590
PACRFXN63_16930
PARKLSG25_12690 LSG25_12695
VEIVeis_0892 Veis_0893
VAPVapar_3818 Vapar_3819
VPDVAPA_1c39310 VAPA_1c39320
LIHL63ED372_00897(suyB) L63ED372_00898(suyA)
HYNF9K07_27975 F9K07_27980
RGERGE_25210(suyB) RGE_25220
ATERMW290_18635 MW290_18640
HARHEAR3336 HEAR3337(uxaA)
URUDSM104443_03898(suyB) DSM104443_03899(suyA)
UPLDSM104440_03459(suyB) DSM104440_03460(suyA)
ACOMCEW83_08370 CEW83_08375
BPRCD521_1331 D521_1332
BEBABWI17_07545 BWI17_07550
DVMDvMF_2003 DvMF_2004 DvMF_2005 DvMF_2006
DDSDdes_2374 Ddes_2375
DFIAXF13_13575 AXF13_13580
DEFCNY67_15440 CNY67_15445
DTRRSDT_0106(suyA) RSDT_0107(suyB)
DMSE8L03_07115 E8L03_07120 E8L03_07380 E8L03_07385
DBADbac_2155 Dbac_2156
DRTDret_2324 Dret_2325
DEOCAY53_05295 CAY53_05300
DALKDSCA_63940 DSCA_63950
DTIDesti_1900 Desti_1901 Desti_3262 Desti_3263
MESOBSQ44_12870 BSQ44_12875
NIYFQ775_22320 FQ775_22325
KMNHW532_06455 HW532_06460
EMXFKV68_25180 FKV68_25185
OCAOCAR_7557 OCAR_7558
OCGOCA5_c05830 OCA5_c05840(garD)
OCOOCA4_c05820 OCA4_c05830(garD)
VGOGJW-30_1_00129(suyB_1) GJW-30_1_00130(suyA)
BOPAXW83_05570 AXW83_05575
BOSBSY19_2608 BSY19_2609
BVVBHK69_18025 BHK69_18030
BOIBLM15_06715 BLM15_06720
MRDMrad2831_5979 Mrad2831_5980
MNOMnod_3705 Mnod_3706
METIDK427_02140 DK427_02145
MMESMMSR116_04775 MMSR116_04780
RVARvan_3576 Rvan_3577
RHZRHPLAN_09780 RHPLAN_09790
CMETK6K41_04840
AUBLXB15_20865 LXB15_20870
LABRCHH27_12020 CHH27_12025
LABPFJ695_09910 FJ695_09915 FJ695_27770 FJ695_27775
PSTGE8M01_21840 E8M01_21845
DSHDshi_2037 Dshi_2038
MALGMALG_01233 MALG_01234
TPROGa0080559_TMP3624 Ga0080559_TMP3625
ROMEI983_18915 EI983_18920
MARUFIU81_03600(suyA) FIU81_03605(suyB)
RSUNHU_04239 NHU_04240
RHMB5V46_17720 B5V46_17725
RBGBG454_15335 BG454_15340
POZI0K15_17255 I0K15_17260
CACTHZ995_04865 HZ995_04870
CMAGCBW24_05850 CBW24_05855
FAQG5B39_15415 G5B39_15420
AMAQGO499_07055 GO499_07060
SRFLHU95_23315 LHU95_23320
SHUMSTHU_05310 STHU_05320
SVCSTVA_07470 STVA_07480
STELSTAQ_07090 STAQ_07100
NCBC0V82_01500 C0V82_01505
ELIOKO353_14440 KO353_14445
NACINUH88_21480 NUH88_21485
PUBSAR11_0842(garD) SAR11_0843
PEGE5R92_01770 E5R92_01775
APMHIMB5_00005030 HIMB5_00005040
BACAFAY30_23705 FAY30_23710
BONA361_10260 A361_10265
CFIRNAF01_04365
APAKAP3564_02000 AP3564_02005
NMKCHR53_24455 CHR53_24460
PSABPSAB_19160 PSAB_19165
PSOPKP014_25870 KP014_25875
AFXJZ786_13615 JZ786_13620
EFFskT53_05830 skT53_05840
NTRB0W44_06075 B0W44_06080
DSYDSY0965 DSY0966 DSY3251 DSY3252
DHDDhaf_2050 Dhaf_2051 Dhaf_4418 Dhaf_4419
DDHDesde_3797 Desde_3798
DDLDesdi_3120 Desdi_3121 Desdi_3123 Desdi_3124
DRUDesru_0086 Desru_0087 Desru_0600 Desru_0601 Desru_1694 Desru_1695 Desru_1700 Desru_1701
