KEGG   COMPOUND: C00735
Entry
C00735                      Compound                               
Name
Cortisol;
Hydrocortisone;
11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione;
Kendall's compound F;
Reichstein's substance M
Formula
C21H30O5
Exact mass
362.2093
Mol weight
362.46
Structure
Remark
Same as: D00088
Reaction
R02834 R02836 R02837 R02838 R02839 R02840 R02841 R02843
R08995
Pathway
map00140  Steroid hormone biosynthesis
map01100  Metabolic pathways
map04080  Neuroactive ligand-receptor interaction
map04927  Cortisol synthesis and secretion
map04934  Cushing syndrome
map04960  Aldosterone-regulated sodium reabsorption
map04976  Bile secretion
map05200  Pathways in cancer
map05215  Prostate cancer
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Module
M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Network
nt06019  Steroid hormone biosynthesis
nt06227  Nuclear receptor signaling (cancer)
nt06272  Prostate cancer
nt06310  CRH-ACTH-cortisol signaling
nt06360  Cushing syndrome
Enzyme
1.1.1.145       1.1.1.146       1.1.1.-         1.3.1.3         
1.14.14.16      1.14.15.4       2.3.1.27        2.8.2.18        
5.3.3.1
Brite
Compounds with biological roles [BR:br08001]
 Steroids
  21-Carbon atoms
   Pregnane derivatives
    C00735  Cortisol
 Hormones and transmitters
  Steroid hormones
   Glucocorticoids
    C00735  Cortisol
Lipids [BR:br08002]
 ST  Sterol lipids
  ST02 Steroids
   ST0203 C21 steroids (gluco/mineralocorticoids, progestogins) and derivatives
    C00735  Cortisol
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Low Potency
    Hydrocortisone
     D00088  Hydrocortisone (JP18/USP/INN)
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D00088  Hydrocortisone (JP18/USP/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Hydrocortisone
    D00088  Hydrocortisone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2452  Cortisones
     D00088  Hydrocortisone (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00088  Hydrocortisone (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone
    D00088  Hydrocortisone (JP18/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone
    D00088  Hydrocortisone (JP18/USP/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
     D00088  Hydrocortisone
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D00088  Hydrocortisone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
    D00088  Hydrocortisone
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D00088  Hydrocortisone
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D00088  Hydrocortisone
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00088  Hydrocortisone
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00088
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00088
Topical steroids potency [br08317.html]
 Classification in the USA
  D00088
Rx-to-OTC switch list in the USA [br08315.html]
 D00088
Other DBs
CAS: 50-23-7
PubChem: 3998
ChEBI: 17650 180955
LIPIDMAPS: LMST02030001
PDB-CCD: HCY[PDBj]
NIKKAJI: J1.908I
LinkDB
KCF data

ATOM        26
            1   C1y C    25.3915  -16.8055
            2   C1y C    24.2081  -17.4875
            3   C1z C    25.3915  -15.4414
            4   C1x C    27.7583  -16.8055
            5   C1y C    23.0247  -16.8055
            6   C1x C    24.1965  -18.8575
            7   C1z C    26.5809  -14.7535
            8   C1x C    24.2081  -14.7535
            9   C1a C    25.3858  -14.0713
            10  C1x C    27.7583  -15.4414
            11  C1z C    21.8356  -17.4875
            12  C1y C    23.0247  -15.4414
            13  C1x C    23.0247  -19.5395
            14  C5a C    26.5866  -13.3893
            15  C2y C    21.8356  -18.8575
            16  C1x C    20.6579  -16.8055
            17  C1a C    21.8239  -16.1233
            18  O1a O    21.8356  -14.7535
            19  C1b C    27.7643  -12.7072
            20  O5a O    25.3975  -12.7072
            21  C2x C    20.6579  -19.5395
            22  C1x C    19.4687  -17.4875
            23  O1a O    28.9534  -13.3951
            24  C5x C    19.4687  -18.8575
            25  O5x O    18.2853  -19.5395
            26  O1a O    27.9332  -14.3911
BOND        29
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1 #Up
            14   11  15 1
            15   11  16 1
            16   11  17 1 #Up
            17   12  18 1 #Up
            18   14  19 1
            19   14  20 2
            20   15  21 2
            21   16  22 1
            22   19  23 1
            23   21  24 1
            24   24  25 2
            25    7  10 1
            26    8  12 1
            27   13  15 1
            28   22  24 1
            29    7  26 1 #Down

