KEGG   ENZYME: 5.3.1.32
Entry
EC 5.3.1.32                 Enzyme                                 
Name
(4S)-4-hydroxy-5-phosphooxypentane-2,3-dione isomerase;
lsrG (gene name);
phospho-AI-2 isomerase;
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione aldose-ketose-isomerase;
(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase;
(4S)-4-hydroxy-5-phosphooxypentane-2,3-dione aldose-ketose-isomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Interconverting aldoses and ketoses, and related compounds
Sysname
(2S)-2-hydroxy-3,4-dioxopentyl phosphate aldose-ketose-isomerase
Reaction(IUBMB)
(2S)-2-hydroxy-3,4-dioxopentyl phosphate = 3-hydroxy-2,4-dioxopentyl phosphate [RN:R10939]
Reaction(KEGG)
R10939
Substrate
(2S)-2-hydroxy-3,4-dioxopentyl phosphate [CPD:C20959]
Product
3-hydroxy-2,4-dioxopentyl phosphate [CPD:C20960]
Comment
The enzyme participates in a degradation pathway of the bacterial quorum-sensing autoinducer molecule AI-2.
History
EC 5.3.1.32 created 2015
Orthology
K11530  (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase
Genes
ECOb1518(lsrG)
ECJJW1511(lsrG)
ECDECDH10B_1649(lsrG)
EBWBWG_1337(lsrG)
ECOKECMDS42_1229(lsrG)
ECEZ2187
ECSECs_2125(lsrG)
ECFECH74115_2131(lsrG)
ETWECSP_2003(lsrG)
ELXCDCO157_1965
EOIECO111_1914(lsrG)
EOHECO103_1648(lsrG)
ECOOECRM13514_1873(lsrG)
ECOHECRM13516_1883(lsrG)
ESLO3K_12890
ESOO3O_12745
ESMO3M_12850
ECKEC55989_1651(lsrG)
EOKG2583_1883(lsrG)
ELRECO55CA74_09230
ELHETEC_1588
EUNUMNK88_1937
ECOAAPECO78_11335
ECXEcHS_A1600(lsrG)
ECMEcSMS35_1654(lsrG)
ECYECSE_1608
ECRECIAI1_1530(lsrG)
EUMECUMN_1786(lsrG)
ECTECIAI39_1781(lsrG)
EOCCE10_1707(lsrG)
EBRECB_01475(yneC)
EBLECD_01475(lsrG)
EBEB21_01486(lsrG)
EBDECBD_2124
ELOEC042_1651
ECLEcolC_2140
EKOEKO11_2298
EKFKO11_15575(lsrG)
EDHEcDH1_2128
EDJECDH1ME8569_1461(lsrG)
ELWECW_m1647(lsrG)
ELLWFL_08065(lsrG)
EFEEFER_1559(lsrG)
ESZFEM44_22695(lsrG)
STYSTY3791
STTt3539
SEXSTBHUCCB_37210
SENTTY21A_17880
STMSTM4079(yneC)
SEOSTM14_4904(yneC)
SEVSTMMW_40441
SEYSL1344_4028(yneC)
SEMSTMDT12_C42260(lsrG)
SEJSTMUK_4064(yneC)
SEBSTM474_4261(lsrg)
SEFUMN798_4422
SETUSTU288_20545
SETCCFSAN001921_20025
SENRSTMDT2_39421
SENDDT104_40881
SENICY43_21330
SEENSE451236_00495
SPTSPA3922(yneC)
SEKSSPA3650
SPQSPAB_05053
SEISPC_4185
SECSCH_3968(yneC)
SEHSeHA_C4410
SHBSU5_0176
SENHCFSAN002069_11675
SEEHSEEH1578_06660
SEESNSL254_A4408
SENNSN31241_46090
SEWSeSA_A4295
SEASeAg_B4325
SENSQ786_20025
SEDSeD_A4478
SEGSG3341(yneC)
SELSPUL_3584
SEGASPUCDC_3570
