KEGG   ENZYME: 6.3.2.33
Entry
EC 6.3.2.33                 Enzyme                                 
Name
tetrahydrosarcinapterin synthase;
H4MPT:alpha-L-glutamate ligase;
MJ0620;
MptN protein
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
Sysname
tetrahydromethanopterin:alpha-L-glutamate ligase (ADP-forming)
Reaction(IUBMB)
ATP + tetrahydromethanopterin + L-glutamate = ADP + phosphate + 5,6,7,8-tetrahydrosarcinapterin [RN:R09594]
Reaction(KEGG)
R09594
Substrate
ATP [CPD:C00002];
tetrahydromethanopterin [CPD:C01217];
L-glutamate [CPD:C00025]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
5,6,7,8-tetrahydrosarcinapterin [CPD:C18802]
Comment
This enzyme catalyses the biosynthesis of 5,6,7,8-tetrahydrosarcinapterin, a modified form of tetrahydromethanopterin found in the Methanosarcinales. It does not require K+, and does not discriminate between ATP and GTP [1].
History
EC 6.3.2.33 created 2010
Pathway
ec00790  Folate biosynthesis
Orthology
K15740  tetrahydromethanopterin:alpha-L-glutamate ligase
Genes
PAQUDMB82_0020250
PINPing_2322
SPOIIMCC21906_01613
SNANI6N98_15575
MCAMCA2864
METUGNH96_03525
MMTMetme_2266
MDNJT25_019340
MDHAYM39_08545
MKOMKLM6_1779
METLU737_14815
MPADKEF85_11470
MELLIVG45_03935
MAHMEALZ_2426
MBUREQU24_09120
MPSYCEK71_02665
MMAIsS8_3393
MMOBF6R98_19015
MEINmethR_P2100
MOZMoryE10_28860
MISZMishRS11D_40140
MESLKKZ03_09090
TCXTcr_1768
HTREPV75_09480
TCYThicy_0311
TAOTHIAE_08710
THIOAYJ59_04455
TMHJX580_01585
MEJQ7A_45
MECQ7C_1773
MPINLGT42_002850
TXAHQN79_09935
TSETHMIRHAS_05250
TZOTHMIRHAT_19060
BLEPAL038_08770
NOCNoc_0259
NHLNhal_3877
NWANwat_0360
NWRE3U44_04670
NTTTAO_1754
NTGNSCAC_0081(mptN)
HAMHALO3126
HAFC8233_03465
HVNEI420_12615
HOLHORIV_23050
HTTHZS52_20065
CAMHLCW13_07760
MMWMmwyl1_0157
MMEMarme_1385
MPCMar181_0123
MPRIMP3633_0137
MFOIJSY38_09950
NIKF5I99_17995
OMEOLMES_4802
SEDSAAY24_01655
COXE0W60_31935
BUGBC1001_3949
BYIBYI23_B014450(rimK)
BUEBRPE67_BCDS01440(rimK)
BUQAC233_22030
BPHBphy_5945 Bphy_6485
BGEBC1002_3222
BPXBUPH_00533
BCAIK788_0001557
PSPWBJG93_19400
PHSC2L64_21810
PTERC2L65_26160 C2L65_34285
BUOBRPE64_BCDS01580(rimK)
VAPVapar_3081
VPDVAPA_1c31450
MPTMpe_A2610
METPC1M51_15090
LCHLcho_3149
RGERGE_40260(rimK)
METRBSY238_3291
MFAMfla_1657
MMBMmol_1343
MEHM301_1553
MEIMsip34_1501
MEPMPQ_1564(rimK)
MBACBN1209_0748(rimK)
MPAUZMTM_11850
SPLBSFPGR_25970
AZAAZKH_p0272
AZDCDA09_11320
THUAC731_004850
THKCCZ27_13245
DDZDSYM_25700
DSDGD606_05870
DMADMR_18070
DCBC3Y92_08250
DGGDGI_0284
DMSE8L03_06215
DSADesal_3089
DHYDESAM_21527
DAFDesaf_1060
DASDaes_1177
DPIBN4_12184
DEJAWY79_17295
PSELGM415_00290
DDNDND132_2927
DSXGD604_07115
DBADbac_2700
DLIdnl_59780
DMMdnm_097390
ADEAdeh_1691
ACPA2cp1_2254
AFWAnae109_2113
ANKAnaeK_2165
DBRDeba_0382
MCIMesci_4261
MESWA9K65_023625
MESMEJ066_29725
PHTBLM14_23795
RGARGR602_PC01569
XAUXaut_1789
XDIEZH22_07505
SNOSnov_0749
STARG3545_09785
LNEFZC33_09340
ANCGBB76_00745
APRAG3A50_16490
APOLK9D25_20195
MPOMpop_1783
MRDMrad2831_0531
METM446_5781
MNOMnod_6005
MORMOC_0686
MAQUMaq22A_c16480(rimK)
MPHYMCBMB27_00108
MEEDA075_05735
METDC0214_10530
METXA3862_28295
METSDK389_20660
METIDK427_18450
MMESMMSR116_16695
MTEADK419_10800
MINDmvi_45920
MOGMMB17_20020
MSLMsil_2388
MTUNMTUNDRAET4_2724
MLGCWB41_06050
HDNHden_1476
HDTHYPDE_31263