» Japanese version

KEGG   DRUG: Hydrocortisone
Entry
D00088                      Drug                                   
Name
Hydrocortisone (JP18/USP/INN);
HC;
Acticort (TN);
Anusol HC (TN);
Colocort (TN);
Cortef (TN);
Hytone (TN);
Plenadren (TN)
Product
CORTEF (Pharmacia & Upjohn Company LLC), CORTEF (REMEDYREPACK), CORTENEMA (ANI Pharmaceuticals), HYDROCORTISONE (Eton Pharmaceuticals)
  Generic
ALA-SCALP (Derm Ventures LLC), ALACORT (Crown Laboratories), ANUSOL (Salix Pharmaceuticals), HYDROCORTISONE (A-S Medication Solutions), HYDROCORTISONE (A-S Medication Solutions), HYDROCORTISONE (A-S Medication Solutions), HYDROCORTISONE (A-S Medication Solutions), HYDROCORTISONE (A-S Medication Solutions), HYDROCORTISONE (ANI Pharmaceuticals), HYDROCORTISONE (ANI Pharmaceuticals), HYDROCORTISONE (Actavis Pharma), HYDROCORTISONE (Actavis Pharma), HYDROCORTISONE (Allegis Holdings LLC), HYDROCORTISONE (American Health Packaging), HYDROCORTISONE (Amneal Pharmaceuticals of New York LLC), HYDROCORTISONE (Asclemed USA), HYDROCORTISONE (Asclemed USA), HYDROCORTISONE (Asclemed USA), HYDROCORTISONE (Aurobindo Pharma Limited), HYDROCORTISONE (AvPAK), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Bryant Ranch Prepack), HYDROCORTISONE (Chartwell RX), HYDROCORTISONE (Chartwell RX), HYDROCORTISONE (Crown Laboratories), HYDROCORTISONE (DIRECT RX), HYDROCORTISONE (DIRECT RX), HYDROCORTISONE (E. Fougera & Co. a division of Fougera Pharmaceuticals), HYDROCORTISONE (E. Fougera & Co. a division of Fougera Pharmaceuticals), HYDROCORTISONE (E. Fougera & Co. a division of Fougera Pharmaceuticals), HYDROCORTISONE (Greenstone LLC), HYDROCORTISONE (Major Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (NuCare Pharmaceuticals), HYDROCORTISONE (PD-Rx Pharmaceuticals), HYDROCORTISONE (Padagis Israel Pharmaceuticals), HYDROCORTISONE (Padagis Israel Pharmaceuticals), HYDROCORTISONE (Preferred Pharmaceuticals), HYDROCORTISONE (Preferred Pharmaceuticals), HYDROCORTISONE (Preferred Pharmaceuticals), HYDROCORTISONE (Preferred Pharmaceuticals), HYDROCORTISONE (Preferred Pharmaceuticals), HYDROCORTISONE (Proficient Rx LP), HYDROCORTISONE (Proficient Rx LP), HYDROCORTISONE (Proficient Rx LP), HYDROCORTISONE (REMEDYREPACK), HYDROCORTISONE (RPK Pharmaceuticals), HYDROCORTISONE (RPK Pharmaceuticals), HYDROCORTISONE (RPK Pharmaceuticals), HYDROCORTISONE (RPK Pharmaceuticals), HYDROCORTISONE (RPK Pharmaceuticals), HYDROCORTISONE (RedPharm Drug), HYDROCORTISONE (RedPharm Drug), HYDROCORTISONE (Redpharm Drug), HYDROCORTISONE (Strides Pharma Science Limited), HYDROCORTISONE (Strides Pharma), HYDROCORTISONE (Taro Pharmaceuticals U.S.A.), HYDROCORTISONE CREAM (Direct_Rx), HYDROCORTISONE RECTAL SUSPENSION (RETENTION) (Chartwell RX LLC), PROCTO-MED HC (Leading Pharma), PROCTO-MED HC (NuCare Pharmaceuticals), PROCTOCORT (Salix Pharmaceuticals), PROCTOSOL-HC (Bryant Ranch Prepack), PROCTOSOL-HC (Sun Pharmaceutical Industries), PROCTOZONE-HC (Bryant Ranch Prepack), PROCTOZONE-HC (Bryant Ranch Prepack), PROCTOZONE-HC (Bryant Ranch Prepack), PROCTOZONE-HC (NuCare Pharmaceuticals), PROCTOZONE-HC (Preferred Pharmaceuticals), PROCTOZONE-HC (Rising Pharma Holdings), TEXACORT (Mission Pharmacal Company)
Formula
C21H30O5
Exact mass
362.2093
Mol weight
362.46
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Dermatological agent
 DG03243  Atopic dermatitis agent
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Same as: C00735
Therapeutic category: 2452
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Product (mixture): D04699<JP> D04776<JP> D04801<JP> D08827<JP> D08828<JP> D11582<US> D11627<US> D11855<US> D12134<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Ulcerative colitis [DS:H01466]
Primary or secondary adrenocortical insufficiency [DS:H01598]
Psoriatic arthritis [DS:H01507]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Ankylosing spondylitis [DS:H01674]
Acute gouty arthritis [DS:H01532]
Systemic lupus erythematosus [DS:H00080]
Pemphigus [DS:H01648]
Severe erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Mycosis fungoides [DS:H01463]
Psoriasis [DS:H01656]
Seborrheic dermatitis [DS:H01652]
Seasonal or perennial allergic rhinitis [DS:H01360]
Bronchial asthma [DS:H00079]
Contact dermatitis [DS:H01357]
Atopic dermatitis [DS:H01358]
Herpes zoster ophthalmicus [DS:H00366]
Optic neuritis [DS:H01717]
Pulmonary tuberculosis [DS:H00342]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Nephrotic syndrome [DS:H01657]
Ulcerative colitis [DS:H01466]
Multiple sclerosis [DS:H01490]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Low Potency
    Hydrocortisone
     D00088  Hydrocortisone (JP18/USP/INN)
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D00088  Hydrocortisone (JP18/USP/INN)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Hydrocortisone
    D00088  Hydrocortisone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2452  Cortisones
     D00088  Hydrocortisone (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00088  Hydrocortisone (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone
    D00088  Hydrocortisone (JP18/USP/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone
    D00088  Hydrocortisone (JP18/USP/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
     D00088  Hydrocortisone
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D00088  Hydrocortisone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
    D00088  Hydrocortisone
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D00088  Hydrocortisone
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D00088  Hydrocortisone
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00088  Hydrocortisone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00088  Hydrocortisone
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00088
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00088
Topical steroids potency [br08317.html]
 Classification in the USA
  D00088
Rx-to-OTC switch list in the USA [br08315.html]
 D00088
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
Other DBs
CAS: 50-23-7
PubChem: 7847156
ChEBI: 17650
PDB-CCD: HCY[PDBj]
LigandBox: D00088
NIKKAJI: J1.908I
LinkDB
KCF data