SETSEN3869(yneC)
SENAAU38_20000
SENOAU37_20015
SENVAU39_20035
SENQAU40_22340
SENLIY59_20495
SENJCFSAN001992_13295
SEEBSEEB0189_021950
SEEPI137_17220
SENBBN855_41550
SENEIA1_19845
SENCSEET0819_04240
SALZEOS98_21915(lsrG)
SFLSF1577
SFXS1703
SFVSFV_1575
SFESFxv_1770(lsrG)
SFNSFy_2262
SFSSFyv_2317
SFTNCTC1_01710(lsrG)
SDYSDY_1624
SDZAsd1617_02176
SHQA0259_11635
ENCECL_04477
ENLA3UG_19780
ECLGEC036_38560
ECLEECNIH2_20260
ECLNECNIH4_03445
ECLIECNIH5_18800
ECLXLI66_19505
ECLYLI62_21505
ECLZLI64_18645
EHMAB284_05865
EXFBFV63_19005
ECLAECNIH3_18890
ECLCECR091_18815
EAUDI57_21480
EKBBFV64_20370
ENOECENHK_19210
EECEcWSU1_03893(lsrG)
ELGBH714_20330
ECANCWI88_03015
ERNBFV67_19040
ECLSLI67_020925
ECHGFY206_21370(lsrG)
ESHC1N69_19870
ENTEnt638_3531
EASEntas_3756
ENRH650_12040
ENXNI40_019295
ENFAKI40_0667
LNICWR52_15695
EBGFAI37_09825(lsrG)
ENDA4308_03875
ENZG0034_19795(lsrG)
ENSHWQ15_04775(lsrG)
ENKLOC22_07550(lsrG)
EHUD5067_0003205(lsrG)
KPNKPN_03502(yneC)
KPUKP1_4799
KPMKPHS_46350
KPPA79E_0615
KPHKPNIH24_05720
KPZKPNIH27_22130
KPVKPNIH29_23025
KPWKPNIH30_23350
KPYKPNIH31_22535
KPGKPNIH32_24200
KPCKPNIH10_23080
KPQKPR0928_22600
KPTVK055_3966
KPOKPN2242_20645
KPRKPR_4706(lsrG)
KPJN559_0669
KPID364_18045
KPAKPNJ1_00657
KPSKPNJ2_00699
KPXPMK1_01020(lsrG)
KPBFH42_13795
KPNEKU54_003235
KPNULI86_03240
KPNKBN49_0605(lsrG)
KVAKvar_0598
KPEKPK_0610(lsrG)
KPKA593_07760
KVDKR75_05025
KVQSP68_11660
KOXKOX_03285
KOEA225_5105
KOYJ415_06480
KOMHR38_01845
KMIVW41_02455
KOKKONIH1_25805
KOCAB185_10520
KQUAVR78_01355
EAEEAE_03925
EARCCG33207
KQVB8P98_03280
KLLBJF97_25460
KLWDA718_03720(lsrG)
KARLGL98_03145(lsrG)
KGRJJJ10_03345(lsrG)
RORRORB6_21845
RONTE10_24510
RPLNB1209_03115
RAODSD31_03285
RTGNCTC13098_00816(lsrG)
REEelectrica_00593(lsrG)
CAMAF384_16550
CAFAL524_06515
CFARCI104_21715
CIRC2U53_13400
CTELGBC03_08050(lsrG)
CNTJT31_09740
CEMLH23_08055
CENLH86_07895
CLAPNCTC11466_04015(lsrG)
ESCEntcl_0619
KLEAO703_18345
KSAC813_18615
KORAWR26_03085(lsrG)
KRDA3780_21650
KPSEIP581_20140(lsrG)
LAXAPT61_03140
LEIC2U54_01590
LEHC3F35_15070
LEEDVA44_03135
LERGNG29_19875(lsrG)
LEAGNG26_19065(lsrG)
LPNUKQ929_02580(lsrG)
LAZA8A57_18270
LEFLJPFL01_3633
LEWDAI21_07795
BUFD8682_18540
BAGEBADSM9389_05570
BFTMNO13_02865(lsrG)
METYMRY16398_06820(lsrG)
AHNNCTC12129_00641(lsrG)
YREHEC60_14925(lsrG)
SGOEA8O29_003715(lsrG)
KINAB182_28925
PDZHHA33_05630(lsrG)
EBCC2U52_11815
EBUCUC76_18750
YPEYPO0407
YPKy3774
YPHYPC_4196
YPAYPA_3878
YPNYPN_0277
YPMYP_3774
YPPYPDSF_3224
