KEGG   ENZYME: 5.3.99.11
Entry
EC 5.3.99.11                Enzyme                                 
Name
2-keto-myo-inositol isomerase;
IolI;
inosose isomerase;
2KMI isomerase.
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
Sysname
2,4,6/3,5-pentahydroxycyclohexanone 2-isomerase
Reaction(IUBMB)
2,4,6/3,5-pentahydroxycyclohexanone = 2D-2,3,5/4,6-pentahydroxycyclohexanone [RN:R09952]
Reaction(KEGG)
R09952
Substrate
2,4,6/3,5-pentahydroxycyclohexanone [CPD:C00691]
Product
2D-2,3,5/4,6-pentahydroxycyclohexanone [CPD:C20251]
Comment
Requires a divalent metal ion for activity. Mn2+, Fe2+ and Co2+ can be used. The enzyme, found in the bacterium Bacillus subtilis, is part of the myo-inositol/D-chiro-inositol degradation pathway leading to acetyl-CoA.
History
EC 5.3.99.11 created 2014
Pathway
ec00562  Inositol phosphate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K06606  2-keto-myo-inositol isomerase
Genes
ECQ: ECED1_0306
STM: STM4427 STM4435
SEO: STM14_5319 STM14_5326
SEV: STMMW_43711 STMMW_43771
SEY: SL1344_4359(iolI1) SL1344_4365(iolI2)
SEM: STMDT12_C45560 STMDT12_C45620
SEJ: STMUK_4413 STMUK_4420
SEB: STM474_4624 STM474_4631
SEF: UMN798_4794 UMN798_4802
SETU: STU288_22205 STU288_22240
SETC: CFSAN001921_18240 CFSAN001921_18270
SENR: STMDT2_42741 STMDT2_42801
SEND: DT104_44151 DT104_44211
SENI: CY43_23070 CY43_23105
SEEN: SE451236_05170 SE451236_05205
SPQ: SPAB_05574 SPAB_05584
SEA: SeAg_B4709 SeAg_B4717
SENS: Q786_21815 Q786_21850
SEEC: CFSAN002050_05545 CFSAN002050_05580
SEEB: SEEB0189_020200 SEEB0189_020235
SENB: BN855_45020 BN855_45100
SENE: IA1_21585 IA1_21620
SENC: SEET0819_06010 SEET0819_06045
SALZ: EOS98_20060 EOS98_20090
CSK: ES15_3063(iolI)
CSZ: CSSP291_14195
CSJ: CSK29544_04268
CCON: AFK62_04535
CDM: AFK67_04495
CUI: AFK65_04440
CMW: AFK63_14150
CTU: CTU_08910
KPN: KPN_04669
KPU: KP1_0551
KPM: KPHS_05220
KPP: A79E_4528
KPH: KPNIH24_02680
KPZ: KPNIH27_02610
KPV: KPNIH29_02770
KPW: KPNIH30_02815
KPY: KPNIH31_05275
KPG: KPNIH32_02825
KPC: KPNIH10_02665
KPQ: KPR0928_02670
KPT: VK055_2789
KPO: KPN2242_01435
KPR: KPR_0646
KPJ: N559_4621
KPI: D364_23775
KPA: KPNJ1_04944
KPS: KPNJ2_04893
KPX: PMK1_02137(iolI)
KPB: FH42_19745
KPNE: KU54_023920
KPNU: LI86_23760
KPNK: BN49_4768
KVA: Kvar_4585
KPE: KPK_4998
KPK: A593_13395
KVD: KR75_10850
KVQ: SP68_17435
KOX: KOX_09355
KOE: A225_0547
