KEGG   ENZYME: 5.5.1.13
Entry
EC 5.5.1.13                 Enzyme                                 
Name
ent-copalyl diphosphate synthase;
ent-kaurene synthase A;
ent-kaurene synthetase A;
ent-CDP synthase;
ent-copalyl-diphosphate lyase (decyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
Sysname
ent-copalyl-diphosphate lyase (ring-opening)
Reaction(IUBMB)
geranylgeranyl diphosphate = ent-copalyl diphosphate [RN:R02068]
Reaction(KEGG)
R02068
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
ent-copalyl diphosphate [CPD:C06089]
Comment
Part of a bifunctional enzyme involved in the biosynthesis of kaurene. See also EC 4.2.3.19 (ent-kaurene synthase)
History
EC 5.5.1.13 created 2002
Pathway
ec00904  Diterpenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K04120  ent-copalyl diphosphate synthase
K20657  ent-copalyl diphosphate/ent-kaurene synthase
K27636  ent-copalyl diphosphate/ent-kaurene/ent-beyerene synthase
Genes
ATH: AT4G02780(GA1)
ALY: 9310964
CRB: 17883900
CSAT: 104707805 104714573 104737446
EUS: EUTSA_v10029352mg
BRP: 103836713 103860100
BNA: 106392263 106426697 106443785 125583685
BOE: 106313827
RSZ: 108826010 130501278
THJ: 104801236
CPAP: 110814715
CIT: 102620281 102623063
CIC: CICLE_v10018875mg CICLE_v10023706mg
PVY: 116130601 116130606 116130619
MINC: 123211143 123223998
TCC: 18613340
GRA: 105790720 105803113
GHI: 107890714 107908163 107912438 107923002
GAB: 108468330 108472513
HSYR: 120143650 120167627
DZI: 111283716 111306089 111313423
EGR: 104456992 104456994 120286860
GMX: 100784193(TPS22) 100807519(TPS1) 100808585(TPS2)
GSJ: 114398379 114406861
PVU: PHAVU_001G151900g PHAVU_001G152100g
VRA: 106757084 106759618
VAR: 108347906 108347925
VUN: 114172203 114190781
VUM: 124840706 124845683
CCAJ: 109797402 109797984
APRC: 113862114 113862726
MTR: 11422426 25497503
TPRA: 123888694 123892879
CAM: 101495301 101496179
PSAT: 127128589
VVO: 131608821 131611203
LJA: 130730621
ADU: 107472867 107492993 107493023
AIP: 107645177 107645180 107645483
AHF: 112696212 112696215 112720124 112756347 112756444 112791136 112791164
LANG: 109333831 109334928
PCIN: 129287858 129296245 129306848 129314894 129314914 129315338 129315421 129316183 129316332 129316382 129316404 129316521 129316523
QSA: O6P43_007022 O6P43_007023 O6P43_007026 O6P43_010625 O6P43_026688 O6P43_026689 O6P43_026693 O6P43_026700
FVE: 101304451 101311730 101312317 105350378
RCN: 112168942 112169264
PPER: 18767747
PMUM: 103334237
PAVI: 110749801
PDUL: 117637679
MDM: 103448353 103448995(CPS)
MSYL: 126590981 126591449 126615623
PXB: 103957280 103960128
ZJU: 107426403 107429475
MNT: 21407792
CSAV: 115703738
CSV: 101214392
CMO: 103491661
BHJ: 120077469
MCHA: 111025355
CMAX: 111466926 111491077
CMOS: 111437474 111464066
CPEP: 111776354 111795944
RCU: 8272032
MEAN: 126688258
JCU: 105649988
HBR: 110643292 110644361 110664957 110669087 110673038
MESC: 110614866 110622660
POP: 7464838 7480038
PEU: 105119675 105126847 105126849 105131430
PALZ: 118049193 118061693
PNZ: 133691656 133694214
JRE: 108981932 109018179 109018342 109018449 109020261
CILL: 122315038 122318277
CAVE: 132170193 132170321 132171730
QSU: 112000653
QLO: 115969891
TWL: 119981709 119981710 119982058 119989499 119990080 119994944 119995644
VVI: 100259570 100264747
VRI: 117903922 117904719 117917632 117918245 117934442
SLY: 544303(CPS)
SPEN: 107021672
SOT: 102585386 102596242
SSTN: 125869604 125873119
SDUL: 129900365
CANN: 107874554
LBB: 132608089 132610116