YPGYpAngola_A0863
YPTA1122_03070
YPWCH59_1454(lsrG)
YPJCH55_2403(lsrG)
YPVBZ15_3164(lsrG)
YPLCH46_507(lsrG)
YPSYPTB0547(yneC)
YPOBZ17_2012(lsrG)
YPIYpsIP31758_3526
YPYYPK_3655
YPBYPTS_0571
YPQDJ40_1820(lsrG)
YPUBZ21_3927(lsrG)
YPRBZ20_1546(lsrG)
YPCBZ23_27(lsrG)
YPFBZ19_4054(lsrG)
YENYE0523
YEPYE105_C0536
YEYY11_37571
YELLC20_04670
YEWCH47_2953(lsrG)
YETCH48_1075(lsrG)
YEFFORC2_3566
YEEYE5303_28041
YSIBF17_11010
YALAT01_3041(lsrG)
YFRAW19_3882(lsrG)
YINCH53_1165(lsrG)
YKRCH54_1908
YROCH64_3156(lsrG)
YAKACZ76_11815
YMADA391_19430
YHID5F51_02960
YCAF0T03_03230(lsrG)
YMOHRD69_08365(lsrG)
SMARSM39_0820(lsrG)
SMACSMDB11_0648(lsrG)
SMWSMWW4_v1c13620(lsrG)
SPESpro_1383
SRRSerAS9_1358
SRLSOD_c12750(lsrG)
SRYM621_07080
SPLYQ5A_006950(lsrG_1)
SRSSerAS12_1358
SRASerAS13_1359
SMAFD781_1309
SLQM495_06370
SERFL085_21650
SERSSERRSCBI_06435
SFWWN53_22865
SFGAV650_18695
SRZAXX16_3786
SERASer39006_021960
SERQCWC46_21970
SERMCLM71_06395
SQUE4343_09240(lsrG)
SFJSAMEA4384070_1444(lsrG)
SOFNCTC11214_05536(lsrG)
SSURATE40_003615
SURIJ0X03_16950(lsrG)
SENPKHA73_07165(lsrG)
RAHRahaq_2581
RACEJHW33_04280(lsrG)
RAQRahaq2_2594
RAAQ7S_12850
ROXBV494_07295
RVCJ9880_17080(lsrG)
EAMEGXP68_13160(lsrG)
RBADH2866_22220(lsrG)
SODSant_3804(lsrG)
PAOPat9b_2703
KLNLH22_09045
PLUplu3148(lsrG)
PLUMA4R40_15725
PAYPAU_01468(lsrG)
PTTVY86_00300
PAKHB0X70_16220
PLUICE143_16210
XBOXBJ1_4103
XBVXBW1_0360(lsrG)
XNEXNC1_4326
XNMXNC2_4175
XDOXDD1_3691(lsrG)
XHOA9255_16445
XBUHGO23_01320(lsrG)
MMKMU9_2076
EHOA9798_12260
HIPCGSHiEE_08230
HIAH733_1680(lsrG)
HICNTHIC486_00207(lsrG)
HSOHS_0056
HSMHSM_1949
PMUPM1279
PMVPMCN06_1944(lsrG)
PULNT08PM_2186
PMPPmu_19400(lsrG)
PMULDR93_523(lsrG)
PSKYA6B44_08115
PATLKGI96_03265(lsrG)
PCAIK7G93_001868(lsrG)
APORDDU33_02760
AAPNT05HA_0830
AATD11S_1391
AAOANH9381_1737
AAND7S_00020
AAHCF65_02215
AACNAANUM_1701
AACTACT75_11360
AVTNCTC3438_00373(lsrG)
PAETNCTC13378_00055(lsrG)
VCYIX92_18770
VCTJV59_20265
VTUIX91_18855
VEUIXK98_00670
VBRA6E01_13985
VSHBSZ05_24700
PAEPA0709
PAEVN297_730
PAEIN296_730
PAUPA14_55140
PAGPLES_46211
PAFPAM18_4327
PNCNCGM2_1375
PAEBNCGM1900_2058
PDKPADK2_22090
PSGG655_21810
PRPM062_03495
PAEPPA1S_23055
PAERPA1R_gp4215
PAEMU769_22840
PAELT223_23580
PAESSCV20265_4805
PAEUBN889_06406
PAEGAI22_11015
PAECM802_728
PAEOM801_729
PMYPmen_1703
PREPCA10_44870
PPSEBN5_1539
PFUWKF707C_44870
PPWPputW619_0727
PPBPPUBIRD1_4407
PPUHB479_22870
PPUTL483_28085
PPUNPP4_46850
PMONX969_22450
PMOTX970_22085
PMOSO165_019660
