KEGG   ENZYME: 5.3.1.29
Entry
EC 5.3.1.29                 Enzyme                                 
Name
ribose-1,5-bisphosphate isomerase;
R15P isomerase;
ribulose 1,5-bisphosphate synthase;
RuBP synthase
Class
Isomerases;
Intramolecular oxidoreductases;
Interconverting aldoses and ketoses, and related compounds
Sysname
alpha-D-ribose 1,5-bisphosphate aldose-ketose-isomerase
Reaction(IUBMB)
alpha-D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate [RN:R10555]
Reaction(KEGG)
R10555
Substrate
alpha-D-ribose 1,5-bisphosphate [CPD:C01151]
Product
D-ribulose 1,5-bisphosphate [CPD:C01182]
Comment
This archaeal enzyme is involved in AMP metabolism and CO2 fixation through type III RubisCO enzymes. The enzyme is activated by cAMP [2].
History
EC 5.3.1.29 created 2013
Pathway
ec00030  Pentose phosphate pathway
ec01100  Metabolic pathways
Orthology
K18237  ribose 1,5-bisphosphate isomerase
Genes
MAQ: Maqu_0074
MARA: D0851_12185
SSE: Ssed_2704
NHL: Nhal_2211
NTT: TAO_1563
CBLY: IPM89_11685
ABAW: D5400_18205
BACA: FAY30_22265
LAGR: FJQ98_14765
HAMY: MUO15_17275
VNE: CFK40_04125
EAV: EH197_23085
ACOL: K5I23_08745 K5I23_13025
SLP: Slip_0714
TPZ: Tph_c27250
LCG: L3BBH23_16140
ERB: A4V01_03310 A4V01_03935
CIU: G4D55_01500 G4D55_02115
KBS: EPA93_25865
KBB: ccbrp13_54110
THUG: KNN16_00865
BPW: WESB_1267(gcn3)
SHYR: LA303_13055
SRB: P148_SR1C001G0163
MJA: MJ_0122
MFE: Mefer_1167
MVU: Metvu_0771
MFS: MFS40622_0999
MJH: JH146_0745
MESG: MLAUSG7_1030
MESA: MLASG1_0747
MIG: Metig_0446
MAE: Maeo_0673
MOK: Metok_1427
AFU: AF_2037
AFG: AFULGI_00023040
APO: Arcpr_1242
AVE: Arcve_0806
AST: Asulf_00197
FPL: Ferp_2476
GAC: GACE_2136
GAH: GAH_00545
PFU: PF0122
PFI: PFC_07590
PHO: PH0208(PH0208)
PAB: PAB2402
PYN: PNA2_0724
PYA: PYCH_16630
PYS: Py04_0275
PYC: TQ32_00430
TKO: TK0185
TON: TON_1296
TGA: TGAM_1633
TSI: TSIB_0548
TBA: TERMP_01301
THE: GQS_08985
THA: TAM4_1574
THM: CL1_1398
TLT: OCC_04330
THS: TES1_1328
TNU: BD01_1733
TEU: TEU_00610
TGY: X802_01085
THV: ADU37_CDS05060
TCH: CHITON_0339
TPEP: A0127_03060
TPIE: A7C91_02100
TGG: A3K92_02045
TCE: A3L02_04540
TBS: A3L01_07270
THH: CDI07_08305
TSL: A3L11_00730
TTD: A3L14_09605
TPRF: A3L09_05105
TRL: A3L10_06685
TPAF: A3L08_00550
THY: A3L12_02280
TIC: FH039_10745
TCQ: TIRI35C_1779
THEM: FPV09_10840
THEI: K1720_05870
PPAC: PAP_04815
MBA: Mbar_A0793
MBY: MSBRM_0258
MBW: MSBRW_0209
MBAR: MSBR2_2119
MBAK: MSBR3_2069
MAC: MA_0379(eif2B2)
MMA: MM_1606