KOY: J415_00390
KOM: HR38_08075
KOK: KONIH1_03000
KOC: AB185_33220
KQU: AVR78_07240
EAE: EAE_09790
EAR: CCG32079
KQV: B8P98_24715
KLL: BJF97_03750
KLW: DA718_25700
KAR: LGL98_22320
KGR: JJJ10_24815
KPAS: LUW96_09550
KLC: K7H21_24975
ROR: RORB6_16190
RON: TE10_04830
RPLN: B1209_24195
RAO: DSD31_23000
RTG: NCTC13098_06588(iolI)
REE: electrica_04540(iolI)
CIE: AN232_01280 AN232_01310
CIX: M4I31_21085(iolI2) M4I31_21115(iolI1)
IZH: FEM41_17570
EBU: CUC76_12705
YEL: LC20_00200
YEF: FORC2_0164
YEE: YE5303_38641
YAL: AT01_2636
YFR: AW19_3419
YIN: CH53_1599
YKR: CH54_2371
YRO: CH64_2445
YAK: ACZ76_08340
YMA: DA391_00600
YHI: D5F51_21310
YCA: F0T03_20985
YMO: HRD69_06290
YAS: N0H69_00695
YKI: HRD70_03585
SMAR: SM39_4134
SMAC: SMDB11_3909
SMW: SMWW4_v1c46180(xylA)
SPE: Spro_4665
SRR: SerAS9_4759
SRL: SOD_c44630
SRY: M621_24310
SPLY: Q5A_024310
SRS: SerAS12_4760
SRA: SerAS13_4760
SMAF: D781_0083 D781_4377
SLQ: M495_23510
SERF: L085_03355
SERS: SERRSCBI_22385
SFW: WN53_06480
SFG: AV650_04450
SRZ: AXX16_0753
SERM: CLM71_22520
SQU: E4343_17425
SFJ: SAMEA4384070_4623
SOF: NCTC11214_01429
SSUR: ATE40_019705
SURI: J0X03_00945
SRHZ: FO014_11110
SENP: KHA73_00420
SNEM: NLX84_23690
SFO: Z042_10570
GQU: AWC35_19255
RBAD: H2866_03120
BGJ: AWC36_04150
BIZ: HC231_14575
ETA: ETA_32950(iolI)
EBI: EbC_42710
EPE: CI789_19830
ERWI: GN242_01115
ERP: LJN55_01415
EGE: EM595_0247
PAM: PANA_3268
PLF: PANA5342_0800(iolI)
PAJ: PAJ_2487
PAQ: PAGR_g0815
PVA: Pvag_3029(iolI) Pvag_pPag30220(iolI)
PAGG: AL522_02315 AL522_22285
PAO: Pat9b_3733
KLN: LH22_03700
PANP: PSNIH2_18535
PAGC: BEE12_05590 BEE12_20040
PALH: B1H58_06325
PANS: FCN45_18110 FCN45_22890
PEY: EE896_01460 EE896_20650
PDIS: D8B20_18395
PER: LAC65_17010
PJI: KTJ90_01415 KTJ90_20710
PANO: OJ965_03980
PGZ: C2E15_01440
PCD: C2E16_01505
MINT: C7M51_03761(iolI)
MTHI: C7M52_03265(iolI)
MHAN: K6958_01195
KPIE: N5580_00870
LRI: NCTC12151_03552(iolI_2)
VEJ: VEJY3_08685
PST: PSPTO_3496(iolI)
PSB: Psyr_3270
PSYR: N018_16410
PSP: PSPPH_3190
PSAV: PSA3335_12885
PAMG: BKM19_019155
PCI: PCH70_17480
PAVL: BKM03_11755
PVD: CFBP1590__3373
PCAB: JGS08_10550
PCOF: POR16_14905
PTRE: I9H09_10360
PSYI: MME58_16765
PAST: N015_10710
PLIJ: KQP88_08390
PFL: PFL_2589(iolL)
PPRC: PFLCHA0_c26540(iolI)
PPRO: PPC_2636(iolL)
PFE: PSF113_2376(iolI)
PFS: PFLU_2578
PFC: PflA506_3032(iolL)
PPZ: H045_10785