PPJRK21_05874
PSJPSJM300_14905
PSTTCH92_16545
PDRH681_07815
PSVPVLB_03555
PSECCCOS191_0697
PSETTHL1_4523
PALLUYA_08965
POJPtoMrB4_43140
PLALFXN65_21715
PSEJHNQ25_15745
PKHJLK41_08900
PTYJWV26_19420
PSEPC4K39_4985 C4K39_4987
PWZJ7655_13380
PTWTUM18999_45780
SLJEGC82_20050
COLWA3Q33_17650
PEAPESP_a0263
PARTPARC_a0255
MMAAFR932_08785
MDNJT25_012595
MDHAYM39_13890
MKOMKLM6_2861
MAHMEALZ_1165(lsrG)
MBUREQU24_07660
MOZMoryE10_16580(lsrG)
MISZMishRS11D_34870(lsrG)
TEETel_10560
TSYTHSYN_23115
THIPN838_25620
TNITVNIR_3137(lsrG_[H])
TTITHITH_13050
TTCFOKN1_2374
CSACsal_0842
HELHELO_3648
HHUAR456_00570
HBEBEI_2929
ZPLZBT109_0011
HAAA5892_13110
PAURFGL86_17125
MMWMmwyl1_0414
MARDIBG28_01835
MARSA8C75_13315
OCEGU3_08270
OCMCBP12_04270
OPFCBP31_14440
ZDFAN401_10650
CDIZCEDIAZO_00815(lsrG)
CNCCNE_BB1p10100 CNE_BB2p00640 CNE_BB2p00650
BSTLBBJ41_22565
BCAIK788_0000013
PHSC2L64_21430
PTERC2L65_26575
VAPVapar_6277
HYLLPB072_16435
HYCE5678_14715
NEUNE0621
NITNAL212_2344
NIINit79A3_1584
NURATY38_00325
URUDSM104443_01142(lsrG)
ATWC0099_13955
APPCAP2UW1_2429
BEBABWI17_21110
PEFA7E78_13450
DGGDGI_2975
PSELGM415_14625
DBADbac_0204 Dbac_1575
DOAAXF15_07010
MXAMXAN_2882
MSDMYSTI_03350
MYMA176_004133
MFBMFUL124B02_18110
CCXCOCOR_02730(lsrG)
MFULILAB_22170
MMASMYMAC_002842
SURSTAUR_1296
AGEAA314_07614
AVMJQX13_29795
MBDMEBOL_000994
CFUSCYFUS_007503
SCLsce1170
SCUSCE1572_08445
PAUUE8A73_001165
SAMYDB32_007970
MCIMesci_6406
MESWA9K65_033065
MESMEJ066_16975
AAKAA2016_1589
AMIHCO731_01541(lsrG)
PHTBLM14_08890
SMESM_b21023
SMKSinme_5077
SMQSinmeB_4064
SMXSM11_pD0953
SMIBN406_06008
SMEGC770_GR4pD0989
SMELSM2011_b21023
SMERDU99_30210
SMDSmed_0841
RHINGR_c06150
AGCBSY240_3527(lsrG)
REIIE4771_PA00078
RGARGR602_PA00061
RJGCCGE525_04450
RADCO657_24085
SZOK8M09_14835
SOJK6301_14510
KAIK32_08840
RPERPE_1227
CHELAL346_05070
LAPACP90_20175
LABRCHH27_00085 CHH27_27480
LABPFJ695_09700
LABTFIU93_26730(lsrG)
LAGGB0E33_03900
SIWGH266_09380
RLIRLO149_c006510
RPONG3256_03950
YPACCEW88_20220
SULIC1J05_01770 C1J05_17180
TOMBWR18_11210
AHTANTHELSMS3_02505
THAACFI11_01745
MALUKU6B_33560
HATRC74_03025
RSPRSP_3507
RSHRsph17029_3152
RSKRSKD131_3673
RCPRCAP_rcc02882
PAMIJCM7686_pAMI4p037
PYEA6J80_12140
PMUTDPM13_10595
RMBK529_019150
THWBMG03_15440
TECAKL02_015085
CACTHZ995_04485
GCEKYE46_14135
NPPPP1Y_Mpl5254
SWISwit_2265
SPHDHY78_14200
SECHB18_15200
SPPHKFK14_08040
SPHJBSL82_14290
RGIRGI145_01595
ROSCTJ15_19730
RMUCFOB66_18780
HTQFRZ44_45520
THACCSC3H3_20680
MAGQMGMAQ_0874
