KEGG ENZYME: 6.3.1.14

ENZYME: 6.3.1.14

Entry

EC 6.3.1.14                 Enzyme

Name

diphthine---ammonia ligase;
diphthamide synthase;
diphthamide synthetase;
DPH6 (gene name);
ATPBD4 (gene name);
diphthine:ammonia ligase (AMP-forming)

Class

Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)

Sysname

diphthine-[translation elongation factor 2]:ammonia ligase (AMP-forming)

Reaction(IUBMB)

ATP + diphthine-[translation elongation factor 2] + NH3 = AMP + diphosphate + diphthamide-[translation elongation factor 2] [RN:R03613]

Reaction(KEGG)

R03613

Substrate

ATP [CPD:C00002];
diphthine-[translation elongation factor 2] [CPD:C01573];
NH3 [CPD:C00014]

Product

AMP [CPD:C00020];
diphosphate [CPD:C00013];
diphthamide-[translation elongation factor 2]

Comment

This amidase catalyses the last step in the conversion of an L-histidine residue in the translation elongation factor EF2 to diphthamide. This factor is found in all archaea and eukaryota, but not in eubacteria, and is the target of bacterial toxins such as the diphtheria toxin and the Pseudomonas exotoxin A (see EC 2.4.2.36, NAD+---diphthamide ADP-ribosyltransferase). The substrate of the enzyme, diphthine, is produced by EC 2.1.1.98, diphthine synthase.

History

EC 6.3.1.14 created 1990 as EC 6.3.2.22, transferred 2010 to EC 6.3.1.14, modified 2013

Orthology

K06927

diphthine-ammonia ligase

Genes

HSA:	89978(DPH6)

PTR:	735941(DPH6)

PPS:	100988692(DPH6)

GGO:	101153919(DPH6)

PON:	100445767(DPH6)

PPYG:

129014071(DPH6)

NLE:	100606699(DPH6)

HMH:	116481617(DPH6)

SSYN:

129482603(DPH6)

MCC:	701401(DPH6)

MCF:	102141727(DPH6)

MTHB:

126958856

MNI:	105492862(DPH6)

CSAB:

103245888(DPH6)

CATY:

105574132(DPH6)

PANU:

101023519(DPH6)

TGE:	112627646(DPH6)

MLEU:

105548611(DPH6)

RRO:	104665652(DPH6)

RBB:	108543693(DPH6)

TFN:	117070908(DPH6)

PTEH:

111554588(DPH6)

CANG:

105504997(DPH6)

CJC:	100394882(DPH6)

SBQ:	101036126(DPH6)

CIMI:

108311881(DPH6)

ANAN:

105725934(DPH6)

CSYR:

103268341(DPH6)

MMUR:

105872397(DPH6)

LCAT:

123621858(DPH6)

PCOQ:

105814292(DPH6)

OGA:	100958185(DPH6) 100958823

MMU:	66632(Dph6)

MCAL:

110290024(Dph6)

MPAH:

110319199(Dph6)

RNO:	362191(Dph6)

MCOC:

116090666(Dph6)

ANU:	117703594(Dph6)

MUN:	110541415(Dph6)

CGE:	100765802(Dph6)

MAUA:

101824309(Dph6)

PROB:

127221763(Dph6)

PLEU:

114697511(Dph6)

MORG:

121465674(Dph6)

MFOT:

126496659

AAMP:

119815584(Dph6)

HGL:	101724973(Dph6)

CPOC:

100726776(Dph6)

CCAN:

109686902

DORD:

105981205(Dph6)

DSP:	122114521(Dph6)

PLOP:

125340327(Dph6)

NCAR:

124976080

MMMA:

107138245(Dph6)

OCU:

100339838

OPI:	101523653(DPH6)

TUP:	102488589(DPH6)

GVR:	103594852 103608713

CFA:	487480(DPH6)

CLUD:

112676169(DPH6)

VVP:	112919924(DPH6)

VLG:	121482008(DPH6)

NPO:	129504165(DPH6)

AML:	100464985(DPH6)

UMR:	103673486(DPH6)

UAH:	113242065(DPH6)

UAR:	123804020(DPH6)

ELK:

111162261

LLV:

125104984

MPUF:

101687016(DPH6)

MNP:	131998686(DPH6)

MLK:	131836082(DPH6)

NVS:	122893698(DPH6)

ORO:	101384735(DPH6)

EJU:	114221435(DPH6)

ZCA:	113909753(DPH6)

MLX:	118003334(DPH6)

NSU:	110585320(DPH6)

LWW:	102729201(DPH6)

FCA:	101094855(DPH6)

PYU:	121041463(DPH6)

PCOO:

112856104(DPH6)

PBG:	122468811(DPH6)

PVIV:

125168605(DPH6)

PTG:	102962514(DPH6)

PPAD:

109263198(DPH6)

PUC:

125909821

AJU:

106969797

HHV:	120224227 120241885(DPH6)

BTA:	767944(DPH6)

BOM:	102266159(DPH6)

BIU:	109564906(DPH6)

BBUB:

102400200(DPH6)

BBIS:

104991635(DPH6)

CHX:	102168266(DPH6)

OAS:	101103817(DPH6)

BTAX:

128054332(DPH6)

ODA:	120853241(DPH6)

CCAD:

122443351(DPH6)

MBEZ:

129562368(DPH6)

SSC:	102166599(DPH6)

CFR:	102515310(DPH6)

CBAI:

105076877(DPH6)

CDK:	105089991(DPH6)

VPC:	102536797(DPH6)

BACU:

102999917

BMUS:

118890660(DPH6)

LVE:	103073700(DPH6)

OOR:	101286626(DPH6)

DLE:	111181579(DPH6)

PCAD:

102986799(DPH6)

PSIU:

116749259(DPH6)

NASI:

112391236(DPH6)

ECB:	100071713(DPH6)

EPZ:

103549169

EAI:	106835154(DPH6)

MYB:	102242552(DPH6)

MYD:	102762328(DPH6)

MMYO:

118649499(DPH6)

MLF:	102436543(DPH6)

MDT:	132239270(DPH6)

PKL:	118723897(DPH6)

EFUS:

103287289(DPH6)

MNA:	107543010(DPH6)

DRO:	112311983(DPH6)

SHON:

118993625(DPH6) 118993721

AJM:	119040266(DPH6)

PDIC:

114493310(DPH6)

PHAS:

123808718(DPH6)

MMF:	118633085(DPH6)

PPAM:

129064374(DPH6)

HAI:	109386232(DPH6) 109386235

RFQ:	117022880(DPH6)

PALE:

102879441(DPH6)

PGIG:

120587215(DPH6)

PVP:	105288610(DPH6)

RAY:	107508077(DPH6)

MJV:	108395481(DPH6)

TOD:	119238455(DPH6)

SARA:

101546897(DPH6)

SETR:

126032530(DPH6)

LAV:	100665153(DPH6)

TMU:

101341843

ETF:	101652435(DPH6)

MDO:	100031655(DPH6)

SHR:	111718835(DPH6)

AFZ:

127549200

PCW:	110213387(DPH6)

TVP:	118829954(DPH6)

OAA:	100092006(DPH6)

GGA:	423294(DPH6)

PCOC:

116229327(DPH6)

MGP:

100545423

CJO:	107314989(DPH6)

TPAI:

128085903(DPH6)

LMUT:

125694469(DPH6)

NMEL:

110401071(DPH6)

APLA:

101791384(DPH6)

ACYG:

106031715(DPH6)

CATA:

118250809(DPH6)

AFUL:

116490097(DPH6)

TGU:	100228635(DPH6)

LSR:	110475282(DPH6)

SCAN:

103826577(DPH6)

PMOA:

120500486(DPH6)

OTC:	121332427(DPH6)

PRUF:

121349582(DPH6)

GFR:	102038484(DPH6)

FAB:	101807633(DPH6)

OMA:	130254244(DPH6)

PHI:	102100472(DPH6)

PMAJ:

107205831(DPH6)

CCAE:

111930341(DPH6)

CCW:	104684337(DPH6)

CBRC:

103620828(DPH6)

ETL:	114055308(DPH6)

ZAB:	102068424(DPH6)

ZLE:	135448220(DPH6)

ACHL:

103799394(DPH6)

SVG:	106862504(DPH6)

MMEA:

130582895(DPH6)

HRT:	120754713(DPH6)

SATI:

136362689(DPH6)

FPG:	101914569(DPH6)

FCH:	102050705(DPH6)

CCRI:

104157275

NNT:	104409948(DPH6)

SHAB:

115606750(DPH6)

ACUN:

113480775(DPH6)

TALA:

104358011(DPH6)

ACHC:

115335627(DPH6)

HALD:

104323079(DPH6)

HLE:	104835947(DPH6)

AGEN:

126049180

GCL:

127017253

MNB:

103775843

DPUB:

104306832(DPH6)

AVIT:

104274788

BRHI:

104496140(DPH6)

EGZ:	104126473(DPH6)

NNI:	104015898(DPH6)

PCRI:

104032103

PCAO:

104052769

PADL:

103914362(DPH6)

AFOR:

103908046(DPH6)

FGA:

104077857

GSTE:

104256768(DPH6)

CLV:	102092941(DPH6)

MUI:

104542843

PGUU:

104465089(DPH6)

PLET:

104625711

CMAC:

104487219

CUCA:

104064866(DPH6)

BREG:

104636065(DPH6)

OHA:	104339001(DPH6)

ACAR:

104521879(DPH6)

CPEA:

104397698(DPH6)

CVF:	104288162(DPH6)

RTD:	128908491(DPH6)

AAM:	106482814(DPH6)

AROW:

112973443(DPH6)

NPD:	112957972(DPH6)

TGT:	104575298(DPH6)

DNE:	112979605(DPH6)

SCAM:

104145944(DPH6)

ASN:	102371902(DPH6)

AMJ:	102576788(DPH6)

CPOO:

109321378(DPH6)

GGN:	109298704(DPH6)

PSS:	102459890(DPH6)

CMY:	102940116(DPH6)

CCAY:

125638400(DPH6)

DCC:	119857197(DPH6)

CPIC:

101943027(DPH6)

TST:	117876661(DPH6)

CABI:

116821647(DPH6)

MRV:	120402830(DPH6)

ACS:	100562724(dph6)

ASAO:

132765583(DPH6)

PVT:	110076865(DPH6)

SUND:

121918378(DPH6)

PBI:	103051724(DPH6)

PMUR:

107285394(DPH6)

CTIG:

120308415(DPH6)

TSR:	106553933(DPH6)

PGUT:

117665721(DPH6)

APRI:

131187684(DPH6)

PTEX:

113442805(DPH6)

NSS:	113410107(DPH6)

VKO:	123026554(DPH6)

PMUA:

114593272(DPH6)

PRAF:

128410354(DPH6)

ZVI:	118082617(DPH6)

HCG:	128340834(DPH6)

GJA:	107111519(DPH6)

STOW:

125427136(DPH6)

EMC:	129324496(DPH6)

XLA:	444081(dph6.L)

XTR:	100497052(dph6)

NPR:	108799324(DPH6)

RTEM:

120920863(DPH6)

BBUF:

120982110(DPH6)

BGAR:

122922141(DPH6)

MUO:	115477986(DPH6)

GSH:	117363773(DPH6)

DRE:	503603(dph6)

SRX:	107724237 107749548

SANH:

107665515(dph6)

SGH:	107554776(dph6)

CCAR:

109054609

CAUA:

113060441(dph6)

CGIB:

127933213

PTET:

122361904(dph6)

LROH:

127179999(dph6)

OMC:	131523309(dph6)

PPRM:

120487950(dph6)

RKG:	130071332(dph6)

MAMB:

125268089(dph6)

CIDE:

127498323

CERY:

137006919(dph6)

MASI:

127455367

TROS:

130559903(dph6)

TDW:	130437251(dph6)

MANU:

129417265(dph6)

IPU:

108269848

IFU:	128612216(dph6)

PHYP:

113538748(dph6)

SMEO:

124389881(dph6)

TFD:	113659299(dph6)

TVC:	132852310(dph6)

TRN:	134325256(dph6)

AMEX:

103047424(dph6)

CMAO:

118823598(dph6)

EEE:	113572703 113591790(dph6)

CHAR:

105896107(dph6)

TRU:	101077017(dph6)

TFS:	130539646(dph6)

TNG:	GSTEN00032006G001

LCO:	104922411(dph6)

NCC:	104942349(dph6)

TBEN:

117478264(dph6)

CGOB:

115027816(dph6)

PGEO:

117468196(dph6)

GACU:

117534886(dph6)

EMAC:

134882050(dph6)

ELY:	117266649(dph6)

EFO:	125901332(dph6)

PLEP:

121954034(dph6)

SLUC:

116057571(dph6)

ECRA:

117935898(dph6)

ESP:	116670230(dph6)

PFLV:

114546786(dph6)

GAT:	120832507(dph6)

PPUG:

119227353(dph6)

AFB:	129103981(dph6)

CLUM:

117751472(dph6)

PSWI:

130201295(dph6)

MSAM:

119900178 119910319(dph6)

SCHU:

122862033(dph6)

CUD:	121525939(dph6)

ALAT:

119004844(dph6)

MZE:	101482267(dph6)

ONL:	100710751(dph6)

OAU:	116326108(dph6)

OLA:	105356906(dph6)

OML:	112149443(dph6)

CSAI:

133462809(dph6)

XMA:	102222678(dph6)

XCO:	114134749(dph6)

XHE:	116709553(dph6)

PRET:

103458761(dph6)

PFOR:

103154794(dph6)

PLAI:

106961434

PMEI:

106906415(dph6)

GAF:	122846436(dph6)

PPRL:

129365347(dph6)

CVG:	107094430(dph6)

CTUL:

119774954(dph6)

GMU:	124856045(dph6)

NFU:	107392174(dph6)

KMR:	108232843(dph6)

ALIM:

106518433(dph6)

NWH:	119427664(dph6)

AOCE:

111573295(dph6)

MCEP:

125023728(dph6)

CSEM:

103379697(dph6)

POV:	109636226(dph6)

SSEN:

122783274(dph6)

HHIP:

117756108(dph6)

HSP:	118116764(dph6)

PPLT:

128450504(dph6)

SMAU:

118286325(dph6)

LCF:

108875040

SDU:	111225729(dph6)

SLAL:

111660122(dph6)

XGL:	120795386(dph6)

HCQ:	109517449(dph6)

SSCV:

125980876

SBIA:

133512964(dph6)

PEE:	133412682(dph6)

PTAO:

133487766(dph6)

BPEC:

110161158(dph6) 110173883

MALB:

109968060(dph6)

BSPL:

114848480(dph6)

SJO:	128375642(dph6)

SASA:

106601537(dph6)

STRU:

115172434(dph6)

OTW:	112261621(dph6)

OMY:	110498341(dph6)

OGO:	124001840(dph6)

ONE:	115146080(dph6)

OKI:	109887605(dph6)

OKE:	118362664(dph6)

SALP:

111968581(dph6)

SNH:	120060398(dph6)

CCLU:

121539456(dph6)

ELS:	105015517(dph6)

SFM:	108919340(dph6)

PKI:	111843588(dph6)

AANG:

118234034(dph6)

LOC:	102685393(dph6)

PSPA:

121324652(dph6)

ARUT:

117416705 117421836

PSEX:

120518459(dph6)

LCM:	102351051(DPH6)

CMK:	103175186(dph6)

RTP:

109927511

CPLA:

122553743(dph6)

HOC:	132817857(dph6)

LERI:

129700316(dph6)

PMRN:

116943288(DPH6)

LRJ:	133342307(DPH6)

BFO:

118414575

BBEL:

109479114

CIN:

100180152

SCLV:

120326470

SPU:

576024

LPIC:

129265493

APLC:

110986338

ARUN:

117293086

AJC:

117115323

SKO:

100368513

DME:	Dmel_CG1578(CG1578)

DER:

6551260

DSE:

6619914

DSI:	Dsimw501_GD15968(Dsim_GD15968)

DYA:	Dyak_GE17596

DAN:

6502958

DSR:

110179611

DPO:

4815352

DPE:

6598352

DMN:

108152890

DWI:

6652914

DGR:

6564883

DMO:	Dmoj_GI14716

DAZ:

108619156

DNV:

108656815

DHE:

111605301

DVI:

6633410

CCAT:

101456184

BOD:

106624054

BDR:

105224941

RZE:

108359614

AOQ:

129237368

TDA:

119669974

MDE:

101887741

SCAC:

106084117

LCQ:

111689730

LSQ:

119604844

GFS:

119633068

ECOE:

129939205

CLON:

129611354

HIS:

119653885

AGA:

1281181

ACOZ:

120952292

AARA:

120901380

AMER:

121590381

ASTE:

118506572

AFUN:

125760891

AMOU:

128297533

AALI:

118468490

AAG:	110680828 5571896

AALB:

109426358 115258087 115266292

ASUA:

134225293

CQU:	CpipJ_CPIJ008398 CpipJ_CPIJ008400

CPII:

120414328

CNS:

116342317

BCOO:

119075241

AME:

411591

ACER:

107993124

ALAB:

122711830

ADR:

102680303

AFLR:

100863196

BIM:

100744165

BBIF:

117214313

BVK:

117232220

BVAN:

117156145

BTER:

100646351

BAFF:

126927646

BPYO:

122571911

BPAS:

132908767

FVI:

122531454

CCAL:

108632135

OBB:

114877338

OLG:

117608575

MGEN:

117220250

NMEA:

116428379

CGIG:

122403287

SOC:

105201757

MPHA:

105828132

AEC:

105151494

ACEP:

105625480

PBAR:

105425226

VEM:

105566286

HST:

105187241

DQU:

106741259

CFO:

105252780

FEX:

115238924

LHU:

105678440

PGC:

109857928

OBO:

105287527

PCF:

106790755

PFUC:

122517881

VPS:

122627039

VCRB:

124431627

VVE:

124947159

NVI:

100116698

CSOL:

105361579

TPRE:

106658338

LHT:

122511251

LBD:

127284629

MDL:

103578395

CGLO:

123274789

FAS:

105265348

DAM:

107043128

AGIF:

122860682

CINS:

118071969

VCAN:

122416373

DSM:

124412902

NPT:

124222115

NFB:

124184919

NLO:

107220074

NVG:

124307338

AROA:

105691872

TCA:

663632

DPA:

109540798

SOY:

115891753

AGRG:

126744389

ATD:

109598175

CSET:

123309241

AGB:

108906113

LDC:

111503164

DVV:

126885681

NVL:

108567777

APLN:

108735055

PPYR:

116169659

OTU:

111416928

BMOR:

101741069

BMAN:

114246347

MSEX:

115441919

DPL:	KGM_211338

BANY:

112054202

MJU:

123873083

NIQ:

126769453

VCD:

124535683

MCIX:

123660776

PMAC:

106719804

PPOT:

106101588

PXU:

106113825

PRAP:

110992933

PBX:

123712856

PNAP:

125051753

ZCE:

119832770

CCRC:

123697247

LSIN:

126967918

AAGE:

121735095

HAW:

110379789

HZE:

124636358

TNL:

113496068

SLIU:

111356491

OFU:

114351542

ATRA:

106130468

GMW:

113514122

PXY:

105381769

PGW:

126373018

LGLY:

125235469

CFEL:

113382745

CCRN:

123291992

API:

100162183

DNX:	107171861 107173869

AGS:

114129070

RMD:

113551725

ACOO:

126840412

DVT:

126905392

BTAB:

109032974

CLEC:

106661200

HHAL:

106686730

NLU:

111058949

MQU:

128984473

PHU:	Phum_PHUM169970

FOC:

113217960

TPAL:

117642067

ZNE:

110828110

CSEC:

111873257

SGRE:

126292005

BROR:

134535177

IEL:

124153910

FCD:

110843893

DPX:	DAPPUDRAFT_198635

DPZ:

124335879

PVM:

113812445

PJA:

122248421

PCHN:

125029465

PMOO:

119580717

HAME:

121859316 121866220

PCLA:

123768967

CQD:

128694816

PTRU:

123502715

ESN:

127005607

MNZ:	135220777 135221248

HAZT:

108671978

EAF:

111696303

LSM:

121118120

TCF:

131884171

PPOI:

119107290

DSV:

119464153

RSAN:

119401706

RMP:

119164291

VDE:

111250872

VJA:

111258689

TUT:

107360450

DPTE:

113788661 113794700

DFR:

124490914

CSCU:

111627398

CVS:

136982387

PTEP:

107442365

ABRU:

129985132

UDV:

129223740

LPOL:

106463540

CEL:	CELE_E01A2.5(dph-6)

CBR:

CBG_12063

CRQ:	GCK72_002234

NAI:	NECAME_03449

BMY:	BM_BM3081(Bm3081)

LOA:	LOAG_01813

HRO:	HELRODRAFT_192994

LGI:	LOTGIDRAFT_138598

PVUL:

126821085

PCAN:

112571353

BGT:

106069187

GAE:

121372355

HRF:

124131877

HRJ:

124270921

CRG:

105333362

CANU:

128177024

CVN:

111129115

OED:

125650470

MYI:

110459198

PMAX:

117323566

MCAF:

127698941

RPHI:

132718499

DPOL:

127871748

MAEA:

128209374

OBI:

106869672

OSN:

115211892

LJP:

135467923

LAK:

106171049

OVI:	T265_12963

EGL:

EGR_02475

LLON:

135485670

NVE:

5521664

EPA:

110232352

ATEN:

116295777

ADF:

107332439

AMIL:

114968054

PDAM:

113686951

SPIS:

111336499

DGT:	114525724 114541825

XEN:

124453165

HMG:

100205848

HSY:

130630184

RES:

135681209

TAD:	TRIADDRAFT_49818

AQU:

100639417

ATH:

AT3G04480

ALY:

9320511

CRB:

17893221

CSAT:

104701366 104744552 104764074

EUS:	EUTSA_v10020155mg

BRP:	103848915 103859035

BNA:	106349636 106438981 106447631 125587671

BOE:	106334011 106343263

RSZ:	108805154 108863209

THJ:

104827285

CPAP:

110825988

CIT:

102624743

CIC:	CICLE_v10019185mg

PVY:

116136417

MINC:

123209262

TCC:

18600065

GRA:

105804621

GHI:	107892726 107926823

GAB:

108474237

HSYR:

120154777 120186121

DZI:	111277117 111296659 111296660

EGR:

104432545

GMX:

100807009

GSJ:

114400147

PVU:	PHAVU_001G114900g

VRA:

106753982

VAR:

108329395

VUN:

114194713

VUM:

124839178

CCAJ:

109796664

APRC:

113861687

MTR:

11425637

TPRA:

123889551

CAM:

101493811

PSAT:

127126613

VVO:

131609948

LJA:

130729918

ADU:

107494379

AIP:	107604801 107647222

AHF:	112696922 112696923 112754787 112757437

LANG:

109331641

PCIN:

129318672

QSA:	O6P43_011253

FVE:	101294087 101294869

RCN:

112195267

PPER:

18775339

PMUM:

103318703

PAVI:

110754347

PDUL:

117632448

MDM:

103434213

MSYL:

126619857

PXB:

103935688

ZJU:

107412319

MNT:

21407235

CSAV:

115719170

CSV:

101206966

CMO:

103485878

BHJ:

120079428

MCHA:

111018223

CMAX:

111465391

CMOS:

111444237

CPEP:

111799056

RCU:

8258634

MEAN:

126674140

JCU:

105647750

HBR:	110643260 110643264

MESC:

110621217

POP:	7487187 7487708

PEU:

105133876

PALZ:

118036487 118050649

PNZ:

133668579

JRE:

108991516

CILL:

122315332

CAVE:

132170686

QSU:

112003069

QLO:

115953010

TWL:

119999948

VVI:

100244247

VRI:

117930727

SLY:

101245449

SPEN:

107018291

SOT:

102584229

SSTN:

125856199

SDUL:

129870369

CANN:

107870276

LBB:

132614059

NTA:	107810033 107831427

NSY:

104218637

NTO:

104105323

NAU:

109238642

INI:

109187093

ITR:

116019893

SIND:

105163797

OEU:	111397972 111403848

EGT:

105977780

SSPL:

121749653 121792384

SMIL:

130997423

SHIS:

125220960

APAN:

127256410

HAN:

110904437

ECAD:

122605943

LSV:

111916346

CCAV:

112508050

DCR:

108204789

CSIN:

114268316

RVL:

131325837

AEW:

130764293

BVG:

104903997

SOE:

110786502

CQI:	110718941 110739892

ATRI:

130799226

MOF:

131153546

NNU:

104602820

MING:

122091109

TSS:

122638863

PSOM:

113319064 113349896

OSA:

9270287

OBR:

102713720

OGL:

127763929

BDI:

100838496

ATS:

109758520

TDC:	119318444 119324053

TAES:

123128904 123139472 123146059

TUA:

125515319

LPER:

127305437

LRD:	124691034 124693455

SBI:

110434488

ZMA:

103627881

MFLO:

136467986 136478296 136478323

SITA:

101785566

SVS:

117841490

PVIR:

120645796 120657557

PHAI:

112877438

PDA:

103721763

EGU:

105055708

MUS:

103999817

ZOF:	121989263 121998209

DCT:

110095883

PEQ:

110031426

AOF:

109827995

MSIN:

131245855

NCOL:

116252959

ATR:

18447174

SMO:	SELMODRAFT_130429 SELMODRAFT_134094

PPP:

112288731

VCN:	VOLCADRAFT_32944

MNG:	MNEG_14629

CSL:	COCSUDRAFT_37397

CVR:	CHLNCDRAFT_35997

APRO:

F751_6486

OLU:	OSTLU_6853

OTA:	OT_ostta09g03340

BPG:	Bathy10g01150

MIS:	MICPUN_63974

MPP:	MICPUCDRAFT_56170

CME:	CYME_CMS447C

GSL:	Gasu_59960

CCP:	CHC_T00005667001

SCE:	YLR143W(DPH6)

SEUB:

DI49_3666

SPAO:

SPAR_L01900

AGO:	AGOS_AGL164W

ERC:

Ecym_4223

KLA:	KLLA0_D16984g

KMX:	KLMA_50514

LTH:	KLTH0G11594g

VPO:	Kpol_1036p86

ZRO:	ZYRO0F14014g

CGR:	2891553(GVI51_M04433)

NDI:	NDAI_0G02460(NDAI0G02460)

TPF:	TPHA_0C00650(TPHA0C00650)

TBL:	TBLA_0A04110(TBLA0A04110)

TGB:	HG536_0C01070

TDL:	TDEL_0F04730(TDEL0F04730)

KAF:	KAFR_0H02150(KAFR0H02150)

KNG:	KNAG_0A02870(KNAG0A02870)

ZMK:	HG535_0F03930

SLUD:

SCDLUD_001792

DHA:	DEHA2B04884g

PIC:	PICST_43636

PGU:	PGUG_03693

SPAA:

SPAPADRAFT_60556 SPAPADRAFT_60558

LEL:	PVL30_001227

LBG:	92209784(LODBEIA_P45880)

CAL:	CAALFM_C203830WA(CaO19.839)

CTP:	CTRG_01289

COT:	CORT_0A10540

CDU:	CD36_18500

CTEN:

18250221(PSN45_004773)

CLU:	CLUG_05377

CLUS:

A9F13_23g00088

CAUR:

CJI96_0000930

PPA:	PAS_chr4_0132

PKZ:	C5L36_0B07880

BNN:	FOA43_002193

BBRX:

BRETT_003796

OPA:	HPODL_00628

YLI:	2907768(YALI2_F00289g)

SLB:	AWJ20_1830(DPH6)

NCR:

NCU02670

NTE:	NEUTE1DRAFT73167(NEUTE1DRAFT_73167)

SMP:	10808594(SMAC4_04330)

PAN:	PODANSg2029 PODANSg2030

PBEL:

QC761_113050

PPSD:

QC762_113050

PPSP:

QC763_113050

PPSA:

QC764_113050

TTT:	THITE_2112245

MTM:	MYCTH_2296812

CTHR:

CTHT_0009350

MGR:

MGG_00500

PPEI:

PpBr36_08667

PGRI:

PgNI_08849

TMN:	UCRPA7_4792

SSCK:

SPSK_02236

FGR:	FGSG_06870

FPU:	FPSE_11795

FPOA:

FPOAC1_010614

FVN:	FVRRES_11613

FVR:	FVEG_05116

FOX:	FOXG_01956

NHE:	NECHADRAFT_38099

FFC:	NCS54_00563100

FKR:	NCS57_00601000

FMU:	J7337_002633

TRE:	TRIREDRAFT_58363

TRR:	M419DRAFT_33976

TASP:

36607119(TrAFT101_003653)

MAW:	19245318(J3458_004692)

MAJ:

MAA_05725

MBRN:

26238710(mug71)

PCHM:

VFPPC_02988

AMUS:

LMH87_003823

PLJ:	28887509(PLICBS_002755)

PTKZ:

JDV02_001094

VAL:	VDBG_04681 VDBG_04682

VDA:	VDAG_04223

CFJ:	CFIO01_03038

CLUP:

CLUP02_05603

CHIG:

CH63R_00705

CDET:

87939423(CDEST_02920)

ELA:	UCREL1_1438

PFY:	PFICI_01826

SSL:	SS1G_04410

BFU:	BCIN_01g05150(Bcdph6)

MBE:

MBM_08301

PSCO:

LY89DRAFT_607075

GLZ:	GLAREA_04499

AFM:	AFUA_4G09070

ACT:	ACLA_048430

NFI:	NFIA_107100

AOR:	AO090023000649

ANG:	An04g03970

ALUC:

AKAW2_51411A

ACHE:

ACHE_10631S

PCS:	N7525_000644

POU:	POX_b02462

TMF:	EYB26_008051

TRG:	TRUGW13939_00698

CIM:	CIMG_08216

CPW:	CPC735_022280

URE:	UREG_02463

ABE:

ARB_00365

TVE:

TRV_04205

PBL:	PAAG_03286

PBN:	PADG_03156

AJE:	HCAG_07093

BGH:	BDBG_00570

PNO:	SNOG_03779

PTE:

PTT_06876

PTRR:

6341026(PtrM4_063880)

BZE:	COCCADRAFT_21958

BSC:	COCSADRAFT_95267

BOR:	COCMIDRAFT_30308

AALT:

CC77DRAFT_1019761

ARAB:

EKO05_0008134

ZTR:	MYCGRDRAFT_73868

PFJ:	MYCFIDRAFT_31828

CBET:

CB0940_11510

BCOM:

BAUCODRAFT_80130

NPA:	UCRNP2_2687

TML:	GSTUM_00009914001

SPO:	2540717(dph6)

SOM:	SOMG_02257(dph6)

CNE:

CNJ02960

CNB:

CNBJ0560

CNG:	CNAG_04868

CGI:	CGB_J0485W CGB_J0500W

CDEU:

CNBG_5796

CDEP:

91090533(L203_106325)

KMG:	30167942(I203_106957)

KNE:	92182769(IAR55_005511)

TMS:	TREMEDRAFT_40163

TASA:

A1Q1_07026

PPL:	POSPLDRAFT_96100

TVS:	TRAVEDRAFT_70252

PCO:	PHACADRAFT_86977

SHS:	STEHIDRAFT_54099

HIR:	HETIRDRAFT_472254

PSQ:	PUNSTDRAFT_22799

ADL:	AURDEDRAFT_156956

FME:	FOMMEDRAFT_142052

GTR:	GLOTRDRAFT_125792

RSX:	RhiXN_04139

LBC:	LACBIDRAFT_245647

CCI:	CC1G_00411

ABP:	AGABI1DRAFT38553(AGABI1DRAFT_38553)

ABV:	AGABI2DRAFT67613(AGABI2DRAFT_67613)

MPR:	MPER_07596

MRR:	Moror_7461

E1B28_004215

SCM:	SCHCO_02498721(SCHCODRAFT_02498721)

SLA:	SERLADRAFT_360402

WSE:	WALSEDRAFT_61134

WIC:	J056_003599

UMA:	UMAG_11559

PFP:	PFL1_01618

SGRA:

EX895_002543

MRT:

MRET_0007

MSYM:

MSY001_2154

PGR:	PGTG_04940

PTRC:

PtA15_11A507

PSTR:

Pst134EA_017357

MLR:	MELLADRAFT_28793

ECU:	ECU08_1840

EIN:	Eint_081790

EHE:	EHEL_081780

ERO:	EROM_081810

NCE:	NCER_100049

VNX:	VNE69_07295

RIE:	OCT59_017827

MBR:	MONBRDRAFT_14389

SRE:	PTSG_01523

DDI:	DDB_G0278373

DPP:	DICPUDRAFT_30664

DFA:

DFA_01168

EDI:	EDI_078790

EIV:	EIN_224420

ACAN:

ACA1_166560 ACA1_379050

PFA:	PF3D7_1222500

PFH:	PFHG_01614

PGAB:

PGSY75_1222500

PLAG:

39742940(PADL01_1223100)

PYO:	PY17X_1439900

PCB:	PCHAS_1439400

PBE:	PBANKA_1437400

PVV:	PVVCY_1403950

PKN:	PKNH_1441600

PVX:	PVX_123755

PCY:	PCYB_144820

PMAL:

PMUG01_14056800(DPH6)

PBRS:

92373705(MKS88_005618)

PREL:

PRELSG_1438100

PCOT:

PCOAH_00054740

TAN:

TA13205

TPV:

TP02_0444

TOT:	TOT_020000430

BEQ:	BEWA_021790

BBO:	BBOV_III005100

BMIC:

BmR1_04g07195

BBIG:

BBBOND_0309560

CPV:

cgd4_610

CHO:	Chro.40077

TET:	TTHERM_00191860

PTM:	GSPATT00008350001 GSPATT00013073001 GSPATT00015871001

FCY:	FRACYDRAFT_160918

NGD:	NGA_0485810

AAF:	AURANDRAFT_22120

PIF:	PITG_00939

PSOJ:

PHYSODRAFT_553661

SPAR:

SPRG_14835

GTT:	GUITHDRAFT_107532

TCR:

503917.14

NGR:	NAEGRDRAFT_31983

MJA:

MJ_0570

MFE:	Mefer_0771

MVU:	Metvu_0750

MFS:	MFS40622_1547

MIF:	Metin_0265

MJH:	JH146_0786

MESG:

MLAUSG7_0091

MESA:

MLASG1_1277

MIG:	Metig_1371

MMP:

MMP0343

MMQ:	MmarC5_1331

MMX:	MmarC6_0609

MMZ:	MmarC7_1344

MMD:

GYY_01760

MMAK:

MMKA1_03510

MMAO:

MMOS7_03770

MMAD:

MMJJ_07130

MAE:

Maeo_1253

MVN:	Mevan_1353

MVO:

Mvol_1678

MOK:	Metok_1456

METF:

CFE53_01860

MTH:

MTH_432

MMG:	MTBMA_c08270

MWO:	MWSIV6_0816

MTEE:

MTTB_07580

METC:

MTCT_0372

METE:

tca_00397

METZ:

METMT2_0553

METK:

FVF72_00255

MTHM:

FZP57_03905

METJ:

FZP68_08950

MST:

Msp_0563

METB:

AW729_04185

MEIS:

PXD04_06615

MRU:

mru_1231

MSI:

Msm_0142

MEB:

Abm4_0818

MMIL:

sm9_0907

MEYE:

TL18_05745

MOL:

YLM1_0669

MARO:

MarbSA_01690

METV:

K4897_01160

MEL:	Metbo_1158

MEW:	MSWAN_1046

METH:

MBMB1_1181

MFC:

BRM9_1386

MFI:	DSM1535_2085

MCUB:

MCBB_1084

MSUB:

BK009_02375

METN:

BK008_10040

METT:

CIT01_00560

METO:

CIT02_02770

MEME:

HYG87_01210

MFEG:

GCM10025860_18880

MEER:

NKF70_00650

MFV:

Mfer_0659

MKA:

MK0644

AFU:

AF_1666

AFG:	AFULGI_00019150

APO:	Arcpr_0678

AVE:	Arcve_0936

AST:	Asulf_01658

FPL:

Ferp_1978

GAC:

GACE_1487

GAH:

GAH_01683

PFU:

PF0828

PFI:

PFC_03325

PHO:	PH1257(PH1257)

PAB:

PAB0759

PYN:	PNA2_0144 PNA2_1836

PYA:	PYCH_00170

PYS:	Py04_0449 Py04_1196

PYC:	TQ32_01380 TQ32_10715

TKO:

TK2280

TON:

TON_1247

TGA:

TGAM_1854

TSI:

TSIB_1787

TBA:	TERMP_01129

THE:

GQS_09435

THA:

TAM4_39

THM:

CL1_1476

TLT:	OCC_09299 OCC_11964

THS:	TES1_0975 TES1_1180

TNU:

BD01_1627

TEU:	TEU_00195 TEU_09235

TGY:	X802_01995 X802_07610

THV:	ADU37_CDS15740 ADU37_CDS19070

TCH:	CHITON_0543 CHITON_1512

TPEP:

A0127_03965

TPIE:

A7C91_01670

TGG:	A3K92_01910

TCE:	A3L02_03940 A3L02_05680

TBS:	A3L01_06845

THH:	CDI07_06815

TSL:	A3L11_01115

TTD:	A3L14_09235

TPRF:

A3L09_03250 A3L09_09485

TRL:	A3L10_06290

TPAF:

A3L08_00130 A3L08_05910

THY:	A3L12_02075 A3L12_04905

TIC:	FH039_10345

TCQ:	TIRI35C_1678

THEM:

FPV09_11270

THEI:

K1720_01805

PPAC:

PAP_02520 PAP_03190

MBA:	Mbar_A2904

MBY:	MSBRM_1435

MBW:	MSBRW_1834

MBAR:

MSBR2_0970

MBAK:

MSBR3_0267

MAC:

MA_1374

MMA:

MM_2359

MMAZ:

MmTuc01_2410

MMJ:	MSMAS_2340

MMAC:

MSMAC_2105

MVC:	MSVAZ_1776

MEK:	MSKOL_1752

MLS:	MSLAZ_0959

METM:

MSMTP_2170

MEF:	MSWH1_2303

MEQ:	MSWHS_2772

MSJ:	MSSAC_1382

MSZ:	MSSIH_1576

MSW:	MSSIT_1670

MTHR:

MSTHT_0845

MTHE:

MSTHC_2426

MHOR:

MSHOH_2962

MFZ:	AOB57_012270

MBU:

Mbur_0466

MMET:

MCMEM_0897

MELO:

J7W08_02725

MMH:

Mmah_0924

MHAZ:

BHR79_08960

MPOT:

BKM01_08785

MEV:	Metev_1538

MZH:	Mzhil_0704

MPY:

Mpsy_0422

MZI:	HWN40_05455

MHZ:	Metho_1047

MEHF:

MmiHf6_02940

MEES:

MmiEs2_05990

MTP:

Mthe_1352

MCJ:

MCON_2598

MHI:

Mhar_1290

MHU:

Mhun_1584

MRTJ:

KHC33_06135

MLA:

Mlab_0933

MEM:	Memar_1634

MBG:	BN140_2003

MEMA:

MMAB1_2595

MCHK:

MchiMG62_17800

MSUM:

OH143_02385

MRC:	R6Y96_06560

MPI:

Mpet_1270

MEND:

L6E24_13760

MEFW:

F1737_05660

MAQE:

RJ40_11775

MFK:	E2N92_12110

MOU:	OU421_11165

MESB:

L1S32_03150

MANQ:

L1994_05510

MBN:

Mboo_0992

MFO:	Metfor_2416

MPL:

Mpal_1086

MPD:

MCP_2153

MEZ:

Mtc_2164

RCI:

RRC12

HAL:

VNG_0391C

HSL:	OE_1579R(dph6)

HANR:

LJ422_01660

HDL:	HALDL1_06100

HHB:	Hhub_1552(dph6)

HAGS:

JT689_02940

HABO:

JRZ79_01440

HNO:	LT974_02945

HLU:	LT972_10855

HALH:

HTSR_1390

HHSR:

HSR6_1462

HSU:	HLASF_0680

HSF:	HLASA_0676

HAHS:

HSRCO_1030(dph6)

SALR:

FQU85_01800

HALR:

EFA46_006650

HJE:	HacjB3_12690

HDO:	MUK72_12625

HALX:

M0R89_10785

HAXZ:

M0R88_11335

HAYC:

NGM10_05130

HAXY:

NGM07_17805

SALI:

L593_03460

SAIM:

K0C01_07805

HARA:

AArcS_2353(dph6)

HMA:

rrnAC0632

HHI:

HAH_1290

HHN:	HISP_06610

HAB:	SG26_14470

HTA:	BVU17_06295

HALJ:

G9465_08340

HSIN:

KDQ40_07015

NPH:	NP_0382A(dph6)

NMO:	Nmlp_1424(dph6)

NHO:	HWV23_13310

NSAL:

HWV07_05505

HUT:

Huta_2709

HTI:

HTIA_2451

HALA:

Hrd1104_07500

HASV:

SVXHr_1868(dph6)

HABN:

HBNXHr_1856(dph6)

HMU:

Hmuk_2825

HALZ:

E5139_01400

HALL:

LC1Hm_2172(dph6)

HAZP:

GBQ70_01400

HALI:

BV210_03915

HSN:	DV733_14310

HDS:	HSR122_2731(dph6)

HRR:	HZS55_01325

HPEL:

HZS54_07880

HLT:	I7X12_13715

HARC:

HARCEL1_02100

SSAI:

N0B31_00765

HAAD:

MW046_08475

HWA:	HQ_1669A(dph6)

HWC:	Hqrw_1786(dph6)

HVO:	HVO_1077(dph6)

HALE:

G3A49_08615

HLN:	SVXHx_1032(dph6)

HME:

HFX_1082

HGI:	ABY42_05245

HLS:	KU306_10055

HBO:	Hbor_22660

HAQ:	DU484_11535

HAJ:	DU500_11810

HAER:

DU502_09175

HRA:	EI982_04430

HLM:	DV707_12185

HALM:

FCF25_11820

HLA:

Hlac_0801

HALP:

DOS48_04185

HALB:

EKH57_06790

HEZZ:

EO776_05675

HALQ:

Hrr1229_000675

HSAI:

HPS36_01335

HAZZ:

KI388_03125

SRUB:

C2R22_06950

HAE:	halTADL_1774

HALN:

B4589_000685

HALG:

HUG10_02230

HALU:

HUG12_14810

HMP:	K6T50_00420

HRE:	K6T36_00435

HRM:	K6T25_00740

HACB:

Hbl1158_07685

HDF:	AArcSl_0908

HAH:	Halar_0789

HTU:

Htur_1353

HSAL:

JMJ58_01980

HAKZ:

J0X25_13635

NMG:	Nmag_2610(dph6)

HXA:	Halxa_3910

NAT:

NJ7G_4097

NPE:	Natpe_3273

NVR:	FEJ81_15675

NPL:	FGF80_14470

NAY:	HYG81_13205

HALY:

HYG82_17120

HJT:	DVR14_06480

HLO:	J0X27_10685

NGE:	Natgr_0658

HRU:	Halru_1211

SAWL:

NGM29_17290

HALV:

NGM15_08260

NOU:	Natoc_0679 Natoc_4175

HLR:	HALLA_07185

HLC:	CHINAEXTREME00490

NAJ:	B1756_04835

NAG:	AArcMg_0664

NAN:	AArc1_2927

NARA:

QQ977_02205 QQ977_10310

NBG:	DV706_01080 DV706_16190

NAS:	GCU68_12650

HDA:	BB347_02330

NAC:	AQV86_05470

MELU:

MTLP_08060

MEAM:

MU439_05565

MEAE:

QEN48_04595

FAC:	FACI_IFERC01G0266

FAI:

FAD_1184

CDIV:

CPM_0882

TAR:	TALC_00308

MAX:	MMALV_02810

MER:	MMINT_05540

MEAR:

Mpt1_c10770

MEUZ:

KRP56_01495

MARC:

AR505_1512

ABI:

Aboo_1093

ACF:	AciM339_1405

APE:

APE_0421

ACJ:

ACAM_0304

SMR:

Smar_1167

SHC:	Shell_1304

IHO:

Igni_0787

IIS:

EYM_00155

IPC:

IPA_07140

DKA:

DKAM_0999

DFD:	Desfe_1117

DMU:	Desmu_0079

THG:	TCELL_0584

HBU:

Hbut_1070

PFM:	Pyrfu_1060

PDL:	Pyrde_0963

PABI:

PABY_07750

PARE:

PYJP_13500

STO:

STK_20480

SOH:	D1869_11230

SSO:

SSO0678

SOL:

Ssol_1736

SSOA:

SULA_1762

SSOL:

SULB_1763

SSOF:

SULC_1761

SSHI:

J5U23_02732

SCAS:

SACC_03050

SAI:

Saci_0103

SACN:

SacN8_00485

SACR:

SacRon12I_00485

SACS:

SUSAZ_00495

SIS:	LS215_1568

SIA:	M1425_1460

SIM:	M1627_1575

SID:

M164_1457

SIY:	YG5714_1464

SIN:	YN1551_1372

SII:

LD85_1667

SIH:

SiH_1418

SIR:

SiRe_1336

SIC:

SiL_1338

SULA:

BFU36_02675

SULE:

GFS03_08370

SULO:

GFS33_00140

SULL:

EWF20_12390

MSE:

Msed_2025

MEMJ:

MJ1HA_2293

MCN:

Mcup_0263

MPRU:

DFR88_08045

MTEN:

GWK48_03920

MJN:	MjAS7_0326

AHO:

Ahos_0557

AMAN:

B6F84_06465

ABRI:

DFR85_09040

ASUL:

DFR86_05520

AAMB:

D1866_10485

ACIH:

HS5_19220

SACD:

HS1genome_0116

SAZO:

D1868_09710

CSTY:

KN1_04720

STEP:

IC006_1395

SMET:

RQ359_000515

SAHS:

HS7_08400

PAI:

PAE2672

PIS:

Pisl_1875

PCL:

Pcal_0164

PAS:

Pars_1010

PYR:

P186_2602

POG:	Pogu_1278 Pogu_1310

TNE:

Tneu_1245

PYW:	PYWP30_00404 PYWP30_01304

CMA:

Cmaq_1530

TTN:	TTX_0088 TTX_0299

TUZ:	TUZN_0170 TUZN_1236

VDI:

Vdis_1754

VMO:

VMUT_0201

VSO:	Vsou_04410

TPE:

Tpen_1107

THB:	N186_06395

TCB:	TCARB_0347

THEL:

IG193_02715

ASC:

ASAC_0411

ACIA:

SE86_00240 SE86_02920

CLG:	Calag_0969 Calag_1396

FFO:	FFONT_0024 FFONT_0041 FFONT_1384

NMR:

Nmar_0530

NIR:	NSED_02670

NKR:	NKOR_02740

NID:	NPIRD3C_1746

NIN:	NADRNF5_1654

NIW:	Nisw_02225

NCL:	C5F47_02715

NOX:	C5F49_02900

NUE:	C5F50_04005

NIP:	NsoK4_05705

NZT:	NZOSNM25_001483

NCT:

NMSP_1144

NIC:	DSQ20_02950

NGA:	Ngar_c26930

NVN:	NVIE_016140

NEV:

NTE_00775

TAA:	NMY3_02348

NFN:	NFRAN_3124

NCV:

NCAV_1332

CSY:	CENSYa_0420

CSU:	CSUB_C1038

NBV:

T478_0392

TAH:	SU86_003435

NIU:	DSQ19_02715

NCK:	QVH35_06720

NDV:

NDEV_0520

CCAI:

NAS2_1008 NAS2_1478

BARC:

AOA65_1520

BARB:

AOA66_1229

NAA:

Nps_03125

NAER:

MJ1_0705

MARH:

Mia14_0811

FLT:	Sv326_1297

MIY:	Micr_00966

NCON:

LC1Nh_0884(asnB)

WAR:	HYS32_02600

PSYT:

DSAG12_00331 DSAG12_03850

AGW:	QT03_C0001G0076

ARG:	QT11_C0001G0581

» show all

Reference

Authors

Moehring TJ, Moehring JM.

Title

Mutant cultured cells used to study the synthesis of diphthamide.

Journal

UCLA Symp Mol Cell Biol New Ser 45:53-63 (1987)

Reference

2 [PMID:3346227]

Authors

Moehring JM, Moehring TJ.

Title

The post-translational trimethylation of diphthamide studied in vitro.

Journal

J Biol Chem 263:3840-4 (1988)

Reference

3 [PMID:23169644]

Authors

Su X, Lin Z, Chen W, Jiang H, Zhang S, Lin H

Title

Chemogenomic approach identified yeast YLR143W as diphthamide synthetase.

Journal

Proc Natl Acad Sci U S A 109:19983-7 (2012)
DOI:10.1073/pnas.1214346109

Sequence

[sce:YLR143W]

Other DBs

ExplorEnz - The Enzyme Database:

6.3.1.14

IUBMB Enzyme Nomenclature:

6.3.1.14

ExPASy - ENZYME nomenclature database:

6.3.1.14

BRENDA, the Enzyme Database:

6.3.1.14

CAS:	114514-33-9

LinkDB

DBGET integrated database retrieval system