PFB: VO64_5690
PMAN: OU5_0764
PTV: AA957_02250
PCG: AXG94_04355
PAZO: AYR47_19720
POI: BOP93_14400
PMED: E3Z27_16640
PMUD: NCTC8068_02987
PTOL: I7845_11450
PFW: PF1751_v1c22360(iolI)
PFF: PFLUOLIPICF725530
PFX: A7318_11610
PLUL: FOB45_08795
PBA: PSEBR_a3352
PBC: CD58_12350
PSK: U771_19295
PCH: EY04_11800
PCZ: PCL1606_36180
PCP: JM49_18060
PSES: PSCI_0434
PSEM: TO66_12605
PSOS: POS17_2594
PFK: PFAS1_22570
PANR: A7J50_2469
PYM: AK972_2363
PVK: EPZ47_12240
PEZ: HWQ56_16480
PBZ: GN234_05915
PSEP: C4K39_2605
PTRT: HU722_0012850
PSAM: HU731_003450
PASG: KSS96_13030
PALV: KSS97_12000
PZA: HU749_018000
PTAE: NCTC10697_01802
PPEG: KUA23_12050
PCAS: LOY40_11490
PFIT: KJY40_11535
PNB: NK667_08695
AVN: Avin_50090
AVL: AvCA_50090
AVD: AvCA6_50090
ACX: Achr_2650 Achr_2660
AVZ: HWI77_18205
GAI: IMCC3135_21485
HCH: HCH_01162
HAHE: ENC22_24855
HBH: E4T21_19425
MARS: A8C75_14450
MRZ: KDW95_03300
GSN: YC6258_05341
ZDF: AN401_06635
ORB: IPMB12_01890
AMAH: DLM_0553
AQS: DKK66_02435
RSO: RSc1245(iolI)
RSE: F504_1273
RPU: CDC45_06420
RSC: RCFBP_20192
RSL: RPSI07_2131
RSN: RSPO_c02128(iolI)
RSM: CMR15_20451
RSY: RSUY_16690
RSG: JK151_10200
RNC: GO999_10190
BUR: Bcep18194_A6013
BCM: Bcenmc03_2714
BCH: Bcen2424_2685
BCJ: BCAL0918
BCEN: DM39_2775
BCEO: I35_2750
BAM: Bamb_2738
BMJ: BMULJ_02648(iolI)
BMU: Bmul_0612
BMK: DM80_2234
BMUL: NP80_2820
BCED: DM42_2386
BDL: AK34_403
BPYR: ABD05_03455
BCON: NL30_26520
BMEC: WJ16_13790
BSTL: BBJ41_15335
BANN: JFN94_13775
BARI: NLX30_15615
BURK: DM992_06545
PACP: FAZ97_27275
DAC: Daci_2926
DTS: BI380_08655
DLA: I6G47_09060
SNN: EWH46_19760
LCH: Lcho_3284
MLO: mlr6178
MLN: A9174_31105
MCI: Mesci_5854 Mesci_5870
MCIC: A4R28_22140
MOP: Mesop_6428 Mesop_6444
MAM: Mesau_05901 Mesau_05917
MESW: A9K65_031590 A9K65_031680
MESM: EJ066_12015
MESP: C1M53_10140
MHUA: MCHK_13135 MCHK_8412
MJR: EB229_31730
MERD: EB233_29595
MOH: IHQ72_34375
HOE: IMCC20628_04046
AAK: AA2016_2139
AMIH: CO731_02248
PHT: BLM14_03330
PHYL: HB779_19905
NKI: KW403_18375
SME: SM_b20711
SMK: Sinme_4317
SMQ: SinmeB_4810
SMX: SM11_pD0201
SMI: BN406_05281
SMEG: C770_GR4pD0199
SMEL: SM2011_b20711
SMER: DU99_26455
SMD: Smed_4269
RHI: NGR_b20550 NGR_c25960
SFH: SFHH103_02447(iolI) SFHH103_05176
SFD: USDA257_c15220 USDA257_c25740
SIX: BSY16_215
SAME: SAMCFNEI73_pC0588
SINO: SS05631_b54180
ESJ: SJ05684_b44410
EAK: EKH55_3681
EMX: FKV68_27725