ATOM        26
            1   C1y C    25.3915  -16.8055
            2   C1y C    24.2081  -17.4875
            3   C1z C    25.3915  -15.4414
            4   C1x C    27.7583  -16.8055
            5   C1y C    23.0247  -16.8055
            6   C1x C    24.1965  -18.8575
            7   C1z C    26.5809  -14.7535
            8   C1x C    24.2081  -14.7535
            9   C1a C    25.3858  -14.0713
            10  C1x C    27.7583  -15.4414
            11  C1z C    21.8356  -17.4875
            12  C1y C    23.0247  -15.4414
            13  C1x C    23.0247  -19.5395
            14  C5a C    26.5866  -13.3893
            15  C2y C    21.8356  -18.8575
            16  C1x C    20.6579  -16.8055
            17  C1a C    21.8239  -16.1233
            18  O1a O    21.8356  -14.7535
            19  C1b C    27.7643  -12.7072
            20  O5a O    25.3975  -12.7072
            21  C2x C    20.6579  -19.5395
            22  C1x C    19.4687  -17.4875
            23  O1a O    28.9534  -13.3951
            24  C5x C    19.4687  -18.8575
            25  O5x O    18.2853  -19.5395
            26  O1a O    27.9332  -14.3911
BOND        29
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1 #Up
            14   11  15 1
            15   11  16 1
            16   11  17 1 #Up
            17   12  18 1 #Up
            18   14  19 1
            19   14  20 2
            20   15  21 2
            21   16  22 1
            22   19  23 1
            23   21  24 1
            24   24  25 2
            25    7  10 1
            26    8  12 1
            27   13  15 1
            28   22  24 1
            29    7  26 1 #Down

» Japanese version   » Back

KEGG   DRUG: Hydrocortisone acetate
Entry
D00165                      Drug                                   
Name
Hydrocortisone acetate (JP18/USP);
Cortifoam (TN);
U-cort (TN)
Product
CORTIFOAM (Meda Pharmaceuticals)
  Generic
U-CORT (Taro Pharmaceuticals U.S.A.)
Formula
C23H32O6
Exact mass
404.2199
Mol weight
404.50
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Same as: C02821
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Product (mixture): D02139<US> D04425<JP> D04806<JP> D04879<JP> D11657<US> D11855<US> D12134<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Ulcerative proctitis [DS:H01466]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D00165  Hydrocortisone acetate (JP18/USP) <US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D00165  Hydrocortisone acetate (JP18/USP) <US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D00165  Hydrocortisone acetate (JP18/USP) <US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D00165  Hydrocortisone acetate (JP18/USP) <US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D00165  Hydrocortisone acetate (JP18/USP) <US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D00165  Hydrocortisone acetate (JP18/USP) <US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D00165  Hydrocortisone acetate (JP18/USP) <US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D00165  Hydrocortisone acetate (JP18/USP) <US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D00165  Hydrocortisone acetate (JP18/USP) <US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Low Potency
    Hydrocortisone
     D00165  Hydrocortisone acetate (JP18/USP)
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D00165  Hydrocortisone acetate (JP18/USP)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Hydrocortisone
    D00165  Hydrocortisone acetate (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for  urogenital organs and anus
  30 Hemorrhoid drugs for external use
   D00165  Hydrocortisone acetate (JP18/USP)
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00165  Hydrocortisone acetate (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone acetate
    D00165  Hydrocortisone acetate (JP18/USP)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone acetate
    D00165  Hydrocortisone acetate (JP18/USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
     D00165  Hydrocortisone acetate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
    D00165  Hydrocortisone acetate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D00165  Hydrocortisone acetate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00165  Hydrocortisone acetate (JP18/USP) <US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00165  Hydrocortisone acetate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00165
Rx-to-OTC switch list in the USA [br08315.html]
 D00165
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
Other DBs
CAS: 50-03-3
PubChem: 7847233
ChEBI: 17609
LigandBox: D00165
NIKKAJI: J4.096G
LinkDB
KCF data

ATOM        29
            1   C1z C    29.2845  -16.8454
            2   C1y C    29.2784  -18.2246
            3   C1z C    30.4784  -16.1589
            4   C1x C    28.0785  -16.1650
            5   C1a C    29.2723  -15.4970
            6   C1y C    28.0848  -18.9235
            7   C1x C    31.6349  -18.1731
            8   C1x C    31.6410  -16.8330
            9   C5a C    30.4845  -14.8105
            10  O1a O    31.7443  -15.7389
            11  C1y C    26.9219  -16.7898
            12  C1y C    26.9406  -18.0576
            13  C1x C    28.0909  -20.2966
            14  C1b C    31.7895  -14.0498
            15  O5a O    29.3216  -14.1364
            16  O1a O    25.7160  -16.1960
            17  C1z C    25.7160  -18.9298
            18  C1x C    26.9035  -20.9706
            19  O7a O    33.1255  -14.8786
            20  C2y C    25.7160  -20.2903
            21  C1x C    24.5346  -18.2555
            22  C1a C    25.7407  -17.5380
            23  C7a C    34.3501  -14.3158
            24  C2x C    24.5346  -20.9769
            25  C1x C    23.3719  -18.9298
            26  C1a C    35.5006  -14.7920
            27  O6a O    34.3748  -12.9056
            28  C5x C    23.3719  -20.2903
            29  O5x O    22.2029  -20.9583
BOND        32
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     3  10 1 #Down
            10    4  11 1
            11    6  12 1
            12    6  13 1
            13    9  14 1
            14    9  15 2
            15   11  16 1 #Up
            16   12  17 1
            17   13  18 1
            18   14  19 1
            19   17  20 1
            20   17  21 1
            21   17  22 1 #Up
            22   19  23 1
            23   20  24 2
            24   21  25 1
            25   23  26 1
            26   23  27 2
            27   24  28 1
            28   28  29 2
            29    7   8 1
            30   11  12 1
            31   18  20 1
            32   25  28 1

» Japanese version   » Back

KEGG   DRUG: Hydrocortisone cypionate
Entry
D00976                      Drug                                   
Name
Hydrocortisone cypionate
Formula
C29H42O6
Exact mass
486.2981
Mol weight
486.64
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Same as: C08176
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D00976  Hydrocortisone cypionate
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D00976  Hydrocortisone cypionate
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D00976  Hydrocortisone cypionate
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D00976  Hydrocortisone cypionate
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D00976  Hydrocortisone cypionate
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D00976  Hydrocortisone cypionate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D00976  Hydrocortisone cypionate
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D00976  Hydrocortisone cypionate
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D00976  Hydrocortisone cypionate
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
     D00976  Hydrocortisone cypionate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
    D00976  Hydrocortisone cypionate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00976  Hydrocortisone cypionate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00976
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
Other DBs
CAS: 508-99-6
PubChem: 7848039
ChEBI: 5783
LigandBox: D00976
NIKKAJI: J6.244H
LinkDB
KCF data