PARHI5S86_04565
PALBEJC50_29250
CBECbei_2715
CBZCbs_2715
CBEILF65_02770
CSRCspa_c23820
CPASClopa_1130
CPATCLPA_c09380
CPAECPAST_c09380
CCKCcar_04110
CTYKCTK_C12280
CDYF3K33_13700
CMAHC1I91_24190
DAIDesaci_2450
HALSD7D81_12355
IFNGM661_09520
PFTJBW_00101
MPAAMKK62_03575
MLLB1R94_19475
MMAGMMAD_32020
NBRO3I_019950
NOZDMB37_00100
GPOGPOL_c44650
SSOII1A49_02550
SAUOBV401_02820
SPUNBFF78_11390
SCHACP983_28625
SLIAHA039_02170 HA039_07615
PBOPACID_26520
AACIASQ49_08780
ACIJJS278_00875(lsrG_2)
AJIC0Z10_02715
TEZBKM78_01185
TLATLA_TLA_00241(lsrG)
MGGMPLG2_3296(lsrG)
KQIF1D05_21970
NGVCDO52_04965
NGNLCN96_17235
NMLNamu_0491
GOBGobs_3619
BSDBLASA_3368
SSYIEKG83_10385
ATLAthai_67480
SYDSyncc9605_1552
SYGsync_2670
SYXSynWH7803_0861
SYNDKR52_03720
SYHSyncc8109_1080
PMMPMM0367
PMJP9211_15071
PMENATL1_14291
CEPCri9333_2605
SCSSta7437_4652
PSUBPelsub_P1696
CAPCLDAP_29440
KBSEPA93_36335
OTEOter_0252
ROOG5S37_13740
AHELQ31a_38290(lsrG)
PNDPla175_46110(lsrG)
PLHVT85_14940(lsrG)
PBORBSF38_03983(lsrG)
AGVOJF2_34750(lsrG)
HBSIPV69_03900
TAERGT409_08860
SSMSpirs_3279
STASTHERM_c12920
STQSpith_0864
SFCSpiaf_2393
SPEREW093_07985
OCKEXM22_14420
LSTLSS_02529
LAJA0128_06790
LMAYDPV73_16315
LKMEFP84_17450
LWLFHG68_07950
SUSAcid_3895
PFERIRI77_05000
GAUGAU_0054
GPHGEMMAAP_00295
GGRHKW67_15325
GBAJ421_0815
PETPEIBARAKI_6865
DRCG0Q07_03940
MCOSGM418_08575
ARACE0W69_015470
HYDPK28_07345
HYEAM218_08870
HYJFHG12_02285
CHKD4L85_26735
MUTGVT53_04645
CIHATE47_07855
CHRSEAG08_19845
MPGTheba_2672
MINFMESINF_1545(lsrG)
NLIG3M70_08470
ALAMRT761_01792(lsrG)
 » show all
Reference
1  [PMID:17274596]
  Authors
Xavier KB, Miller ST, Lu W, Kim JH, Rabinowitz J, Pelczer I, Semmelhack MF, Bassler BL
  Title
Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria.
  Journal
ACS Chem Biol 2:128-36 (2007)
DOI:10.1021/cb600444h
  Sequence
[eco:b1518]
Reference
2  [PMID:21454635]
  Authors
Marques JC, Lamosa P, Russell C, Ventura R, Maycock C, Semmelhack MF, Miller ST, Xavier KB
  Title
Processing the interspecies quorum-sensing signal autoinducer-2 (AI-2): characterization of phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerization by LsrG protein.
  Journal
J Biol Chem 286:18331-43 (2011)
DOI:10.1074/jbc.M111.230227
  Sequence
[eco:b1518]
Other DBs
ExplorEnz - The Enzyme Database: 5.3.1.32
IUBMB Enzyme Nomenclature: 5.3.1.32
ExPASy - ENZYME nomenclature database: 5.3.1.32
BRENDA, the Enzyme Database: 5.3.1.32
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