ENU: PYH37_002046
EGI: PZN02_005788
EAD: OV14_a0856 OV14_b1383
EAH: FA04_24380
ATU: Atu4555
ARA: Arad_9586
ATA: AWN88_10430
AGR: AGROH133_13936
ATF: Ach5_42510(iolI)
ARO: B0909_14750
AGT: EYD00_14715
ALF: CFBP5473_21830
ASAL: CFBP5507_16600
RIR: BN877_II0196 BN877_p0455
RPUS: CFBP5875_14865
RET: RHE_PE00448
REC: RHECIAT_PA0000371
REL: REMIM1_PD00471
REP: IE4803_PA00407
REI: IE4771_PC00420
RLE: pRL110624
RLT: Rleg2_6026
RLG: Rleg_7181
RLB: RLEG3_05720
RLU: RLEG12_01495
RTR: RTCIAT899_PC07030
RHL: LPU83_pLPU83d0180
RGA: RGR602_PC00464
RHN: AMJ98_PD00457
RPHA: AMC79_PB00380
RHX: AMK02_PE00464
RHV: BA939_26020
RHK: Kim5_PB00440
REZ: AMJ99_PC00458
RHR: CKA34_26595
RGR: FZ934_08355 FZ934_26665
RAD: CO657_32065
ROY: G3A56_24610
RII: FFM53_030935
RHID: FFM81_030410
RBQ: J2J99_29180
RLN: J0663_26720
RBAN: J2J98_26025
RRG: J3P73_31235
RLS: HB780_05020
RROS: D4A92_23760
RAW: NE851_05905
RSUL: N2599_26910
RLW: RlegWSM1455_31565
NGL: RG1141_PA12110
NGG: RG540_PA06870
RHT: NT26_0567
SHZ: shn_13540
SOJ: K6301_10785
PDES: FE840_019585
BQB: J4P68_0025620
BAPI: BBC0122_003790
STAR: G3545_19980
LNE: FZC33_31010
MNO: Mnod_7806
CHEL: AL346_12360
CDQ: BOQ54_05105
DNP: N8A98_21615
HDI: HDIA_1418
AUA: M673_18895
JIE: OH818_00970 OH818_01100
TSO: IZ6_06850 IZ6_06880
PSF: PSE_p0065
OAT: OAN307_c20150
OTM: OSB_26350
CMAR: IMCC12053_2612
YAN: AYJ57_20180
AHT: ANTHELSMS3_01348
SAGU: CDO87_03130
PDE: Pden_1677
PYE: A6J80_02360
PZH: CX676_09885
PARO: CUV01_06175
PAAK: FIU66_01025
PKD: F8A10_19085
PLIA: E4191_23510
PSAP: JHX88_11020
DON: BSK21_15055
RBZ: B9057_15550
GFU: KM031_12935
SALO: EF888_10330
ACR: Acry_2319
AMV: ACMV_25510(iolI) ACMV_P1_01130(iolI)
PIJ: QEJ31_08750
BSU: BSU39680(iolI)
BSR: I33_4137
BSL: A7A1_1974
BSH: BSU6051_39680(iolI)
BSY: I653_19500
BSUT: BSUB_04210(iolI)
BSUL: BSUA_04210(iolI)
BSUS: Q433_21905
BSO: BSNT_10655(iolI)
BSN: BSn5_10865
BSQ: B657_39680(iolI)
BSX: C663_3887(iolI)
BSP: U712_20070
BSS: BSUW23_19800(iolI)
BST: GYO_4375
BLI: BL00238(iolI)
BLD: BLi04243(iolI)
BLH: BaLi_c42340(iolI)
BAY: RBAM_036700(iolI)
BAQ: BACAU_3684(iolI)
BYA: BANAU_3854(iolI)
BAMP: B938_18820
BQY: MUS_4359(iolI)
BAML: BAM5036_3590(iolI)
BAMA: RBAU_3797(iolI)
BAMN: BASU_3579(iolI)
BAMB: BAPNAU_3861(iolI)
BAMT: AJ82_20705
BAMY: V529_39370(iolI)
BMP: NG74_03844(iolI)
BAO: BAMF_3780(iolI)
BAZ: BAMTA208_19990(iolI)