ATOM        35
            1   C1z C    25.0600   -9.1000
            2   C1y C    25.0600  -10.5000
            3   C1z C    26.2500   -8.4000
            4   C1x C    23.9400   -8.4700
            5   C1a C    24.9900   -7.8400
            6   C1y C    23.9400  -11.2000
            7   C1x C    27.4400  -10.5000
            8   C1x C    27.4400   -9.1000
            9   C5a C    26.2500   -7.0700
            10  O1a O    27.5800   -8.1200
            11  C1y C    22.7500   -9.1700
            12  C1y C    22.7500  -10.5000
            13  C1x C    23.9400  -12.5300
            14  C1b C    27.5100   -6.3700
            15  O5a O    24.9900   -6.3700
            16  O1a O    21.4900   -8.4700
            17  C1z C    21.5600  -11.2000
            18  C1x C    22.7500  -13.2300
            19  O7a O    28.7000   -7.1400
            20  C2y C    21.5600  -12.5300
            21  C1x C    20.3700  -10.5000
            22  C1a C    21.4900   -9.8700
            23  C7a C    29.8900   -6.4400
            24  C2x C    20.3700  -13.2300
            25  C1x C    19.1800  -11.2000
            26  C1b C    31.1500   -7.1400
            27  O6a O    29.8900   -5.0400
            28  C5x C    19.1800  -12.6000
            29  C1b C    32.3400   -6.4400
            30  O5x O    17.9900  -13.3000
            31  C1y C    33.5300   -7.1400
            32  C1x C    33.9500   -8.4700
            33  C1x C    34.6500   -6.3000
            34  C1x C    35.3500   -8.4700
            35  C1x C    35.8400   -7.1400
BOND        39
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     3  10 1 #Down
            10    4  11 1
            11    6  12 1
            12    6  13 1
            13    9  14 1
            14    9  15 2
            15   11  16 1 #Up
            16   12  17 1
            17   13  18 1
            18   14  19 1
            19   17  20 1
            20   17  21 1
            21   17  22 1 #Up
            22   19  23 1
            23   20  24 2
            24   21  25 1
            25   23  26 1
            26   23  27 2
            27   24  28 1
            28   26  29 1
            29   28  30 2
            30   29  31 1
            31   31  32 1
            32   31  33 1
            33   32  34 1
            34   33  35 1
            35    7   8 1
            36   11  12 1
            37   18  20 1
            38   25  28 1
            39   34  35 1

» Japanese version   » Back

KEGG   DRUG: Hydrocortisone sodium phosphate
Entry
D00977                      Drug                                   
Name
Hydrocortisone sodium phosphate (JP18/USP);
Hydrocortone phosphate (TN)
Formula
C21H29O8P. 2Na
Exact mass
486.1395
Mol weight
486.40
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Therapeutic category: 2452
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D00977  Hydrocortisone sodium phosphate (JP18/USP) <JP>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D00977  Hydrocortisone sodium phosphate (JP18/USP) <JP>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D00977  Hydrocortisone sodium phosphate (JP18/USP) <JP>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D00977  Hydrocortisone sodium phosphate (JP18/USP) <JP>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D00977  Hydrocortisone sodium phosphate (JP18/USP) <JP>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D00977  Hydrocortisone sodium phosphate (JP18/USP) <JP>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D00977  Hydrocortisone sodium phosphate (JP18/USP) <JP>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D00977  Hydrocortisone sodium phosphate (JP18/USP) <JP>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D00977  Hydrocortisone sodium phosphate (JP18/USP) <JP>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D00977  Hydrocortisone sodium phosphate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2452  Cortisones
     D00977  Hydrocortisone sodium phosphate (JP18/USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
     D00977  Hydrocortisone sodium phosphate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
    D00977  Hydrocortisone sodium phosphate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D00977  Hydrocortisone sodium phosphate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00977  Hydrocortisone sodium phosphate (JP18/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00977  Hydrocortisone sodium phosphate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00977
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
Other DBs
CAS: 6000-74-4
PubChem: 7848040
ChEBI: 5781
LigandBox: D00977
NIKKAJI: J8.330E
LinkDB
KCF data

ATOM        32
            1   C1z C    13.5800  -13.7200
            2   C1y C    13.5800  -15.0500
            3   C1z C    14.7700  -13.0200
            4   C1x C    12.3900  -13.0200
            5   C1a C    13.5800  -12.3900
            6   C1y C    12.4600  -15.7500
            7   C1x C    15.9600  -15.0500
            8   C1x C    15.9600  -13.7200
            9   C5a C    14.7700  -11.6900
            10  O1a O    16.1000  -12.7400
            11  C1y C    11.2700  -13.7200
            12  C1y C    11.2700  -15.1200
            13  C1x C    12.4600  -17.1500
            14  C1b C    15.9600  -10.9900
            15  O5a O    13.5100  -10.9900
            16  O1a O    10.0100  -13.0200
            17  C1z C    10.0800  -15.7500
            18  C1x C    11.2700  -17.7800
            19  O2b O    17.1500  -11.7600
            20  C2y C    10.0800  -17.1500
            21  C1x C     8.8900  -15.1200
            22  C1a C    10.0100  -14.4900
            23  P1b P    18.4100  -11.0600
            24  C2x C     8.9600  -17.8500
            25  C1x C     7.7000  -15.7500
            26  C5x C     7.7000  -17.2200
            27  O5x O     6.5100  -17.8500
            28  O1c O    18.9700  -12.3200 #-
            29  O1c O    19.6000  -10.2900 #-
            30  O1c O    17.6400   -9.8700
            31  Z   Na   20.7200  -12.3200 #+
            32  Z   Na   21.3500  -10.2900 #+
BOND        33
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     3  10 1 #Down
            10    4  11 1
            11    6  12 1
            12    6  13 1
            13    9  14 1
            14    9  15 2
            15   11  16 1 #Up
            16   12  17 1
            17   13  18 1
            18   14  19 1
            19   17  20 1
            20   17  21 1
            21   17  22 1 #Up
            22   19  23 1
            23   20  24 2
            24   21  25 1
            25   24  26 1
            26   26  27 2
            27    7   8 1
            28   11  12 1
            29   18  20 1
            30   25  26 1
            31   23  28 1
            32   23  29 1
            33   23  30 2