NTA: 107809496 107819352 107832422(NtCPS)
NSY: 104217342 104217889
NTO: 104117658 104121515
NAU: 109211878 109217158
INI: 109158259(CPS1)
ITR: 116015103
SIND: 105163273 105165295
OEU: 111384641 111411797
EGT: 105953222 105954081 105954116 105954117 105975169 105975177 105975321 105975322
SSPL: 121753378 121757143 121762885 121785344 121802217
SMIL: 131008214 131015105 131015110 131016246 131025133
SHIS: 125190513 125200575 125212702 125219486 125223885 125224056
APAN: 127248712 127255778 127258781 127259428
HAN: 110884117 110910286 110922746 110928585
ECAD: 122583086 122589008 122597253 122607123 122609194
LSV: 111886441
CCAV: 112504426 112504645 112518094 112518210
DCR: 108215027 108221652
CSIN: 114314501
RVL: 131314400 131314402 131314403 131323816
AEW: 130762562 130790514 130791486
BVG: 104898566
SOE: 110797142
CQI: 110703048 110704325
ATRI: 130813689
MOF: 131155345 131157652 131157684
NNU: 104596661 104611948
MING: 122071256 122085101 122092041
TSS: 122643769 122648925 122668330
PSOM: 113350098 113350926
OSA: 4329013(CPS1) 9266189(CPS2)
OBR: 102712336
OGL: 127761380 127763326
BDI: 100825198
ATS: 109734065 109734071 109737607
TDC: 119273021 119303875 119331265 119333090 119338716 119340453 119365260
TAES: 100286847 123057210 123089307 123107348 123149797 123149798 123160464 123166683 123171483
TUA: 125520986 125524309 125547194 125551712
LPER: 127294967 127294979
LRD: 124646644 124649063 124650454 124650524
SBI: 8064919
ZMA: 542165(an2) 542253(an1)
MFLO: 136488955 136493840 136539089 136539124
SITA: 101783621 101784049
SVS: 117837121 117840955
PVIR: 120651058 120689545
PHAI: 112877796
PDA: 103697749 103698066 103698242 103699834 103699922 120105661
EGU: 105042778
MUS: 103995767 103996438
ZOF: 121972022 121977045 122051412 122055681
DCT: 110096881
PEQ: 110024537
AOF: 109832398
MSIN: 131222599
NCOL: 116255368
ATR: 18428889
PPP: 112284636
MGR: MGG_01949
PPEI: PpBr36_10643
PGRI: PgNI_12055 PgNI_12444
FMU: J7337_005030
TASP: 36612063(TrAFT101_010790)
PCHM: VFPPC_09474
BZE: COCCADRAFT_113213
BSC: COCSADRAFT_104215
BOR: COCMIDRAFT_30863
 » show all
Reference
1  [PMID:4331199]
  Authors
Fall RR, West CA.
  Title
Purification and properties of kaurene synthetase from Fusarium moniliforme.
  Journal
J Biol Chem 246:6913-28 (1971)
Reference
2  [PMID:7994182]
  Authors
Sun TP, Kamiya Y
  Title
The Arabidopsis GA1 locus encodes the cyclase ent-kaurene synthetase A of gibberellin biosynthesis.
  Journal
Plant Cell 6:1509-18 (1994)
DOI:10.1105/tpc.6.10.1509
  Sequence
[ath:AT4G02780]
Reference
3  [PMID:9268298]
  Authors
Kawaide H, Imai R, Sassa T, Kamiya Y
  Title
Ent-kaurene synthase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase in fungal gibberellin biosynthesis.
  Journal
J Biol Chem 272:21706-12 (1997)
DOI:10.1074/jbc.272.35.21706
  Sequence
[ag:BAA22426]
Reference
4  [PMID:10803977]
  Authors
Toyomasu T, Kawaide H, Ishizaki A, Shinoda S, Otsuka M, Mitsuhashi W, Sassa T
  Title
Cloning of a full-length cDNA encoding ent-kaurene synthase from Gibberella fujikuroi: functional analysis of a bifunctional diterpene cyclase.
  Journal
Biosci Biotechnol Biochem 64:660-4 (2000)
DOI:10.1271/bbb.64.660
  Sequence
[ag:BAA84917]
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.13
IUBMB Enzyme Nomenclature: 5.5.1.13
ExPASy - ENZYME nomenclature database: 5.5.1.13
BRENDA, the Enzyme Database: 5.5.1.13
CAS: 9055-64-5
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