KEGG   ENZYME: 6.2.1.11
Entry
EC 6.2.1.11                 Enzyme                                 
Name
biotin---CoA ligase;
biotinyl-CoA synthetase;
biotin CoA synthetase;
biotinyl coenzyme A synthetase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
biotin:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + biotin + CoA = AMP + diphosphate + biotinyl-CoA [RN:R01075]
Reaction(KEGG)
R01075;
(other) R01074 R03762
Substrate
ATP [CPD:C00002];
biotin [CPD:C00120];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
biotinyl-CoA [CPD:C01894]
History
EC 6.2.1.11 created 1972
Pathway
ec00780  Biotin metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:14257635]
  Authors
CHRISTNER JE, SCHLESINGER MJ, COON MJ.
  Title
ENZYMATIC ACTIVATION OF BIOTIN. BIOTINYL ADENYLATE FORMATION.
  Journal
J Biol Chem 239:3997-4005 (1964)
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.11
IUBMB Enzyme Nomenclature: 6.2.1.11
ExPASy - ENZYME nomenclature database: 6.2.1.11
BRENDA, the Enzyme Database: 6.2.1.11
CAS: 37318-60-8
LinkDB

KEGG   REACTION: R03762
Entry
R03762                      Reaction                               
Name
biotin:CoA ligase (AMP-forming);
biotinyl-5'-AMP:CoA biotinyltransferase
Definition
Biotinyl-5'-AMP + CoA <=> AMP + Biotinyl-CoA
Equation
C05921 + C00010 <=> C00020 + C01894
Comment
the second step of two-step reaction (see R01075, R01074+R03762)
followng after R01074
Reaction class
RC00004  C00010_C01894
RC00070  C00020_C05921
RC02816  C01894_C05921
Enzyme
6.2.1.11
Pathway
rn00780  Biotin metabolism
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.11
     R03762  Biotinyl-5'-AMP + CoA <=> AMP + Biotinyl-CoA
LinkDB

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