| Entry |
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| Name |
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| Class |
Ligases;
Forming carbon-carbon bonds;
Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
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| Sysname |
acetophenone:carbon-dioxide ligase (ADP-forming)
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| Reaction(IUBMB) |
2 ATP + acetophenone + HCO3- + H2O + H+ = 2 ADP + 2 phosphate + 3-oxo-3-phenylpropanoate [RN: R05453]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
The enzyme is involved in anaerobic degradation of ethylbenzene. No activity with acetone, butanone, 4-hydroxy-acetophenone or 4-amino-acetophenone.
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| History |
EC 6.4.1.8 created 2011
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K10701 | acetophenone carboxylase |
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| Genes |
| EBA: | c1A100(apc4) c1A102(apc3) c1A105(apc1) c1A200(apc2) c1A97(apc5) |
| ABRE: | pbN1_00090(apcE) pbN1_00100(apcD) pbN1_00110(apcC) pbN1_00130(apcA) |
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| Reference |
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| Authors |
Jobst B, Schuhle K, Linne U, Heider J |
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| Title |
ATP-dependent carboxylation of acetophenone by a novel type of carboxylase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 6.4.1.8 |
| ExPASy - ENZYME nomenclature database: | 6.4.1.8 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 6.4.1.8 |
| BRENDA, the Enzyme Database: | 6.4.1.8 |
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| LinkDB |
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