» Japanese version   » Back

KEGG   DRUG: Hydrocortisone sodium succinate
Entry
D00978                      Drug                                   
Name
Hydrocortisone sodium succinate (JP18/USP);
A-hydrocort (TN);
Solu-cortef (TN)
Product
SOLU-CORTEF (Cardinal Health 107), SOLU-CORTEF (HF Acquisition Co. LLC), SOLU-CORTEF (HF Acquisition Co. LLC), SOLU-CORTEF (Pharmacia & Upjohn Company LLC)
Formula
C25H33O8. Na
Exact mass
484.2073
Mol weight
484.51
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Dermatological agent
 DG03243  Atopic dermatitis agent
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Same as: C08178
Therapeutic category: 2452
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Asthma [DS:H00079]
Atopic dermatitis [DS:H01358]
Contact dermatitis [DS:H01357]
Perennial or seasonal allergic rhinitis [DS:H01360]
Bullous dermatitis herpetiformis [DS:H01362]
Mycosis fungoides [DS:H01463]
Pemphigus [DS:H01648]
Severe erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Ulcerative colitis [DS:H01466]
Acquired (autoimmune) hemolytic anemia [DS:H01585]
Diamond-Blackfan anemia [DS:H00237]
Pure red cell aplasia [DS:H01586]
Multiple sclerosis [DS:H01490]
Nephrotic syndrome [DS:H01657]
Pulmonary tuberculosis [DS:H00342]
Ankylosing spondylitis [DS:H01674]
Psoriatic arthritis [DS:H01507]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Dermatomyositis [DS:H01604]
Temporal arteritis [DS:H01698]
Polymyositis [DS:H01604]
Systemic lupus erythematosus [DS:H00080]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D00978  Hydrocortisone sodium succinate (JP18/USP) <JP/US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D00978  Hydrocortisone sodium succinate (JP18/USP) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D00978  Hydrocortisone sodium succinate (JP18/USP) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D00978  Hydrocortisone sodium succinate (JP18/USP) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D00978  Hydrocortisone sodium succinate (JP18/USP) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D00978  Hydrocortisone sodium succinate (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D00978  Hydrocortisone sodium succinate (JP18/USP) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D00978  Hydrocortisone sodium succinate (JP18/USP) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D00978  Hydrocortisone sodium succinate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D00978  Hydrocortisone sodium succinate (JP18/USP)
 Inflammatory Bowel Disease Agents
  Glucocorticoids
   Hydrocortisone
    D00978  Hydrocortisone sodium succinate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2452  Cortisones
     D00978  Hydrocortisone sodium succinate (JP18/USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
     D00978  Hydrocortisone sodium succinate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D00978  Hydrocortisone sodium succinate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
    D00978  Hydrocortisone sodium succinate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D00978  Hydrocortisone sodium succinate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D00978  Hydrocortisone sodium succinate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D00978  Hydrocortisone sodium succinate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00978  Hydrocortisone sodium succinate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00978
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
Other DBs
CAS: 125-04-2
PubChem: 7848041
ChEBI: 5782
LigandBox: D00978
NIKKAJI: J5.365A
LinkDB
KCF data

ATOM        34
            1   C1z C    20.9235  -16.1233
            2   C1y C    20.9409  -17.4723
            3   C1z C    22.0855  -15.4342
            4   C1x C    19.7729  -15.4518
            5   C1a C    20.9231  -14.8152
            6   C1y C    19.7846  -18.1554
            7   C1x C    23.2184  -17.5247
            8   C1x C    23.2710  -16.0999
            9   C5a C    22.1496  -13.8520
            10  O1a O    23.4403  -15.0020
            11  C1y C    18.5875  -16.1349
            12  C1y C    18.5935  -17.4840
            13  C1x C    19.7846  -19.5044
            14  C1b C    23.3877  -13.1980
            15  O5a O    20.9351  -13.1512
            16  O1a O    17.3613  -15.4401
            17  C1z C    17.4431  -18.1613
            18  C1x C    18.6109  -20.1935
            19  O7a O    24.5848  -13.9512
            20  C2y C    17.4548  -19.5161
            21  C1x C    16.2577  -17.4956
            22  C1a C    17.4310  -16.8708
            23  C7a C    25.7994  -13.2505
            24  C2x C    16.2693  -20.2109
            25  C1x C    15.0839  -18.1730
            26  C1b C    27.0082  -13.9512
            27  O6a O    25.7877  -11.8373
            28  C5x C    15.0605  -19.6037
            29  C1b C    28.2170  -13.2505
            30  O5x O    13.8751  -20.2402
            31  C6a C    29.4141  -13.9512
            32  O6a O    29.4081  -15.3351
            33  O6a O    30.5761  -13.1980 #-
            34  Z   Na   33.3791  -13.5130 #+
BOND        36
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     3  10 1 #Down
            10    4  11 1
            11    6  12 1
            12    6  13 1
            13    9  14 1
            14    9  15 2
            15   11  16 1 #Up
            16   12  17 1
            17   13  18 1
            18   14  19 1
            19   17  20 1
            20   17  21 1
            21   17  22 1 #Up
            22   19  23 1
            23   20  24 2
            24   21  25 1
            25   23  26 1
            26   23  27 2
            27   24  28 1
            28   26  29 1
            29   28  30 2
            30   29  31 1
            31   31  32 2
            32   31  33 1
            33    7   8 1
            34   11  12 1
            35   18  20 1
            36   25  28 1