BQL: LL3_04103(iolI)
BXH: BAXH7_04101(iolI)
BAMI: KSO_000740
BAMC: U471_38290
BAMF: U722_19550
BSIA: CWD84_00845
BAE: BATR1942_17850
BVM: B9C48_18750
BSON: S101395_04956(iolI)
BHT: DIC78_11080
BMOJ: HC660_38870(iolI)
BIQ: AN935_20185
BGY: BGLY_4628(iolI)
BIT: BIS30_09715
BSHI: LGQ02_18855
BCAB: EFK13_20370(iolI)
BRY: M0696_20225(iolI)
BJS: MY9_4099
BACP: SB24_10410
BACB: OY17_02025
BACY: QF06_18305
BACL: BS34A_42940(iolI)
BALM: BsLM_4011
BACS: AUL54_11430
BMQ: BMQ_3475(iolI)
BMD: BMD_3469(iolI)
BEO: BEH_02280
BHA: BH2315(iolI)
BGI: BGM20_14110
GKA: GK1892(iolI)
GTK: GT3570_08995
GLI: GLN3_02685
GMC: GY4MC1_2175
GSE: GT50_18765
GSR: GS3922_07100
GEJ: A0V43_07015
PTB: DER53_15260
PARG: PspKH34_20900(iolI)
TAP: GZ22_16895
PPSR: I6J18_08960(iolI)
PFRI: L8956_04510(iolI)
GRC: GI584_06580
POF: GS400_06430
NDT: L1999_25505
MEKU: HUW50_10370(iolI) HUW50_23070
MLIT: KDJ21_025745(iolI)
BLEN: NCTC4824_04070(iolI_4)
LWI: UE46_13185
BTHS: CNY62_11325
BHUI: LOK74_09385
PMQ: PM3016_2229
PTA: HPL003_12830
PKB: B4V02_03380
PAIH: ASL14_05150
PALB: EJC50_00225
PBK: Back11_16420(lolI)
PRZ: GZH47_21090
PLYC: GXP70_25420
PKA: PQ456_10065
PUI: PUW25_12460
AACO: K1I37_13285(iolI)
AFAS: NZD89_14310(iolI)
NTR: B0W44_10845
LRH: LGG_00271(iolI)
LRG: LRHM_0267
LRL: LC705_00262(iolI)
LRA: LRHK_273
LRO: LOCK900_0255
LRC: LOCK908_0271
LZE: KG087_01180
LGN: ABM34_10280
CTYK: CTK_C07490
CRS: FQB35_05060
CPRF: K7H06_11085
RUM: CK1_18000
RGV: NQ502_11405 NQ502_13310
FPR: FP2_24950
BYL: A4V09_01410
BPRO: PMF13cell1_05203(iolI_1)
BLAB: EYS05_00790
BMAS: LK422_05075
BPRL: CL2_16300
ARF: AR1Y2_1058
ACAC: EYQ97_11955
VGU: HYG85_18995
MFUN: GXM21_00220
PUF: UFO1_1236 UFO1_3158
PFT: JBW_01424
MCOO: MCOO_22950
NEX: NE857_22305
RXY: Rxyl_1715
RUB: GBA63_18080 GBA63_18090
CAP: CLDAP_26120
CCZ: CCALI_02114
RBA: RB9367(lolI)
PSL: Psta_2217
PIR: VN12_01655(iolI)
RUL: UC8_32270(iolI_3)
RML: FF011L_35360(iolI_2)
MFF: MFFC18_36660(iolI_2)
ROL: CA51_44730(iolI_2)
AHEL: Q31a_31820(iolI)
LCRE: Pla8534_39900(iolI_1) Pla8534_42280(iolI_2) Pla8534_43160(iolI_3)
AAGG: ETAA8_24790(iolI_1) ETAA8_31970(iolI_2)
BVO: Pan97_03890(iolI)
PLM: Plim_3702
PEH: Spb1_02020(iolI_1)
PBS: Plabr_4063
PLH: VT85_09750(iolI_1)
FMR: Fuma_04272(iolI_2)
GMR: GmarT_45540(iolI_1) GmarT_57710(iolI_2)
GIM: F1728_14800 F1728_22280
GPN: Pan110_43670(iolI_2) Pan110_60010(iolI_3)