MMJ: MSMAS_3063
MMAC: MSMAC_3082
MVC: MSVAZ_3086
MEK: MSKOL_3049
MLS: MSLAZ_0192
METM: MSMTP_2960
MEF: MSWH1_0276
MEQ: MSWHS_0281
MSJ: MSSAC_0356
MSZ: MSSIH_0312
MSW: MSSIT_0317
MTHR: MSTHT_2157
MTHE: MSTHC_1125
MHOR: MSHOH_3785
MFZ: AOB57_005110
MBU: Mbur_1938
MMET: MCMEM_0162
MELO: J7W08_10875
MMH: Mmah_0172
MHAZ: BHR79_02620
MPOT: BKM01_05680
MEV: Metev_2236
MZH: Mzhil_1979
MPY: Mpsy_1650
MZI: HWN40_00750
MMAV: RE476_09600
MSEB: RE474_06380
MHZ: Metho_2361
MTP: Mthe_1262
MCJ: MCON_0206
MHI: Mhar_2272
MHU: Mhun_2314
MRTJ: KHC33_16265
MLA: Mlab_0557
MEM: Memar_2067
MBG: BN140_1619
MEMA: MMAB1_2076
MCHK: MchiMG62_23860
MSUM: OH143_04615
MRC: R6Y96_00655
MPI: Mpet_0507
MEND: L6E24_05325
MEFW: F1737_08655
MAQE: RJ40_06575
MFK: E2N92_06730
MOU: OU421_09525
MESB: L1S32_00720
MANQ: L1994_08805
MBN: Mboo_2432
MFO: Metfor_0217
MPL: Mpal_0257
MPD: MCP_2142
RCI: RRC408(eif2b2)
HAL: VNG_1853G(eif2ba)
HSL: OE_3610R
HANR: LJ422_07465
HDL: HALDL1_14315
HHB: Hhub_3205
HAGS: JT689_08810
HABO: JRZ79_07215
HNO: LT974_12750
HLU: LT972_02130
HALH: HTSR_1620 HTSR_1864
HHSR: HSR6_1688 HSR6_1933
HSU: HLASF_0414 HLASF_1916
HSF: HLASA_0413 HLASA_1902
HAHS: HSRCO_2537(gcd2-3)
SALR: FQU85_07280
HALR: EFA46_000470 EFA46_013245
HJE: HacjB3_07320
HALX: M0R89_03730
HAXZ: M0R88_03930
HAYC: NGM10_11220
HAXY: NGM07_08265
HARA: AArcS_1091(gcd22)
HHI: HAH_1030(eif2BD1) HAH_2467(eif2BD2)
HHN: HISP_05295 HISP_12560
HAB: SG26_04865 SG26_12965
HTA: BVU17_12000
HALJ: G9465_13080
NPH: NP_1050A NP_3202A
NMO: Nmlp_1786(tif2Bd) Nmlp_3000(tif2Ba)
NHO: HWV23_07735 HWV23_14670
NSAL: HWV07_10115 HWV07_18135
HUT: Huta_1398
HTI: HTIA_1280
HALA: Hrd1104_02275
HMU: Hmuk_2762
HALZ: E5139_01105
HALL: LC1Hm_2107
HAZP: GBQ70_01105
HALI: BV210_01305 BV210_10815
HSN: DV733_06015 DV733_10460
HDS: HSR122_0293(gcd2)
HRR: HZS55_15410
HPEL: HZS54_18445
HLT: I7X12_20190
HARC: HARCEL1_09145
SSAI: N0B31_04365
HWA: HQ_2713A
HWC: Hqrw_3064
HVO: HVO_0966
HALE: G3A49_04815
HLN: SVXHx_0919
HME: HFX_0963
HGI: ABY42_04635
HLS: KU306_09425
HBO: Hbor_21590
HLM: DV707_08745
HALM: FCF25_05415
HLA: Hlac_2269
HALP: DOS48_11410
HALB: EKH57_13805
HEZZ: EO776_12580
HALQ: Hrr1229_009495
HSS: J7656_03745
HSAI: HPS36_09065
HAZZ: KI388_11125
SRUB: C2R22_06170
HAE: halTADL_0175
HALN: B4589_001370
HALG: HUG10_03090
HALU: HUG12_13770
HMP: K6T50_01445
HRE: K6T36_01245
HRM: K6T25_00075
HDF: AArcSl_0991
HAH: Halar_2167
HTU: Htur_0571 Htur_3564
HSAL: JMJ58_06260 JMJ58_10535
