Entry |
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Name |
lutein isomerase;
RPE65 (gene name);
meso-zeaxanthin isomerase
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Class |
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
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Sysname |
lutein Delta4-Delta5-isomerase
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Reaction(IUBMB) |
lutein = meso-zeaxanthin [RN: R12003]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
The enzyme is found in the retinal pigment epithelium (RPE) of vertebrates. It also has the activity of EC 3.1.1.64, retinoid isomerohydrolase.
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History |
EC 5.3.3.22 created 2018
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Orthology |
K11158 | retinoid isomerohydrolase / lutein isomerase |
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Genes |
XLA: | 379961(rpe65.S) 447613(rpe65.L) |
DRE: | 100004076(rpe65c) 393724(rpe65a) |
SRX: | 107705134 107708597 107743896 107752442 |
SANH: | 107657893 107693590 107700531 |
SGH: | 107549757 107562849 107599830(rpe65) 107600304 |
CCAR: | 109054720 109054721 109058080 109106900 |
CAUA: | 113046454 113069845 113107075 |
CGIB: | 127951348 127964249 128018068 |
PTET: | 122351041 122357548(rpe65a) |
LROH: | 127169921(rpe65c) 127183024(rpe65a) |
OMC: | 131527276(rpe65a) 131545344 |
PPRM: | 120461548(rpe65a) 120473993 120481924 |
RKG: | 130091596 130100114(rpe65a) |
MAMB: | 125251988(rpe65a) 125279955 |
CIDE: | 127506450 127517170 |
CERY: | 137003303(rpe65a) 137026297 |
MASI: | 127424183 127440766 |
TROS: | 130554641(rpe65a) 130567812 |
TDW: | 130418097(rpe65a) 130440191 |
MANU: | 129413845 129441437(rpe65a) |
AMEX: | 103023405(rpe65a) 125806042 |
CMAO: | 118812952 118826161(rpe65a) |
EEE: | 113581111(rpe65) 113589215 |
CHAR: | 105894984 105898922(rpe65a) |
TRU: | 101062285 101065379(rpe65) |
TFS: | 130528909 130538854(rpe65a) |
TNG: | GSTEN00016195G001 GSTEN00023173G001 |
LCO: | 104935905(rpe65) 104936272 |
TBEN: | 117488911(rpe65a) 117495541 |
CGOB: | 115006939 115022075(rpe65) |
PGEO: | 117445814 117462834(rpe65a) |
GACU: | 117558429(rpe65a) 117560449(rpe65c) |
EMAC: | 134866364(rpe65a) 134869075(rpe65c) |
ELY: | 117253333 117271695(rpe65a) |
EFO: | 125895624 125902002(rpe65a) |
PLEP: | 121937702 121951236(rpe65a) |
SLUC: | 116038155 116046008(rpe65a) |
ECRA: | 117950031 117954781(rpe65a) |
PFLV: | 114561069 114564889(rpe65) |
GAT: | 120816104(rpe65a) 120823503 |
PPUG: | 119206198(rpe65a) 119217183 |
AFB: | 129089079(rpe65a) 129095162 |
CLUM: | 117729342 117746744(rpe65a) |
PSWI: | 130194209 130197636(rpe65a) |
CANA: | 137782042(rpe65a) 137793513 |
MSAM: | 119900319 119902021(rpe65a) |
SCHU: | 122877807 122887382(rpe65a) |
CUD: | 121512430 121520043(rpe65a) |
ALAT: | 119011324(rpe65a) 119028714 |
ASTR: | 137598723 137612707(rpe65a) |
OAU: | 116315493 116318669(rpe65a) |
OLA: | 101163729 101172024(rpe65) |
OML: | 112147229(rpe65a) 112150125 |
CSAI: | 133452787(rpe65a) 133457852 |
XMA: | 102217285(rpe65) 102231785 |
XHE: | 116722033 116726470 116730884 |
PRET: | 103463130 103479670 103479672 |
PFOR: | 103131468 103135788(rpe65) |
PLAI: | 106951621(rpe65) 106964853 |
PMEI: | 106930879(rpe65) 106932818 |
GAF: | 122839182 122841139(rpe65a) |
PPRL: | 129361794(rpe65a) 129373830 |
CVG: | 107090023(rpe65) 107101167 |
CTUL: | 119789901 119795652(rpe65a) |
GMU: | 124870182(rpe65a) 124873461 |
NFU: | 107383888(rpe65) 107393007 |
KMR: | 108241705(rpe65a) 108249795 |
ALIM: | 106531270 106533754 |
NWH: | 119414550(rpe65a) 119430516 |
AOCE: | 111577418(rpe65) 111583702 |
MCEP: | 125009440 125010667(rpe65a) |
CSEM: | 103396306 103399738 |
POV: | 109640235 109641398(rpe65) |
SSEN: | 122758609 122780954 |
HHIP: | 117760857 117778748(rpe65a) |
HSP: | 118118098(rpe65a) 118121062 |
PPLT: | 128448550 128454881(rpe65a) |
SMAU: | 118311257(rpe65a) 118318305 |
LCF: | 108879593 108883387(rpe65a) |
SDU: | 111223483 111231109(rpe65) |
SLAL: | 111653254(rpe65) 111671744 |
XGL: | 120790833 120798784(rpe65a) |
HCQ: | 109521243(rpe65) 109525455 |
SSCV: | 125976127 125985297(rpe65a) |
SBIA: | 133503595 133510995(rpe65a) |
PEE: | 133406167 133412052(rpe65a) |
PTAO: | 133480941 133489392(rpe65a) |
BPEC: | 110159583 110172291 |
MALB: | 109952235 109957756 |
BSPL: | 114844894(rpe65a) 114853594 |
SASA: | 106569137 106584339 106613887 |
STRU: | 115157162 115158369 115192515 |
OTW: | 112244994 112250987 112260591 |
OMY: | 110521549 110524415 110530459(rpe65a) |
OGO: | 123996963 124009989 124037071 |
ONE: | 115108415 115114543 115145473 |
OKI: | 109874676 109882208 109902606 |
OKE: | 118359148 118390921 118401672 |
SALP: | 111956276 111971359 111975570 |
SNH: | 120051829 120055213 120055319 |
CCLU: | 121532692 121534650 121539895 |
ELS: | 105011682(rpe65) 105019406 |
SFM: | 108919070(rpe65) 108935006 |
AANG: | 118225022 118228866 |
» show all
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Reference |
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Authors |
Shyam R, Gorusupudi A, Nelson K, Horvath MP, Bernstein PS |
Title |
RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye. |
Journal |
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Sequence |
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Other DBs |
ExplorEnz - The Enzyme Database: | 5.3.3.22 |
ExPASy - ENZYME nomenclature database: | 5.3.3.22 |
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LinkDB |
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