KEGG   ENZYME: 6.3.4.7
Entry
EC 6.3.4.7                  Enzyme                                 
Name
ribose-5-phosphate---ammonia ligase;
5-phosphoribosylamine synthetase;
ribose 5-phosphate aminotransferase;
ammonia-ribose 5-phosphate aminotransferase
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
Sysname
ribose-5-phosphate:ammonia ligase (ADP-forming)
Reaction(IUBMB)
ATP + ribose 5-phosphate + NH3 = ADP + phosphate + 5-phosphoribosylamine [RN:R01053]
Reaction(KEGG)
R01053
Substrate
ATP [CPD:C00002];
ribose 5-phosphate [CPD:C00117];
NH3 [CPD:C00014]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
5-phosphoribosylamine [CPD:C03090]
History
EC 6.3.4.7 created 1972
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:5699059]
  Authors
Reem GH.
  Title
Enzymatic synthesis of 5'-phosphoribosylamine from ribose 5-phosphate and ammonia, an alternate first step in purine biosynthesis.
  Journal
J Biol Chem 243:5695-701 (1968)
Other DBs
ExplorEnz - The Enzyme Database: 6.3.4.7
IUBMB Enzyme Nomenclature: 6.3.4.7
ExPASy - ENZYME nomenclature database: 6.3.4.7
BRENDA, the Enzyme Database: 6.3.4.7
CAS: 9082-52-4
LinkDB

KEGG   REACTION: R01053
Entry
R01053                      Reaction                               
Name
ribose-5-phosphate:ammonia ligase (ADP-forming)
Definition
ATP + D-Ribose 5-phosphate + Ammonia <=> ADP + Orthophosphate + 5-Phosphoribosylamine
Equation
C00002 + C00117 + C00014 <=> C00008 + C00009 + C03090
Reaction class
RC00002  C00002_C00008
RC00431  C00117_C03090
Enzyme
6.3.4.7
Pathway
rn00230  Purine metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 6. Ligase reactions
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.7
     R01053  ATP + D-Ribose 5-phosphate + Ammonia <=> ADP + Orthophosphate + 5-Phosphoribosylamine
Other DBs
RHEA: 13780
LinkDB

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