HAKZ: J0X25_10240
NMG: Nmag_2966
HXA: Halxa_1680 Halxa_3413
NAT: NJ7G_4171
NPE: Natpe_0259 Natpe_3491
NPL: FGF80_09535 FGF80_15055
NAY: HYG81_12595
HALY: HYG82_19630
HJT: DVR14_07590
HLO: J0X27_12180
NGE: Natgr_1133 Natgr_2288
HRU: Halru_1540
SAWL: NGM29_17185
HALV: NGM15_08410
NOU: Natoc_0402 Natoc_2480
HLC: CHINAEXTREME02065 CHINAEXTREME06955
NAJ: B1756_00190 B1756_04360
NAG: AArcMg_0285 AArcMg_3194
NAN: AArc1_3103
NARA: QQ977_00030
NBG: DV706_08855
NAS: GCU68_03210 GCU68_07770
HDA: BB347_11090 BB347_11970
MEAM: MU439_02375
MEAE: QEN48_07895
TAR: TALC_00199
MAX: MMALV_01860
MER: MMINT_06510 MMINT_17710
MEAR: Mpt1_c12760
MEUZ: KRP56_01045
MARC: AR505_1643
ABI: Aboo_0331
ACF: AciM339_0726
SMR: Smar_1357
SHC: Shell_1087 Shell_1088
DKA: DKAM_0459 DKAM_0460
DFD: Desfe_0599
DMU: Desmu_0715
TAG: Tagg_0676 Tagg_0677
THG: TCELL_1141
HBU: Hbut_0498
PDL: Pyrde_1813 Pyrde_1814
PABI: PABY_18100 PABY_18110
PARE: PYJP_01020 PYJP_01030
TPE: Tpen_0384
THB: N186_02935 N186_02940
TCB: TCARB_1655 TCARB_1656
THF: MA03_08045 MA03_08050
THEL: IG193_05630 IG193_05635
CLG: Calag_1023
CCAI: NAS2_1493 NAS2_1494
BARC: AOA65_0862 AOA65_0864
FLT: Sv326_0527
LOKI: Lokiarch_30180
LOB: NEF87_003641
PSYT: DSAG12_01252
 » show all
Reference
1  [PMID:17303759]
  Authors
Sato T, Atomi H, Imanaka T
  Title
Archaeal type III RuBisCOs function in a pathway for AMP metabolism.
  Journal
Science 315:1003-6 (2007)
DOI:10.1126/science.1135999
  Sequence
[tko:TK0185]
Reference
2  [PMID:23065974]
  Authors
Aono R, Sato T, Yano A, Yoshida S, Nishitani Y, Miki K, Imanaka T, Atomi H
  Title
Enzymatic characterization of AMP phosphorylase and ribose-1,5-bisphosphate isomerase functioning in an archaeal AMP metabolic pathway.
  Journal
J Bacteriol 194:6847-55 (2012)
DOI:10.1128/JB.01335-12
  Sequence
[tko:TK0185]
Reference
3  [PMID:22511789]
  Authors
Nakamura A, Fujihashi M, Aono R, Sato T, Nishiba Y, Yoshida S, Yano A, Atomi H, Imanaka T, Miki K
  Title
Dynamic, ligand-dependent conformational change triggers reaction of ribose-1,5-bisphosphate isomerase from Thermococcus kodakarensis KOD1.
  Journal
J Biol Chem 287:20784-96 (2012)
DOI:10.1074/jbc.M112.349423
  Sequence
[tko:TK0185]
Other DBs
ExplorEnz - The Enzyme Database: 5.3.1.29
IUBMB Enzyme Nomenclature: 5.3.1.29
ExPASy - ENZYME nomenclature database: 5.3.1.29
BRENDA, the Enzyme Database: 5.3.1.29
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