» Japanese version   » Back

KEGG   DRUG: Hydrocortisone succinate
Entry
D01442                      Drug                                   
Name
Hydrocortisone succinate (JP18)
Formula
C25H34O8
Exact mass
462.2254
Mol weight
462.53
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Same as: C12888
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D01442  Hydrocortisone succinate (JP18)
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D01442  Hydrocortisone succinate (JP18)
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D01442  Hydrocortisone succinate (JP18)
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D01442  Hydrocortisone succinate (JP18)
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D01442  Hydrocortisone succinate (JP18)
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D01442  Hydrocortisone succinate (JP18)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D01442  Hydrocortisone succinate (JP18)
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D01442  Hydrocortisone succinate (JP18)
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D01442  Hydrocortisone succinate (JP18)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
     D01442  Hydrocortisone succinate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
    D01442  Hydrocortisone succinate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01442  Hydrocortisone succinate (JP18)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01442  Hydrocortisone succinate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01442
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
Other DBs
CAS: 2203-97-6
PubChem: 7848505
ChEBI: 31677
LigandBox: D01442
NIKKAJI: J7.358J
LinkDB
KCF data

ATOM        33
            1   C1y C    22.3789  -17.5209
            2   C1y C    21.1942  -18.2036
            3   C1z C    22.3789  -16.1552
            4   C1x C    24.7483  -17.5209
            5   C1y C    20.0095  -17.5209
            6   C1x C    21.1825  -19.5751
            7   C1z C    23.5695  -15.4666
            8   C1x C    21.1942  -15.4666
            9   C1a C    22.3731  -14.7837
            10  C1x C    24.7483  -16.1552
            11  C1z C    18.8191  -18.2036
            12  C1y C    20.0095  -16.1552
            13  C1x C    20.0095  -20.2578
            14  C5a C    23.5753  -14.1010
            15  O1a O    24.9118  -15.0931
            16  C2y C    18.8191  -19.5751
            17  C1x C    17.6401  -17.5209
            18  C1a C    18.8074  -16.8380
            19  O1a O    18.8191  -15.4666
            20  C1b C    24.7542  -13.4181
            21  O5a O    22.3848  -13.4181
            22  C2x C    17.6401  -20.2578
            23  C1x C    16.4497  -18.2036
            24  O7a O    25.9447  -14.1067
            25  C5x C    16.4497  -19.5751
            26  O5x O    15.2650  -20.2578
            27  C7a C    27.1454  -13.4076
            28  C1b C    28.3513  -14.0988
            29  C1b C    29.5571  -13.4007
            30  C6a C    30.7630  -14.0917
            31  O6a O    27.1407  -12.0114
            32  O6a O    30.7674  -15.4879
            33  O6a O    31.9699  -13.3897
BOND        36
            1     3   8 1
            2     3   9 1 #Up
            3     4  10 1
            4     5  11 1
            5     5  12 1
            6     6  13 1
            7     7  14 1 #Up
            8     7  15 1 #Down
            9    11  16 1
            10   11  17 1
            11   11  18 1 #Up
            12   12  19 1 #Up
            13   14  20 1
            14   14  21 2
            15   16  22 2
            16   17  23 1
            17   20  24 1
            18   22  25 1
            19   25  26 2
            20    7  10 1
            21    8  12 1
            22   13  16 1
            23   23  25 1
            24   24  27 1
            25    1   2 1
            26   27  28 1
            27    1   3 1
            28   28  29 1
            29    1   4 1
            30   29  30 1
            31    2   5 1
            32   27  31 2
            33    2   6 1
            34   30  32 2
            35    3   7 1
            36   30  33 1

» Japanese version   » Back

KEGG   DRUG: Hydrocortisone butyrate
Entry
D01619                      Drug                                   
Name
Hydrocortisone butyrate (JP18/USP);
Locoid (TN)
Product
HYDROCORTISONE BUTYRATE (Oceanside Pharmaceuticals), LOCOID (Bausch Health US), LOCOID LIPOCREAM (Bausch Health US)
  Generic
HYDROCORTISONE BUTYRATE (Glenmark Pharmaceuticals), HYDROCORTISONE BUTYRATE (Lupin Pharmaceuticals), HYDROCORTISONE BUTYRATE (Oceanside Pharmaceuticals), HYDROCORTISONE BUTYRATE (Oceanside Pharmaceuticals), HYDROCORTISONE BUTYRATE (Taro Pharmaceuticals U.S.A.), HYDROCORTISONE BUTYRATE (The J. Molner Company LLC)
Formula
C25H36O6
Exact mass
432.2512
Mol weight
432.55
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Dermatological agent
 DG03243  Atopic dermatitis agent
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Therapeutic category: 2646
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07AB02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Atopic dermatitis [DS:H01358]
Seborrheic dermatitis [DS:H01652]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
    D07AB Corticosteroids, moderately potent (group II)
     D07AB02 Hydrocortisone butyrate
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Medium Potency
    Hydrocortisone
     D01619  Hydrocortisone butyrate (JP18/USP)
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D01619  Hydrocortisone butyrate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01619  Hydrocortisone butyrate (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D01619  Hydrocortisone butyrate (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone butyrate
    D01619  Hydrocortisone butyrate (JP18/USP)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Hydrocortisone butyrate
    D01619  Hydrocortisone butyrate (JP18/USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
     D01619  Hydrocortisone butyrate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01619  Hydrocortisone butyrate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
    D01619  Hydrocortisone butyrate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D01619  Hydrocortisone butyrate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01619  Hydrocortisone butyrate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01619  Hydrocortisone butyrate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01619  Hydrocortisone butyrate
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01619
Topical steroids potency [br08317.html]
 Classification in the USA
  D01619
 Classification in Japan
  D01619
Rx-to-OTC switch list in Japan [br08314.html]
 D01619
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
Other DBs
CAS: 13609-67-1
PubChem: 7848682
ChEBI: 31674
LigandBox: D01619
NIKKAJI: J8.130B
LinkDB
KCF data