HMCHYPMC_1626
HNIW911_13180
FILBN1229_v1_0585
FIYBN1229_v1_0587
MCGGL4_1785
METGHT051_10185
MSCBN69_1354
MBRYB1812_01095
MROSEHO51_13060
MHEYH2LOC_003820
MPARF7D14_05055
MTWCQW49_13490
PLEOOHA_1_01034(rimK)
HDIHDIA_2313(lysX)
LAPACP90_05820
LABRCHH27_14855
LABTFIU93_11455(lysX)
LAGGB0E33_17375
YANAYJ57_18930
PABYGa0080574_TMP3824
MALUKU6B_45100
TGLHFZ77_12215
PALXGQA70_00045
RHCRGUI_1595
RMBK529_021915
LITFPZ52_13040
PALWPSAL_037890(rimK)
GBEGbCGDNIH1_0772
GBHGbCGDNIH2_0772
GBCGbCGDNIH3_0772
GBSGbCGDNIH4_0772
ALIAZOLI_p10699 AZOLI_p10888
ABQABAZ39_25475
ABFAMK58_22325
ATIAL072_27015
AZTTSH58p_01210
AZMDM194_17145
AOZHUE56_08915
MAGQMGMAQ_0159
BACWQR42_02385
ANXACH33_11280
ATHEK3F53_07725
HASHalsa_0948
SFBCP974_23765
ATLAthai_62040
PSLPsta_3185
PIRVN12_14460(lysX)
MFFMFFC18_17590(rimK_2)
AHELQ31a_62580(lysX_2)
LCREPla8534_62270(rimK_3)
AAGGETAA8_05130(lysX)
BVOPan97_33080(rimK_2)
RLCK227x_27850(rimK_2)
LPAVPLANPX_1004
AMUCPan181_44390(lysX)
PNDPla175_40190(lysX)
PEHSpb1_33560(lysX)
PBSPlabr_4808
PLHVT85_05470(lysX)
FMRFuma_00365(lysX_1)
GPNPan110_11870(rimK_1)
MRIMal4_29790(rimK_1)
SDYNMal52_18790(lysX)
PLONPla110_18950(rimK_2)
TIMGMBLW1_05850
LRSPX52LOC_02774
FTJFTUN_8523
ULIETAA1_18390(lysX)
PBORBSF38_00162(lysX)
AGVOJF2_59290(lysX)
NLIG3M70_11550
MOXDAMO_0462
MJAMJ_0620
MFEMefer_0208
MVUMetvu_0791
MFSMFS40622_1033
MIFMetin_0376
MJHJH146_0844
MESGMLAUSG7_0282(mptN)
MESAMLASG1_1392(mptN)
MIGMetig_0603
MMPMMP0702
MMQMmarC5_0874
MMXMmarC6_0182
MMZMmarC7_1729
MMDGYY_02745
MMAKMMKA1_07550(mptN)
MMAOMMOS7_07480(mptN)
MMADMMJJ_02750(lysX_1)
MAEMaeo_0564
MVNMevan_1580
MVOMvol_0278
MOKMetok_1010
METFCFE53_02140
MBAMbar_A3203
MBYMSBRM_1601
MBWMSBRW_1532
MBARMSBR2_0806
MBAKMSBR3_0066
MACMA_3268(rimK)
MMAMM_0111
MMAZMmTuc01_0117
MMJMSMAS_1220
MMACMSMAC_2562
MVCMSVAZ_2319
MEKMSKOL_2330
MLSMSLAZ_1472
METMMSMTP_1203
MEFMSWH1_2073
MEQMSWHS_3023
MSJMSSAC_1749
MSZMSSIH_2466
MSWMSSIT_2508
MTHRMSTHT_0138
MTHEMSTHC_0590
MHORMSHOH_2484
MFZAOB57_001770
MBUMbur_1276(mptN)
MMETMCMEM_1723
MELOJ7W08_07655
MMHMmah_1581
MHAZBHR79_05815
MEVMetev_0291
MZHMzhil_1580
MPYMpsy_2609
MZIHWN40_09855
MHZMetho_1409
MTPMthe_1118
MCJMCON_0555(mptN)
MHIMhar_2185
MHUMhun_1105
MRTJKHC33_08600
MLAMlab_1175
MEMMemar_1015
MBGBN140_2303
MEMAMMAB1_3062
MCHKMchiMG62_11390
MPIMpet_1310
MPLMpal_2364
SOLSsol_0158
SSOASULA_0150
SSOLSULB_0151
SSOFSULC_0150
SSHIJ5U23_01141
SACNSacN8_04820
SISLS215_0174
SIAM1425_0143
SIMM1627_0143
SIDM164_0162
SIYYG5714_0147
SINYN1551_2746
SIILD85_0147
SIHSiH_0147
SIRSiRe_0143
SICSiL_0134
SULABFU36_10505
SULEGFS03_02265
SULOGFS33_08960
MHKDFR87_03205
MPRUDFR88_03120
MTENGWK48_08920
PISPisl_1747
VDIVdis_2361
VMOVMUT_0713
BARCAOA65_2016(mptN)
LOKILokiarch_28770(mptN)
 » show all
Reference
1  [PMID:12909715]
  Authors
Li H, Xu H, Graham DE, White RH
  Title
Glutathione synthetase homologs encode alpha-L-glutamate ligases for methanogenic coenzyme F420 and tetrahydrosarcinapterin biosyntheses.
  Journal
Proc Natl Acad Sci U S A 100:9785-90 (2003)
DOI:10.1073/pnas.1733391100
  Sequence
[mja:MJ_0620]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.33
IUBMB Enzyme Nomenclature: 6.3.2.33
ExPASy - ENZYME nomenclature database: 6.3.2.33
BRENDA, the Enzyme Database: 6.3.2.33
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