KEGG   ENZYME: 6.5.1.9
Entry
EC 6.5.1.9                  Enzyme                                 
Name
cyclic 2,3-diphosphoglycerate synthase;
cpgS (gene name)
Class
Ligases;
Forming phosphoric-ester bonds;
Ligases that form phosphoric-ester bonds (only sub-subclass identified to date)
Sysname
(2R)-2,3-bisphosphoglycerate ligase (cyclizing)
Reaction(IUBMB)
ATP + 2,3-diphospho-D-glycerate = ADP + phosphate + cyclic 2,3-bisphosphoglycerate [RN:R03298]
Reaction(KEGG)
R03298
Substrate
ATP [CPD:C00002];
2,3-diphospho-D-glycerate [CPD:C01159]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
cyclic 2,3-bisphosphoglycerate [CPD:C06189]
Comment
The enzyme is present in a number of methanogenic archaeal genera that accumulate cyclic 2,3-bisphosphoglycerate as a thermoprotectant. Activity is stimulated by potassium ions.
History
EC 6.5.1.9 created 2020
Orthology
K05716  cyclic 2,3-diphosphoglycerate synthase
Genes
SRIMCP984_00235
RXYRxyl_1657
RRDRradSPS_1599
RUBGBA63_11675
RMARGBA65_09400
MTHMTH_223
MMGMTBMA_c06720
MWOMWSIV6_0635(cpgS)
MTEEMTTB_08650
METCMTCT_0185
METEtca_00203(cpgS)
METZMETMT2_0667
METKFVF72_01190
MTHMFZP57_03020
METJFZP68_08055
MSTMsp_0129
METBAW729_06490
MRUmru_1017
MSIMsm_0091
MEBAbm4_0688
MMILsm9_0977(cpgS)
MEYETL18_05485
MOLYLM1_0561
MAROMarbSA_04390
METVK4897_00875
MELMetbo_1369
MEWMSWAN_0900
METHMBMB1_1062(cpgS)
MFCBRM9_1264
MFIDSM1535_1947(cpgS)
MCUBMCBB_0929(cpgS)
MSUBBK009_02895
METNBK008_10615
METTCIT01_09550
METOCIT02_02095
MEMEHYG87_09925
MFVMfer_0077
MKAMK0505
PFUPF0079
PFIPFC_07805
PHOPH0150(PH0150)
PABPAB2252
PYNPNA2_0686
PYAPYCH_14400
PYSPy04_0158
TKOTK1039
TONTON_0743
TGATGAM_0725(cdpgs)
TSITSIB_0160
TBATERMP_00452
THEGQS_01210
THATAM4_882
THMCL1_1940
TLTOCC_11502
TNUBD01_0984
TEUTEU_10715
TGYX802_06785
THVADU37_CDS00770
TCHCHITON_0181
TPEPA0127_10020
TPIEA7C91_09860
TGGA3K92_03145
TCEA3L02_08275
TBSA3L01_04480
THHCDI07_04395
TSLA3L11_08580
TTDA3L14_06430
TPRFA3L09_05015
TRLA3L10_02095
TPAFA3L08_07430
THYA3L12_07815
TICFH039_08735
TCQTIRI35C_1153(cpgS)
THEMFPV09_00945
THEIK1720_03865
PPACPAP_07615
 » show all
Reference
1  [PMID:2226838]
  Authors
Lehmacher A, Vogt AB, Hensel R
  Title
Biosynthesis of cyclic 2,3-diphosphoglycerate. Isolation and characterization of 2-phosphoglycerate kinase and cyclic 2,3-diphosphoglycerate synthetase from Methanothermus fervidus.
  Journal
FEBS Lett 272:94-8 (1990)
DOI:10.1016/0014-5793(90)80456-s
Reference
2  [PMID:9811660]
  Authors
Matussek K, Moritz P, Brunner N, Eckerskorn C, Hensel R.
  Title
Cloning, sequencing, and expression of the gene encoding cyclic 2, 3-diphosphoglycerate synthetase, the key enzyme of cyclic 2, 3-diphosphoglycerate metabolism in Methanothermus fervidus.
  Journal
J Bacteriol 180:5997-6004 (1998)
DOI:10.1128/JB.180.22.5997-6004.1998
  Sequence
[mfv:Mfer_0077]
Other DBs
ExplorEnz - The Enzyme Database: 6.5.1.9
IUBMB Enzyme Nomenclature: 6.5.1.9
ExPASy - ENZYME nomenclature database: 6.5.1.9
BRENDA, the Enzyme Database: 6.5.1.9
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