ATOM        31
            1   C1z C    23.4455  -15.4741
            2   C1y C    23.4632  -16.8359
            3   C1z C    24.6253  -14.7814
            4   C1x C    22.2892  -14.7991
            5   C1y C    22.3069  -17.5227
            6   C1x C    25.8286  -16.8824
            7   C1x C    25.8169  -15.4506
            8   C5a C    24.6136  -13.4138
            9   O7a O    25.9754  -14.4939
            10  C1y C    21.0976  -15.4918
            11  C1y C    21.1036  -16.8476
            12  C1x C    22.3069  -18.8845
            13  C1b C    25.8581  -12.7564
            14  O5a O    23.3868  -12.7035
            15  O1a O    19.8767  -14.7874
            16  C1z C    19.9472  -17.5285
            17  C1x C    21.1270  -19.5712
            18  O1a O    27.0672  -13.5018
            19  C2y C    19.9590  -18.8963
            20  C1x C    18.7614  -16.8594
            21  C2x C    18.7732  -19.5889
            22  C1x C    17.5758  -17.5402
            23  C5x C    17.5581  -18.9783
            24  O5x O    16.3665  -19.6182
            25  C7a C    27.1852  -15.1923
            26  C1b C    28.3980  -14.4902
            27  C1b C    29.6109  -15.1923
            28  C1a C    30.8237  -14.4902
            29  O6a O    27.1860  -16.5967
            30  C1a C    23.3905  -14.2074
            31  C1a C    19.9850  -16.2632
BOND        34
            1     3   8 1 #Up
            2     3   9 1 #Down
            3     4  10 1
            4     5  11 1
            5     5  12 1
            6     8  13 1
            7     8  14 2
            8    10  15 1 #Up
            9    11  16 1
            10   12  17 1
            11   13  18 1
            12   16  19 1
            13   16  20 1
            14   19  21 2
            15   20  22 1
            16   21  23 1
            17   23  24 2
            18    6   7 1
            19   10  11 1
            20   17  19 1
            21   22  23 1
            22    9  25 1
            23    1   2 1
            24   25  26 1
            25    1   3 1
            26   26  27 1
            27    1   4 1
            28   27  28 1
            29    2   5 1
            30   25  29 2
            31    2   6 1
            32    1  30 1 #Up
            33    3   7 1
            34   16  31 1 #Up

» Japanese version   » Back

KEGG   DRUG: Hydrocortisone probutate
Entry
D01886                      Drug                                   
Name
Hydrocortisone probutate (USAN);
Hydrocortisone butyrate propionate (JAN);
Hydrocortisone buteprate;
Pandel (TN)
Product
PANDEL (ANI Pharmaceuticals)
Formula
C28H40O7
Exact mass
488.2774
Mol weight
488.61
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Dermatological agent
 DG03243  Atopic dermatitis agent
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Same as: C13358
Therapeutic category: 2646
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07AB11 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D01886  Hydrocortisone probutate (USAN) <JP/US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D01886  Hydrocortisone probutate (USAN) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D01886  Hydrocortisone probutate (USAN) <JP/US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D01886  Hydrocortisone probutate (USAN) <JP/US>
    D07AB Corticosteroids, moderately potent (group II)
     D07AB11 Hydrocortisone buteprate
      D01886  Hydrocortisone probutate (USAN) <JP/US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D01886  Hydrocortisone probutate (USAN) <JP/US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D01886  Hydrocortisone probutate (USAN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D01886  Hydrocortisone probutate (USAN) <JP/US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D01886  Hydrocortisone probutate (USAN) <JP/US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D01886  Hydrocortisone probutate (USAN) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Medium Potency
    Hydrocortisone
     D01886  Hydrocortisone probutate (USAN)
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D01886  Hydrocortisone probutate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01886  Hydrocortisone probutate (USAN); Hydrocortisone butyrate propionate (JAN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
     D01886  Hydrocortisone probutate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01886  Hydrocortisone probutate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
    D01886  Hydrocortisone probutate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D01886  Hydrocortisone probutate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01886  Hydrocortisone probutate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01886  Hydrocortisone probutate (USAN) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01886
Topical steroids potency [br08317.html]
 Classification in Japan
  D01886
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
Other DBs
CAS: 72590-77-3
PubChem: 7848948
ChEBI: 31675
LigandBox: D01886
NIKKAJI: J68.592E
LinkDB
KCF data

ATOM        35
            1   C1y C    13.5800  -11.5500
            2   C1y C    12.3900  -12.2500
            3   C1z C    13.5800  -10.2200
            4   C1x C    15.8900  -11.5500
            5   C1y C    11.2000  -11.5500
            6   C1x C    12.3900  -13.5800
            7   C1z C    14.7700   -9.5200
            8   C1x C    12.3900   -9.5200
            9   C1a C    13.5800   -8.8200
            10  C1x C    15.8900  -10.2200
            11  C1z C    10.0100  -12.2500
            12  C1y C    11.2000  -10.2200
            13  C1x C    11.2000  -14.2800
            14  C5a C    14.7700   -8.1200
            15  C2y C    10.0100  -13.5800
            16  C1x C     8.8200  -11.5500
            17  C1a C    10.0100  -10.8500
            18  O1a O    10.0100   -9.5200
            19  O5a O    13.5800   -7.4200
            20  C2x C     8.8200  -14.2800
            21  C1x C     7.6300  -12.2500
            22  C5x C     7.6300  -13.5800
            23  O5x O     6.4400  -14.2800
            24  C1b C    15.9600   -7.4200
            25  O7a O    17.1500   -8.1200
            26  C7a C    18.3400   -7.4200
            27  C1b C    19.5300   -8.1200
            28  C1a C    20.7200   -7.4200
            29  O6a O    18.3400   -6.0200
            30  O7a O    15.9600   -8.8200
            31  C7a C    17.1500   -9.5200
            32  C1b C    18.4100   -8.8900
            33  C1b C    19.6000   -9.5900
            34  C1a C    20.8600   -8.9600
            35  O6a O    17.1500  -10.9200
BOND        38
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1 #Up
            14   11  15 1
            15   11  16 1
            16   11  17 1 #Up
            17   12  18 1 #Up
            18   14  19 2
            19   15  20 2
            20   16  21 1
            21   20  22 1
            22   22  23 2
            23    7  10 1
            24    8  12 1
            25   13  15 1
            26   21  22 1
            27   14  24 1
            28   24  25 1
            29   25  26 1
            30   26  27 1
            31   27  28 1
            32   26  29 2
            33    7  30 1 #Down
            34   30  31 1
            35   31  32 1
            36   32  33 1
            37   33  34 1
            38   31  35 2