MRI: Mal4_09140(iolI_1) Mal4_10340(iolI_2)
SDYN: Mal52_13050(iolI_1) Mal52_43710(iolI_3)
PLON: Pla110_21140(iolI)
GES: VT84_20340(iolI_3)
GMS: SOIL9_28570
TIM: GMBLW1_35150 GMBLW1_36810
LRS: PX52LOC_01491 PX52LOC_02919
FTJ: FTUN_7451 FTUN_8561
ULI: ETAA1_14240(iolI_1) ETAA1_35930(iolI_2)
TSPH: KIH39_04985 KIH39_24290
IPA: Isop_1865
SACI: Sinac_2839 Sinac_5014
PBOR: BSF38_05397(iolI_4)
AGV: OJF2_23210(iolI_1)
HBS: IPV69_04355
TPI: TREPR_0400
SSM: Spirs_0749 Spirs_1115
SBU: SpiBuddy_0497
SASS: MUG09_02705
PDI: BDI_2741
PARC: CI960_19945
PMER: INE87_02912(iolI)
PGIN: FRZ67_13865
HHY: Halhy_3562
PGS: CPT03_00520
MGOT: MgSA37_01693
MUH: HYN43_014500
MGIN: FRZ54_03270
MRUB: DEO27_014705
MGOS: DIU38_014860
AGD: FRZ59_06750
CMR: Cycma_0741
CAMU: CA2015_0619
ALM: AO498_05695
SLI: Slin_5789
SRD: SD10_25250
SMON: AWR27_18230
SPIR: CWM47_15825
SPIK: EXU85_01820
SPIB: G8759_05315
STAE: HNV11_01820
PSEZ: HME7025_02470(iolI)
RHOZ: GXP67_28790
DFE: Dfer_0291
DSN: HWI92_01465
DYC: NFI80_09805
DFQ: NFI81_01940
DCN: MUK70_02610
RSI: Runsl_4375
RUN: DR864_02780
RUP: DTQ70_08580
EOL: Emtol_3339
FAE: FAES_1171(lolI)
FIB: A6C57_08825
ALS: DJ013_07680
ADD: HUW48_12805
ASWU: HUW51_04280
FBT: D770_18295
CHK: D4L85_29185
RBI: RB2501_12032
MARB: CJ263_16550
EMAR: D1013_05615
TLE: Tlet_1865
TTA: Theth_1106
PHY: AJ81_01115
DTH: DICTH_1667
DTU: Dtur_1777
 » show all
Reference
1  [PMID:12112707]
  Authors
Zhang RG, Dementieva I, Duke N, Collart F, Quaite-Randall E, Alkire R, Dieckman L, Maltsev N, Korolev O, Joachimiak A
  Title
Crystal structure of Bacillus subtilis ioli shows endonuclase IV fold with altered Zn binding.
  Journal
Proteins 48:423-6 (2002)
DOI:10.1002/prot.10159
  Sequence
[bsu:BSU39680]
Reference
2  [PMID:16461681]
  Authors
Yoshida K, Yamaguchi M, Morinaga T, Ikeuchi M, Kinehara M, Ashida H
  Title
Genetic modification of Bacillus subtilis for production of D-chiro-inositol, an investigational drug candidate for treatment of type 2 diabetes and polycystic ovary syndrome.
  Journal
Appl Environ Microbiol 72:1310-5 (2006)
DOI:10.1128/AEM.72.2.1310-1315.2006
  Sequence
[bsu:BSU39680]
Other DBs
ExplorEnz - The Enzyme Database: 5.3.99.11
IUBMB Enzyme Nomenclature: 5.3.99.11
ExPASy - ENZYME nomenclature database: 5.3.99.11
BRENDA, the Enzyme Database: 5.3.99.11
LinkDB

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