DKUDesku_3257 Desku_3258
AACXDEACI_3907 DEACI_3908
DGIDesgi_0071 Desgi_0072
SAYTPY_1962(uxaA) TPY_1963
SAPSulac_2158 Sulac_2159
MASMahau_2704 Mahau_2705
LPILLIP_0417 LIP_0418 LIP_1984 LIP_1985
RHARHA1_ro08847(suyA) RHA1_ro08848(suyB)
RKOJWS14_47765 JWS14_47770
SATKSA2016_2187 SA2016_2188
GYUFE374_10310
MPHMLP_21600 MLP_21610
PLANA1s21148_06285 A1s21148_06290
PVNA7sIIA15_00840 A7sIIA15_00845
RXYRxyl_2590 Rxyl_2591
RUBGBA63_01435 GBA63_01440
MRBMrub_2462 Mrub_2463
MREK649_10215 K649_10220
MSVMesil_1011 Mesil_1012
MTAIMtai_v1c20770 Mtai_v1c20780
TNACTN_1545 CTN_1546
TTATheth_1763 Theth_1764
PHYAJ81_05180 AJ81_05185
DTUDtur_0481 Dtur_0482
TACTa1392 Ta1393
STOSTK_25590 STK_25600
SSOSSO1259(garD) SSO1260
SOLSsol_2216 Ssol_2217
SSOASULA_2250 SULA_2251
SSOLSULB_2251 SULB_2252
SSOFSULC_2248 SULC_2249
SSHIJ5U23_02055 J5U23_02056
SCASSACC_24590 SACC_24600
SISLS215_0489 LS215_0490
SIAM1425_0434 M1425_0435
SIMM1627_0445 M1627_0446
SIDM164_0471 M164_0472
SIYYG5714_0443 YG5714_0444
SINYN1551_2572 YN1551_2573
SIILD85_0490 LD85_0491
SIHSiH_0939 SiH_0940
SIRSiRe_0429 SiRe_0430
SICSiL_0462 SiL_0463
SULABFU36_12935 BFU36_12940
SULEGFS03_03720 GFS03_03725
SULOGFS33_07510 GFS33_07515
MSEMsed_1123 Msed_1124
MEMJMJ1HA_1252 MJ1HA_1253
MHKDFR87_12100 DFR87_12105
MPRUDFR88_00905 DFR88_00910
MTENGWK48_07245 GWK48_07250
AHOAhos_0318 Ahos_0319
AMANB6F84_05000 B6F84_05005
ABRIDFR85_12640 DFR85_12645
ACIHHS5_05250 HS5_05260
CSTYKN1_13270 KN1_13280
SAHSHS7_03840 HS7_03850
CMACmaq_1140 Cmaq_1141
TUZTUZN_0136 TUZN_0137
VMOVMUT_1151 VMUT_1152
 » show all
Reference
1  [PMID:12013276]
  Authors
Graham DE, White RH.
  Title
Elucidation of methanogenic coenzyme biosyntheses: from spectroscopy to genomics.
  Journal
Nat Prod Rep 19:133-47 (2002)
DOI:10.1039/b103714p
Reference
2  [PMID:15758220]
  Authors
Rein U, Gueta R, Denger K, Ruff J, Hollemeyer K, Cook AM
  Title
Dissimilation of cysteate via 3-sulfolactate sulfo-lyase and a sulfate exporter in Paracoccus pantotrophus NKNCYSA.
  Journal
Microbiology 151:737-47 (2005)
DOI:10.1099/mic.0.27548-0
  Sequence
Reference
3  [PMID:20007648]
  Authors
Denger K, Cook AM
  Title
Racemase activity effected by two dehydrogenases in sulfolactate degradation by Chromohalobacter salexigens: purification of (S)-sulfolactate dehydrogenase.
  Journal
Microbiology 156:967-74 (2010)
DOI:10.1099/mic.0.034736-0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.24
IUBMB Enzyme Nomenclature: 4.4.1.24
ExPASy - ENZYME nomenclature database: 4.4.1.24
BRENDA, the Enzyme Database: 4.4.1.24
CAS: 1256650-35-7
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