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KEGG   DRUG: Hydrocortisone valerate
Entry
D02288                      Drug                                   
Name
Hydrocortisone valerate (USP);
Westcort (TN)
Product
  Generic
HYDROCORTISONE VALERATE (Cosette Pharmaceuticals), HYDROCORTISONE VALERATE (Cosette Pharmaceuticals), HYDROCORTISONE VALERATE (Glenmark Pharmaceuticals), HYDROCORTISONE VALERATE (Lupin Pharmaceuticals), HYDROCORTISONE VALERATE (Taro Pharmaceuticals U.S.A.), HYDROCORTISONE VALERATE CREAM (Bryant Ranch Prepack), HYDROCORTISONE VALERATE CREAM (Encube Ethicals Private Limited)
Formula
C26H38O6
Exact mass
446.2668
Mol weight
446.58
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
ATC code: A01AC03 A07EA02 C05AA01 D07AA02 D07XA01 H02AB09 S01BA02 S01CB03 S02BA01
Chemical structure group: DG00012
Product (DG00012): D00088<JP/US> D00165<US> D00977<JP> D00978<JP/US> D01619<JP/US> D01886<JP/US> D02288<US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Structure map
map07225  Glucocorticoid and mineralocorticoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AC Corticosteroids for local oral treatment
     A01AC03 Hydrocortisone
      D02288  Hydrocortisone valerate (USP) <US>
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07E INTESTINAL ANTIINFLAMMATORY AGENTS
    A07EA Corticosteroids acting locally
     A07EA02 Hydrocortisone
      D02288  Hydrocortisone valerate (USP) <US>
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AA Corticosteroids
     C05AA01 Hydrocortisone
      D02288  Hydrocortisone valerate (USP) <US>
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AA Corticosteroids, weak (group I)
     D07AA02 Hydrocortisone
      D02288  Hydrocortisone valerate (USP) <US>
   D07X CORTICOSTEROIDS, OTHER COMBINATIONS
    D07XA Corticosteroids, weak, other combinations
     D07XA01 Hydrocortisone
      D02288  Hydrocortisone valerate (USP) <US>
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
    H02AB Glucocorticoids
     H02AB09 Hydrocortisone
      D02288  Hydrocortisone valerate (USP) <US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BA Corticosteroids, plain
     S01BA02 Hydrocortisone
      D02288  Hydrocortisone valerate (USP) <US>
   S01C ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
    S01CB Corticosteroids/antiinfectives/mydriatics in combination
     S01CB03 Hydrocortisone
      D02288  Hydrocortisone valerate (USP) <US>
  S02 OTOLOGICALS
   S02B CORTICOSTEROIDS
    S02BA Corticosteroids
     S02BA01 Hydrocortisone
      D02288  Hydrocortisone valerate (USP) <US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Medium Potency
    Hydrocortisone
     D02288  Hydrocortisone valerate (USP)
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Hydrocortisone
   D02288  Hydrocortisone valerate (USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
     D02288  Hydrocortisone valerate
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
    D02288  Hydrocortisone valerate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D02288  Hydrocortisone valerate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D02288  Hydrocortisone valerate (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02288
Topical steroids potency [br08317.html]
 Classification in the USA
  D02288
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00012  Hydrocortisone
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00012  Hydrocortisone
Other DBs
CAS: 57524-89-7
PubChem: 7849347
LigandBox: D02288
NIKKAJI: J14.546G
LinkDB
KCF data

ATOM        32
            1   C1y C    15.2600   -7.7700
            2   C1y C    14.0700   -8.4700
            3   C1z C    15.2600   -6.4400
            4   C1x C    17.5700   -7.7700
            5   C1y C    12.8800   -7.7700
            6   C1x C    14.0700   -9.8000
            7   C1z C    16.4500   -5.7400
            8   C1x C    14.0700   -5.7400
            9   C1a C    15.2600   -5.0400
            10  C1x C    17.5700   -6.4400
            11  C1z C    11.6900   -8.4700
            12  C1y C    12.8800   -6.4400
            13  C1x C    12.8800  -10.5000
            14  C5a C    16.4500   -4.3400
            15  C2y C    11.6900   -9.8000
            16  C1x C    10.5000   -7.7700
            17  C1a C    11.6900   -7.0700
            18  O1a O    11.6900   -5.7400
            19  C1b C    17.6400   -3.6400
            20  O5a O    15.2600   -3.6400
            21  C2x C    10.5000  -10.5000
            22  C1x C     9.3100   -8.4700
            23  O1a O    18.8300   -4.3400
            24  C5x C     9.3100   -9.8000
            25  O5x O     8.1200  -10.5000
            26  O7a O    17.6745   -5.0613
            27  C7a C    18.8397   -5.7615
            28  C1b C    20.0658   -5.0820
            29  C1b C    21.2960   -5.8210
            30  C1b C    22.5127   -5.1462
            31  C1a C    23.7480   -5.8876
            32  O6a O    18.8155   -7.1399
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1 #Up
            14   11  15 1
            15   11  16 1
            16   11  17 1 #Up
            17   12  18 1 #Up
            18   14  19 1
            19   14  20 2
            20   15  21 2
            21   16  22 1
            22   19  23 1
            23   21  24 1
            24   24  25 2
            25    7  10 1
            26    8  12 1
            27   13  15 1
            28   22  24 1
            29    7  26 1 #Down
            30   26  27 1
            31   27  28 1
            32   28  29 1
            33   29  30 1
            34   30  31 1
            35   27  32 2

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